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1. 发明授权

US06689755B1 Method of stabilizing biologically active substances 有权
标题翻译：稳定生物活性物质的方法
公开(公告)号：US06689755B1
公开(公告)日：2004-02-10
申请号：US09184866
申请日：1998-11-03
申请人： Rolf-Dieter Gabel , Markus Mattern , Gerhard Winter , Alexander Wirl , Heinrich Woog
发明人： Rolf-Dieter Gabel , Markus Mattern , Gerhard Winter , Alexander Wirl , Heinrich Woog
IPC分类号： C08B3000
CPC分类号： A61K9/1617 , A61K9/1623 , A61K47/183 , B01D1/18 , F26B3/02 , Y10S435/81 , Y10S514/911 , Y10S514/97
摘要： The present invention relates to a rapid and readily reproducible process for stabilizing biologically active substances by combining the biologically active substance witha a stabilizingmixture and drying the resulting mixture into a dry, amorphous product by means of convection drying. The invention also relates to the amorphous, microscopically homogeneous products which are obtained by this process, are in the form of powders and have a uniform geometric, in particular spherical, shape. The invention furthermore relates to the use of substance mixtures for stabilizing biologically active material, in particular proteins by means of spray drying.
摘要翻译：本发明涉及通过将生物活性物质与稳定混合物组合并通过对流干燥将所得混合物干燥成干燥的无定形产物来稳定生物活性物质的快速和容易重现的方法。本发明还涉及通过该方法获得的无定形，微观均匀的产品，其为粉末形式并且具有均匀的几何形状，特别是球形的形状。本发明还涉及物质混合物用于通过喷雾干燥来稳定生物活性物质，特别是蛋白质的用途。

2. 发明授权

US06261376B1 Thermally-Inhibited pregelatinized non-granular starches and flours 有权
标题翻译：耐热预胶化非粒状淀粉和面粉
公开(公告)号：US06261376B1
公开(公告)日：2001-07-17
申请号：US09436671
申请日：1999-11-10
申请人： Roger Jeffcoat , Chung-Wai Chiu , Manish B. Shah , David J. Thomas , Douglas J. Hanchett
发明人： Roger Jeffcoat , Chung-Wai Chiu , Manish B. Shah , David J. Thomas , Douglas J. Hanchett
IPC分类号： C08B3000
CPC分类号： C08B30/14 , A23L29/212 , A23L29/219 , C08B30/12
摘要： Thermally-inhibited, pregelatinized non-granular starches and flours are prepared by pregelatinizing the starch or flour and thermally inhibiting the starch or flour by dehydrating the starch or flour to anhydrous or substantially anhydrous and then heat treating the dehydrated starch. The pregelatinization may be carried out prior to or after the thermal inhibition using known methods which disrupt the granular structure such by drum drying or jet cooking and spray-drying. Preferably the starch or flour is adjusted to a pH above 7.0 prior to the thermal inhibition. The starch may be dehydrated by heating the starch in a suitable heating apparatus, by extracting the water from the starch using a solvent such as ethanol, or by freeze drying the starch. Preferably the starch or flour is treated with a solvent to remove proteins and/or lipids and thus prevent off flavors.
摘要翻译：通过将淀粉或面粉预胶化并通过将淀粉或面粉脱水至无水或基本上无水，然后热处理脱水淀粉来热抑制淀粉或面粉来制备耐热抑制的预胶化非粒状淀粉和面粉。预胶凝化可以在热抑制之前或之后使用已知的方法进行，这些方法通过鼓干燥或喷射蒸煮和喷雾干燥来破坏颗粒结构。优选地，在热抑制之前将淀粉或面粉调节至高于7.0的pH。可以通过在合适的加热装置中加热淀粉，使用溶剂如乙醇从淀粉中提取水，或通过冷冻干燥淀粉来使淀粉脱水。优选地，用溶剂处理淀粉或面粉以除去蛋白质和/或脂质，从而防止异味。

3. 发明授权

US06179926B2 Process for steeping corn and steepwater having a low reducing sugar content made therefrom 有权
标题翻译：浸渍由其制成的还原糖含量低的玉米和浸水的浸渍方法
公开(公告)号：US06179926B2
公开(公告)日：2001-01-30
申请号：US09290099
申请日：1999-04-12
申请人： Ricky D. Kiser , Ling Du
发明人： Ricky D. Kiser , Ling Du
IPC分类号： C08B3000
CPC分类号： C08B30/10 , C08B30/044
摘要： A corn steeping process wherein the pH is adjusted to from about 4.2 to about 5.5 at a time between about 4 hours after fresh steepwater is introduced to about 1 hour before the separation of the steepwater from the corn. The process provides a steepwater having a low reducing sugar content while also providing good starch yields.
摘要翻译：一种玉米浸渍方法，其中在将新鲜的浸水引入约1小时之前，在从玉米中分离陡峭的水之前，在约4小时之间的时间将pH调节至约4.2至约5.5。该方法提供了具有低还原糖含量的浸水，同时还提供了良好的淀粉产量。

4. 发明授权

US06803459B2 Branched starches and branched starch hydrolyzates 有权
标题翻译：支链淀粉和支链淀粉水解产物
公开(公告)号：US06803459B2
公开(公告)日：2004-10-12
申请号：US10226809
申请日：2002-08-23
申请人： Richard L. Antrim
发明人： Richard L. Antrim
IPC分类号： C08B3000
CPC分类号： C12P19/18 , A23L29/35 , C08B30/00 , C08B30/18
摘要： The present invention provides a starch that includes at least one glucose polymer having greater than 4% alpha 1-6 glycosidic linkages. The present invention further provides a starch hydrolyzate that includes at least one glucose oligomer having greater than 4% alpha 1-6 glycosidic linkages. The starch and starch hydrolyzate present invention have improved aqueous solution stability and are less likely to retrograde than are solutions of unbranched linear starches or starch hydrolyzates.
摘要翻译：本发明提供了包含至少一种具有大于4％的α1-6糖苷键的葡萄糖聚合物的淀粉。本发明还提供一种包含至少一种具有大于4％的α1-6糖苷键的葡萄糖低聚物的淀粉水解产物。本发明的淀粉和淀粉水解产物具有改进的水溶液稳定性，并且不如直链淀粉或淀粉水解物的溶液更不易逆行。

5. 发明授权

US06692577B2 Process for purifying maltose 有权
标题翻译：麦芽糖的纯化方法
公开(公告)号：US06692577B2
公开(公告)日：2004-02-17
申请号：US10034597
申请日：2001-12-28
申请人： Heikki Heikkilä , Mika Mänttäri , Mirja Lindroos , Marianne Nyström
发明人： Heikki Heikkilä , Mika Mänttäri , Mirja Lindroos , Marianne Nyström
IPC分类号： C08B3000
CPC分类号： C13B20/165 , C13K13/002
摘要： The invention relates to a process for purifying a maltose-containing liquor from a undesired impurities, such as maltotriose. The process of the invention is characterized by nanofiltering said liquor and recovering a purified maltose solution as the permeate.
摘要翻译：本发明涉及一种从不希望的杂质如麦芽三糖中纯化含麦芽糖的液体的方法。本发明的方法的特征在于对所述液体进行纳米过滤并回收作为渗透物的纯化麦芽糖溶液。

6. 发明授权

US06770148B1 Peritoneal dialysis solution containing modified icodextrins 失效
公开(公告)号：US06770148B1
公开(公告)日：2004-08-03
申请号：US09206063
申请日：1998-12-04
申请人： Annamaria Naggi , Enrico Petrella , Giangiacomo Torri , Benito Casu
发明人： Annamaria Naggi , Enrico Petrella , Giangiacomo Torri , Benito Casu
IPC分类号： C08B3000
CPC分类号： A61K31/718
摘要： The present invention provides a peritoneal dialysis solution that contains heat stable osmotic agents such as D-glucitols, gluconic acids and alkylglycosides produced the reduction, oxidation or glycosylation of icodextrins respectively. As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduces the amount of bioincompatible materials in the sterilized peritoneal dialysis solutions. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.

7. 发明授权

US06755914B2 Crystalline mixture solid composition and preparation thereof 失效
标题翻译：结晶混合物固体组合物及其制备
公开(公告)号：US06755914B2
公开(公告)日：2004-06-29
申请号：US10030981
申请日：2002-01-16
申请人： Ryuzo Ueno , Akihiko Tabata , Junya Honda , Yojiro Furukawa , Sho Arai
发明人： Ryuzo Ueno , Akihiko Tabata , Junya Honda , Yojiro Furukawa , Sho Arai
IPC分类号： C08B3000
CPC分类号： C07H15/04 , A23L27/34
摘要： A crystalline mixture solid composition comprising &agr;-D-glucopyranosyl-1,1-mannitol (GPM), &agr;-D-glucopyranosyl-1,6-sorbitol (GPS-6) and a small amount of &agr;-D-glucopyranosyl-1,1-sorbitol (GPS-1) and a production process therefor. The above crystalline mixture solid composition is produced by mixing a hydrophilic solvent with a solid composition or aqueous solution comprising 50 to 80 wt % of GPM, 1 to 50 wt % of GPS-6 and 0.01 to 20 wt % of GPS-1, separating solid matter from a liquid, and removing water and the solvent from the solid matter and can be obtained as a thin scale crystal.
摘要翻译：包含α-D-吡喃葡萄糖基-1,1-甘露醇（GPM），α-D-吡喃葡萄糖基-1,6-山梨糖醇（GPS-6）和少量α-D-吡喃葡萄糖基-1的结晶混合物固体组合物， 1-山梨糖醇（GPS-1）及其制备方法。上述结晶混合物固体组合物通过将亲水性溶剂与固体组合物或包含50-80重量％GPM，1至50重量％的GPS-6和0.01至20重量％的GPS-1的水溶液混合来制备，分离来自液体的固体物质，并且从固体物质中除去水和溶剂，并且可以作为薄标尺晶体获得。

8. 发明授权

US06451121B2 Thermally-inhibited non-pregelatinized granular starches and flours and process for their preparation 失效
标题翻译：耐热非预胶化粒状淀粉和面粉并进行制备
公开(公告)号：US06451121B2
公开(公告)日：2002-09-17
申请号：US09798520
申请日：2001-03-02
申请人： Chung-Wai Chiu , Eleanor Schiermeyer , David J. Thomas , Manish B. Shah , Douglas J. Hanchett , Roger Jeffcoat
发明人： Chung-Wai Chiu , Eleanor Schiermeyer , David J. Thomas , Manish B. Shah , Douglas J. Hanchett , Roger Jeffcoat
IPC分类号： C08B3000
CPC分类号： A23G9/34 , A21D2/186 , A21D6/00 , A21D6/003 , A23C9/137 , A23C19/0765 , A23G3/346 , A23G9/52 , A23G2200/06 , A23L7/111 , A23L7/165 , A23L7/198 , A23L9/10 , A23L19/09 , A23L19/18 , A23L21/15 , A23L21/18 , A23L23/00 , A23L27/60 , A23L27/63 , A23L29/212 , A23L29/219 , A23L29/225 , A23P20/12 , C08B30/12 , C08B30/14
摘要： Thermally-inhibited starches and flours which are functionally equivalent to chemically-crosslinked starches are prepared by a process which comprises the steps of dehydrating a granular starch or flour to anhydrous or substantially anhydrous (
摘要翻译：在功能上等同于化学交联淀粉的热抑制淀粉和面粉通过包括以下步骤的方法制备，所述方法包括以下步骤：将颗粒状淀粉或面粉脱水至无水或基本无水（<1％水分）并热处理脱水淀粉或面粉一段时间并且足以抑制淀粉的温度（例如，120-180℃长达20小时）。优选地，在脱水之前将淀粉的pH调节至中性或更高（例如，pH 8-9.5）。脱水可以是与热处理同时进行的热脱水或通过用溶剂（例如乙醇）萃取或通过冷冻干燥进行的非热脱水。

9. 发明授权

US06755915B1 Method for the preparation of starch particles 有权
标题翻译：淀粉颗粒的制备方法
公开(公告)号：US06755915B1
公开(公告)日：2004-06-29
申请号：US09869706
申请日：2001-10-01
申请人： Jeroen Johannes Gerardus Van Soest , Frank Hubertus Maria Stappers , Renée Josie Gide Van Schijndel , Kornelis Fester Gottlieb , Herman Feil
发明人： Jeroen Johannes Gerardus Van Soest , Frank Hubertus Maria Stappers , Renée Josie Gide Van Schijndel , Kornelis Fester Gottlieb , Herman Feil
IPC分类号： C08B3000
CPC分类号： C08J3/16 , C08B31/003 , C08B31/006 , C08J2303/02
摘要： A method for the preparation of starch particles in a two-phase system comprises at least the following steps: a) a preparation of a first phase comprising a dispersion of starch in water; b) preparation of a dispersion or emulsion of the first phase in a second liquid phase, with the proviso that the second phase is not water; c) cross-linking of the starch present in the first phase; d) separating the starch particles thus formed. According to a first aspect of the invention the second phase consists of a hydrophobic liquid and step b) consists in forming an oil-in-water emulsion, which is then inverted to a water-in-oil emulsion. According to a second aspect of the invention, the second phase consists of a water-miscible non-solvent for starch. Starch particles of very small particles size can be produced in a controlled manner by means of this method.
摘要翻译：在两相体系中制备淀粉颗粒的方法至少包括以下步骤：a）包含淀粉在水中的分散体的第一相的制备; b）在第二液相中制备第一相的分散体或乳液，条件是第二相不是水; c）第一相中存在的淀粉的交联; d）分离由此形成的淀粉颗粒。根据本发明的第一方面，第二相由疏水性液体组成，步骤b）包括形成水包油乳液，然后将其倒入油包水乳液中。根据本发明的第二方面，第二相由用于淀粉的水混溶性非溶剂组成。可以通过该方法以受控的方式制备非常小粒径的淀粉颗粒。

10. 发明授权

US06709526B1 Melt processable starch compositions 有权
标题翻译：可熔融加工的淀粉组合物
公开(公告)号：US06709526B1
公开(公告)日：2004-03-23
申请号：US09914965
申请日：2001-09-06
申请人： Valerie Ann Bailey , Larry Neil Mackey , Paul Dennis Trokhan
发明人： Valerie Ann Bailey , Larry Neil Mackey , Paul Dennis Trokhan
IPC分类号： C08B3000
CPC分类号： D01F8/10 , A61L15/28 , C08J5/18 , C08J2303/02 , C08L3/02 , C08L3/12 , D01F9/00 , Y10T428/24124 , Y10T428/249924 , Y10T428/268 , Y10T428/269 , Y10T428/2857 , Y10T428/29 , Y10T428/2913 , Y10T428/2929 , Y10T428/298 , Y10T442/3146 , Y10T442/3171 , Y10T442/60 , Y10T442/637 , Y10T442/642 , Y10T442/643 , Y10T442/68 , Y10T442/681 , Y10T442/697 , Y10T442/698 , Y10T442/699 , A61L15/42 , A61L15/20 , C08L2666/02
摘要： The present invention relates to a starch composition comprising starch, a polymer that is substantially compatible with starch and has a weight-average molecular weight of at least 500,000 such that the polymer forms effective entanglements or associations with neighboring starch molecules, and preferably at least one additive to improve melt flow and melt processability. The additive may be a hydroxyl plasticizer, a hydroxyl-free plasticizer, a diluent, or mixtures thereof. The composition is melt processable on conventional thermoplastic equipment. The composition is especially suitable for uniaxial and biaxial extensional processes to make fibers, films, foams and like products.
摘要翻译：本发明涉及包含淀粉的淀粉组合物，该淀粉基本上与淀粉相容并且具有至少500,000的重均分子量，使得聚合物与相邻的淀粉分子形成有效的缠结或缔合，优选至少一种添加剂以改善熔体流动和熔融加工性能。添加剂可以是羟基增塑剂，不含羟基的增塑剂，稀释剂或其混合物。该组合物可在常规热塑性设备上熔融加工。该组合物特别适用于制造纤维，薄膜，泡沫等产品的单轴和双轴拉伸工艺。

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