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1. 发明授权

US10537660B2 Resorbable, amino acid-based poly(ester urea)s scaffold for vascular graft tissue engineering 有权
公开(公告)号：US10537660B2
公开(公告)日：2020-01-21
申请号：US15032809
申请日：2014-10-29
申请人： The University of Akron
发明人： Matthew Becker , Darrell Reneker , Yaohua Gao
IPC分类号： A61L27/18 , A61L27/58 , C08G71/02 , A61F2/07 , D01D5/00 , D01F6/68 , D01F6/84 , A61F2/82
摘要： Embodiments relate to amino acid-based poly(ester urea)s with amino acid residues selected L-leucine, L-isoleucine, L-valine or combinations thereof. The amino acid-based poly(ester urea)S may optionally include a second amino acid residue selected from proteinogenic amino acids and non-proteinogenic amino acids. The amino acid-based poly(ester urea)s are particular useful for the preparation of vascular grafts. Due to the biocompatibility of the amino acid-based poly(ester urea)s, vascular grafts prepared from amino acid-based poly(ester urea)s with small internal diameters (i.e. less than 5 mm) may be prepared and inserted into a patient or animal, and provide a substantial decrease in the risk of failure compared to conventional polymers used in vascular grafts.

2. 发明授权

US5283297A Artificial hair from poly amino acid urethane fiber 失效
标题翻译：来自聚氨基甲酸乙酯纤维的人造头发
公开(公告)号：US5283297A
公开(公告)日：1994-02-01
申请号：US831579
申请日：1992-02-07
申请人： Yasuyoshi Miyachi , Nobuo Ito , Masako Koyama
发明人： Yasuyoshi Miyachi , Nobuo Ito , Masako Koyama
IPC分类号： C08G18/60 , A41G3/00 , A63H3/44 , C08G18/83 , C08G69/02 , C08G69/26 , D01F6/68 , D01F6/70 , D01F6/78
CPC分类号： A41G3/0083 , A63H3/44 , D01F6/68 , D01F6/78
摘要： An artificial hair made of a fibers comprising a poly-.alpha.-amino acid derivative insoluble to water and alcohols and represented by one of the following general formulae (1)-(4): ##STR1## providing that R in each of the above formula (1)-(4) is R.sup.a, R.sup.b and R.sup.c represented, respectively, by the following general formula (5), (6) or (7): ##STR2## or made or polyamino acid urethane fiber comprising a copolymer of an amino acid N-carboxy anhydride and a polyurethane, in which the copolymer is subjected to an amidation reaction with an organic diamine and an organic amine having amino groups and mercapto groups or disulfide groups and to shaping into a fibrous form.The artificial hair has a dyeability, shape retainability, natural and soft and flexible feeling, excellent tough and brushing property, as well as has natural color and gloss and toughness like that natural protein fiber.
摘要翻译：一种由纤维构成的人造毛发，其包含不溶于水和醇的聚（α） - 氨基酸衍生物，并由以下通式（1） - （4）之一表示：（*化学结构*）（1）（ *化学结构*）（2）（*化学结构*）（3）或（*化学结构*）（4）使上述式（1） - （4）中的R为Ra，Rb和Rc 分别由以下通式（5），（6）或（7）表示：（-CH2）kCONR1（CH2）1NR2R3，（5）（-CH2）kCONR1（CH2）1SR2，（6）（ - kCOOR'，H，R'OR-CH2CH2SMe，（7）或包含氨基酸N-羧酸酐和聚氨酯的共聚物的制备或聚氨基酸聚氨酯纤维，其中共聚物与有机二胺进行酰胺化反应和具有氨基和巯基或二硫键的有机胺，并成型为纤维状。人造头发具有可染性，形状保持性，自然柔软柔软的感觉，优异的韧性和刷牙性，以及具有天然色素和光泽和韧性的天然蛋白纤维。

3. 发明授权

US3089749A Production of artificial threads 失效
公开(公告)号：US3089749A
公开(公告)日：1963-05-14
申请号：US16176261
申请日：1961-12-01
申请人： COURTAULDS LTD
发明人： BALLARD DENIS G H
IPC分类号： C08G69/10 , D01F6/60 , D01F6/68 , D01F6/76
CPC分类号： C08G69/10 , D01F6/68

4. 发明授权

US11208736B2 Methods of generating highly-crystalline recombinant spider silk protein fibers 有权
公开(公告)号：US11208736B2
公开(公告)日：2021-12-28
申请号：US16141787
申请日：2018-09-25
申请人： Bolt Threads, Inc.
发明人： Amir Ahmad Bakhtiary Davijani , Steven Tom , Maxime Boulet-Audet , Paul Andre Guerette , Lindsay Wray , Nicole Elizabeth Subler , Zoya Nasir Zulfiqar , Hua Li , Jessica Wang
IPC分类号： D01D5/06 , D01F6/68 , D02J13/00 , D02J1/22 , D01D1/02 , D01F4/02
摘要： Provided herein are scalable methods of processing wet-spun fiber comprising recombinant spider silk polypeptides to generate a three-dimensional crystalline lattice of beta-sheet structures in the fiber.

5. 发明授权

US11174572B2 Composite molding composition including fibroin-like protein, and method for producing composite molding composition 有权
公开(公告)号：US11174572B2
公开(公告)日：2021-11-16
申请号：US16326081
申请日：2017-07-24
申请人： RIKEN , SPIBER INC.
发明人： Keiji Numata , Kousuke Tsuchiya , Junichi Sugahara , Takaoki Ishii , Hongfang Chi
IPC分类号： D01F4/02 , D01F4/00 , D01D1/02 , A61L27/22 , D01D5/16 , D01F1/10 , D01F6/68
摘要： Provided are a composite molding composition such as a composite film and a composite fiber that have properties such as an improved tensile strength, strain and toughness as a result of blending a peptide or polyamino acid having a β-sheet structure with a natural or artificially modified fibroin-derived protein; a method for producing such composite molding composition; and a method for improving the physical properties of a composite molding composition containing a fibroin-derived protein.

6. 发明申请

US20180298151A1 Methods and Compositions for Synthesizing Improved Silk Fibers 审中-公开
公开(公告)号：US20180298151A1
公开(公告)日：2018-10-18
申请号：US16016483
申请日：2018-06-22
申请人： Bolt Threads, Inc.
发明人： Daniel M. Widmaier , David N. Breslauer , Joshua Kittleson , Brendan Turner , Lindsay Wray
IPC分类号： C08H1/00 , D01F11/02 , B29C47/00 , D01F4/02 , D01F4/00 , D01D5/00 , D01D1/02 , C12P21/02 , C12P21/00 , D01F6/68 , B29C47/88 , C07K14/435 , B29L31/00
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.

7. 发明申请

US20160250382A1 RESORBABLE, AMINO ACID-BASED POLY(ESTER UREA)S SCAFFOLD FOR VASCULAR GRAFT TISSUE ENGINEERING 审中-公开
标题翻译：基于氨基酸的聚氨酯（ESTER UREA）S SCAFFOLD for VASCULAR GRAFT TISSUE ENGINEERING
公开(公告)号：US20160250382A1
公开(公告)日：2016-09-01
申请号：US15032809
申请日：2014-10-29
申请人： Matthew Becker , Darrell Reneker , Yaohua Gao
发明人： Matthew Becker , Darrell Reneker , Yaohua Gao
IPC分类号： A61L27/18 , C08G71/02 , A61F2/82 , D01F6/68 , D01F6/84 , A61F2/07 , A61L27/58 , D01D5/00
摘要： Embodiments relate to amino acid-based poly(ester urea)s with amino acid residues selected L-leucine, L-isoleucine, L-valine or combinations thereof. The amino acid-based poly(ester urea)S may optionally include a second amino acid residue selected from proteinogenic amino acids and non-proteinogenic amino acids. The amino acid-based poly(ester urea)s are particular useful for the preparation of vascular grafts. Due to the biocompatibility of the amino acid-based poly(ester urea)s, vascular grafts prepared from amino acid-based poly(ester urea)s with small internal diameters (i.e. less than 5 mm) may be prepared and inserted into a patient or animal, and provide a substantial decrease in the risk of failure compared to conventional polymers used in vascular grafts.
摘要翻译：实施方案涉及具有选择L-亮氨酸，L-异亮氨酸，L-缬氨酸或其组合的氨基酸残基的氨基酸基聚（酯脲）。基于氨基酸的聚（酯尿素）S可以任选地包括选自蛋白质氨基酸和非蛋白质氨基酸的第二氨基酸残基。基于氨基酸的聚（酯尿素）对于制备血管移植物是特别有用的。由于基于氨基酸的聚（酯尿素）的生物相容性，可以制备由具有小内径（即小于5mm）的氨基酸基聚（酯尿素）制备的血管移植物并将其插入患者或动物，与血管移植物中使用的常规聚合物相比，可大大降低失败风险。

8. 发明授权

US09192624B2 Medical material and method for manufacturing same 有权
标题翻译：医疗材料及其制造方法
公开(公告)号：US09192624B2
公开(公告)日：2015-11-24
申请号：US13911776
申请日：2013-06-06
申请人： Ajinomoto Co., Inc.
发明人： Manabu Kitazawa , Satoru Ohashi , Yoko Masuzawa , Kousaku Ohkawa , Yasuhiko Tabata
IPC分类号： A61K31/785 , D01F6/68 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , A61L27/00 , D01D5/00
CPC分类号： A61K31/785 , A61L27/00 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , D01D5/0038 , D01F6/68 , C08L77/00
摘要： The present invention aims to provide a medical material which is safe for the live body, has high biocompatibility and is useful for promotion of cell differentiation. The present invention produces a medical material for promoting cell differentiation, which contains polyamino acid as a main component, wherein the polyamino acid contains at least one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue optionally containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain.
摘要翻译：本发明的目的在于提供对活体安全的医疗用材料，具有高的生物相容性，对促进细胞分化是有用的。本发明生产含有聚氨基酸作为主要成分的促进细胞分化的医药材料，其中聚氨基酸含有选自丙氨酸残基，缬氨酸残基，亮氨酸中的至少一种氨基酸残基残基，异亮氨酸残基，苯丙氨酸残基，甘氨酸残基，谷氨酰胺残基，任选含有侧链保护基的天冬氨酸残基，任选地含有侧链保护基的酪氨酸残基，任选含有侧链中的保护基，任选地含有侧链保护基的赖氨酸残基，以及任选地在侧链中含有保护基的谷氨酸残基。

9. 发明授权

US09173980B2 Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates 有权
标题翻译：表现出增强的结晶和水解速率的生物可吸收聚合物组合物
公开(公告)号：US09173980B2
公开(公告)日：2015-11-03
申请号：US13842265
申请日：2013-03-15
申请人： ETHICON, INC.
发明人： Sasa Andjelic , Benjamin D. Fitz
IPC分类号： C08L67/04 , A61L31/06 , A61L27/18 , C08L69/00 , C08L101/16 , D01D5/098 , D01F6/62 , D01F6/68 , D01F6/86 , B29D7/00 , D04H1/56 , A61L27/58 , A61L31/14 , B29C71/00
CPC分类号： A61L31/06 , A61L27/18 , A61L27/58 , A61L31/148 , B29C71/00 , B29D7/00 , C08L67/04 , C08L69/00 , C08L101/16 , C08L2203/02 , C08L2205/02 , D01D5/0985 , D01F6/625 , D01F6/68 , D01F6/86 , D04H1/56 , Y10T442/609 , C08L2666/18
摘要： A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.
摘要翻译：双峰生物可吸收聚合物组合物。所述组合物包含第一量聚合以具有第一分子量分布的生物可吸收聚合物; 所述第二量的所述生物可吸收聚合物被聚合以具有重均分子量在约10,000至约50,000道尔顿之间的第二分子量分布，所述第一分子量分布与所述第二分子量分布的重均分子量比为至少约二比一; 其中所述第一和第二量的所述生物可吸收聚合物的基本均匀的共混物以约50/50至约95/5重量/重量％的比例形成。还公开了医疗装置，制造医疗装置的方法和熔融吹制半结晶聚合物共混物的方法。

10. 发明授权

US5171505A Process for spinning polypeptide fibers 失效
标题翻译：纺丝多肽纤维的工艺
公开(公告)号：US5171505A
公开(公告)日：1992-12-15
申请号：US618505
申请日：1990-11-28
申请人： Robert L. Lock
发明人： Robert L. Lock
IPC分类号： D01F1/02 , C07K14/00 , D01F6/68
CPC分类号： C07K14/001 , D01F6/68
摘要： Polypeptide fibers, fiber spinnable solutions, and a process for forming polypeptide fibers are disclosed. The invention includes forming polypeptide fibers from spinning solutions containing a polypeptide, and a solvent selected from the group consisting of hexafluoroisopropanol, and a mixture of formic acid and at least one lithium halide.

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