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1. 发明公开

US20240261243A1 NITRIC OXIDE DONORS, COMPOSITIONS, AND METHODS OF USE 审中-公开
公开(公告)号：US20240261243A1
公开(公告)日：2024-08-08
申请号：US18036120
申请日：2021-09-03
申请人： KNOW BIO, LLC
发明人： John Kelly Simons , Kyle Kimble , Nathan Stasko , Rebecca Anthouard McDonald , Madyson Chambers , Adam Cockrell
IPC分类号： A61K31/198 , A01N33/26 , A01N51/00 , A01N59/00 , A01N59/16 , A01P1/00 , A61K31/655 , A61K33/24 , A61K47/69 , A61L2/18 , A61P31/04 , A61P31/14
CPC分类号： A61K31/198 , A01N33/26 , A01N51/00 , A01N59/00 , A01N59/16 , A01P1/00 , A61K31/655 , A61K33/24 , A61K47/6951 , A61L2/18 , A61P31/04 , A61P31/14 , A61L2202/24
摘要： Disclosed are compositions comprising NO donors formulated for effectively treating disease states, such as microbial infections, including Covid-19 infections. Mucoadhesive agents, chelating agents, and gallium enable highly efficacious formulations for treating infections, particularly when the nature of the pathogenic species is unknown.

2. 发明申请

US20220304304A1 Compositions of Dicarboxylic Acid Derivatives 有权
公开(公告)号：US20220304304A1
公开(公告)日：2022-09-29
申请号：US17615637
申请日：2020-06-04
申请人： UPL LTD
发明人： Alan Bruno Pirotte , Emma Louise Hawkins , Cameron Seath Gibb , Alexander Kenneth Zorzitto , Sarah Jane Maude , Sheldon Park
IPC分类号： A01N33/26 , A01N59/20
摘要： The present invention relates to agricultural compositions containing dicarboxylic acid hydrazides and transition metal ions, and the preparation thereof. The compositions are useful in the treatments of plants or seeds as an anti-sprout agent, growth regulator and/or pest control agent. In particular, it relates to maleic hydrazide combined with copper, nickel, manganese, iron or zinc. The transition metal ions improve the storage stability of the dicarboxylic acid hydrazide and prevent generation of free hydrazine.

3. 发明授权

US09351494B2 Honeybee repellents and uses thereof 有权
标题翻译：蜜蜂驱虫剂及其用途
公开(公告)号：US09351494B2
公开(公告)日：2016-05-31
申请号：US14269115
申请日：2014-05-03
申请人： Inscent, Inc.
发明人： Daniel F. Woods , Spiros Dimitratos , Robin W. Justice
IPC分类号： C07D239/34 , A01N43/54 , A01N47/38 , A01N43/78 , A01N43/56 , A01N43/90 , A01N43/12 , A01N43/84 , C07D239/54 , A01N33/26 , A01N35/02
CPC分类号： A01N43/54 , A01N33/26 , A01N35/02 , A01N43/12 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/78 , A01N43/84 , A01N43/86 , A01N43/88 , A01N43/90 , A01N47/38 , C07D239/34 , C07D239/54 , A01N47/40 , A01N51/00 , A01N2300/00 , A01N25/00
摘要： The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents.
摘要翻译：本说明书公开了表现出类似于2-庚酮的驱虫性质的蜜蜂驱避剂，包含这种排斥剂的组合物，从哺乳动物排斥蜜蜂的用途，位置，植物，由该驱虫剂处理的结构，以及治疗哺乳动物，位置，植物，通过应用这种驱虫剂的结构。

4. 发明授权

US08921344B2 Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives 有权
标题翻译： 2-羟基-5-苯基偶氮苯甲酸衍生物的制剂和用途
公开(公告)号：US08921344B2
公开(公告)日：2014-12-30
申请号：US11592854
申请日：2006-11-03
申请人： Lorin Johnson
发明人： Lorin Johnson
IPC分类号： A01N51/00 , A61K31/655 , A01N33/26 , A61K31/606 , A61K31/635 , A61K31/66
CPC分类号： A61K31/606 , A61K31/635 , A61K31/655 , A61K31/66 , Y02A50/469
摘要： A method of increasing the bioavailability of 5-aminosalicylate compound by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of 5-aminosalicylate compound in a suitable container and associated with printed labeling which describes the increased bioavailability of the medication in the container when taken with food.
摘要翻译：提供了一种通过向食物施用口服剂型来提高5-氨基水杨酸酯化合物的生物利用度的方法，以及在合适的容器中包含5-氨基水杨酸酯化合物的口服剂型并与印刷标签相关的制品描述了当与食物一起服食时在容器中药物的生物利用度的增加。

5. 发明授权

US08110563B1 Fire ant killer (“F.A.K.”)/ insecticide 有权
标题翻译：火蚂蚁杀手（“F.A.K”）/杀虫剂
公开(公告)号：US08110563B1
公开(公告)日：2012-02-07
申请号：US12471373
申请日：2009-05-23
申请人： Harold V. Hutchins
发明人： Harold V. Hutchins
IPC分类号： A01N33/26 , A01N37/22 , A61K31/21
CPC分类号： A01N53/00 , A01N25/02 , A01N31/14 , A01N31/16 , A01N43/80 , A01N2300/00
摘要： The present invention features a composition for killing fire ants. In some embodiments, the composition comprises an insecticide and a triclosan composition. In some embodiments, the composition is a liquid composition.
摘要翻译：本发明的特征在于用于杀死蚂蚁的组合物。在一些实施方案中，组合物包含杀虫剂和三氯生组合物。在一些实施方案中，组合物是液体组合物。

6. 发明授权

US08058264B2 Pharmaceutical compositions comprising CB1 cannabinoid receptor antagonists and potassium channel openers for the treatment of obesity and related conditions 有权
标题翻译：包含CB1大麻素受体拮抗剂和用于治疗肥胖症和相关病症的钾通道开放剂的药物组合物
公开(公告)号：US08058264B2
公开(公告)日：2011-11-15
申请号：US11257056
申请日：2005-10-25
申请人： Michael Firnges , Peter-Colin Gregory , Jochen Antel , Josephus Hubertus Maria Lange , Harald Waldeck
发明人： Michael Firnges , Peter-Colin Gregory , Jochen Antel , Josephus Hubertus Maria Lange , Harald Waldeck
IPC分类号： A01N33/26 , A61K31/535
CPC分类号： A61K31/00 , A61K31/40 , A61K31/415 , A61K31/4152 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/54 , A61K31/655 , A61K45/06 , G01N33/6872 , G01N33/948 , G01N2500/00 , G01N2800/042 , G01N2800/044 , A61K2300/00
摘要： Described is a novel combination therapy for diabetes mellitus type I and/or for obesity and its concomitant and/or secondary diseases or conditions, in particular the metabolic syndrome and/or syndrome X, and/or diabetes mellitus type II, by administering a combination of at least one KATP channel opener as a first active agent and at least one CB1 cannabinoid receptor antagonist as a second active agent. The invention is further directed to such novel combination therapy wherein a dually acting compound with combined KATP channel opening and CB1 antagonistic properties is used. The invention also relates to novel pharmaceutical compositions comprising KATP channel openers and CB1 antagonists and the use of said pharmaceutical compositions in the treatment, delayed progression, delayed onset of and/or inhibition of diabetes mellitus type 1, and the prophylaxis and treatment, of obesity as well as the prophylaxis, treatment, delayed onset and/or inhbition of its concomitant and/or secondary diseases or conditions, in particular the metabolic syndrome and/or syndrome X, and/or diabetes mellitus type II, in mammals and humans. The invention is further directed to such novel pharmaceutical compositions comprising a dually acting compound with combined KATP channel opening and CB1 antagonistic properties.
摘要翻译：描述了通过施用组合来描述I型糖尿病和/或用于肥胖及其伴随和/或继发疾病或病症，特别是代谢综合征和/或综合征X和/或II型糖尿病的新型联合治疗的至少一种KATP通道开放剂作为第一活性剂和至少一种CB1大麻素受体拮抗剂作为第二活性剂。本发明进一步涉及这种新型联合治疗，其中使用具有组合的KATP通道开放和CB1拮抗性质的双作用化合物。本发明还涉及包含KATP通道开放剂和CB1拮抗剂的新型药物组合物，以及所述药物组合物在治疗，延迟进展，延迟发作和/或抑制1型糖尿病以及预防和治疗肥胖症中的用途以及其伴随和/或继发疾病或病症，特别是哺乳动物和人类的代谢综合征和/或综合征X和/或II型糖尿病的预防，治疗，延迟发作和/或吸收。本发明还涉及这种新型药物组合物，其包含具有组合的KATP通道开口和CB1拮抗性质的双作用化合物。

7. 发明申请

US20100204045A1 Systemicity Enhancers 审中-公开
标题翻译：全身性增强剂
公开(公告)号：US20100204045A1
公开(公告)日：2010-08-12
申请号：US12679765
申请日：2008-09-10
申请人： Yvonne Dieckmann , Michael Ishaque , Ingo Muenster , Laurent Picard , Angelika Benz , Juergen Langewald , Klaus Kreuz , Harald Koehle , Felix Christian Goerth , Roman Benedikt Raether , Jurith Montag , Ursula Huber-Moulliet , Wolfgang Kerl
发明人： Yvonne Dieckmann , Michael Ishaque , Ingo Muenster , Laurent Picard , Angelika Benz , Juergen Langewald , Klaus Kreuz , Harald Koehle , Felix Christian Goerth , Roman Benedikt Raether , Jurith Montag , Ursula Huber-Moulliet , Wolfgang Kerl
IPC分类号： A01N25/26 , A01N25/00 , A01N43/56 , A01N33/26 , A01P3/00 , A01P7/04
CPC分类号： A01N25/10 , A01N47/02 , A01N47/34 , A01N43/56 , A01N2300/00
摘要： A copolymer obtainable by polymerization of a) at least one compound of the formula (I) (monomer α) where R1 and R2, independently of one another, are in each case H or CH3, R3 is C6-C10-aryl or C7-C12-aralkyl which can carry one or more identical or different C1-C9-alkyl and/or C1-C5-alkoxy substituents, and n is an integer from 0 to 100, b) at least one compound chosen from the group of N-vinylamides, N-vinyllactams, N-vinylimines and N-vinylamines with 2 to 15 carbon atoms (monomer β), c) if appropriate one or more different difunctional crosslinker components and d) if appropriate one or more different regulators and e) if appropriate one or more further copolymerizable components (monomer γ) is useful for increasing the systemicity of a pesticide.
摘要翻译：通过a）至少一种式（I）化合物（单体α）可以得到的共聚物，其中R 1和R 2彼此独立地为H或CH 3，R 3为C 6 -C 10 - 芳基或C 7 -C 10 - 可以携带一个或多个相同或不同的C 1 -C 9 - 烷基和/或C 1 -C 5 - 烷氧基取代基的C 12 - 芳烷基，n是0至100的整数，b）至少一种选自N- 乙烯基酰胺，N-乙烯基内酰胺，N-乙烯基亚胺和具有2至15个碳原子的N-乙烯基胺（单体和bgr），c）如果合适的话一个或多个不同的双官能交联剂组分，和d）如果合适的话一个或多个不同的调节剂和e）合适的一种或多种其它可共聚组分（单体γ）可用于增加农药的系统性。

8. 发明申请

US20090041869A1 METHOD OF REDUCING INSECT RESISTANT PESTS IN TRANSGENIC CROPS 审中-公开
标题翻译：减少转基因抗虫药物的方法
公开(公告)号：US20090041869A1
公开(公告)日：2009-02-12
申请号：US12251578
申请日：2008-10-15
申请人： DANIEL J. COSGROVE
发明人： DANIEL J. COSGROVE
IPC分类号： A01N65/00 , A01N37/08 , A01N43/40 , A01N33/26 , A01N43/647 , A01N57/12 , A01N43/36 , A01N43/56 , A01N37/44 , A61K38/16 , A01N43/04 , A61P7/00
CPC分类号： C12N15/8286 , A01N25/00 , Y02A40/162
摘要： The present invention discloses Resistance Management (RM) practices that are critical to safeguard Bacillus thuringiensis as a natural resource and sustain genetically modified corn expressing Bt toxins as a suitable method for ECB and WCRW management. A useful tool in developing RM strategies is to develop laboratory selected colonies that exhibit high levels of resistance to a particular toxin. The availability of selected strains allows determination of the genetic expression of resistance (i.e., dominant vs. recessive, autosomal vs. sex-linked) and whether or not the resistance mechanism is specific for a given toxin. In addition, the availability of resistant strains will allow estimation of the particular resistance allele frequency in the field, and provides a tool to identify the biochemical and physiological basis of resistance and a means to develop molecular probes to monitor the evolution of resistance in the field.
摘要翻译：本发明公开了对保护苏云金芽孢杆菌作为天然资源和维持转基因玉米表达Bt毒素作为ECB和WCRW管理的合适方法至关重要的实践。开发RM策略的有用工具是开发对特定毒素具有高水平抗性的实验室选择的菌落。所选择的菌株的可用性允许测定抗性的遗传表达（即显性与隐性，常染色体与性别相关的）以及抗性机制是否对给定毒素是特异性的。此外，抗性菌株的可用性将允许估计现场的特定抗性等位基因频率，并且提供了鉴定抗性的生物化学和生理学基础的工具，以及开发分子探针以监测野外抗性进化的手段。

9. 发明申请

US20080176280A1 CHIMERIC RETINOID X RECEPTORS AND THEIR USE IN A NOVEL ECDYSONE RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM 有权
公开(公告)号：US20080176280A1
公开(公告)日：2008-07-24
申请号：US11841597
申请日：2007-08-20
申请人： Marianna Zinovjevna Kapitskaya , Subba Reddy Palli
发明人： Marianna Zinovjevna Kapitskaya , Subba Reddy Palli
IPC分类号： A01N33/26 , A01N37/34 , A01N37/18 , C07K14/705 , C12N5/06 , C07H21/04 , C12P21/06
CPC分类号： C12N15/635 , C07K14/005 , C07K14/39 , C07K14/70567 , C07K14/721 , C07K2319/00 , C07K2319/70 , C07K2319/74 , C07K2319/80 , C12N15/1055 , C12N15/63
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor/chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

10. 发明申请

US20070265231A1 Hydrazide Compounds for Combating Animal Pests 审中-公开
公开(公告)号：US20070265231A1
公开(公告)日：2007-11-15
申请号：US11791919
申请日：2005-11-30
申请人： Michael Hofmann , Michael Rack , David Kuhn , Deborah Culbertson , Douglas Anspaugh
发明人： Michael Hofmann , Michael Rack , David Kuhn , Deborah Culbertson , Douglas Anspaugh
IPC分类号： A01N33/26 , A01P5/00 , A01P7/00 , C07C243/18 , C07C243/42
CPC分类号： A01N43/10
摘要： The present invention relates to new hydrazide compounds which are useful for combating animal pests, in particular insects, arachnids and nematodes and to the salts thereof. The invention also relates to a method for combating insects, nematodes and arachnids. The hydrazide compounds of the invention are described by the general formula (I) wherein . . . is absent or a covalent bond; A is an optionally substituted cyclic radical selected from phenyl, naphthyl and a 5- or 6-membered heterocyclic radical with 1 to 4 heteroatoms which are selected, independently of one another, from O, N and S, the 5- or 6-membered heterocyclic radical may have a carbonyl group as ring member; Q is selected from the group consisting of a single bond, C1-C4 alkylidene, O—-C1-C4 alkylidene, S—C1-C4 alkylidene and NR9—C1-C4 alkylidene, wherein the alkylidene group in the last four mentioned radicals is unsubstituted or carries 1, 2, 3 or 4 substituents selected from OH, ═O, halogen, C1-C4 haloalkyl and C1-C4 alkoxy; or A-Q may together be C1-C10-alkyl, which may be substituted by 1 or 2 substituents selected from the group consisting of ═O, OH, C1-C4-alkoxy, C1-C4-alkylthio, halogen or C1-C4-alkylcarbonyloxy, X is C═O, C═S or SO2; Ar is an optionally substituted aromatic radical selected from phenyl, naphthyl, pyridyl, pyrimidyl, furyl and thienyl; and R1 to R6 and R9 are as described in the claims and the specification.

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