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1. 发明授权

US11624708B2 Image processing techniques in multiplexed fluorescence in-situ hybridization 有权
公开(公告)号：US11624708B2
公开(公告)日：2023-04-11
申请号：US17124305
申请日：2020-12-16
申请人： Applied Materials, Inc.
发明人： Yun-Ching Chang , Dan Xie , Chloe Kim
IPC分类号： G06T5/00 , G01N21/64 , G02B21/00 , C12Q1/6841 , G02B21/16 , G02B21/36 , G06T5/20 , G06T5/50 , G06T7/00 , G16B50/40 , G06V10/30 , G06V10/75 , G06V20/69 , G01N21/75
摘要： A fluorescent in-situ hybridization imaging and analysis system includes a flow cell to contain a sample to be exposed to fluorescent probes in a reagent, a fluorescence microscope to obtain sequentially collect a plurality of images of the sample at a plurality of different combinations of imaging parameters, and a data processing system. The data processing system includes an online pre-processing system configured to sequentially receive the images from the fluorescence microscope as the images are collected and perform on-the-fly image pre-processing to remove experimental artifacts of the image and to provide RNA image spot sharpening, and an offline processing system configured to, after the plurality of images are collected, perform registration of images having a same field of view and to decode intensity values in the plurality of images to identify expressed genes.

2. 发明授权

US11619586B2 System for imaging and selective illumination of targets within a sample 有权
公开(公告)号：US11619586B2
公开(公告)日：2023-04-04
申请号：US17370184
申请日：2021-07-08
申请人： X Development LLC
发明人： Benoit Schillings , Anupama Thubagere Jagadeesh
IPC分类号： G01N21/64 , G02B21/00 , G02B21/36 , G02B21/16 , A61L2/10
摘要： A system, including an optical imaging assembly configured to image a sample at an object plane to an image plane; an image sensor arranged at the image plane and configured to capture images of the sample for a field of view of the system; a light source configured to emit light having a wavelength, λ; a spatial light modulator (SLM) arranged to receive the light emitted from the light source and to provide a spatially modulated light pattern; one or more optical elements arranged to receive the spatially modulated light pattern from the SLM and to direct the spatially modulated light pattern to the image plane; and an electronic controller in communication with the image sensor and the spatial light modulator, the electronic controller being programmed to identify one or more targets in the field of view of the optical imaging assembly and to control the spatial light modulator to selectively direct light from the light source to the one or more targets identified by the electronic controller.

3. 发明申请

US20230071083A1 Super-Resolution Optical Microscope 有权
公开(公告)号：US20230071083A1
公开(公告)日：2023-03-09
申请号：US17466502
申请日：2021-09-03
申请人： Wisconsin Alumni Research Foundation
发明人： Shimon Kolkowitz , Aedan Gardill , Matthew Cambria
IPC分类号： G02B27/58 , G02B21/06 , G02B5/18 , G02B21/16 , G02B21/36 , G02B27/42 , G01N21/64
摘要： A super-resolution microscope avoids the need for complex phase plate optics normally used to produce a doughnut-shaped depletion beam by employing low-intensity regions of common diffraction patterns such as an Airy disk.

4. 发明申请

US20230022632A1 MICROSCOPY IMAGING SYSTEM AND METHODS 有权
公开(公告)号：US20230022632A1
公开(公告)日：2023-01-26
申请号：US17812494
申请日：2022-07-14
申请人： University of Rochester
发明人： Qiang Yang , Jennifer Hunter , Keith Parkins
IPC分类号： A61B3/13 , A61B3/12 , G02B21/16 , G02B21/00
摘要： A microscopy imaging system comprises a fluorescence lifetime imaging microscopy (FLIM) system comprising a pulsed light source configured to direct a plurality of excitation light pulses onto a sample, a photo detector configured to detect emitted fluorescent photons created by the plurality of excitation pulses interacting with the sample, and a FLIM data acquisition system configured to measure the time interval between the excitation light pulses and the detected emitted fluorescent photons, a scanning light microscopy (SLM) system comprising a SLM data acquisition system, a fast scanning mirror and a slow scanning mirror, wherein the mirrors are configured to scan the light pulses across the sample; and a data processing system communicatively connected to the FLIM and SLM systems. Microscopy imaging methods are also disclosed.

5. 发明授权

US11562584B2 Systems and methods to reduce scattering in temporal focusing multiphoton microscopy 有权
公开(公告)号：US11562584B2
公开(公告)日：2023-01-24
申请号：US16844323
申请日：2020-04-09
申请人： Massachusetts Institute of Technology
发明人： Jong Kang Park , Dushan Wadduwage , Yi Xue , Elly Nedivi , Peter T. C. So , Christopher Rowlands , Kalen Berry
IPC分类号： G02B21/00 , G06V20/69 , A61B1/00 , G01N21/64 , G02B21/06 , G02B21/16 , G01N1/28
摘要： Systems and methods herein provide improved, high-throughput multiphoton imaging of thick samples with reduced emission scattering. The systems and methods use structured illumination to modify the excitation light. A reconstruction process can be applied to the resulting images to recover image information free of scattering. The disclosed systems and methods provide high throughput, high signal-to-noise ratio, and high resolution images that are depth selective.

6. 发明授权

US11530990B2 Light-sheet microscope with parallelized 3D image acquisition 有权
公开(公告)号：US11530990B2
公开(公告)日：2022-12-20
申请号：US17135679
申请日：2020-12-28
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： Reto P. Fiolka
IPC分类号： G01N21/64 , G02B21/36 , G02B21/16 , G02B21/00 , G02B27/14 , G02B27/10
摘要： This disclosure includes an imaging system that is configured to image in parallel multiple focal planes in a sample uniquely onto its corresponding detector while simultaneously reducing blur on adjacent image planes. For example, the focal planes can be staggered such that fluorescence detected by a detector for one of the focal planes is not detected, or is detected with significantly reduced intensity, by a detector for another focal plane. This enables the imaging system to increase the volumetric image acquisition rate without requiring a stronger fluorescence signal. Additionally or alternatively, the imaging system may be operated at a slower volumetric image acquisition rate (e.g., that of a conventional microscope) while providing longer exposure times with lower excitation power. This may reduce or delay photo-bleaching (e.g., a photochemical alteration of the dye that causes it to no longer be able to fluoresce), thereby extending the useful life of the sample.

7. 发明申请

US20220390734A1 METHOD AND SYSTEM FOR IMAGING A BLOOD SAMPLE 有权
公开(公告)号：US20220390734A1
公开(公告)日：2022-12-08
申请号：US17882702
申请日：2022-08-08
申请人： S.D. Sight Diagnostics Ltd.
发明人： Joseph Joel POLLAK , Arnon HOURI YAFIN , Seth J. SALPETER
IPC分类号： G02B21/34 , G01N1/28 , G01N1/38 , G01N21/64 , G02B21/00 , G02B21/36 , G02B21/16
摘要： Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface and a closed top, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described.

8. 发明申请

US20220390367A1 AN OPTICAL IMAGING SYSTEM 有权
公开(公告)号：US20220390367A1
公开(公告)日：2022-12-08
申请号：US17773005
申请日：2020-10-27
申请人： Oxford Nanoimaging Limited
发明人： Matthias Steiner
IPC分类号： G01N21/45 , G02B21/00 , G02B21/16 , G01N21/64
摘要： An optical system is presented for optically imaging a sample including a nanoscale object. The optical system includes an imaging lens, an illumination source configured to provide an excitation light, a detector and a substrate for supporting the sample. A sample interface, arranged to reflect the excitation light, is formed between the sample and a first side of the substrate facing the sample when the sample is applied on the substrate. The optical imaging system is arranged such that the excitation light is sent into the substrate via the imaging lens and such that the detector receives a reference light and a scattered light. The reference light comprises a part of the excitation light reflected at the sample interface and collected by the imaging lens and the scattered light comprises a part of the excitation light scattered by the nanoscale object and collected by the imaging lens. The optical system is configured such that the nanoscale object is imaged at the detector, in response to the excitation light, by an optical contrast of an interference pattern between the reference light and the scattered light. The substrate comprises an optical coating disposed on the first side of the substrate such that the sample is in contact with the optical coating when the sample is applied on the substrate. A degree of reflection of the excitation light at the sample interface is such that the optical contrast is larger compared to the optical contrast obtained with the sample interface formed without the optical coating.

9. 发明授权

US11513330B2 Fluorescence microscope apparatus and fluorescence microscope system 有权
公开(公告)号：US11513330B2
公开(公告)日：2022-11-29
申请号：US16651286
申请日：2018-06-19
申请人： Sony Corporation
发明人： Suguru Dowaki
IPC分类号： G01N21/64 , G02B21/08 , G02B21/16 , G02B21/36 , G02B27/48
摘要： Disclosed is a technology for illuminating a specimen in a desired uniform illumination pattern and capturing an image of a wide field of view in a low background illumination environment.
Provided, for example, is a fluorescence microscope apparatus including a first illumination optics, a second illumination optics, and an imaging optics. The first illumination optics includes a first light source for exciting fluorescence in a specimen, a spatial light modulation element, and a first illumination optical member for uniformly illuminating the spatial light modulation element. The second illumination optics includes a second illumination optical member for forming an image of a light beam from the spatial light modulation element on a specimen surface. The imaging optics includes an imaging optical member and an imaging element. The imaging optical member captures an image of the specimen surface.

10. 发明申请

US20220373464A1 CONTROL SYSTEM AND METHOD FOR DETERMINING AN ILLUMINATION INTENSITY IN A FLUORESCENCE MICROSCOPE AND CORRESPONDING MICROSCOPE SYSTEM 有权
公开(公告)号：US20220373464A1
公开(公告)日：2022-11-24
申请号：US17734164
申请日：2022-05-02
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Kai RITSCHEL , Christian SCHUMANN
IPC分类号： G01N21/64 , G02B21/16 , G02B21/36
摘要： A control system for automatedly determining an illumination intensity of at least one light source of a fluorescence microscope is provided. The control system is configured to automatedly determine, after a change in a light path, a control value for the illumination intensity of the at least one light source in order to achieve a desired value of an inspection parameter characterizing sample inspection. The light path comprises at least one of: an illumination path from the at least one light source to the sample and an imaging path from the sample to at least one detector. Determining the control value is based on: (i) a value of the illumination intensity that was set before the change in the light path, (ii) a value of the inspection parameter used before the change in the light path, and (iii) a physical model of the light path.

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