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1. 发明申请

US20230133890A1 LIVING HINGE SEAL FOR SILICONE-FREE SYRINGE BARREL 有权
公开(公告)号：US20230133890A1
公开(公告)日：2023-05-04
申请号：US18051621
申请日：2022-11-01
申请人： Merit Medical Systems, Inc.
发明人： Michael Dean Haslam , Richard P. Jenkins
IPC分类号： A61M5/315 , A61M5/31
摘要： A syringe assembly void of silicone is disclosed. The syringe assembly includes a syringe plunger and a syringe barrel. The syringe plunger includes a handle and a plunger tip. The plunger tip includes a wiper extending from a hinge configured to allow the wiper to flex proximally and distally. The wiper includes a proximal circumferential seal and a distal circumferential seal. The proximal circumferential seal is configured to seal against an internal surface of the syringe barrel when the syringe plunger is displaced proximally and a negative pressure is generated within the syringe barrel. The distal circumferential seal is configured to seal against the internal surface of the syringe barrel when the syringe plunger is displaced distally and a positive pressure is generated within the syringe barrel. The syringe barrel includes internal detents to retain the syringe plunger within the syringe barrel.

2. 发明授权

US11638786B2 Medicament delivery device 有权
公开(公告)号：US11638786B2
公开(公告)日：2023-05-02
申请号：US16846999
申请日：2020-04-13
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Winfried Huthmacher , Peter Nober
IPC分类号： A61M5/315 , A61M5/32 , A61M5/31
摘要： Described is a medicament delivery device (1), comprising a body (2), a container carrier (7) for retaining a medicament container within the body (2) and being slidably disposed in the body (2), a sleeve (6) slidably coupled to body (2), and a piston rod (11) coupled to the body (2) and the container carrier (7). The piston rod (11) and the container carrier (7) provide a feedback as the container carrier (7) moves from a first position (P1) to a second position (P2) relative to the body (2).

3. 发明授权

US11628257B2 Method for reducing an amount of subvisible particles in a pharmaceutical composition 有权
公开(公告)号：US11628257B2
公开(公告)日：2023-04-18
申请号：US16316736
申请日：2017-07-11
申请人： Becton Dickinson France
发明人： Tzvetelina Chevolleau , Benoit Fremon , Jean-Bernard Hamel , Sébastien Jouffray
IPC分类号： A61M5/31
摘要： The invention relates to a method for reducing an amount of sub visible particles in a pharmaceutical composition contained in a medical injection device comprising a container (1) including a barrel (10) lubricated with a lubricant coating (2) in contact with the pharmaceutical composition, and a stopper (14) in sliding engagement within the barrel (10), the container comprising a region (130, 121, 123) extending distally from the distal end (100) of the barrel which is not accessible to the stopper. During formation of said lubricant coating (2) on the inner wall of the barrel, the method comprises limiting lubricant from being deposited into said region (130, 121, 123) extending distally from the distal end (100) of the barrel.

4. 发明授权

US11623051B2 Automatic injection device 有权
公开(公告)号：US11623051B2
公开(公告)日：2023-04-11
申请号：US16271622
申请日：2019-02-08
申请人： ELCAM MEDICAL AGRICULTURAL COOPERATIVE ASSOCIATION LTD.
发明人： David Daily , Lior Raday
IPC分类号： A61M5/32 , A61M5/20 , A61M5/24 , A61M5/31
摘要： An automatic injection device including a housing element, at least one resilient element arranged to be located within the housing element, a syringe including at least one syringe piston, a needle guard adapted for selectable positioning with respect to the housing element and a selectable driving element adapted, when actuated, to be driven by the at least one resilient element for initially displacing the syringe relative to the housing element from a non-penetration position to a penetration position and thereafter displacing the at least one syringe piston in the syringe to effect drug delivery and displacing the needle guard into a needle guarding position.

5. 发明授权

US11617871B2 Methods and apparatus for disinfecting and reflux prevention flush syringe assembly 有权
公开(公告)号：US11617871B2
公开(公告)日：2023-04-04
申请号：US17076111
申请日：2020-10-21
申请人： Becton, Dickinson and Company
发明人： Girum Yemane Tekeste
IPC分类号： A61M39/16 , A61M39/02 , A61M5/31 , A61M5/315 , A61M5/34 , A61M39/10 , A61M39/00
摘要： Embodiments of the invention are directed to flush syringe assemblies comprising an integrated contamination-prevention device integrated with device connector flushing positioned so that the practitioner cannot forget to apply disinfectant. The flush syringe assemblies comprise a barrel with an elongate plunger rod disposed therein and a cap comprising a passageway. The plunger rod includes a stopper of which at least a portion can be embedded in the passageway of the cap to form a plug in the cap. Methods of flushing a vascular access device (VAD) while providing a flush syringe assembly described herein are also disclosed.

6. 发明申请

US20230098397A1 SYRINGE WITH A PATIENT CONTACT SURFACE 有权
公开(公告)号：US20230098397A1
公开(公告)日：2023-03-30
申请号：US17992115
申请日：2022-11-22
申请人： Becton, Dickinson and Company
发明人： Kevin WATTS , Roger HOECK , Lance Lee JACOBI , Amit Uday LIMAYE
IPC分类号： A61M5/46 , A61M5/42 , A61M5/178 , A61M5/31
摘要： A syringe and needle hub for a syringe has distal patient-facing side having a surface for contact with the subject’s skin during injection. The contact surface is formed by a distal face of a post supporting a cannula and an outer collar surrounding the post. The axial distance between the distal face of the post and the distal face of the collar provided a contact surface with a radius of curvature to control the desired injection. The syringe barrel can have finger flanges extending outwardly where the flanges have a tactile member such as a dimple projecting from a proximal face of the flange and recess in a distal face of the flange.

7. 发明授权

US11612697B2 Non-fluoropolymer tie layer and fluoropolymer barrier layer 有权
公开(公告)号：US11612697B2
公开(公告)日：2023-03-28
申请号：US14876229
申请日：2015-10-06
申请人： W. L. Gore & Associates, Inc.
发明人： Edward C. Gunzel
IPC分类号： A61M5/315 , B32B27/08 , B32B27/28 , A61M5/31
摘要： A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

8. 发明授权

US11612687B2 Drug delivery device 有权
公开(公告)号：US11612687B2
公开(公告)日：2023-03-28
申请号：US16348515
申请日：2017-11-07
申请人： SENSILE MEDICAL AG
发明人： Regina Marbet
IPC分类号： A61M5/14 , A61M5/142 , A61M39/22 , A61M5/315 , A61M5/145 , A61M5/158 , A61M5/31 , A61M5/20 , A61J1/20 , A61M5/178
摘要： A drug delivery device comprising a delivery unit (2) including an internal reservoir (8), a subcutaneous delivery mechanism (6), a pump for pumping liquid from the internal reservoir to the subcutaneous delivery system, and a liquid filling mechanism (12) configured for injecting liquid from an external vial (16) or reservoir into the internal reservoir. The liquid filling mechanism comprises a filling port (14) and a valve mechanism (18) selectively operable to: open a first fluid path (54) extending from the filling port to the internal fluid reservoir and close a second fluid path (56) extending from the internal reservoir to the subcutaneous delivery member, or close the first fluid path and open the second fluid path. The valve mechanism comprises a valve housing (48) fixedly mounted in relation to a housing of the drug delivery device and a valve stem (50) rotatably received within the valve housing, whereby the first fluid path and the second fluid path are selectively operated by the rotational position of the valve stem in relation to the valve housing, such that when the valve stem is in a first position, the first fluid path is open while the second fluid path is closed, and when the valve stem is in a second position, the second fluid path is open while the first fluid path is closed.

9. 发明授权

US11607499B2 Drug delivery device 有权
公开(公告)号：US11607499B2
公开(公告)日：2023-03-21
申请号：US16642647
申请日：2018-09-13
申请人： SANOFI
发明人： Matthew Meredith Jones , William Geoffrey Arthur Marsh
IPC分类号： A61M5/315 , A61M5/31
摘要： The disclosure relates to a drug delivery device for expelling a pre-determined or pre-settable amount of a liquid medicament formulation which improves the stalling behavior and indicates the stalling state to the user. The device comprises:
a medicament reservoir attached to a housing and
an expelling mechanism configured for acting against the medicament reservoir in order to expel a portion of the liquid medicament formulation therefrom, the expelling mechanism comprising an arrangement of a threaded nut in a fixed axial relation to the housing and a lead screw in threaded engagement with the threaded nut, the threaded nut and the lead screw being rotatable relative to each other by a rotational input interface, a mechanical energy reservoir (for storing energy, the stored energy being releasable from the energy reservoir by a rotational interface, a drive train having upstream and downstream interfaces; and a trigger movable relative to the housing.

10. 发明授权

US11602598B1 Prefilled syringe with pegfilgrastim having optimized dose and methods related thereto 有权
公开(公告)号：US11602598B1
公开(公告)日：2023-03-14
申请号：US17198404
申请日：2021-03-11
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Florence Roger , Fabien Vaudant , Thierry Rimlinger , Christian Ebert , Rodrigue Chatton , Alexander Degen , Kevin Reitz , Torsten Brandenburger
IPC分类号： C07K14/535 , A61K38/19 , A61K47/10 , A61M5/31 , A61M5/178 , A61M5/315 , A61K38/18
摘要： A prefilled syringe and a method of filling a syringe with a pegfilgrastim solution to provide a target extracted volume of pegfilgrastim solution from the syringe are described. A method includes selecting the target extracted volume of pegfilgrastim solution, determining an estimated drug transfer loss, determining an estimated syringe dead volume, filling the syringe with a volume of pegfilgrastim solution comprising at least the target extracted volume plus the estimated drug transfer loss plus the estimated syringe dead volume.

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