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1. 发明申请

US20230111669A1 IMMUNISATION OF LARGE MAMMALS WITH LOW DOSES OF RNA 有权
公开(公告)号：US20230111669A1
公开(公告)日：2023-04-13
申请号：US18080164
申请日：2022-12-13
申请人： GLAXOSMITHKLINE BIOLOGICALS SA
发明人： Andrew GEALL
IPC分类号： C12N15/117 , C12N15/86 , A61K39/155 , A61K39/39 , A61K39/12 , A61P31/12 , A61P37/04 , A61K48/00
摘要： RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3 μg/kg to 150 μg/kg. The delivered RNA can elicit an immune response in the large mammal.

2. 发明申请

US20230094580A1 AMPHIPHILIC OLIGODEOXYNUCLEOTIDE CONJUGATES AS ADJUVANT ENHANCERS 有权
公开(公告)号：US20230094580A1
公开(公告)日：2023-03-30
申请号：US17930042
申请日：2022-09-06
申请人： Wayne State University
发明人： Haipeng Liu , Chunsong Yu
IPC分类号： A61K39/39 , A61K47/54 , C12N15/117
摘要： Amphiphilic oligonucleotide conjugates that enhance adjuvant function are disclosed. The conjugates typically include: a lipophilic component, and conjugated thereto (directly or indirectly) an immunomodulating oligonucleotide that, if it were not conjugated to the lipophilic component, would suppress TLR7 and/or TLR8 stimulation. In the presence of albumin, these conjugates significantly enhance adjuvant function, in particular the function of TLR7/8-mediated adjuvants such as an imidazoquinolinamine. The conjugates can be administered, along with an adjuvant compound, to a subject in order to cause and/or enhance an immune response (for instance, to an infectious agent or a cancer antigen) in the subject.

3. 发明授权

US11583581B2 Methods of treating a retroviral infection 有权
公开(公告)号：US11583581B2
公开(公告)日：2023-02-21
申请号：US15760424
申请日：2016-09-21
申请人： GILEAD SCIENCES, INC.
发明人： Matthias Schroff , Manuel Schmidt , Kerstin Kapp , Alfredo Zurlo , Ole Schmeltz Sogaard , Martin Tolstrup , Rasmus Offersen
IPC分类号： A61K39/39 , A61K31/711 , C12N15/113 , C12N15/117 , A61K39/00
摘要： The invention relates to a non-coding sequence of deoxyribonucleic acids comprising at least one sequence motif N1N2CGN3N4, wherein N is a nucleotide comprising A, C, T, or G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine and T is deoxy-thymidine for the treatment of viral infections. In particular, the non-coding sequence of deoxyribonucleic acids is used in combination with antiretroviral therapy and/or histone de-acetylase inhibitors.

4. 发明申请

US20220401467A1 OLIGONUCLEOTIDES, COMPOSITIONS AND METHODS THEREOF 有权
公开(公告)号：US20220401467A1
公开(公告)日：2022-12-22
申请号：US17177111
申请日：2021-02-16
申请人： WAVE LIFE SCIENCES LTD.
发明人： Jason Jingxin Zhang , Naoki Iwamoto , Christopher J. Francis , Chandra Vargeese , David Charles Donnell Butler , Sethumadhavan Divakaramenon , Genliang Lu , Subramanian Marappan
IPC分类号： A61K31/7125 , A61P21/00 , C12N15/117 , A61K31/7088
摘要： The present disclosure pertains to the recognition that immune responses mediated by CpG oligonucleotides can be affected by the stereochemistry of modified internucleotidic linkages such as phosphorothioates. In some embodiments, the present disclosure relates to chirally controlled CpG oligonucleotide compositions comprising CpG oligonucleotides comprising multiple modified internucleotidic linkages such as phosphorothioate linkages, wherein the oligonucleotides comprise one or more CpG region motifs having defined stereochemistry patterns of chiral internucleotidic linkages. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are capable of agonizing an immune response. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are antagonistic. Methods for making and using chirally controlled CpG oligonucleotide compositions are also described. In some embodiments, no immune modulation is desired, and the present disclosure provides methods of identifying chirally controlled oligonucleotide compositions which have decreased immune modulation.

5. 发明申请

US20220396796A1 RNA FOR CANCER THERAPY 有权
公开(公告)号：US20220396796A1
公开(公告)日：2022-12-15
申请号：US17571893
申请日：2022-01-10
申请人： CureVac AG
发明人： Mariola FOTIN-MLECZEK , Aleksandra KOWALCZYK , Regina HEIDENREICH , Ulrike GNAD-VOGT , Ute KLINKHARDT , Katja FIEDLER
IPC分类号： C12N15/117 , A61K38/20 , A61K39/00 , A61P35/00
摘要： The present invention relates to RNA, particularly an immunostimulatory RNA (isRNA), a coding RNA or a combination thereof, for use in the treatment or prophylaxis of a disease, in particular a tumor and/or cancer disease. The present invention also provides pharmaceutical compositions, and a kit comprising the RNA(s). Further, the invention also comprises medical uses of the RNA(s) and compositions comprising the RNA(s).

6. 发明申请

US20220378818A1 OLIGONUCLEOTIDE-BASED THERAPY FOR ULCERATIVE COLITIS 有权
公开(公告)号：US20220378818A1
公开(公告)日：2022-12-01
申请号：US17636317
申请日：2020-08-21
申请人： INDEX PHARMACEUTICALS AB
发明人： Peter Zerhouni , Pernilla Sandwall , Thomas Knittel
IPC分类号： A61K31/7125 , C12N15/117 , A61K9/00 , A61P29/00
摘要： The present invention provides an oligonucleotide comprising the sequence 5′-GGAACAGTTCGTCCATGGC-3′ (SEQ ID NO:2) for use in the treatment of an inflammatory bowel disease in a human subject via topical administration to the colon, wherein the subject has not been subjected to colonic cleaning prior to said administration.

7. 发明授权

US11478545B2 FHSS hotspot device and methods 有权
公开(公告)号：US11478545B2
公开(公告)日：2022-10-25
申请号：US16321466
申请日：2016-09-16
申请人： Shai Waxman
发明人： Shai Waxman
IPC分类号： H04B1/715 , A61K39/35 , A61P37/08 , A61K31/58 , A61K38/16 , C12N15/117 , H04B1/04 , H04B1/16 , H04B1/7156 , H04B1/40 , H04B1/713 , A61K39/00
摘要： A wireless wideband transceiver may be able to communicate with multiple frequency-hopped spread-spectrum (FHSS) devices concurrently over multiple frequencies over a short range by including a plurality of digital chains corresponding to the FHSS physical channels, individually and dynamically compensated for in-phase/quadrature imbalance in the transmit and/or receive portion. To further improve communications the transceiver may also mitigate cross interference between adjacent channel signals that are received and/or transmitted simultaneously, avoid false reception and/or transmission of co-channel signals, delay respective FHSS channels transmissions relative to other channels transmissions, speed up connection to FHSS devices and coordinate Time Division Duplexing (TDD) operation according to application dependent TX/RX binary pattern. A device that includes such a transceiver (FHSS-hotspot) may enable the concurrent usage of multiple commercially available FHSS peripheral devices without the need for additional personal host devices to be carried along with them, and in addition enable the concurrent usage of multiple commercially available FHSS personal data devices while reducing their radiation and/or latency and/or usage cost and/or power, to establish a localized multi-device multimedia session, and/or to interface with a communications network to communicate with remote parties, and/or to interface with broadcast devices to stream contents.

8. 发明申请

US20220296632A1 MRNA FUNCTIONALIZATION METHOD 有权
公开(公告)号：US20220296632A1
公开(公告)日：2022-09-22
申请号：US17745314
申请日：2022-05-16
申请人： THE UNIVERSITY OF TOKYO , KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
发明人： Satoshi UCHIDA , Keiji ITAKA , Kazunori KATAOKA , Naoto YOSHINAGA
IPC分类号： A61K31/7115 , A61K47/69 , A61K39/00 , C12N15/117
摘要： The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.

9. 发明申请

US20220202846A1 IMMUNOSTIMULATING COMPOSITION 有权
公开(公告)号：US20220202846A1
公开(公告)日：2022-06-30
申请号：US17310002
申请日：2020-01-09
申请人： OSAKA UNIVERSITY , DAICEL CORPORATION
发明人： Tomoyuki NISHIKAWA , Yasufumi KANEDA , Kunihiko YAMASHITA , Ayano SUZUKI , Kazuhiro TERAI
IPC分类号： A61K31/713 , C12N15/117 , A61P35/00
摘要： An object of the present disclosure is at least to provide a technique for stimulating immunity in mammals, and the object is fulfilled by double-stranded RNA composed of: RNA composed of a base sequence represented by a sequence A below; and RNA composed of a base sequence represented by a sequence B below, each base of an (N)13-25 portion in the base sequence represented by the sequence A and the base sequence represented by the sequence B being or not being complementary bases, and all of the bases of (N)5-10 portions in the base sequence represented by the sequence A and the base sequence represented by the sequence B being complementary bases, and a Tm value of the (N)5-10 portion being 20° C. or higher: Sequence A: 5′-UUGUCAUAUGGACAAGUCCAAGACU(N)13-25(N)5-10-3′ (SEQ ID No: 1), and Sequence B: 5′-(N)5-10(N)13-25AGUCUUGGACUUGUCCAUAUGACAA-3′ (SEQ ID No: 2).

10. 发明申请

US20220177887A1 RNA-NANOSTRUCTURED DOUBLE ROBOTS AND METHODS OF USE THEREOF 有权
公开(公告)号：US20220177887A1
公开(公告)日：2022-06-09
申请号：US17553603
申请日：2021-12-16
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： Yung CHANG , Hao YAN , Xiaodong QI , Fei ZHANG
IPC分类号： C12N15/117 , A61K39/00
摘要： Described herein are immuno-stimulatory RNA nanostructures (which comprises a single-stranded RNA (ssRNA) molecule, wherein the ssRNA molecule forms at least one paranemic cohesion crossover), as well as compositions and methods of use thereof.

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