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1. 发明授权

US09695118B2 Benzamide derivative 有权
公开(公告)号：US09695118B2
公开(公告)日：2017-07-04
申请号：US14396678
申请日：2013-04-24
申请人： Chugai Seiyaku Kabushiki Kaisha
发明人： Takeshi Murata , Satoshi Niizuma , Sousuke Hara , Hatsuo Kawada , Kihito Hada , Hideaki Shimada , Hiroshi Tanaka , Yoshito Nakanishi
IPC分类号： C07D213/82 , C07D487/08 , C07C321/28 , C07D309/14 , C07C317/14 , C07D401/12 , C07D403/04 , C07C317/34 , C07D241/04 , C07C323/42 , C07D263/34 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/56 , C07D295/14 , C07D211/68 , C07D295/16 , C07D213/62 , C07C317/40 , C07C323/48
CPC分类号： C07C321/28 , C07C317/14 , C07C317/34 , C07C317/40 , C07C323/42 , C07C323/48 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/56 , C07D211/68 , C07D213/62 , C07D213/82 , C07D241/04 , C07D263/34 , C07D295/14 , C07D295/16 , C07D309/14 , C07D401/12 , C07D403/04 , C07D487/08
摘要： The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

2. 发明申请

US20130190338A1 SULFUR DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS 有权
公开(公告)号：US20130190338A1
公开(公告)日：2013-07-25
申请号：US13794494
申请日：2013-03-11
申请人： ALLERGAN, INC.
发明人： HAIQING YUAN , RICHARD L. BEARD , XIAOXIA LIU , JOHN E. DONELLO , VEENA VISWANATH , MICHAEL E. GARST
IPC分类号： C07D405/12 , C07C311/21 , C07D233/64 , C07D417/12 , C07C321/30 , C07C317/44 , C07D333/34 , C07D207/09 , C07D207/46 , C07D307/82 , C07C317/34
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

3. 发明授权

US07361689B2 Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof 失效
标题翻译：抗菌1-（4-单和二卤甲基磺酰基苯基）-2-酰基氨基-3-氟丙酮及其制备方法
公开(公告)号：US07361689B2
公开(公告)日：2008-04-22
申请号：US11018156
申请日：2004-12-21
申请人： Dale E. Shuster , Scott Hecker , Tomasz W. Glinka , Rajeshwar Singh , Zhuoyi Su
发明人： Dale E. Shuster , Scott Hecker , Tomasz W. Glinka , Rajeshwar Singh , Zhuoyi Su
IPC分类号： A61K31/16 , C07C317/34
CPC分类号： C07F9/094 , A61K31/165 , A61K31/661 , C07C317/32 , C07F9/091 , Y02A50/475
摘要： Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3, CH2N3, CH2CN, CH(R2)NH2 or CH X1X2; where R2 is H, CH3 or CH2OH, and X1 and X2 are independently selected halogens; and R3 is CH2Cl, CH2F, CHF2, CHCl2 or CH2OH are disclosed. The compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.
摘要翻译：具有化学结构的新型氟苯尼考化合物：或其药学上可接受的盐或其溶剂化物或其前药，其中R 1是CHCl 2，CHClF，CHF CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 3 CH （R 2）NH 2或CH X 1 X 2 2; 其中R 2是H，CH 3或CH 2 OH，X 1和X 2 是独立选择的卤素; 和R 3是CH 2 CH 2，CH 2 F，CHF 2，CHCl 2， SUB或CH 2 OH。该化合物可用于治疗和/或预防广泛范围的患者中的细菌感染，例如但不限于鸟类，鱼类，贝类和哺乳动物。

4. 发明申请

US20050123849A1 Electrophotographic organophotoreceptors with novel charge transport materials 有权
标题翻译：具有新型电荷传输材料的电子照相有机光感受器
公开(公告)号：US20050123849A1
公开(公告)日：2005-06-09
申请号：US10983020
申请日：2004-11-05
申请人： Kam Law , Nusrallah Jubran , Zbigniew Tokarski , Alan Katritzky , Ritu Jain , Rexiat Maimait
发明人： Kam Law , Nusrallah Jubran , Zbigniew Tokarski , Alan Katritzky , Ritu Jain , Rexiat Maimait
IPC分类号： C07C251/84 , C07C317/34 , C07D207/34 , C07D231/38 , C07D249/18 , C07D257/06 , C07D333/48 , G03G5/06 , G03G5/10 , G03G9/12 , G03G15/10 , C07D231/18
CPC分类号： C07D231/38 , C07C251/84 , C07C317/34 , C07C2603/18 , C07D207/34 , C07D249/18 , C07D257/06 , C07D333/48 , G03G5/0616 , G03G5/0618 , G03G5/062 , G03G5/0661
摘要： This invention relates to a novel organophotoreceptor that includes: (a) a charge transport material comprising a fluorenone hydrazone having a) least two fluorenone alkylsulfonylphenylhydrazone groups, b) at least two fluorenone pyrrolylhydrazone groups, c) at least two fluorenone benzotriazolylhydrazone groups, d) at least two fluorenone sulfolanylhydrazone groups, e) at least two fluorenone pyrazolylhydrazone groups, f) at least two fluorenone naphthylhydrazone groups, g) at least two fluorenone tetrazolylhydrazone groups, h) at least two fluorenone stilbenylhydrazone groups, or i) at least two fluorenone(9H-fluoren-9-ylidene)benzylhydrazone groups. Some of these fluoreneones may be represented by the formula where n is an integer between 2 and 6, inclusive; R1 is hydrogen, alkyl, or aryl; R2 is alkylsulfonylphenyl or one of its derivatives; X is a linking group having the formula —(CH2)m—, branched or linear. The compounds may form electrostatic imaging systems in combination with (b) a charge generating compound; and (c) an electrically conductive substrate.
摘要翻译：本发明涉及一种新型有机光感受器，其包括：（a）电荷传输材料，其包含芴酮腙，其具有a）至少两个芴酮烷基磺酰基苯腙基团，b）至少两个芴酮吡咯基腙基团，c）至少两个芴酮苯并三唑基腙基团，d）至少两个芴酮砜基腙基团，e）至少两个芴酮吡唑基腙基团，f）至少两个芴酮萘基腙基团，g）至少两个芴酮四唑腙基团，h）至少两个芴酮茋基腙基团，或i）至少两个芴酮（9H-芴-9-亚基）苄腙基团。这些芴酮中的一些可以由下式表示：其中n是2和6之间的整数，包括端值在内; R 1是氢，烷基或芳基; R 2是烷基磺酰基苯基或其衍生物之一; X是具有下式的连接基团 - （CH 2 CH 2）m - 支链或直链。所述化合物可以与（b）产生电荷的化合物组合形成静电成像系统; 和（c）导电基板。

5. 发明申请

US20030208006A1 Aromatic imide and aromatic methylidynetrissulfonyl compounds and method of making 有权
标题翻译：芳香酰亚胺和芳香族甲基亚磺酰基化合物及其制备方法
公开(公告)号：US20030208006A1
公开(公告)日：2003-11-06
申请号：US10436325
申请日：2003-05-12
申请人： 3M Innovative Properties Company
发明人： Steven Joseph Hamrock
IPC分类号： C08F008/34 , C07C317/12 , C07C317/34
CPC分类号： C07C303/36 , C07C311/48
摘要： A method is provided for making aromatic-imide and aromatic-methylidynetrissulfonyl species by reaction of aromatic species with a reactant according to formula (I): (XnullSO2-)m-QHnull(nullSO2nullR1)nnullnull(I) wherein Q is C or N; wherein each X is independently selected from the group consisting of halogens, typically F or Cl; wherein each R1 is independently selected from the group consisting of aliphatic and aromatic groups, which may or may not be saturated, unsaturated, straight-chain, branched, cyclic, heteroatomic, polymeric, halogenated, fluorinated or substituted; wherein m is greater than 0; wherein mnullnnull2 when Q is N; and wherein mnullnnull3 when Q is C. Ar may be derived from an aromatic polymeric compound. In addition, compounds are provided according to the formula: (ArnullSO2-)m-QHnull(nullSO2nullR1)n wherein R1 comprises a highly acidic group selected from sulfonic acid, carboxylic acid and phosphonic acid, and Ar is derived from an aromatic compound.
摘要翻译：通过芳香族物质与式（I）的反应物的反应制备芳香族 - 酰亚胺和芳香族 - 亚甲基三磺酰基物质的方法：（X-SO 2 - ）m-QH - （ - SO 2 -R 1）n（I）其中 Q是C或N; 其中每个X独立地选自卤素，通常为F或Cl; 其中每个R 1独立地选自脂族和芳族基团，其可以是饱和的，不饱和的，直链的，支链的，环状的，杂原子的，聚合的，卤代的，氟化的或取代的; 其中m大于0; 其中当Q为N时m + n = 2; 且当Q为C时m + n = 3。Ar可以衍生自芳族聚合物。另外，根据下式可以提供化合物：（Ar-SO 2 - ）m -QH - （ - SO 2 -R 1）n其中R 1包括选自磺酸，羧酸和膦酸的高度酸性基团，Ar衍生来自芳香族化合物。

6. 发明申请

US20030191337A1 Crystal of bicalutamide and production method thereof 失效
标题翻译：比卡鲁胺水晶及其制备方法
公开(公告)号：US20030191337A1
公开(公告)日：2003-10-09
申请号：US10362410
申请日：2003-02-24
发明人： Tetsuya Shintaku , Tadashi Katsura , Nobushige Itaya
IPC分类号： C07C317/34
CPC分类号： C07C315/06 , C07B2200/13 , C07C315/02 , C07C317/46
摘要： The present invention relates to a crystal of bicalutamide having a defined form, as well as economical and industrially practical production methods of bicalutamide and a crystal thereof, which are superior in environmental benignity and safety. Accordingly, the present invention provides a production method of bicalutamide represented by the formula (I): 1 which includes at least a step of reacting a compound represented by the formula (3): 2 with an oxidizing agent, a production method of a crystal of bicalutamide, as well as a crystal form of bicalutamide as defined by X-ray diffraction (XRD) or solid 13C NMR measurement.
摘要翻译：本发明涉及具有规定形式的比卡鲁胺的结晶，以及环境友好性和安全性优异的经济和工业实用的比卡鲁胺及其结晶的生产方法。因此，本发明提供由式（I）表示的比卡鲁胺的制造方法：其至少包括使式（3）表示的化合物与氧化剂反应的步骤：比卡鲁胺结晶的制造方法，以及由X射线衍射（XRD）或固体13 C NMR测定所定义的比卡鲁胺的晶体形式。

7. 发明授权

US5877196A N-�4-(imidazolyl or pyrazolyl)phenyl(oxy, sulfinyl, sulfenyl or sulfonyl)alkyl!carboxamides, sulfonamides or phosphoramides having antiarrhythmic properties 失效
标题翻译： N- [4-（咪唑基或吡唑基）苯基（氧基，亚磺酰基，亚磺酰基或磺酰基）烷基]甲酰胺，具有抗心律失常性质的磺酰胺或磷酰胺
公开(公告)号：US5877196A
公开(公告)日：1999-03-02
申请号：US800313
申请日：1997-02-14
申请人： Andrew Stephen Tomcufcik , Joseph William Hinson
发明人： Andrew Stephen Tomcufcik , Joseph William Hinson
IPC分类号： A61K31/66 , A61K31/16 , A61K31/38 , A61K31/41 , C07C233/65 , C07C237/42 , C07C311/04 , C07C311/17 , C07C317/28 , C07C317/34 , C07C323/39 , C07C323/49 , C07C327/48 , C07C327/52 , C07D207/30 , C07D207/32 , C07D207/325 , C07D207/333 , C07D231/12 , C07D233/54 , C07D233/64 , C07D239/26 , C07D257/04 , C07D277/20 , C07D277/24 , C07D333/02 , C07D417/12 , C07D521/00 , C07F9/6506 , A61K31/415 , A61K31/40
CPC分类号： C07D207/333 , C07C311/17 , C07C317/34 , C07C323/49 , C07C327/48 , C07C327/52 , C07D207/325 , C07D231/12 , C07D233/56 , C07D239/26 , C07D249/08 , C07D257/04 , C07D277/24 , C07D417/12
摘要： The present invention relates to substituted .omega.-�phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl! �alkyl, alkenyl or alkynyl!amine carboxamides, sulfonamides and phosphonylamides which are useful as antiarrhythmic agents.
摘要翻译：本发明涉及可用作抗心律不齐剂的取代的ω-[苯氧基，苯硫基，苯基亚磺酰基，苯基磺酰基] [烷基，烯基或炔基]胺甲酰胺，磺酰胺和膦酰基酰胺。

8. 发明授权

US5596122A Use of disulfonyl methanes for the control of parasites 失效
标题翻译：使用二磺酰甲烷来控制寄生虫
公开(公告)号：US5596122A
公开(公告)日：1997-01-21
申请号：US429270
申请日：1995-04-25
申请人： David I. Wickiser
发明人： David I. Wickiser
IPC分类号： A01N31/00 , A01N47/02 , A01P7/00 , A61K31/085 , A61K31/10 , A61K31/14 , A61K31/275 , A61K31/415 , A61K31/425 , A61K31/495 , A61K31/505 , A61P33/00 , A61P33/10 , C07C7/14 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/34 , C07C317/36 , C07C381/12 , C07C309/29 , C07C309/31
CPC分类号： A61K31/425 , A01N47/02 , A61K31/085 , A61K31/10 , A61K31/14 , A61K31/275 , C07C317/14 , C07C317/22
摘要： The present invention is directed to disulfonyl methane compounds for the control of parasites in vertebrate animals.
摘要翻译：本发明涉及用于控制脊椎动物中寄生虫的二磺酰甲烷化合物。

9. 发明授权

US5340804A 1,5-diphenyl-3-formazancarbonitril parasiticides 失效
标题翻译： 1,5-二苯基-3-甲酰基碳氮化物
公开(公告)号：US5340804A
公开(公告)日：1994-08-23
申请号：US961605
申请日：1992-10-15
申请人： David I. Wickiser
发明人： David I. Wickiser
IPC分类号： A61K31/275 , A61K31/415 , A61K31/425 , A61K31/495 , A61K31/505 , A61P33/10 , C07C255/66 , C07C257/22 , C07C309/65 , C07C317/34 , C07C323/35 , C07C323/48 , C07C245/04 , A01N33/12 , A01N33/26 , C07C245/06
CPC分类号： C07C323/48 , A61K31/275 , A61K31/415 , A61K31/425 , A61K31/495 , A61K31/505 , C07C255/66 , C07C309/65
摘要： The present invention is directed to the use of 1,5-diaryl-3 -formazancarbonitrile compounds for the control of parasites in vertebrate animals.
摘要翻译：本发明涉及1,5-二芳基-3-甲脒腈化合物在脊椎动物中控制寄生虫的用途。

10. 发明授权

US4906634A Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents 失效
标题翻译：新型N- [4-（氨基取代）苯基]甲磺酰胺及其作为心血管药物的用途
公开(公告)号：US4906634A
公开(公告)日：1990-03-06
申请号：US165315
申请日：1988-03-08
申请人： Stanley S. Greenberg , William C. Lumma, Jr. , Klaus Nickisch , Ronald A. Wohl
发明人： Stanley S. Greenberg , William C. Lumma, Jr. , Klaus Nickisch , Ronald A. Wohl
IPC分类号： C07C311/08 , C07C317/34 , C07C323/37 , C07D207/06 , C07D211/14 , C07D211/46 , C07D243/08 , C07D295/135
CPC分类号： C07D295/135 , C07C311/08 , C07C317/34 , C07C323/37 , C07D207/06 , C07D211/14 , C07D211/46 , C07D243/08 , C07C2101/02 , C07C2101/14
摘要： Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents, especially as antiarrhythmic agents are described. Pharmaceutical formulations containing such compounds are also discussed.

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