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1. 发明申请

US20230046027A1 MICROBE-BASED SYSTEMS, COMPOSITIONS, AND METHODS THEREOF 有权
公开(公告)号：US20230046027A1
公开(公告)日：2023-02-16
申请号：US17791676
申请日：2021-01-12
申请人： University of Washington
发明人： Bruce J. Godfrey , Mari-Karoliina Henriikka Winkler , David Stahl
IPC分类号： C02F3/34 , C12N1/20 , C12N11/04 , C02F3/30
摘要： The present disclosure describes a microorganism support structure, including a gas-permeable layer comprising two opposing surfaces; a microorganism adhesive coats at least one surface of the gas-permeable layer; and a microorganism disposed on the microorganism adhesive-coated surface of the layer. The microorganism adhesive enhances the adhesion of the microorganism on the layer compared to a gas-permeable layer that does not have the microorganism adhesive.

2. 发明授权

US11542531B2 Biocatalytic microcapsules for catalyzing gas conversion 有权
公开(公告)号：US11542531B2
公开(公告)日：2023-01-03
申请号：US15411337
申请日：2017-01-20
申请人： Lawrence Livermore National Security, LLC
发明人： Sarah Baker , Joshuah K. Stolaroff , Congwang Ye
IPC分类号： C12P7/04 , B01J31/00 , B01J31/06 , C12N11/04 , C12N11/084 , C12N11/089 , C12N11/082 , C12N11/096 , C12N11/087
摘要： According to one embodiment, a microcapsule for selective catalysis of gases, the microcapsule comprising: a polymeric shell permeable to one or more target gases; and at least one biocatalyst disposed in an interior of the polymeric shell. In more embodiments, methods of forming such microcapsules include: emulsifying at least one biocatalyst in a polymer precursor mixture; emulsifying the polymer precursor mixture in an aqueous carrier solution; crosslinking one or more polymer precursors of the polymer precursor mixture to form a plurality of microcapsules each independently comprising: a polymeric shell permeable to one or more target gases; and at least one biocatalyst disposed in an interior of the polymeric shell. In further embodiments, corresponding methods of using the inventive microcapsules for catalyzing one or more target gases using include: exposing a plurality of the biocatalytic microcapsules to the one or more target gases.

3. 发明申请

US20220340863A1 HYDROGEL COMPOSITIONS COMPRISING PROTIST CELLS 有权
公开(公告)号：US20220340863A1
公开(公告)日：2022-10-27
申请号：US17642391
申请日：2020-09-11
申请人： THE UNIVERSITY OF MELBOURNE , GRAINS RESEARCH AND DEVELOPMENT CORPORATION
发明人： Helen JACOBE , Ruth Elizabeth HAITES , Sameera SIRISENA
IPC分类号： C12N1/10 , A01N25/04 , C12N11/04 , C12N11/08 , C12N11/12
摘要： The present disclosure relates to hydrogels composition comprising protist cells. In particular, the present disclosure relates to hydrogel compositions which may be used to encapsulate or suspend ciliated protist cells, and methods of preparing the same. The present disclosure further relates to methods of infecting molluscs with a ciliated protist cell, and methods and compositions for stabilising ciliated protist cells.

4. 发明申请

US20220170051A1 NOVEL ENZYME NANOPARTICLES HAVING METHANE OXIDATION ACTIVITY 有权
公开(公告)号：US20220170051A1
公开(公告)日：2022-06-02
申请号：US17599153
申请日：2020-03-20
申请人： Korea University Research and Business Foundation
发明人： Jeewon LEE , Hyun Jin KIM
IPC分类号： C12P7/04 , C12N9/02 , C12N11/04 , C12N9/96
摘要： The present invention relates to novel enzyme nanoparticles capable of converting methane into methanol, in which key active sites of methane-oxidizing bacteria are fused with each other and expressed on a protein that can be self-assembled in cells to form nanoparticles, and specifically to enzyme nanoparticles including a protein having methane monooxygenase (MMO) activity and active sites of the methane oxidase, a method for production thereof, a recombinant microorganism into which a nucleic acid encoding the protein and the active site of the methane oxidase is introduced, and immobilized enzyme nanoparticles including the enzyme nanoparticles loaded on a carrier.

5. 发明申请

US20220081471A1 STABLE DRY POWDER COMPOSITION COMPRISING BIOLOGICALLY ACTIVE MICROORGANISMS AND/OR BIOACTIVE MATERIALS AND METHODS OF MAKING 有权
公开(公告)号：US20220081471A1
公开(公告)日：2022-03-17
申请号：US17530036
申请日：2021-11-18
申请人： Advanced Bionutrition Corp.
发明人： Mordechai Harel , Roger Drewes , Brian Carpenter , Elena Artimovich
IPC分类号： C07K14/00 , A61K9/06 , A61K9/14 , A61K9/19 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , C12N1/04 , C12N1/20 , C12N11/04 , A23L29/00 , A23L33/00 , A23L33/135 , A23L33/15 , A23K40/30 , A23K10/18 , A23K20/174 , A23K20/189 , A23K50/42 , A23K50/80
摘要： The present invention relates to embedding live or dead microorganisms and/or bioactive materials in a protective dry formulation matrix, wherein the formulation includes the bioactive microorganism or material, a formulation stabilizer agent, and a protective agent. The formulation is prepared by dispersing all the solid components in a solution, with or without a vacuum, and cooling the solution to a temperature above its freezing temperature. The methods include a primary drying step of the formulation at a desired temperature and time period, and an accelerated secondary drying step under maximum vacuum and elevated temperature, to achieve a final desirable water activity of the dry material.

6. 发明申请

US20220010345A1 OPTIMIZED METHOD FOR PRODUCING A COMPOSITION CONTAINING ISOMALTULOSE 有权
公开(公告)号：US20220010345A1
公开(公告)日：2022-01-13
申请号：US17480273
申请日：2021-09-21
申请人： Südzucker Aktiengesellschaft Mannheim/Ochsenfurt
发明人： Wolfgang Wach , Thomas Rose
IPC分类号： C12P19/12 , C12P19/24 , C12N11/04 , C12N11/02
摘要： The present invention relates to a method for producing a composition containing isomaltulose from a substrate containing sucrose comprising the steps of: a) contacting the substrate containing sucrose with a particulate carrier-immobilized sucrose isomerase biomass and b) obtaining a composition containing isomaltulose, characterized in that the median particle size d(0.5) of the carrier-immobilized sucrose isomerase biomass is from 370 to 550 μm. The carrier can be an alginate or a polyvinyl alcohol carrier.

7. 发明申请

US20210389252A1 METHOD FOR PREPARING SOLID-STATE PHOTONIC CRYSTAL IPN COMPOSITE FUNCTIONALIZED WITH ENZYME, PHOTONIC CRYSTAL IPN COMPOSITE PREPARED BY THE METHOD AND BIOSENSOR USING THE PHOTONIC CRYSTAL IPN COMPOSITE 有权
公开(公告)号：US20210389252A1
公开(公告)日：2021-12-16
申请号：US17051631
申请日：2019-02-20
申请人： Kyungpook National University Industry-Academic Cooperation Foundation
发明人： Soo Young PARK , Kyung Gyu NOH
IPC分类号： G01N21/75 , C12N11/04 , C12Q1/58 , C09K19/58
摘要： The present invention relates to a method for preparing a solid-state photonic crystal IPN composite functionalized with an enzyme, a photonic crystal IPN composite prepared by the method, and a biosensor using the photonic crystal IPN composite. The method of the present invention includes (1) mixing a nonreactive chiral dopant with a reactive nematic mesogen, curing the mixture, and removing the chiral dopant while maintaining a helical structure, to form a solid-state helical photonic crystal structure, (2) infiltrating a PAA hydrogel into the internal space of the photonic crystal structure, followed by curing to form an IPN-structured composite, and (3) immobilizing an enzyme in the IPN-structured composite. The PAA hydrogel is infiltrated into the solid-state helical photonic crystal structure and the enzyme is immobilized such that a pH change caused by the enzymatic reaction induces shrinkage and expansion of the PAA hydrogel, leading to a color change.

8. 发明授权

US11066660B2 Technique for aggregating macromolecules together with cells 有权
公开(公告)号：US11066660B2
公开(公告)日：2021-07-20
申请号：US15573765
申请日：2016-05-12
申请人： Public University Corporation Yokohama City University
发明人： Nobuhiko Kojima
IPC分类号： C12N11/04 , C12N11/08 , C12N5/071
摘要： The present invention provides a technique for efficiently aggregating a polymer such as ECM together with cells.
A method for preparing a polymer-loaded cell or cell aggregate, comprising adding a solution containing a polymer and at least one cell to a medium containing a swellable material to thereby aggregate the polymer together with the cell. A method for controlling the property and/or the function of a cell or a cell aggregate, comprising culturing the polymer-loaded cell or cell aggregate prepared by the above-described method. A method for culturing a cell or a cell aggregate, comprising: preparing a polymer capsule filled with a cell or a cell aggregate by adding a solution containing a polymer and at least one cell to a medium containing a swellable material to thereby aggregate the polymer together with the cell; and culturing the cell or cell aggregate within the capsule.
For constructing 3D cell tissues, a method using U-bottom 96-well plates or the hanging-drop method is conventionally used. In the present invention, 2000 cells can be mixed with 1 μl of ECM-containing medium so that ECM and the cells are allowed to aggregate simultaneously. When the efficiency in this case is taken as 1, ECM can only be mixed in 3D cell tissues at a calculated efficiency of approx. 1/12000 in the method using U-bottom 96-well plates or approx. 1/2400 in the hanging drop method. Therefore, according to the present invention, it is possible to reduce the cost of ECM can be reduced to about several thousand to ten thousand times less. Besides, it is possible to efficiently use artificial ECM that cannot be synthesized in a large quantity or rare ECM that can only be extracted in an extremely small quantity for such a reason that the source is a small organism.

9. 发明申请

US20210198653A1 DELIVERING ENZYME USING AN INJECTABLE HYDROGEL DEPOT 有权
公开(公告)号：US20210198653A1
公开(公告)日：2021-07-01
申请号：US17201526
申请日：2021-03-15
申请人： Saint Louis University
发明人： Adriana M. Montaño , Silviya Petrova Zustiak , Era Jain
IPC分类号： C12N11/04 , A61K47/69 , A61M5/178 , A61K47/10 , A61K9/00 , C12N9/16 , C12N9/10 , A61P3/00 , C12N9/24 , A61K47/34
摘要： Compositions and methods for delivering enzymes in enzyme hydrogel formulations are disclosed. More particularly, the present disclosure relates to injectable enzyme hydrogel formulations and delivery of injectable enzyme hydrogel formulations. Also disclosed are methods for GALNS enzyme replacement therapy and lysosomal enzyme replacement therapy.

10. 发明申请

US20210163917A1 ENZYME FORMULATION AND METHOD FOR DEGRADATION 有权
公开(公告)号：US20210163917A1
公开(公告)日：2021-06-03
申请号：US17116978
申请日：2020-12-09
申请人： Battelle Memorial Institute
发明人： Katarzyna Hanna Kucharzyk , Ramanathan Lalgudi
IPC分类号： C12N11/04 , B09C1/10 , C12N11/10
摘要： An enzyme formulation includes an encapsulated fungal enzyme which is effective for degrading at least one material selected from the group consisting of hydrocarbons, vulcanized rubber, synthetic rubber, natural rubber, vulcanized polymers and perfluorinated compounds. A degradation method includes treating one of the above-mentioned materials with an encapsulated fungal enzyme to degrade the material.

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