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1. 发明授权

US06740751B2 Methods and compositions for stabilizing microtubules and intermediate filaments in striated muscle cells 失效
公开(公告)号：US06740751B2
公开(公告)日：2004-05-25
申请号：US09908988
申请日：2001-07-18
申请人： Eric N. Olson , Jeffrey A. Spencer
发明人： Eric N. Olson , Jeffrey A. Spencer
IPC分类号： C12N1512
CPC分类号： C07K14/4716 , A61K38/00 , C07K14/47
摘要： The present invention discloses new muscle ring finger (MURF) proteins designate MURF-1, MURF-2 and MURF-3. The genes encoding these MURFs also are provided. MURFs interact with microtubules and thus play a role in cytoskeletal function, mitosis and cell growth. Thus, the uses of MURFs in diagnosis, treatment and drug screening, in particular relation to cardiomyopathies, are described.

2. 发明授权

US06733990B1 Nucleic acid encoding 15571, a GPCR-like molecule of the secretin-like family 失效
标题翻译：编码15571的核酸，一种类胰蛋白样家族的GPCR样分子
公开(公告)号：US06733990B1
公开(公告)日：2004-05-11
申请号：US09631603
申请日：2000-08-03
申请人： Martin R. Hodge , Clare Lloyd , Nadine S. Weich
发明人： Martin R. Hodge , Clare Lloyd , Nadine S. Weich
IPC分类号： C12N1512
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q2600/156
摘要： Novel GPCR-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GPCR-like proteins, the invention further provides isolated GPCR-like fusion proteins, antigenic peptides, and anti-GPCR-like antibodies. The invention also provides GPCR-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GPCR-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新的GPCR样多肽，蛋白质和核酸分子。除了分离的全长GPCR样蛋白之外，本发明还提供了分离的GPCR样融合蛋白，抗原肽和抗GPCR样抗体。本发明还提供了GPCR样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经导入或破坏了GPCR样基因的非人转基因动物。还提供了利用本发明组合物的诊断，筛选和治疗方法。

3. 发明授权

US06723535B2 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US06723535B2
公开(公告)日：2004-04-20
申请号：US09906700
申请日：2001-07-16
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： C12N1512
CPC分类号： C07K16/18
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

4. 发明授权

US06709839B1 SYK-UBP proteins, compositions and methods of use 有权
标题翻译： SYK-UBP蛋白，组合物和使用方法
公开(公告)号：US06709839B1
公开(公告)日：2004-03-23
申请号：US09404967
申请日：1999-09-24
申请人： Ying Luo , Helena Mancebo
发明人： Ying Luo , Helena Mancebo
IPC分类号： C12N1512
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

5. 发明授权

US06706871B1 Growth factor antagonist materials and methods 失效
标题翻译：生长因子拮抗剂的材料和方法
公开(公告)号：US06706871B1
公开(公告)日：2004-03-16
申请号：US10082902
申请日：2002-02-26
申请人： Dennis G. Ballinger , Julie Reeder Montgomery
发明人： Dennis G. Ballinger , Julie Reeder Montgomery
IPC分类号： C12N1512
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention provides nucleic acids encoding Sprouty related human growth factor antagonist proteins (designated FGFAn-Hy), the polypeptides encoded by these nucleic acids and uses of these and related products.
摘要翻译：本发明提供编码Sprouty相关的人生长因子拮抗蛋白（称为FGFAn-Hy）的核酸，由这些核酸编码的多肽以及这些和相关产物的用途。

6. 发明授权

US06703495B2 Polynucleotides encoding human transporter protein 失效
标题翻译：编码人转运蛋白的多核苷酸
公开(公告)号：US06703495B2
公开(公告)日：2004-03-09
申请号：US09875811
申请日：2001-06-06
申请人： D. Wade Walke , John Scoville
发明人： D. Wade Walke , John Scoville
IPC分类号： C12N1512
CPC分类号： C07K14/47
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译：公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。

7. 发明授权

US06596855B2 Probes for chondrogenesis 失效
标题翻译：软骨形成探针
公开(公告)号：US06596855B2
公开(公告)日：2003-07-22
申请号：US09881578
申请日：2001-06-14
申请人： Thomas M. Hering , Brian Johnstone
发明人： Thomas M. Hering , Brian Johnstone
IPC分类号： C12N1512
CPC分类号： G01N33/6887 , C07K14/47 , C07K14/4702 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.
摘要翻译：提供了细胞中检测和分期软骨形成的标记物。一方面，标记是分离的多核苷酸，以下称为CZF-1和CZF-2及其片段。在一个实施方案中，CZF-1多核苷酸包含SEQ ID NO.1所示的开放阅读框序列。在一个实施方案中，CZF-2多核苷酸包含SEQ ID NO：1所示的开放阅读框序列。在另一方面，标记是对CZF-1或CZF-2编码的蛋白质具有免疫特异性的抗体。提供了使用本标记鉴定已经开始分化成软骨细胞的细胞的方法。本发明还涉及CZ-1蛋白和CZ-2蛋白以及与CZF-1或CZF-2或其区域的编码序列互补的多核苷酸或寡核苷酸。

8. 发明授权

US06548270B1 DNA encoding human acid-sensing ion channel BNaC4 (ASIC4) 有权
标题翻译：编码人酸感应离子通道BNaC4（ASIC4）的DNA
公开(公告)号：US06548270B1
公开(公告)日：2003-04-15
申请号：US09518959
申请日：2000-03-03
申请人： Adrienne Elizabeth Dubin , Jayashree Pyati , Rene Huvar , Mark G. Erlander
发明人： Adrienne Elizabeth Dubin , Jayashree Pyati , Rene Huvar , Mark G. Erlander
IPC分类号： C12N1512
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding human acid sensing ion channel BnaC4 has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：已经克隆并表征编码人感应离子通道BnaC4的DNA。重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

9. 发明授权

US06531585B1 Steroid/thyroid hormone receptor-related gene which is inappropriately expressed in human hepatocellular carcinoma and which is a retinoic acid receptor 失效
标题翻译：在人肝细胞癌中不适当表达的类固醇/甲状腺激素受体相关基因，其是视黄酸受体
公开(公告)号：US06531585B1
公开(公告)日：2003-03-11
申请号：US07649342
申请日：1991-02-01
申请人： Hugues Blaudin de The , Agnes Marchio , Pierre Tiollais , Anne Dejean
发明人： Hugues Blaudin de The , Agnes Marchio , Pierre Tiollais , Anne Dejean
IPC分类号： C12N1512
CPC分类号： C07K14/70567 , C12Q1/6876 , C12Q2600/158
摘要： A previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, which has been named hap, is similar to that of the DNA-binding hormone receptors. Six out of seven hepatoma and hepatoma-derived cell-lines express a 2.5 kb hap mRNA species which is undetectable in normal adult and fetal livers, but present in all nonhepactic tissues analyzed. Low stringency hybridization experiments revealed the existence of hap related genes in the human genome. The cloned DNA sequence is useful in the preparation of pure hap protein and as a probe in the detection and isolation of complementary DNA and RNA sequences. The hap protein is a retinoic acid (RA) receptor identified as RAR-&bgr;.
摘要翻译：将以前分离的乙肝病毒（HBV）整合到与肝细胞癌（HCC）连接的147bp的细胞DNA片段中作为探针，从人肝cDNA文库克隆相应的互补DNA。核苷酸序列分析显示，已命名为hap的细胞基因的整体结构与DNA结合激素受体的结构相似。七个肝癌和肝癌细胞系中有六个表达了2.5kb的hap mRNA，在正常成年和胎儿肝脏中是不可检测的，但存在于所有非肝脏组织中。低严格杂交实验揭示了人类基因组中hap相关基因的存在。克隆的DNA序列可用于制备纯hap蛋白，并用作检测和分离互补DNA和RNA序列的探针。 hap蛋白是鉴定为RAR-β的视黄酸（RA）受体。

10. 发明授权

US06525188B2 Nuclear retinoic acid co-receptor 失效
标题翻译：核视黄酸共受体
公开(公告)号：US06525188B2
公开(公告)日：2003-02-25
申请号：US09909325
申请日：2001-07-19
申请人： Eva L. K. Enmark , Jan-Ake Gustafsson
发明人： Eva L. K. Enmark , Jan-Ake Gustafsson
IPC分类号： C12N1512
CPC分类号： C07K14/70567 , A61K38/00
摘要： This invention provides an isolated receptor having the amino acid sequence of FIG. 1 (SEQ ID NO:2) or substantially the same amino acid sequence as the amino acid sequence shown in FIG. 1 (SEQ ID NO:2) or an amino acid sequence functionally similar to that sequence, and DNA sequences encoding such a receptor.
摘要翻译：本发明提供了具有图1的氨基酸序列的分离的受体。 1（SEQ ID NO：2）或与图1所示的氨基酸序列基本相同的氨基酸序列。 1（SEQ ID NO：2）或与该序列功能相似的氨基酸序列，以及编码这种受体的DNA序列。

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