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1. 发明授权

US10703698B2 Compounds which activate estrogen receptors and compositions and methods of using the same 有权
公开(公告)号：US10703698B2
公开(公告)日：2020-07-07
申请号：US16067676
申请日：2017-01-06
申请人： The Board of Trustees of the University of Illinois , Board of Regents of the University of Texas System
发明人： John A. Katzenellenbogen , Benita Katzenellenbogen , Sung Hoon Kim , Zeynep Madak-Erdogan , Philip Shaul
IPC分类号： A61K31/047 , A61K31/055 , A61K31/05 , A61K31/025 , C07C39/17 , C07C39/06 , C07C39/42 , C07C235/34 , C07C255/47 , A61P25/00 , A61P35/00 , C07C49/755 , C07C43/196 , C07C49/733 , C07C39/12 , C07C39/14 , C07C57/38 , C07C39/367 , C07C39/23
摘要： Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.

2. 发明授权

US09901536B2 Composition for improving skin, containing pomegranate concentrate as active ingredient 有权
公开(公告)号：US09901536B2
公开(公告)日：2018-02-27
申请号：US15327845
申请日：2014-08-04
申请人： HLSCIENCE CO., LTD. , Hae-Yeon Lee
发明人： Hae-Yeon Lee
IPC分类号： A61K47/00 , A61Q19/02 , A61K36/00 , C07C39/12 , A61K8/97 , A23L33/105 , A61K8/49 , A61Q19/00 , A61Q19/08
CPC分类号： A61K8/97 , A23L33/105 , A23V2002/00 , A61K8/498 , A61K2800/85 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： The present disclosure relates to an effect of promoting hyaluronic acid synthesis of a pomegranate concentrate. A pomegranate concentrate, prepared by treating pomegranate with a starch-degrading enzyme and passing the same through a heating concentration process and having an ellagic acid content of 0.8 mg/g or higher and a polyphenol content of 8 mg/g or higher, has an effect of promoting hyaluronic acid. According to the present disclosure, hyaluronic acid synthesis can be promoted and skin moisturization can be improved by administering a food or pharmaceutical composition containing the pomegranate concentrate as an active ingredient to a subject in need of promotion of hyaluronic acid synthesis.

3. 发明授权

US09868751B2 Phosphonium compound, epoxy resin composition including the same and semiconductor device prepared from the same 有权
公开(公告)号：US09868751B2
公开(公告)日：2018-01-16
申请号：US14918916
申请日：2015-10-21
申请人： SAMSUNG SDI CO., LTD.
发明人： Min Gyum Kim , Ki Hyeok Kwon , Dong Hwan Lee , Joo Young Chung , Jin Min Cheon , Jin Woo Choi
IPC分类号： C07F9/54 , C08L63/00 , H01L23/29 , H01L23/31 , C08K5/50 , C07C233/65 , C07C233/75 , C07C235/66 , C07C323/20 , C07C39/08 , C07C39/17 , C07C49/83 , C08G59/68 , C09D163/00 , C08K5/49 , H01L23/00 , C07C259/10 , C07C235/64 , C07C39/12 , C08G59/62
CPC分类号： C07F9/5442 , C07C39/08 , C07C39/12 , C07C39/17 , C07C233/65 , C07C235/64 , C07C235/66 , C07C259/10 , C07C323/20 , C07C2603/18 , C08G59/621 , C08G59/688 , C08K5/49 , C08K5/50 , C09D163/00 , H01L23/295 , H01L23/3121 , H01L24/13 , H01L24/16 , H01L24/29 , H01L24/32 , H01L24/81 , H01L24/92 , H01L2224/131 , H01L2224/16225 , H01L2224/16227 , H01L2224/2929 , H01L2224/29298 , H01L2224/32225 , H01L2224/73204 , H01L2224/81192 , H01L2224/92125 , H01L2924/14 , H01L2924/181 , H01L2924/00012 , H01L2924/014 , H01L2924/00
摘要： A phosphonium compound, an epoxy resin composition, a method of preparing a phosphonium compound, and a semiconductor device encapsulated with the epoxy resin composition, the compound being represented by Formula 1:

4. 发明授权

US09481618B2 Cyclopolyarylene compound and method of manufacturing same 有权
标题翻译：环戊二烯基化合物及其制造方法
公开(公告)号：US09481618B2
公开(公告)日：2016-11-01
申请号：US14003512
申请日：2012-03-09
申请人： Kenichiro Itami , Yasutomo Segawa , Akiko Yagi
发明人： Kenichiro Itami , Yasutomo Segawa , Akiko Yagi
IPC分类号： C07C15/20 , C07C1/28 , C07C41/30 , C07C43/188 , C07C1/22 , C07C2/64 , C07C39/12 , C07C43/20 , C07C35/52 , C07C43/192
CPC分类号： C07C15/20 , C07C1/22 , C07C1/28 , C07C2/64 , C07C35/52 , C07C39/12 , C07C41/30 , C07C43/188 , C07C43/192 , C07C43/20 , C07C2601/16 , C07C2602/10 , C07C2603/90 , C07C13/64
摘要： A cyclopolyarylene compound represented by Formula (1): wherein k is the same or different, and each represents 0, 1 or 2; m is the same or different, and each represents 1, 2 or 3; and n represents 3, 4, 5 or 6.

5. 再颁专利

USRE46151E1 Method for the production of 4,4′-[1-(trifluoromethyl)alkylidene]-bis-(2,6-diphenylphenols) 有权
标题翻译：制备4,4' - [1-（三氟甲基）亚烷基] - 双（2,6-二苯基苯酚）
公开(公告)号：USRE46151E1
公开(公告)日：2016-09-20
申请号：US14321865
申请日：2014-07-02
申请人： BASF SE
发明人： Gabriele Gralla , Gunnar Heydrich , Klaus Ebel , Wolfgang Krause
IPC分类号： C07C39/16 , C07C39/12 , C07C45/74 , C07C37/07 , C07C37/20 , C07C37/62
CPC分类号： C07C45/74 , C07C37/07 , C07C37/20 , C07C37/62 , C07C49/613 , C07C49/653 , C07C39/15 , C07C39/367
摘要： The present invention relates to a process for preparing 4,4′-[1-(trifluoromethyl)alkylidene]bis(2,6-diphenylphenols), in particular for preparing 4,4′-[1-(trifluoromethyl)ethylidene]bis(2,6-diphenylphenol), which comprises the self-condensation of cyclohexanone in the presence of a basic catalyst to form tricyclic condensation products, dehydrogenation of the resulting tricyclic condensation products in the presence of a supported transition metal catalyst in the condensed phase to form 2,6-diphenylphenol and reaction of the 2,6-diphenylphenol with a trifluoromethyl ketone. The invention further provides an improved process for preparing 2,6-diphenylphenol by aldol self-condensation of cyclohexanone.
摘要翻译：本发明涉及一种制备4,4' - [1-（三氟甲基）亚烷基]双（2,6-二苯基苯酚）的方法，特别是制备4,4' - [1-（三氟甲基）亚乙基]双（ 2,6-二苯基苯酚），其包括环己酮在碱性催化剂存在下的自缩合以形成三环缩合产物，所得三环缩合产物在冷凝相中负载的过渡金属催化剂存在下脱氢形成 2,6-二苯基苯酚和2,6-二苯基苯酚与三氟甲基酮的反应。本发明还提供了通过环己酮的醛醇自缩合制备2,6-二苯基苯酚的改进方法。

6. 发明授权

US09139571B2 Methods of making fused ring compounds 有权
标题翻译：稠环化合物的制备方法
公开(公告)号：US09139571B2
公开(公告)日：2015-09-22
申请号：US13314735
申请日：2011-12-08
申请人： Meng He , Anil Kumar
发明人： Meng He , Anil Kumar
IPC分类号： C07D413/00 , C07C41/00 , C07C39/12 , C07D405/04 , C07D407/04
CPC分类号： C07C39/17 , C07C37/11 , C07C41/01 , C07C51/353 , C07C2602/08 , C07C2603/40 , C07D307/33 , C07D311/94 , C07D405/04 , C07D407/04
摘要： The present invention relates to methods of making fused ring compounds, such as indeno-fused naphthols, and fused ring indenopyran compounds, such as indeno-fused naphthopyrans, that each employ an unsaturated compound represented by the following Formula II. Referring to the unsaturated compound of Formula II: Ring-A can be selected from optionally substituted aryl (e.g., phenyl); m can be, for example, from 0 to 4; R1 for each m can be selected from optionally substituted hydrocarbyl (e.g., C1-C6 alkyl) optionally interrupted with at least one linking group (e.g., —O—); and R3 and R16 can each be independently selected from, for example, hydrogen or optionally substituted hydrocarbyl, such as C1-C8 alkyl. When Ring-A is a phenyl group, the unsaturated compound represented by Formula II can be referred to as an unsaturated indanone acid/ester compound, or an indenone acid/ester compound (depending on whether R16 is hydrogen, or an optionally substituted hydrocarbyl group).
摘要翻译：本发明涉及使稠合环化合物如茚并稠合的萘酚和茚并稠合的萘并吡喃化合物，如茚并稠合的萘并吡喃，各自使用由下式II表示的不饱和化合物的方法。关于式II的不饱和化合物：环-A可以选自任选取代的芳基（例如苯基）; m可以是例如0至4; 每个m的R 1可以选自任选被至少一个连接基团（例如-O-）中断的任选取代的烃基（例如C 1 -C 6烷基）; 并且R 3和R 16各自独立地选自例如氢或任选取代的烃基，例如C 1 -C 8烷基。当环A是苯基时，由式II表示的不饱和化合物可以称为不饱和茚酮酸/酯化合物或茚酮酸/酯化合物（取决于R 16是氢还是任选取代的烃基）。

7. 发明授权

US08507724B2 Compounds for use in the treatment of pain 有权
标题翻译：用于治疗疼痛的化合物
公开(公告)号：US08507724B2
公开(公告)日：2013-08-13
申请号：US13133569
申请日：2009-12-09
申请人： Martin Leuwer , Paul O'Neill , Neil Berry , Gertrud Haeseler
发明人： Martin Leuwer , Paul O'Neill , Neil Berry , Gertrud Haeseler
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , C07C39/12 , C07C43/20
CPC分类号： C07C39/367 , C07C39/15 , C07C43/23 , C07C235/46
摘要： The present invention concerns compounds derived from the anaethetic propofol. The compounds may be useful in the treatment of pain, particularly, but not exclusively, chronic pain and central pain sensitisation.
摘要翻译：本发明涉及衍生自异步异丙酚的化合物。该化合物可用于治疗疼痛，特别是但不限于，慢性疼痛和中枢性疼痛敏化。

8. 发明授权

US08455540B2 Gossypol and apogossypol derivatives, preparation thereof and uses thereof 失效
标题翻译：棉酚和果聚糖衍生物，其制备及其用途
公开(公告)号：US08455540B2
公开(公告)日：2013-06-04
申请号：US12746339
申请日：2008-12-05
申请人： Jacques Mortier , Anne-Sophie Castanet , Nguyet Trang Thanh Chau
发明人： Jacques Mortier , Anne-Sophie Castanet , Nguyet Trang Thanh Chau
IPC分类号： A61K31/35 , C07C39/12
CPC分类号： C07C43/23 , C07B2200/07 , C07C41/18 , C07C41/26 , C07C41/30 , C07C51/09 , C07C51/353 , C07C65/21 , C07C65/24
摘要： Gossypol and apogossypol derivatives of general formula (1), preparation thereof and use thereof.
摘要翻译：棉酚和通式（1）的聚苯三酚衍生物，其制备及其用途。

9. 发明申请

US20120197005A1 CONTAINERLESS SYNTHESIS OF AMORPHOUS AND NANOPHASE ORGANIC MATERIALS 有权
标题翻译：不规则合成非晶态和纳米有机材料
公开(公告)号：US20120197005A1
公开(公告)日：2012-08-02
申请号：US13361164
申请日：2012-01-30
申请人： Chris J. Benmore , Johann R. Weber
发明人： Chris J. Benmore , Johann R. Weber
IPC分类号： C07K14/00 , B01J19/00 , C07H21/00 , C07D223/18 , C07D241/04 , C07C39/12 , C07D233/54 , C07D233/56 , C07C59/76 , C07C307/02 , C07C321/00 , G01N25/00 , C07D215/58
CPC分类号： B01J19/10
摘要： The invention provides a method for producing a mixture of amorphous compounds, the method comprising supplying a solution containing the compounds; and allowing at least a portion of the solvent of the solution to evaporate while preventing the solute of the solution from contacting a nucleation point. Also provided is a method for transforming solids to amorphous material, the method comprising heating the solids in an environment to form a melt, wherein the environment contains no nucleation points; and cooling the melt in the environment.
摘要翻译：本发明提供一种制备无定形化合物混合物的方法，该方法包括提供含有该化合物的溶液; 并允许溶液的至少一部分溶剂蒸发，同时防止溶液的溶质接触成核点。还提供了将固体转化为无定形材料的方法，该方法包括在环境中加热固体以形成熔体，其中环境不含成核点; 并在环境中冷却熔体。

10. 发明申请

US20120108854A1 GREEN AND ATOM-ECONOMICAL PROCESSES FOR PRODUCING PHENOLIC ANTIOXIDANTS 有权
标题翻译：用于生产苯酚抗氧化剂的绿色和原子经济方法
公开(公告)号：US20120108854A1
公开(公告)日：2012-05-03
申请号：US13382683
申请日：2010-07-06
申请人： Mahmood Sabahi , Thomas Robert Nicholas
发明人： Mahmood Sabahi , Thomas Robert Nicholas
IPC分类号： C07C39/12
CPC分类号： C07C37/11 , C07C37/16 , C07C67/08 , C07C2601/16 , C08K5/13 , C07C39/15 , C07C69/007 , C07C69/16
摘要： Processes for producing 1,3,5-trimethyl-2,4,6-tris(3,5-dialkyl-4-hydroxybenzyl)benzene are provided, in particular such processes that utilize 2,6-di-tert-butylphenol, paraformaldehyde, a secondary amine, mesitylene, and acetic acid.
摘要翻译：提供了制备1,3,5-三甲基-2,4,6-三（3,5-二烷基-4-羟基苄基）苯的方法，特别是使用2,6-二叔丁基苯酚，多聚甲醛，仲胺，均三甲苯和乙酸。

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