专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180250277A1 POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR 审中-公开
公开(公告)号：US20180250277A1
公开(公告)日：2018-09-06
申请号：US15857889
申请日：2017-12-29
申请人： H. Lundbeck A/S
发明人： Jorgen Eskildsen , Anette Graven Sams , Ask Puschl
IPC分类号： A61K31/44 , A61K31/436 , C07D405/12 , C07D491/056 , A61K31/4355 , A61K31/443 , A61K31/4427 , A61K31/4433 , A61K31/505 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/647 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/84 , C07D213/85 , C07D239/34
CPC分类号： A61K31/44 , A61K31/4355 , A61K31/436 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/647 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/84 , C07D213/85 , C07D239/34 , C07D405/12 , C07D491/056
摘要： The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

2. 发明授权

US10059667B2 Antidiabetic compounds 有权
公开(公告)号：US10059667B2
公开(公告)日：2018-08-28
申请号：US15110894
申请日：2015-02-03
申请人： MERCK SHARP & DOHME CORP. , Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Cangming Yang , Rui Zhang
发明人： Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Cangming Yang
IPC分类号： C07D211/42 , A61K45/06 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/44 , C07D231/20 , A61K31/4985 , C07D401/04 , C07D239/52 , C07C217/52 , C07D205/04 , C07D491/056 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/12 , C07D209/52 , C07D209/54 , C07D211/22 , C07D213/30 , C07D213/64 , C07D213/65 , C07D213/69 , C07D307/86 , C07D307/88 , C07C59/72 , C07D205/12 , C07D213/647
CPC分类号： C07D211/42 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/4985 , A61K45/06 , C07C59/72 , C07C217/52 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D205/12 , C07D207/08 , C07D207/10 , C07D207/12 , C07D209/52 , C07D209/54 , C07D211/22 , C07D213/30 , C07D213/64 , C07D213/647 , C07D213/65 , C07D213/69 , C07D231/20 , C07D239/52 , C07D265/30 , C07D307/86 , C07D307/88 , C07D401/04 , C07D491/056 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

3. 发明授权

US09878982B2 Pyridine derivatives and anti-mycobacterial use thereof 有权
公开(公告)号：US09878982B2
公开(公告)日：2018-01-30
申请号：US15325824
申请日：2015-07-09
申请人： CISEN PHARMACEUTICAL CO., LTD.
发明人： Zhaozhong Ding , Shuhui Chen , Zhigang Huang , Wei Luo , Zhe Cai , Yepeng Wang , Dongdong Tang
IPC分类号： C07D213/64 , C07D401/04 , C07D405/04 , C07D409/04 , A61K31/44 , C07D213/643 , C07D213/647 , C07D213/57 , C07D417/04
CPC分类号： C07D213/643 , A61K31/44 , C07D213/57 , C07D213/64 , C07D213/647 , C07D213/74 , C07D401/04 , C07D401/06 , C07D405/04 , C07D409/04 , C07D417/04
摘要： Disclosed are a method for preparing a series of novel pyridine derivatives and a use thereof. Such derivatives can be used in the treatment of related diseases caused by mycobacteria, in particular diseases caused by pathogenic mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium and Mycobacterium marinum.

4. 发明申请

US20160332968A1 ANTIDIABETIC COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：US20160332968A1
公开(公告)日：2016-11-17
申请号：US15110894
申请日：2015-02-03
申请人： Harry CHOBANIAN , Duane DEMONG , Yan Guo , Zhiyong Hu , Barbara PIO , Christopher PLUMMER , Dong XIAO , Cangming YANG , Rui ZHANG , Merck Sharp & Dohme Corp. , Michael MILLER
发明人： Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Michael Yang
IPC分类号： C07D211/42 , C07D211/22 , C07D205/04 , C07D209/54 , C07D209/52 , C07D207/12 , C07D205/12 , C07C217/52 , C07D401/04 , C07D265/30 , C07C59/72 , C07D213/64 , C07D213/69 , C07D239/52 , C07D231/20 , C07D307/88 , C07D491/056 , C07D307/86 , C07D213/30 , C07D213/647 , C07D207/08
CPC分类号： C07D211/42 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/4985 , A61K45/06 , C07C59/72 , C07C217/52 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D205/12 , C07D207/08 , C07D207/10 , C07D207/12 , C07D209/52 , C07D209/54 , C07D211/22 , C07D213/30 , C07D213/64 , C07D213/647 , C07D213/65 , C07D213/69 , C07D231/20 , C07D239/52 , C07D265/30 , C07D307/86 , C07D307/88 , C07D401/04 , C07D491/056 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症

5. 发明授权

US08765790B2 Positive allosteric modulators of nicotinic acetylcholine receptor 有权
公开(公告)号：US08765790B2
公开(公告)日：2014-07-01
申请号：US13934355
申请日：2013-07-03
申请人： H. Lundbeck A/S
发明人： Jørgen Eskildsen , Anette Graven Sams , Ask Püschl
IPC分类号： C07D213/647 , C07D405/12 , A61K31/44 , C07D239/34 , A61K31/4433 , A61K31/505 , C07D213/71 , C07D491/056 , C07D213/84 , A61K31/443 , C07D213/61 , A61K45/06 , C07D213/85 , C07D213/65 , A61K31/4427 , C07D213/74 , A61K31/4355 , C07D213/40
CPC分类号： A61K31/44 , A61K31/4355 , A61K31/436 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/647 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/84 , C07D213/85 , C07D239/34 , C07D405/12 , C07D491/056
摘要： The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

6. 发明申请

US20140010898A1 New positive allosteric modulators of nicotinic acetylcholine receptor 有权
公开(公告)号：US20140010898A1
公开(公告)日：2014-01-09
申请号：US13934355
申请日：2013-07-03
申请人： H. Lundbeck A/S
发明人： Jorgen Eskildsen , Anette Graven Sams , Ask Püschl
IPC分类号： C07D213/647 , A61K45/06 , A61K31/443 , A61K31/4433 , A61K31/44 , C07D405/12
CPC分类号： A61K31/44 , A61K31/4355 , A61K31/436 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/647 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/84 , C07D213/85 , C07D239/34 , C07D405/12 , C07D491/056
摘要： The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

7. 发明授权

US5089511A Insecticides and nematicides 失效
标题翻译：杀虫剂和杀虫剂
公开(公告)号：US5089511A
公开(公告)日：1992-02-18
申请号：US467040
申请日：1990-01-18
申请人： Werner Bonin , Jean-Pierre Demoute , Jean Tessier
发明人： Werner Bonin , Jean-Pierre Demoute , Jean Tessier
IPC分类号： C07D209/48 , A01N53/00 , A01N53/02 , A23K1/16 , B01J27/122 , C07B37/04 , C07B61/00 , C07C67/343 , C07C69/743 , C07C235/06 , C07C253/30 , C07C255/37 , C07C255/39 , C07C327/44 , C07D213/64 , C07D213/647 , C07D213/68 , C07D233/72 , C07D307/45 , C07D309/38 , C07F7/18
CPC分类号： C07D213/647 , A01N53/00 , A23K20/00
摘要： A process for the preparation of trifluoromethylvinyl compounds in all their possible steroisomeric forms and mixtures thereof comprising reacting a salt of trifluoroacetic acid with a halovinyl compound in the presence of a cuprous salt to obtain the same stero-specific compound and all possible stero-isomeric forms and mixtures thereof of 1R, trans compounds of the formula ##STR1## wherein R is an alcohol residue used in pyrethrinoid series, or an alcohol residue capable of blocking the acid function, and Z is aryl or haloaryl and the double bond has Z geometry having pesticide activity.

8. 发明授权

US4808749A Cyclopropane carboxylic esters and acids 失效
标题翻译：环丙烷羧酸酯和酸
公开(公告)号：US4808749A
公开(公告)日：1989-02-28
申请号：US932179
申请日：1986-11-18
申请人： Jacques Martel , Jean Tessier , Andre Teche
发明人： Jacques Martel , Jean Tessier , Andre Teche
IPC分类号： A01N53/00 , A01N53/02 , A23K1/16 , A61K31/22 , A61K31/225 , C07D213/64 , C07D213/647 , C07D233/74 , C07F9/40 , C07C121/46 , C07C53/134
CPC分类号： C07D213/647 , A01N53/00 , A23K20/105 , A23K20/111 , A61K31/22 , A61K31/225 , C07D233/74 , C07F9/4006
摘要： Novel esters in all possible isomeric forms of the formula ##STR1## wherein R is selected from the group consisting of (a) optionally unsaturated alkyl of 1 to 8 carbon atoms and optionally unsaturated cycloalkyl or cycloalkyl-alkyl of 3 to 8 carbon atoms optionally substituted with at least one member of the group consisting of halogen, --OH, --SH, --OR', --SR', --NO.sub.2, ##STR2## --CN, --SO.sub.3 H, --PO.sub.4 H.sub.2, ##STR3## --SO.sub.2 AlK.sub.2, --SO.sub.3 AlK.sub.3, aryl optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF.sub.3, --OCF.sub.3, --SCF.sub.3 and ##STR4## R' is alkyl of 1 to 8 carbon atoms, R" and R"' are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, AlK.sub.1, AlK.sub.2 and AlK.sub.3 are individually alkyl of 1 to 18 carbon atoms, (b) aryl of 6 to 14 carbon atoms optionally substituted with at least one substitutent selected from the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --OCF.sub.3, --CF.sub.3 and --SCF.sub.3 and (c) heterocycle optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF.sub.3, --OCF.sub.3 and --SCF.sub.3, B is selected from the group consisting of optionally unsaturated alkyl of 1 to 18 carbon atoms, optionally unsaturated cycloalkyl of 3 to 18 carbon atoms and the remainder of an alcohol used in synthesis of pyrethrinoid esters, X is halogen and the ethylenic double bond may have Z or E geometry having parasitic activity, especially insecticidal acaricidal and nematocidal activity.
摘要翻译：式（Ⅰ）的所有可能异构体形式的新型酯，其中R选自（a）1-8个碳原子的任选不饱和烷基和任选不饱和的环烷基或3-8个碳原子的环烷基 - 烷基，被至少一个由卤素，-OH，-SH，-OR'，-SR'，-NO 2，-CN，-SO 3 H，-PO 4 H 2，-SO 2 AlK 2，-SO 3 AlK 3 任选被-OH，1-8个碳原子的烷氧基，1-8个碳原子的烷基，卤素，-CF 3，-OCF 3，-SCF 3和R'中的至少一个成员取代的芳基是 1至8个碳原子的烷基，R“和R”'分别选自氢和1至8个碳原子的烷基，AlK1，AlK2和AlK3分别为1至18个碳原子的烷基（ b）6至14个碳原子的芳基，任选被至少一个选自-OH，1至8个碳原子的烷氧基，1〜 8个碳原子，卤素，-OCF 3，-CF 3和-SCF 3和（c）任选被至少一个选自-OH，1-8个碳原子的烷氧基，1至8个碳原子的烷基取代的杂环，卤素，-CF 3，-OCF 3和-SCF 3，B选自任选不饱和的1至18个碳原子的烷基，任选地具有3至18个碳原子的不饱和环烷基，剩余的用于合成除虫菊酯的醇 X是卤素，烯键式双键可具有具有寄生活性的Z或E几何形状，特别是杀虫杀螨和杀线虫活性。

9. 发明授权

US4732903A Certain cyclopropyl dicarboxylates having pesticidal and insecticidal activity 失效
标题翻译：某些具有杀虫活性和杀虫活性的环丙基二羧酸酯
公开(公告)号：US4732903A
公开(公告)日：1988-03-22
申请号：US756396
申请日：1985-07-17
申请人： Jacques Martel , Jean Tessier , Andre Teche
发明人： Jacques Martel , Jean Tessier , Andre Teche
IPC分类号： A01N53/00 , A23K1/16 , A61K31/22 , C07D209/48 , C07D213/64 , C07D213/647 , C07D233/72 , C07D307/20 , C07D307/45 , C07D309/12 , C07D213/55 , A01N43/40 , C07C69/743 , C07C121/75
CPC分类号： C07D213/647 , A01N53/00 , A23K20/105 , A23K20/111 , A23K20/132 , A61K31/22 , C07D209/48 , C07D233/72 , C07D307/20 , C07D307/42 , C07D309/12
摘要： Novel isomers and mixtures thereof of cyclopropane carboxylic acid derivatives with a 3-unsaturated side chain of the formula ##STR1## wherein A' is selected from the group consisting of wherein B is selected from the group consisting of --CH.sub.2 --, ##STR2## --O-- and --S--, R.sub.4 is selected from the group consisting of hydrogen, --CH.sub.3,--C.tbd.N--CONH.sub.2, --CSNH.sub.2 and --C.tbd.CH, n is an integer from 0, 1 or 2 and R.sub.5 is selected from the group consisting of halogen and --CH.sub.3 ##STR3## wherein R.sub.13 is selected from the group consisting of hydrogen and ##STR4## wherein R.sub.13 has the above definition and the benzoyl is in the 3- or 4-position, ##STR5## wherein R.sub.14 is selected from the group consisting of hydrogen, methyl, ethynyl and --CN and R.sub.15 and R.sub.16 are individually selected from the group consisting of hydrogen, bromine and fluorine and ##STR6## wherein R.sub.14 has the above definition, p is 0, 1 or 2, each R.sub.17 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, --CF.sub.3, 3,4-methylenedioxy, chlorine, bromine and fluorine B' is selected from the group consisting of --O-- and --S-- and R is selected from the group consisting of alkyl of 1 to 18 carbon atoms substituted with one or more, optionally different functional groups, aryl of 6 to 14 carbon atoms optionally substituted with one or more optionally different functional groups, the double bond having Z or E geometry having insecticidal and nematocidal activity as well as plant and animal acaricidal activity and their preparation.
摘要翻译：环丙烷羧酸衍生物与式（I）所示的3-不饱和侧链的新颖异构体及其混合物，其中A'选自由下列组成的组：其中B选自： -CH 2 - ， -O-和-S-，R 4选自氢，-CH 3，-C 3BOND N CONH 2，-CSNH 2和-C 3 CH 3，n是0的整数，（3）其中R 13选自氢和（4）其中R 13具有上述基团，其中R 13选自氢和（14）其中R 14选自氢，甲基，乙炔基和-CN，R 15和R 16分别选自氢，，溴和氟，并且其中R 14具有上述定义，p为0,1或2，每个R 17选自1至4个碳原子的烷基 1至4个碳原子的烷氧基，1至4个碳原子的烷硫基，1至4个碳原子的烷基磺酰基，-CF 3，3,4-亚甲二氧基，氯，溴和氟B'选自： -O-和-S-，并且R选自被一个或多个任选不同的官能团取代的1至18个碳原子的烷基，任选被一个或多个任选不同的官能团取代的6至14个碳原子的芳基组，具有Z或E几何形状的双键具有杀虫和杀线虫活性以及植物和动物杀螨活性及其制备。

10. 发明授权

US4587255A Isomers of 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid-.alpha.-methyl-(6-phenoxy-2-picolyl)ester, processes for producing them, and their use for controlling pests 失效
标题翻译： 3-（2,2-二氯乙烯基）-2,2-二甲基环丙烷甲酸-α-甲基 - （6-苯氧基-2-吡啶甲基）酯的异构体，其制备方法及其用于防治害虫
公开(公告)号：US4587255A
公开(公告)日：1986-05-06
申请号：US559544
申请日：1983-12-08
申请人： Peter Ackermann , Laurenz Gsell , Boris Kohler
发明人： Peter Ackermann , Laurenz Gsell , Boris Kohler
IPC分类号： A01N53/00 , A01N53/08 , C07D213/64 , C07D213/647 , A01N43/40
CPC分类号： C07D213/647 , A01N53/00
摘要： Novel isomers of the compound of the formula ##STR1## are described, and processes for producing these compounds and their use for controlling pests are given.
摘要翻译：描述了式“IMAGE”化合物的新异构体，并且给出了这些化合物的制备方法及其用于防治害虫的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式