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1. 发明授权

US09409853B2 Polyglycerol partial esters, preparation and use thereof 有权
标题翻译：聚甘油偏酯，其制备和用途
公开(公告)号：US09409853B2
公开(公告)日：2016-08-09
申请号：US14564408
申请日：2014-12-09
申请人： Dominik Schuch , Wolfgang Berkels , Oliver Springer , Christian Hartung , Hilke Condé , Baerbel Klann-Metz
发明人： Dominik Schuch , Wolfgang Berkels , Oliver Springer , Christian Hartung , Hilke Condé , Baerbel Klann-Metz
IPC分类号： C07C59/00 , C07C69/52 , C07C67/08 , A61K8/37 , C07C69/732 , A61K8/39 , A61Q1/14 , A61Q5/02 , A61Q15/00 , A61K8/86 , A61Q19/10
CPC分类号： C07C69/52 , A61K8/375 , A61K8/39 , A61K8/86 , A61K2800/30 , A61K2800/49 , A61Q1/14 , A61Q5/02 , A61Q15/00 , A61Q19/10 , C07C67/08 , C07C69/732
摘要： Polyglycerol partial esters of a specific composition which are capable of solubilizing very hydrophobic, oil-soluble substances in aqueous solution are provided. The preparation and use of these polyglycol ether-free solubilizers in cosmetic formulations are also disclosed.
摘要翻译：提供了能够将非常疏水的油溶性物质溶解在水溶液中的特定组合物的聚甘油偏酯。还公开了这些不含聚乙二醇醚的增溶剂在化妆品制剂中的制备和使用。

2. 发明授权

US09364454B2 Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers 有权
标题翻译：神经保护素D1 /保护素D1及其天然立体异构体的抗炎作用
公开(公告)号：US09364454B2
公开(公告)日：2016-06-14
申请号：US13625865
申请日：2012-09-24
申请人： Charles N. Serhan , Nicos A. Petasis , Bruce D. Levy
发明人： Charles N. Serhan , Nicos A. Petasis , Bruce D. Levy
IPC分类号： C07C59/00 , A61K31/202 , C07C59/42 , C07C69/732
CPC分类号： A61K31/202 , C07C59/42 , C07C69/732
摘要： The invention describes novel isolated, purified, 10,17-dihydroxy-docosahexaenoic acids, esters, derivatives and their preparation.
摘要翻译：本发明描述了新的分离，纯化的10,17-二羟基 - 二十二碳六烯酸，酯，衍生物及其制备方法。

3. 发明授权

US09273264B2 Ester compound, lubricant base oil, lubricant, grease base oil, and grease 有权
标题翻译：酯化合物，润滑剂基础油，润滑剂，油脂基础油和油脂
公开(公告)号：US09273264B2
公开(公告)日：2016-03-01
申请号：US14008890
申请日：2012-03-23
申请人： Yoshio Hironaka , Hiroki Sekiguchi
发明人： Yoshio Hironaka , Hiroki Sekiguchi
IPC分类号： C07C59/00 , C10M105/34 , C10M105/38
CPC分类号： C10M105/34 , C07C43/13 , C07C69/24 , C10M105/38 , C10M2207/2815 , C10M2207/2835 , C10N2220/022 , C10N2230/02 , C10N2240/02 , C10N2240/204 , C10N2250/10
摘要： An ester compound is represented by the following formula (1). In the formula: R1 and R2 each independently represent an alkyl group having 5 to 18 carbon atoms; R3n represents a hydrogen atom or an alkyl group having at most 5 carbon atoms; R4n represents hydrogen or CH2OR5n; R5n represents an alkyl group having 5 to 18 carbon atoms; and n represents an integer of 1 to 3.
摘要翻译：酯化合物由下式（1）表示。式中，R 1和R 2各自独立地表示碳原子数为5〜18的烷基。 R3n表示氢原子或至多5个碳原子的烷基; R4n表示氢或CH2OR5n; R5n表示碳原子数5〜18的烷基。 n表示1〜3的整数。

4. 发明授权

US08653300B2 Method for making hindered phenolic antioxidant 失效
标题翻译：阻碍酚类抗氧化剂的制备方法
公开(公告)号：US08653300B2
公开(公告)日：2014-02-18
申请号：US12461153
申请日：2009-08-03
申请人： Dein-Run Fung , Jung-Jen Chuang , Zhang-Jian Huang , Chung-Yu Chen
发明人： Dein-Run Fung , Jung-Jen Chuang , Zhang-Jian Huang , Chung-Yu Chen
IPC分类号： C07C59/00 , C07C65/03
CPC分类号： C07C67/03 , C07C67/52 , C07C69/732
摘要： A method for making a hindered phenolic antioxidant based on Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate uses a methanol solution containing alkali metal methoxide as a catalyst solution, wherein the catalyst solution is filtered with a filter device with a filter pore diameter of less than 50 μm to remove insoluble matters therefrom before used in a transesterification process where methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate and 1-Octadecanol are taken as reactants to obtain a crude product of Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate having high conversion rate and low color, and the crude product further undergoes a purification process for crystallization, filtering and drying to obtain a product of Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate having high purity and low color.
摘要翻译：制备基于3-（3,5-二 - 叔丁基-4-羟基苯基）丙酸十八烷基酯的受阻酚类抗氧化剂的方法使用含有碱金属甲醇盐的甲醇溶液作为催化剂溶液，其中催化剂溶液用过滤装置，过滤器孔径小于50um，以除去不溶性物质，然后使用3-（3,5-二叔丁基-4-羟基苯基）丙酸甲酯和1-十八烷醇作为酯交换反应反应物，得到具有高转化率和低颜色的3-十八烷基3-（3,5-二叔丁基-4-羟基苯基）丙酸十八烷基酯的粗产物，粗产物进一步进行结晶，过滤和干燥的纯化过程得到纯度高，颜色低的3-十八烷基3-（3,5-二叔丁基-4-羟基苯基）丙酸十八烷基酯的产物。

5. 发明授权

US08604229B2 Lipoxin analogs and methods for the treatment of periodontal disease 有权
标题翻译：脂氧素类似物和治疗牙周病的方法
公开(公告)号：US08604229B2
公开(公告)日：2013-12-10
申请号：US13346543
申请日：2012-01-09
申请人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
发明人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
IPC分类号： C07C59/00
CPC分类号： A61K31/202 , A61K31/22 , A61K31/365 , C07B2200/07 , C07C69/732 , C07C69/736 , C07C229/30 , C07C235/28 , C07C259/06 , C07C2601/16 , A61K2300/00
摘要： This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond the oral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
摘要翻译：本发明提供了新的脂氧素类似物，含有类似物的组合物，以及使用这些化合物和组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其它形式的牙周病。本发明还提供了含有COX-2抑制剂的组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其他形式的牙周病。此外，本发明提供使用含有脂氧素类似物，COX-2抑制剂或两者的组合物来预防与牙周疾病相关的口腔以外的全身疾病的方法。

6. 发明授权

US08575380B2 Branched polyethylene glycol linked with diacyl glycerol, process for producing the same, and polyethylene glycol modified liposome 有权
标题翻译：与二酰基甘油连接的分支聚乙二醇，其制备方法和聚乙二醇改性的脂质体
公开(公告)号：US08575380B2
公开(公告)日：2013-11-05
申请号：US13653624
申请日：2012-10-17
申请人： NOF Corporation
发明人： Fumiaki Manabe , Yuji Yamamoto
IPC分类号： C07C51/00 , C07C59/00
CPC分类号： C08G65/2615 , C08G65/2609 , C08G65/3322 , C08G2650/54
摘要： Provided is a polyethylene glycol derivative which contains two PEG chains, which is bound to a diacylglycerol, which has high purity, and which enhances the stability of liposomes. Polyethylene glycol is represented by the following formula (1) and which is bound to a diacylglycerol: In Formula (1), R1 is a hydrocarbon group containing 1 to 7 carbon atoms, R2 is an alkyl or alkenyl group containing 9 to 21 carbon atoms, n is the average number of moles of added polyethylene glycol chains, 10≦n≦100, and X is a linker site between branched polyethylene glycol and the diacylglycerol and is represented by the following formula (2): —(CH2)l-Y—(CH2)m- (2) In Formula (2), Y is an ether bond, an ester bond, a urethane bond, an amide bond, or a carbonate bond and l and m are an integer of 0 to 6.
摘要翻译：提供了含有两个PEG链的聚乙二醇衍生物，其与纯度高的二酰基甘油结合，并且增强了脂质体的稳定性。聚乙二醇由下式（1）表示，其与二酰基甘油结合：式（1）中，R 1为含有1〜7个碳原子的烃基，R 2为含有碳原子数为9〜21的烷基或链烯基，n是加成的聚乙二醇链的平均摩尔数，10≤n≤100，X是支化聚乙二醇和二酰基甘油之间的连接位点，并由下式（2）表示： - （CH 2）1 Y- （CH2）m-（2）在式（2）中，Y是醚键，酯键，氨基甲酸酯键，酰胺键或碳酸键，l和m是0-6的整数。

7. 发明授权

US08552062B2 Methods for the treatment of metabolic disorders such as diabetes 有权
标题翻译：治疗代谢性疾病如糖尿病的方法
公开(公告)号：US08552062B2
公开(公告)日：2013-10-08
申请号：US11535779
申请日：2006-09-27
申请人： Shalini Sharma , Reid W. von Borstel , Kirvin L. Hodge
发明人： Shalini Sharma , Reid W. von Borstel , Kirvin L. Hodge
IPC分类号： A61K31/19 , A61K31/192 , C07C59/00 , C07C57/03 , C07C57/30 , C07C57/38
CPC分类号： C07B41/12 , A01N37/10 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/41 , A61K31/4196 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07C59/68 , C07C59/90 , C07C67/47 , C07C69/738 , C07C209/68 , C07C217/22 , C07C233/31 , C07C233/47 , C07C235/78 , C07C235/84 , C07C259/06 , C07C323/52 , C07C323/59 , C07C2601/02 , C07C2601/04 , C07C2602/04 , C07D213/30 , C07D213/55 , C07D249/10 , C07D249/12 , C07D257/04 , C07D333/16 , C07D333/24 , Y10S514/866
摘要： Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
摘要翻译：公开了可用于治疗各种代谢紊乱（例如胰岛素抵抗综合征，糖尿病，高脂血症，脂肪肝疾病，恶病质，肥胖症，动脉粥样硬化和动脉硬化）的化合物。

8. 发明授权

US08536223B2 Use of PUFAs for treating skin inflammation 有权
标题翻译：使用PUFA治疗皮肤炎症
公开(公告)号：US08536223B2
公开(公告)日：2013-09-17
申请号：US13318290
申请日：2010-04-29
申请人： Adam Kelliher , Angus Morrison , Phil Knowles
发明人： Adam Kelliher , Angus Morrison , Phil Knowles
IPC分类号： A61K31/225 , A61K31/20 , C07C59/00 , A23D9/00
CPC分类号： A61K9/0014 , A61K31/202 , A61K31/573 , A61K45/06 , C07C59/42
摘要： The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, for use in treating various skin disorders.
摘要翻译：本发明提供了一种化合物，其为式（I）的多不饱和脂肪酸（PUFA）衍生物或其药学上可接受的盐或溶剂合物，用于治疗各种皮肤病。

9. 发明授权

US08519173B2 Plant growth regulator 失效
标题翻译：植物生长调节剂
公开(公告)号：US08519173B2
公开(公告)日：2013-08-27
申请号：US13395948
申请日：2010-09-13
申请人： Mineyuki Yokoyama
发明人： Mineyuki Yokoyama
IPC分类号： C07C59/00 , A01N25/00
CPC分类号： C07C59/90 , A01N37/42 , A01N53/00 , C07C2601/02
摘要： Provided is a plant growth regulator having for an active ingredient thereof an α-ketol fatty acid derivative represented by the following general formula (1)
摘要翻译：本发明提供一种具有活性成分的植物生长调节剂，其由以下通式（1）表示的α-酮醇脂肪酸衍生物，

10. 发明授权

US08435766B2 Enzymatic oil recuperation process 有权
标题翻译：酶油回收过程
公开(公告)号：US08435766B2
公开(公告)日：2013-05-07
申请号：US12661429
申请日：2010-03-17
申请人： Marc Kellens , Wim De Greyt
发明人： Marc Kellens , Wim De Greyt
IPC分类号： C12P7/64 , C07C59/00
CPC分类号： C12P7/6445 , C12P7/6418
摘要： A process for the recuperation of acylglycerols or acylglycerols containing free fatty acids from gums, present as aqueous emulsions, said gums being obtained by subjecting triglyceride oil to one or more degumming processes, said recuperation process comprising the steps of: subjecting said gums to enzymatic hydrolysis catalyzed by one or more enzymes with phospholipase activity; allowing said gums to separate into two or more phases, said two or more phases including at least an oily phase and an aqueous phase; and recuperating said oily phase comprising acylglycerols or acylglycerols containing free fatty acids; wherein said enzymatic hydrolysis is accelerated by adding at least part of the one or more enzymes with phospholipase activity to at least part of the water used in the recuperation and/or at least one degumming process; and/or at least part of said triglyceride oils treated in said degumming process; and/or by facilitating mixing at least part of said one or more enzymes with phospholipase activity into said gums by increasing the triglyceride oil content of said gums; and an oil obtained by this process.
摘要翻译：一种由作为水性乳液存在的来自树胶的含有游离脂肪酸的酰基甘油或酰基甘油的回收方法，所述树胶通过使甘油三酯油进行一种或多种脱胶方法而获得，所述还原方法包括以下步骤：使所述树胶经酶促水解由一种或多种具有磷脂酶活性的酶催化; 允许所述树胶分离成两个或更多个相，所述两个或更多个相包括至少一个油相和一个水相; 并使包含含有游离脂肪酸的酰基甘油或酰基甘油的所述油相回收; 其中所述酶水解通过将至少部分一种或多种具有磷脂酶活性的酶加到至少部分用于还原和/或至少一种脱胶过程中的水中来加速; 和/或在所述脱胶过程中处理的所述甘油三酯油的至少一部分; 和/或通过增加所述牙龈的甘油三酯油含量，促进将至少部分所述一种或多种酶与磷脂酶活性混合到所述牙龈中; 和通过该方法获得的油。

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