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1. 发明申请

US20230130333A1 METHOD FOR MANUFACTURING PHOSPHONATE ESTERS AND METHOD FOR MANUFACTURING PHOSPHATE ESTERS 有权
公开(公告)号：US20230130333A1
公开(公告)日：2023-04-27
申请号：US17908176
申请日：2021-03-03
申请人： FUJIFILM Wako Pure Chemical Corporation
发明人： Shu KOBAYASHI , Yuki SAITO
IPC分类号： C07F9/144 , C07F9/142 , C07F9/58 , C07F9/145 , C07H19/10 , C07H19/207 , C07F9/143 , B01J31/04
摘要： The present invention provides a method for efficiently manufacturing a phosphonate ester by phosphonylating an alcohol under mild conditions, and a method for manufacturing a phosphate ester. In the method for manufacturing a phosphonate ester of the present invention, a compound represented by the formula (1) is reacted with a compound represented by the formula (2) in the presence of a zinc catalyst to obtain a compound represented by the formula (3). X represents an organic group. R1 represents an alkyl group. R2 represents an organic group.

2. 发明申请

US20160037034A1 NEAR-INFRARED-RAY-ABSORBING COMPOSITION, NEAR-INFRARED-RAY CUT FILTER USING SAME, MANUFACTURING METHOD THEREFOR, CAMERA MODULE, AND MANUFACTURING METHOD THEREFOR 有权
标题翻译：近红外吸收组合物，使用其的近红外线切割过滤器，其制造方法，相机模块及其制造方法
公开(公告)号：US20160037034A1
公开(公告)日：2016-02-04
申请号：US14876287
申请日：2015-10-06
申请人： FUJIFILM CORPORATION
发明人： Takeshi INASAKI , Takashi KAWASHIMA , Seiichi HITOMI , Kouitsu SASAKI
IPC分类号： H04N5/225 , C07F7/18 , C07F9/30 , C07F9/40 , G02B5/20 , C07F9/12 , C07F9/09 , C07F9/143 , C07F9/58 , C07F1/08 , C07F9/06
CPC分类号： H04N5/2254 , C07F1/08 , C07F7/1804 , C07F9/06 , C07F9/098 , C07F9/12 , C07F9/143 , C07F9/304 , C07F9/4021 , C07F9/58 , C09B57/10 , G02B5/208 , G02B5/22 , H04N5/2257 , H04N5/33
摘要： Provided are a near-infrared-ray-absorbing composition having strong near-infrared shielding properties when a cured film is produced, a near-infrared-ray cut filter, a manufacturing method therefor, a camera module, and a manufacturing method therefor. The near-infrared-ray-absorbing composition includes a copper complex obtained by reacting a compound (A) having at least two coordination sites with a copper component.
摘要翻译：提供了当制备固化膜时具有强近红外屏蔽性能的近红外光吸收组合物，近红外线截止滤光器，其制造方法，相机模块及其制造方法。近红外线吸收组合物包括通过使具有至少两个配位点的化合物（A）与铜成分反应而获得的铜络合物。

3. 发明授权

US07851515B2 Hydrolysis-stable self-etching single-component dental adhesive 有权
标题翻译：水解稳定自腐蚀单组份牙科粘合剂
公开(公告)号：US07851515B2
公开(公告)日：2010-12-14
申请号：US11212065
申请日：2005-08-25
申请人： Ulrich Salz , Angela Mucke , Jorg Zimmermann , Norbert Moszner , Frank Zeuner , Volker Rheinberger
发明人： Ulrich Salz , Angela Mucke , Jorg Zimmermann , Norbert Moszner , Frank Zeuner , Volker Rheinberger
IPC分类号： C07F9/06 , C07F9/113 , C07F9/143 , A61K6/083 , A61K6/08 , A61K6/00 , A61C5/00 , C08F20/58 , C08F220/54
CPC分类号： A61K6/083 , A61K6/0017 , A61K6/0023 , A61K6/0835 , C08L33/00
摘要： Dental composition containing (i) at least one acid (meth)acrylamide monomer which has two or more polymerizable groups, (ii) at least one acid monomer which has only one polymerizable group and (iii) at least one polymerization initiator.
摘要翻译：含有（i）至少一种具有两个或多个可聚合基团的酸（甲基）丙烯酰胺单体，（ii）至少一种仅具有一个可聚合基团的酸单体和（iii）至少一种聚合引发剂）的牙科组合物。

4. 发明授权

US5344951A Production of alkyl phosphites 失效
标题翻译：亚磷酸烷基酯的生产
公开(公告)号：US5344951A
公开(公告)日：1994-09-06
申请号：US31838
申请日：1993-03-16
申请人： Abbas Kadkhodayan
发明人： Abbas Kadkhodayan
IPC分类号： C07F9/141 , C07F9/142 , C07F9/143
CPC分类号： C07F9/143 , C07F9/142
摘要： This invention relates to an improved process for producing diesters of phosphorous acid. The process comprises (a) reacting phosphorous acid with monohydric alcohol in a petroleum distillate solvent while maintaining a reaction mass temperature within the range of from about 130.degree. to about 138.degree. C., and (b) refluxing the reaction mass during the reaction, wherein the phosphorous acid contains about 20 up to about 35 wt. % water, the molar ratio of alcohol to phosphorous acid used is within the range of from about 2.0:1 to about 4.0:1, and water is removed from the reaction mass essentially as it is formed during steps (b) and (c).
摘要翻译：本发明涉及一种生产亚磷酸二酯的改进方法。该方法包括（a）在石油馏出物溶剂中使亚磷酸与一元醇反应，同时保持反应物质温度在约130℃至约138℃的范围内，和（b）在反应期间回流反应物质，其中所述亚磷酸含有约20至约35wt。％的水，所使用的醇与亚磷酸的摩尔比在约2.0:1至约4.0:1的范围内，并且基本上在步骤（b）和（c）中形成的水从反应物质中除去，。

5. 发明授权

US4256911A 16-Substituted prostaglandin intermediate 失效
标题翻译： 16-取代前列腺素中间体
公开(公告)号：US4256911A
公开(公告)日：1981-03-17
申请号：US158043
申请日：1980-06-09
申请人： George W. Holland , Jane L. Jernow , Perry Rosen
发明人： George W. Holland , Jane L. Jernow , Perry Rosen
IPC分类号： A61K9/20 , A61K31/19 , A61K31/215 , C07C53/21 , C07C53/50 , C07C405/00 , C07D307/93 , C07D307/935 , C07D309/12 , C07F9/143 , C07F9/40 , C07F9/50 , C07F9/54 , C07C69/63
CPC分类号： C07D307/935 , A61K31/19 , A61K31/215 , A61K9/20 , C07C405/00 , C07C405/0033 , C07C405/0066 , C07C53/21 , C07C53/50 , C07C69/63 , C07D307/93 , C07D309/12 , C07F9/143 , C07F9/4006 , C07F9/50 , C07F9/5407
摘要： A process for producing optically active 16-substituted prostaglandins and new 16-substituted prostaglandins produced thereby which are useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy.
摘要翻译：用于制备光学活性的16-取代的前列腺素和由此产生的新的16-取代的前列腺素的方法，其可用作心血管药剂和用于诱发怀孕女性的劳动和终止妊娠的药剂。

6. 发明授权

US4246426A 11-Substituted prostaglandins 失效
标题翻译： 11替代前列腺素
公开(公告)号：US4246426A
公开(公告)日：1981-01-20
申请号：US25972
申请日：1979-04-02
申请人： George W. Holland , Jane L. Jernow , Perry Rosen
发明人： George W. Holland , Jane L. Jernow , Perry Rosen
IPC分类号： A61K9/20 , A61K31/19 , A61K31/215 , C07C53/21 , C07C53/50 , C07C405/00 , C07D307/93 , C07D307/935 , C07D309/12 , C07F9/143 , C07F9/40 , C07F9/50 , C07F9/54 , C07C177/00
CPC分类号： C07D307/935 , A61K31/19 , A61K31/215 , A61K9/20 , C07C405/00 , C07C405/0033 , C07C405/0066 , C07C53/21 , C07C53/50 , C07D307/93 , C07D309/12 , C07F9/143 , C07F9/4006 , C07F9/50 , C07F9/5407
摘要： 11-Substituted prostaglandins E.sub.1, E.sub.2 and F.sub.2.alpha. useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.
摘要翻译： 11-取代的前列腺素E1，E2和F2α可用作心血管药物，并用作诱导怀孕女性的劳动和终止妊娠的药剂以及制备这些前列腺素的方法。

7. 发明授权

US4059576A 11-Substituted prostaglandins 失效
公开(公告)号：US4059576A
公开(公告)日：1977-11-22
申请号：US614051
申请日：1975-09-17
申请人： George William Holland , Jane Liu Jernow , Perry Rosen
发明人： George William Holland , Jane Liu Jernow , Perry Rosen
IPC分类号： A61K9/20 , A61K31/19 , A61K31/215 , C07C53/21 , C07C53/50 , C07C405/00 , C07D307/93 , C07D307/935 , C07D309/12 , C07F9/143 , C07F9/40 , C07F9/50 , C07F9/54 , C07C177/00
CPC分类号： C07D307/935 , A61K31/19 , A61K31/215 , A61K9/20 , C07C405/00 , C07C405/0033 , C07C405/0066 , C07C53/21 , C07C53/50 , C07D307/93 , C07D309/12 , C07F9/143 , C07F9/4006 , C07F9/50 , C07F9/5407
摘要： 11-Substituted prostaglandins E.sub.1, E.sub.2 and F.sub.2.alpha. useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.

8. 发明申请

US20120195861A1 METHODS AND COMPOSITIONS FOR PRODUCING GERM CELLS FROM PERIPHERAL BLOOD DERIVED GERMLINE STEM CELLS 有权
标题翻译：用于从外周血衍生的胃肠细胞产生细胞的方法和组合物
公开(公告)号：US20120195861A1
公开(公告)日：2012-08-02
申请号：US13006752
申请日：2011-01-14
申请人： Jonathan L. Tilly , Joshua Johnson
发明人： Jonathan L. Tilly , Joshua Johnson
IPC分类号： A61K35/14 , C12N5/075 , A61P15/08 , C12Q1/68 , A61K38/18 , A61K38/30 , A61K31/164 , A61P15/18 , A61P15/16 , A61K31/56 , C12N5/02 , A61K31/661 , C07F9/143 , A61K31/203 , C07C53/134 , C07K14/475 , C07K14/50 , C07K14/495 , C07K14/51 , C07C233/18 , A61B17/435 , C12N5/0789
CPC分类号： C12N5/0611 , A61B17/43 , A61K35/14 , A61K35/28 , A61K2035/124 , C12N5/0609 , C12N5/0634 , C12N2506/11 , C12P21/06
摘要： Described herein are the use of peripheral blood derived germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
摘要翻译：本文描述了外周血来源的生殖系干细胞及其祖细胞的使用，其分离方法及其使用方法。

9. 发明授权

US08193384B2 Polymer-bound phosphitylating reagents for the synthesis of organophosphorus compounds 失效
标题翻译：用于合成有机磷化合物的聚合物结合的磷酸化试剂
公开(公告)号：US08193384B2
公开(公告)日：2012-06-05
申请号：US11972254
申请日：2008-01-10
申请人： Keykavous Parang , Yousef Ahamdibeni
发明人： Keykavous Parang , Yousef Ahamdibeni
IPC分类号： C07F9/48 , C07F9/22 , C07F9/24 , C07F9/26 , C07F9/141 , C07F9/142 , C07F9/143 , C07F9/144 , C07F9/145 , C07F9/146
CPC分类号： C07H21/02
摘要： The synthesis and biochemical utility of modified oligonucleotides containing diphosphodiester internucleotide linkages. The synthesis of these compounds was carried out using diphosphitylating reagents. Oligonucleotides containing diphosphate diester bridges wherein said oligonucleotides are synthesized via a solid-phase synthesis strategy to form modified oligonucleotides. Diphosphitylating, triphosphitylating, tetraphosphitylating, β-triphosphitylating, bifunctional diphosphitylating, bifunctional triphosphitylating, and bifunctional tetraphosphitylating reagents wherein, the phosphorus atoms are linked together through oxygen, sulfur, amino, or methylene groups and/or are substituted with chlorine, diisopropylamine and cyanoethoxy groups.
摘要翻译：含有二磷酸二酯核苷酸键的修饰寡核苷酸的合成和生物化学实用性。这些化合物的合成使用二磷酸化试剂进行。含有二磷酸二酯桥的寡核苷酸，其中所述寡核苷酸通过固相合成策略合成以形成修饰的寡核苷酸。双磷化，三磷酸化，四磷酸化，三磷酸化，双官能二磷酸化，双功能三磷酸化，双功能四磷酸化试剂，其中磷原子通过氧，硫，氨基或亚甲基连接在一起，和/或被氯，二异丙胺和氰基乙氧基团体

10. 发明授权

US6008398A Non-nucleotide phosphorus ester oligomers 失效
标题翻译：非核苷酸磷酯低聚物
公开(公告)号：US6008398A
公开(公告)日：1999-12-28
申请号：US595264
申请日：1996-02-01
申请人： Robert Gerard Gentles , Alan F. Cook , Morris Jonathan Rudolph , Reza Fathi
发明人： Robert Gerard Gentles , Alan F. Cook , Morris Jonathan Rudolph , Reza Fathi
IPC分类号： C07B59/00 , C07B61/00 , C07D233/60 , C07F9/141 , C07F9/143 , C07F9/144 , C07F9/145 , C07F9/24 , C07F9/572 , C07F9/58 , C07F9/6506 , C07F9/6509 , C07F9/6539 , C07F9/655 , C07F9/6561 , C07F9/6574 , C07F9/6578 , C07F9/40
CPC分类号： C07F9/6578 , C07B59/004 , C07F9/1411 , C07F9/1414 , C07F9/143 , C07F9/144 , C07F9/145 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/65062 , C07F9/650958 , C07F9/6539 , C07F9/65515 , C07F9/6561 , C07F9/65616 , C40B40/00 , Y02P20/55
摘要： A phosphorus ester oligomer having the structure: wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labeling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.1 is independently selected from the group consisting of (i) a non-vicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a non-vicinal or alicyclic diol, any of which can further include a detectable label, and n is at least two. Preferred R.sub.1 moieties include condensation products of alicyclic diols and polycyclic diols; also the non-nucleotide monomers thereof, and the use of the oligomers as selective target-binding compounds.
摘要翻译：具有以下结构的磷酯低聚物：其中A可以在每个单体单元中相同或不同，并且各自独立地选自氧，硫，低级烷基，取代或未取代的烷基氨基，取代或未取代的芳基氨基和氨基烷基; B1和B2可以相同或不同，各自独立地选自氢，低级烷基，标记基团，保护基，氨基磷酸酯或磷酸酯酯; R 1可以在每个单体单元中相同或不同，并且在至少一个非核苷酸单体单元中，R 1独立地选自（i）与氢键供体官能团连接的非连接二醇; （ii）选自醚的氢键受体; （iii）连接到疏水官能团的非连位二醇或连接到脂族或脂环族疏水官能团的连位二醇（iv）连接到环取代的阴离子官能团上的二醇和（v）连接到非邻位的阳离子部分或脂环族二醇，其中任何一种可进一步包括可检测标记，并且n为至少两个。优选的R1部分包括脂环族二醇和多环二醇的缩合产物; 也是其非核苷酸单体，以及低聚物作为选择性靶结合化合物的用途。

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