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1. 发明授权

US11142496B2 Method for synthesis of 9-cis-beta-carotene and formulations thereof 有权
公开(公告)号：US11142496B2
公开(公告)日：2021-10-12
申请号：US16303604
申请日：2017-05-21
申请人： Ramot at Tel-Aviv University Ltd.
发明人： Ehud Gazit , Ludmila Buzhansky , Michael Ioffe , Alon Sayer
IPC分类号： C07C403/24 , C07C45/60 , C07C67/00 , A61K9/00 , A61K31/015 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/44 , C07C67/44 , C07C403/02 , C07C403/00
摘要： The present invention relates to a method for total chemical synthesis of 9-cis-β-carotene (9CBC), and further provides stable formulations thereof.

2. 发明授权

US10029970B2 Method for producing specific α, β-unsaturated aldehydes 有权
公开(公告)号：US10029970B2
公开(公告)日：2018-07-24
申请号：US15518355
申请日：2015-10-15
申请人： DSM IP ASSETS B.V.
发明人： Werner Bonrath , Thomas Netscher , Jan Schuetz , Bettina Wuestenberg
IPC分类号： C07C45/00 , C07C403/00 , C07C45/51 , C07C47/225 , C07C11/12 , C07C5/23
摘要： The present invention relates to an improved method for producing specific α, β-unsaturated aldehydes.

3. 发明授权

US07696396B2 Method for extraction and concentration of carotenoids using supercritical fluids 有权
标题翻译：使用超临界流体提取和浓缩类胡萝卜素的方法
公开(公告)号：US07696396B2
公开(公告)日：2010-04-13
申请号：US11971532
申请日：2008-01-09
申请人： Hans Schonemann , Anthony Gudinas , Kara Williams , Paula Wetmore , Val Krukonis
发明人： Hans Schonemann , Anthony Gudinas , Kara Williams , Paula Wetmore , Val Krukonis
IPC分类号： C07C45/00 , C07C403/00 , C07C7/00
CPC分类号： C07C403/24 , C09B61/00 , Y02P20/544
摘要： Carotenoids are extracted and/or enriched from a mixture containing such compounds. The extraction/enrichment process involves the use of liquefied or supercritical solvents to extract lipids and carotenoids from carotenoid-containing substrates. The extraction process can also be performed in two steps in which lipids and carotenoids are first removed from a carotenoid-containing substrate with a liquefied or supercritical solvent, and subsequently a liquefied or supercritical gas is used to separate the lipids from the carotenoids. The two step process can be reversed to first extract lipids with the liquefied or supercritical gas, and subsequently use the solvent to extract the carotenoids. The process is also applicable to yield an organic solvent-free product from a carotenoid-containing source that was first extracted using an organic solvent.
摘要翻译：从含有这些化合物的混合物中提取和/或富集类胡萝卜素。提取/富集过程涉及使用液化或超临界溶剂从含类胡萝卜素的底物中提取脂质和类胡萝卜素。提取过程也可以在两个步骤中进行，其中首先用液化或超临界溶剂从含类胡萝卜素的底物中除去脂质和类胡萝卜素，随后使用液化或超临界气体从类胡萝卜素中分离脂质。可以颠倒两步过程，首先用液化或超临界气体萃取脂质，随后使用溶剂萃取类胡萝卜素。该方法也适用于从含有类胡萝卜素的源产生无机溶剂产物，该产物首先用有机溶剂萃取。

4. 发明授权

US07470822B2 C10 dialdehyde, synthetic method thereof, and synthetic method of beta-carotene using the same 失效
标题翻译： C10二醛，其合成方法和使用其的β-胡萝卜素的合成方法
公开(公告)号：US07470822B2
公开(公告)日：2008-12-30
申请号：US11576580
申请日：2005-07-15
申请人： Sangho Koo , Samar Kumar Guha
发明人： Sangho Koo , Samar Kumar Guha
IPC分类号： C07C45/00 , C07C47/21 , C07C403/00
CPC分类号： C07C47/21 , C07C17/02 , C07C29/147 , C07C45/29 , C07C51/09 , C07C51/38 , C07C67/08 , C07C403/24 , C07C2601/16 , C07C21/14 , C07C57/02 , C07C57/13 , C07C69/602 , C07C33/14 , C07C33/035
摘要： The novel intermediate compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the practical synthetic process for preparing β-carotene by the use of the above novel compound are disclosed. The synthesis of β-carotene is characterized by the double elimination reactions of the C40 compound containing both the benzenesulfonyl group and the group X (either halogen or ether), which can be prepared by the coupling reaction of the novel C10 dialdehyde with two equivalents of the C15 allylic sulfone, followed by the functional group transformation of the resulting C40 diol either to the corresponding halide or to the ether, to produce the fully conjugated polyene chain.
摘要翻译：公开了可以有效地用于合成基于砜化学的类胡萝卜素化合物的新型中间体化合物及其制备方法，以及通过使用上述新化合物制备β-胡萝卜素的实际合成方法。 β-胡萝卜素的合成的特征在于含有苯磺酰基和X基团（卤素或醚）的C 40化合物的双重消除反应，其可以通过新的C10二醛与两当量的 C15烯丙基砜，随后将所得C 40二醇的官能团转化为相应的卤化物或醚，以产生完全共轭的多烯链。

5. 发明授权

US07015014B2 Isolation of carotenoid crystals 有权
标题翻译：类胡萝卜素晶体的分离
公开(公告)号：US07015014B2
公开(公告)日：2006-03-21
申请号：US10182328
申请日：2001-01-29
申请人： Albert Schaap , Mieke Sibeijn , Johannes Hendrik Wolf
发明人： Albert Schaap , Mieke Sibeijn , Johannes Hendrik Wolf
IPC分类号： C12P23/00 , C12N1/14 , C12N1/16 , C07C403/00
CPC分类号： C07C403/24 , C08F2/32
摘要： The present invention relates to a crystalline carotenoid compound, such as β-carotene, with a purity of at least 95% and with substantially no solvent enclosed in the crystal lattice. The present invention further describes a process to prepare such a highly pure crystalline carotenoid compound from microbial biomass, without the use of a solvent extraction and/or an anti-solvent crystallization process.
摘要翻译：本发明涉及一种结晶类胡萝卜素化合物，如β-胡萝卜素，其纯度至少为95％，基本上没有溶剂包封在晶格中。本发明还描述了一种从微生物生物质制备这种高纯度结晶类胡萝卜素化合物的方法，而不使用溶剂萃取和/或抗溶剂结晶方法。

6. 发明申请

US20050272963A1 Method for the production of acetylene alcohols 审中-公开
标题翻译：生产乙炔醇的方法
公开(公告)号：US20050272963A1
公开(公告)日：2005-12-08
申请号：US10523925
申请日：2003-07-23
申请人： Jochem Henkelmann , Alois Kindler , Jan-Dirk Arndt , Katrin Klass
发明人： Jochem Henkelmann , Alois Kindler , Jan-Dirk Arndt , Katrin Klass
IPC分类号： C07B61/00 , C07C29/42 , C07C33/042 , C07C33/048 , C07C33/14 , C07C33/48 , C07C403/00 , C07C33/04 , C07F1/02
CPC分类号： C07C29/42 , C07C403/08 , C07C2601/16 , C07C33/042 , C07C33/048 , C07C33/14 , C07C33/48
摘要： The present invention relates to a process for preparing acetylene alcohols of the general formula I where R1 and R2 may be the same or different and are each independently hydrogen, a saturated or a mono- or polyunsaturated C1-C30-alkyl, aryl, cycloalkylalkyl or cycloalkyl radical, each of which may optionally be substituted, or a group of the general formula (II) where R3 and R4 may be the same or different and are each independently hydrogen or a saturated or a mono- or polyunsaturated C1-C30-alkyl, aryl, cycloalky alkyl or cycloalkyl radical, each of which may optionally be substituted, and the dashed line may represent an additional double bond, by monoethynylating a ketone of the general formula R1—CO—R2 by (a) reacting lithium with a C1-C10-alkyl halide (b) feeding in acetylene gas (c) adding the ketone.
摘要翻译：本发明涉及一种制备通式I的乙炔醇的方法，其中R 1和R 2可以相同或不同，各自独立地为氢，饱和的或单或多不饱和C 1 -C 30 - 烷基，芳基，环烷基烷基或环烷基，其各自可以任选被取代，或一个通式（II）其中R 3和R 4可以相同或不同，各自独立地为氢或饱和或单不饱和或不饱和的C 1〜其中每一个可以被任选地被取代，并且虚线可以代表另外的双键，通过使通式（I）的酮单乙炔基化，通过（a）使锂与C 1 -C 10 - 烷基 - 取代的C 1 -C 10 - 烷基卤化物（b）在乙炔气中进料（c）加入酮。

7. 发明申请

US20030004144A1 Vitamin d analogues 失效
标题翻译：维生素d类似物
公开(公告)号：US20030004144A1
公开(公告)日：2003-01-02
申请号：US09787664
申请日：2001-03-20
发明人： Kai Holst Hansen
IPC分类号： A61K031/59 , C07C401/00 , C07C403/00
CPC分类号： C07C401/00
摘要： Compounds of the formula I 1 wherein X represents hydrogen or hydroxy; R1 and R2, which may be the same or different, represent hydrogen, (C1-C4)alkyl optionally substituted with one hydroxyl group or one or more fluorine atoms, or, together with the carbon atom to which they are attached, R1 and R2 form a (C3-C5)carbocyclic ring; R3 represents (C1-C4)alkyl, (C1-C4)alkoxy or a halogen atom, such as fluorine, chlorine, bromine, or iodine, and in-vivo hydrolyzable esters thereof with pharmaceutically acceptable acids, may be used in the prophylaxis and/or treatment of dieases characterized by abnormal cell differentiation and/or cell proliferation.
摘要翻译：式I的化合物，其中X表示氢或羟基; R1和R2可以相同或不同，表示氢，任选被一个羟基或一个或多个氟原子取代的（C 1 -C 4）烷基，或与它们所连接的碳原子一起，R 1和R 2 形成（C 3 -C 5）碳环; R3表示（C1-C4）烷基，（C1-C4）烷氧基或卤原子，例如氟，氯，溴或碘，并且其体内可水解的酯与药学上可接受的酸可用于预防和 /或以异常细胞分化和/或细胞增殖为特征的病毒的治疗。

8. 发明申请

US20020188162A1 High purity 9,9-bis-(hydroxyphenyl)-fluorene and method for the preparation and purification thereof 失效
标题翻译：高纯度9,9-双 - （羟基苯基） - 芴及其制备和纯化方法
公开(公告)号：US20020188162A1
公开(公告)日：2002-12-12
申请号：US10118573
申请日：2002-04-08
申请人： Ferrania, S.p.A.
发明人： Simone Angiolini , Mauro Avidano
IPC分类号： C08G059/00 , C08G065/08 , C08G065/14 , C07C015/02 , C07C403/00
CPC分类号： C07C39/17 , C07C37/685 , C07C37/84 , C07C2603/18
摘要： A 9,9-bis (4-hydroxyphenyl) fluorene compound showing a melting curve maximum of at least 226.00null C. and a melting curve width at 5% equal to or lower than 1.30null C. A purification process for the preparation of 9,9-bis (4-hydroxyphenyl) fluorene compounds comprising a first purification step employing acetonitrile and a second purification step employing a solvent selected from the group consisting of aliphatic alcools, a mixture of aromatic hydrocarbons and aliphatic alco-hols and a mixture of aromatic hydrocarbons and nitrites. A synthesis method for the preparation of 9,9-bis (4-hydroxyphenyl) fluorene compounds comprising the steps of (a) reacting in an organic solvent a phenol compound with a 9-fluorenone in the presence of an acidic condensing agent, (b) separating the crude 9,9-bis (4-hydroxyphenyl) fluorene, and (c) purifying the crude 9,9-bis (4-hydroxyphenyl) fluorene, wherein the purifying method comprises a first purification step employing acetonitrile solvent and a second purification step employing a solvent selected from the group consisting of aliphatic alcools, a mixture of aromatic hydrocarbons and aliphatic alcohols and a mixture of aromatic hydrocarbons and nitrites.
摘要翻译： 9,9-双（4-羟基苯基）芴化合物，其熔解曲线最大值为至少226.00℃，熔解曲线宽度为5％等于或低于1.30℃。制备9 包括使用乙腈的第一纯化步骤的9-双（4-羟基苯基）芴化合物和使用选自脂族醇，芳族烃和脂族醇醚的混合物和芳香族混合物的溶剂的第二纯化步骤的第二纯化步骤碳氢化合物和亚硝酸盐。一种制备9,9-双（4-羟基苯基）芴化合物的合成方法，包括以下步骤：（a）在酸性缩合剂存在下，在有机溶剂中使酚化合物与9-芴酮反应，（b ）分离粗制9,9-双（4-羟基苯基）芴，和（c）纯化9,9-双（4-羟基苯基）芴原油，其中纯化方法包括使用乙腈溶剂的第一纯化步骤和第二步纯化步骤，使用选自脂族醇，芳族烃和脂族醇的混合物以及芳族烃和亚硝酸盐的混合物的溶剂。

9. 发明申请

US20020099039A1 Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same 失效
公开(公告)号：US20020099039A1
公开(公告)日：2002-07-25
申请号：US10035211
申请日：2002-01-04
申请人： TEIJIN LIMITED
发明人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
IPC分类号： A61K031/59 , C07C401/00 , C07C403/00
CPC分类号： C07C401/00 , C07F7/1804 , Y02P20/55
摘要： Compounds expressed by the following general formula (1), 1 nullwherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)null. 2 The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

10. 发明申请

US20020049344A1 NEW VITAMIN D DERIVATIVES WITH CARBO-OR HETEROCYCLIC SUBSTITUENTS AT C-25, A PROCESS FOR THEIR PRODUCTION, INTERMEDIATE PRODUCTS AND THEIR USE FOR PRODUCING MEDICAMENTS 失效
标题翻译： C-25的新型维生素D衍生物，其生产，中间产品及其生产药物的使用方法C-25
公开(公告)号：US20020049344A1
公开(公告)日：2002-04-25
申请号：US09180018
申请日：1998-12-11
发明人： ANDREAS STEINMEYER , GERALD KIRSCH , GUNTER NEFF , KATICA SCHWARZ , RUTH THIEROFF-EKERDT , HERBERT WIESINGER , MARTIN HABEREY , MARIANNE FAHNRICH
IPC分类号： C07C403/00 , C07J053/00 , C07C401/00 , A61K031/59 , A61K031/58 , C07D263/08 , C07D413/00 , C07D263/12
CPC分类号： C07D207/333 , C07C35/32 , C07C401/00 , C07D233/64 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/24 , C07D307/42 , C07D333/16
摘要： The invention concerns new vitamin D derivatives of general formula (I) a process for their production, their use for production of medicaments, and intermediate products used in the process. 1
摘要翻译：本发明涉及通式（I）的新维生素D衍生物，其生产方法，其用于制备药物的用途以及该方法中使用的中间产物。

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