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1. 发明授权

US08492442B2 Medicinal composition, food or drink having effect of enhancing parasympathetic nervous activity 有权
标题翻译：具有促进副交感神经活动作用的药物组合物，食物或饮料
公开(公告)号：US08492442B2
公开(公告)日：2013-07-23
申请号：US12593468
申请日：2008-03-28
申请人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura , Katsuya Nagai
发明人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura , Katsuya Nagai
IPC分类号： A01N31/00 , A61K31/10 , C07C63/00 , C07C65/00
CPC分类号： A61K35/747 , A23L33/10 , A23V2002/00 , A61K31/19 , A61K35/744 , A61K35/745 , A23V2250/042 , A23V2200/322
摘要： It is intended to provide a safe composition for treating a disease or condition relating to autonomic nervous activity which has an autonomic nervous control effect; in particular, an effect of enhancing parasympathetic nervous activity. Thus, a medicinal composition, a food or a drink containing L-phenyl lactic acid and/or D-phenyl lactic acid and having an autonomic nervous control effect is provided.
摘要翻译：旨在提供一种用于治疗与具有自主神经控制作用的自主神经活动有关的疾病或病症的安全组合物; 特别是增强副交感神经活动的作用。因此，提供了含有L-苯基乳酸和/或D-苯基乳酸并具有自主神经控制作用的药物组合物，食品或饮料。

2. 发明授权

US08318781B2 G-protein-conjugated receptor agonist 失效
标题翻译： G蛋白偶联受体激动剂
公开(公告)号：US08318781B2
公开(公告)日：2012-11-27
申请号：US12597281
申请日：2008-04-25
申请人： Gozoh Tsujimoto , Akira Hirasawa , Naoki Miyata , Takayoshi Suzuki , Yoshiyuki Takahara , Masaji Ishiguro , Mie Hata
发明人： Gozoh Tsujimoto , Akira Hirasawa , Naoki Miyata , Takayoshi Suzuki , Yoshiyuki Takahara , Masaji Ishiguro , Mie Hata
IPC分类号： A01N43/40 , A01N43/78 , A01N37/12 , A01N37/44 , A01N43/00 , A61K31/445 , A61K31/425 , A61K31/33 , C07D213/72 , C07D213/78 , C07D277/82 , C07C63/00 , C07C65/00
CPC分类号： C07C311/51 , C07C217/18 , C07D213/74 , C07D215/12 , C07D257/04
摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].
摘要翻译：公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂，胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂垂体激素分泌障碍或脂质调味剂/调味剂。芳烷基羧酸化合物由通式（I）表示。（I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

3. 发明申请

US20120041226A1 WATER VAPOUR ASSISTED OZONOLYSIS OF CARBON NANOTUBES 审中-公开
标题翻译：碳纳米管的水蒸气辅助臭氧分解
公开(公告)号：US20120041226A1
公开(公告)日：2012-02-16
申请号：US13256253
申请日：2010-02-27
申请人： Helmut Meyer , Stefan Bahnmüller , Julia Hitzbleck , Zhong Zhang , Lu-Qi Liu , Ke Peng , Hongchao Li
发明人： Helmut Meyer , Stefan Bahnmüller , Julia Hitzbleck , Zhong Zhang , Lu-Qi Liu , Ke Peng , Hongchao Li
IPC分类号： C07C51/255 , C07C65/00 , B82Y30/00 , B82Y40/00
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/174 , C01B2202/34 , C01B2202/36
摘要： The present invention relates to an improved process of ozonolysis of carbon nanotubes assisted by water vapour. The improved methodology provides an eco-friendly, cheaper, practical and efficient approach to functionalize carbon nanotubes with oxygen-containing moieties for further chemical functionalization and composite dispersion.
摘要翻译：本发明涉及由水蒸气辅助的碳纳米管的臭氧分解的改进方法。改进的方法提供了一种环保，便宜，实用和有效的方法，用含氧部分官能化碳纳米管用于进一步的化学官能化和复合分散。

4. 发明申请

US20080293695A1 Salts of physiologically active and psychoactive alkaloids and amines simultaneously exhibiting bioavailability and abuse resistance 审中-公开
标题翻译：生理活性和精神活性生物碱和胺的盐同时具有生物利用度和耐滥用性
公开(公告)号：US20080293695A1
公开(公告)日：2008-11-27
申请号：US11805225
申请日：2007-05-22
申请人： David William Bristol , Clifford Riley King , Joseph Pike Mitchener, JR. , Vicki Haynes Audia
发明人： David William Bristol , Clifford Riley King , Joseph Pike Mitchener, JR. , Vicki Haynes Audia
IPC分类号： A61K31/55 , A61K31/192 , A61K31/195 , A61P25/30 , C07C65/00 , C07D223/14 , C07C69/76 , C07C229/02 , A61K31/205 , A61K31/235
CPC分类号： A61K31/192 , A61K31/195 , A61K31/205 , A61K31/235 , A61K31/55
摘要： Drug substances comprising a pharmaceutically acceptable organic acid addition salt 6f amine containing pharmaceutically active compounds useful for the treatment of a therapeutic ailment administration and exhibiting prophylactic properties when employed in non-therapeutic administration.
摘要翻译：药物物质含有药学上可接受的有机酸加成盐6f胺，其含有用于治疗治疗性疾病的药物活性化合物，并且在非治疗性给药中使用时具有预防性。

5. 发明申请

US20080255111A1 Tissue Factor Production Inhibitor 审中-公开
标题翻译：组织因子生产抑制剂
公开(公告)号：US20080255111A1
公开(公告)日：2008-10-16
申请号：US11571367
申请日：2005-07-01
申请人： Naoki Terasaka , Ayano Hiroshima
发明人： Naoki Terasaka , Ayano Hiroshima
IPC分类号： A61K31/5377 , C07D239/88 , A61K31/517 , A61K31/404 , C07D209/20 , A61K31/24 , C07C229/52 , C07C65/00 , A61K31/192 , A61P7/02 , C07D413/04
CPC分类号： A61K9/06 , A61K9/10 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K9/4875 , A61K31/18 , A61K31/192 , A61K31/381 , A61K31/404 , A61K31/44 , A61K31/517 , C07D209/12 , C07D239/90 , C07D333/24 , C07D401/14 , C07D409/06 , C07D409/12
摘要： A medicament which has an activity of inhibiting production of tissue factor and comprises an LXR ligand as an active ingredient; and a medicament for treatment and/or prophylaxis of vascular restenosis following angioplasty, endarterectomy, percutaneous transluminal coronary angioplasty (PTCA) or stent implantation, or treatment and/or prophylaxis of blood coagulation diseases, diseases induced by platelet aggregation including stable or unstable angina pectoris, cardiovascular and cerebrovascular diseases including thromboembolism formation diseases accompanying diabetes, rethrombosis following thrombolysis, cerebral ischemic attack, infarction, stroke, ischemia-derived dementia, peripheral artery disease, thromboembolism formation diseases during use of an aorta-coronary artery bypass, glomerulosclerosis, renal embolism, tumor or cancer metastasis, which comprises an LXR ligand as an active ingredient.
摘要翻译：具有抑制组织因子产生的活性的药物，其包含LXR配体作为活性成分; 以及用于治疗和/或预防血管成形术，内膜切除术，经皮腔内冠状动脉成形术（PTCA）或支架植入术后的血管再狭窄或治疗和/或预防血液凝固疾病，由血小板聚集引起的疾病的药物，包括稳定或不稳定的心绞痛，包括伴随糖尿病的血栓栓塞形成疾病，溶栓后血栓形成，脑缺血发作，梗死，中风，局部缺血性痴呆，外周动脉疾病，主动脉 - 冠状动脉旁路使用期间的血栓栓塞形成疾病，肾小球硬化，肾栓塞的心血管和脑血管疾病，肿瘤或癌转移，其包含LXR配体作为活性成分。

6. 发明授权

US07425644B2 Method of purifying pravastatin 失效
标题翻译：纯化普伐他汀的方法
公开(公告)号：US07425644B2
公开(公告)日：2008-09-16
申请号：US10996238
申请日：2004-11-23
申请人： Vilmos Keri , Istvan Melczer
发明人： Vilmos Keri , Istvan Melczer
IPC分类号： C07C69/74 , C07C69/66 , C07C65/00
CPC分类号： C07C67/52 , A61K31/185 , A61K31/225 , A61K31/366 , C07C67/56 , C07C69/33
摘要： The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof.
摘要翻译：本发明提供了纯普伐他汀组合物和纯的美质素组合物及其制备方法。

7. 发明申请

US20080176956A1 Modified Green Tea Polyphenol Formulations 有权
标题翻译：改性绿茶多酚配方
公开(公告)号：US20080176956A1
公开(公告)日：2008-07-24
申请号：US12063139
申请日：2006-08-10
申请人： Stephen D. Hsu
发明人： Stephen D. Hsu
IPC分类号： A61K31/05 , C07C39/12 , C07C65/00 , A61P17/00 , A61Q99/00 , C11D3/20
CPC分类号： A61K31/353 , A61K31/43 , A61K31/496 , A61K31/546 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K36/82 , A61K38/12
摘要： Modified green tea polyphenols and methods of their use are provided. One aspect provides compounds and compositions containing green tea polyphenols with one on more ester-linked fatty acids.
摘要翻译：提供了改良的绿茶多酚及其使用方法。一方面提供了含有多个酯连接的脂肪酸的绿茶多酚的化合物和组合物。

8. 发明授权

US06936734B2 Process for manufacturing unsaturated carboxylic acid anhydrides 失效
标题翻译：制备不饱和羧酸酐的方法
公开(公告)号：US06936734B2
公开(公告)日：2005-08-30
申请号：US10068849
申请日：2002-02-11
申请人： Bardo Schmitt , Joachim Knebel , Wolfgang Klesse , Andrea Wittkowski , Benedikt Laux
发明人： Bardo Schmitt , Joachim Knebel , Wolfgang Klesse , Andrea Wittkowski , Benedikt Laux
IPC分类号： C07B61/00 , C07C51/56 , C07C51/573 , C07C57/04 , C07C65/00
CPC分类号： C07C51/56 , C07C57/04
摘要： The present invention relates to a process for preparing an unsaturated carboxylic acid anhydride by reacting an unsaturated carboxylic acid and a lower aliphatic carboxylic acid anhydride in the presence of a stabilizer and catalyst that contains a metal salt of an anionic organic compound which has at least one carboxyl group.
摘要翻译：本发明涉及一种在稳定剂和含有阴离子有机化合物的金属盐的催化剂存在下使不饱和羧酸和低级脂族羧酸酐反应制备不饱和羧酸酐的方法，所述阴离子有机化合物的金属盐具有至少一个羧基。

9. 发明授权

US06909015B2 Aromatic polyetherketones 失效
标题翻译：芳香聚醚酮
公开(公告)号：US06909015B2
公开(公告)日：2005-06-21
申请号：US10203479
申请日：2001-02-09
申请人： David John Kemmish , Brian Wilson
发明人： David John Kemmish , Brian Wilson
IPC分类号： C08G61/12 , C07C65/00
CPC分类号： C08G61/12
摘要： The invention relates to polyetherketones and to a process for the preparation of aromatic polyetherketones which process comprises: a) self-condensing a compound of formula (I) wherein n represents 0 or 1 in the presence of an alkyl or optionally substituted aryl sulphonic acid solvent and in the absence of phosphorous pentoxide; or b) condensing a compound of general formula (II) and a compound of general formula (III) wherein p and q independently represent 0 or 1, in the presence of an alkyl or optionally substituted aryl sulphonic acid solvent and in the absence of phosphorous pentoxide; or c) a combination of a) and b)
摘要翻译：本发明涉及聚醚酮和制备芳族聚醚酮的方法，该方法包括：a）在烷基或任选取代的芳基磺酸溶剂存在下，将式（I）化合物自缩合，其中n表示0或1 并且在不存在五氧化二磷的情况下; 或b）在烷基或任选取代的芳基磺酸溶剂的存在下，在不存在磷的情况下，将通式（II）的化合物和通式（III）的化合物（其中p和q独立地表示0或1）五氧化二或c）a）和b）

10. 发明申请

US20050014974A1 Process for the manufacture of isobutyric anhydride 失效
标题翻译：制造异丁酸酐的方法
公开(公告)号：US20050014974A1
公开(公告)日：2005-01-20
申请号：US10824618
申请日：2004-04-15
申请人： Jean-Michel Paul , Patrick Busca
发明人： Jean-Michel Paul , Patrick Busca
IPC分类号： C07C51/083 , C07C51/56 , C07C53/124 , C07C65/00
CPC分类号： C07C51/083 , C07C51/56 , C07C53/08 , C07C53/124
摘要： This process for the manufacture of isobutyric anhydride by reacting acetic anhydride with isobutyric acid, distilling the acetic acid generated as it is formed, is characterized in that the reactor is initially loaded with at least a portion of one of the reagents and a portion of the other such that the reagents are in an excess molar ratio relative to the stoichiometry of one of the reagents, and the reaction is carried out while adding the remainder of the reagents as the reaction progresses and according to the place left free in the reactor by the distillation of the acetic acid produced by the reaction, until the desired overall molar ratio of the reagents is reached.
摘要翻译：用于通过使乙酸酐与异丁酸反应制备异丁酸酐的方法，蒸馏生成的乙酸，其特征在于反应器最初装载有至少一部分试剂和一部分试剂其它使得试剂相对于一种试剂的化学计量为过量的摩尔比，并且当反应进行时加入其余试剂并根据反应器中剩余的位置由反应器中的位置进行反应蒸馏通过反应产生的乙酸，直到达到所需试剂的总摩尔比。

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