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1. 发明授权

US11576968B2 Hepatitis C virus immunogenic compositions and methods of use thereof 有权
公开(公告)号：US11576968B2
公开(公告)日：2023-02-14
申请号：US17122627
申请日：2020-12-15
申请人： The Governors of the University of Alberta , Helmholtz Center for Infection Research
发明人： Michael Houghton , Abdolamir Landi , Carlos A. Guzman , Thomas Ebensen , Darren Hockman , John L. Law , Michael Logan
IPC分类号： A61K39/00 , A61K39/29 , C07K16/28 , A61K39/12 , C12N15/86 , A61P31/14 , A61P37/04 , C07K14/005 , A61K39/39 , C01F11/02 , C07D323/00 , C07K14/18 , C07K14/28 , C07K14/33 , C07K14/34
摘要： The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.

2. 发明申请

US20210009551A1 COMPOUNDS AND METHODS FOR TREATING FIBROSIS OR CANCER 有权
公开(公告)号：US20210009551A1
公开(公告)日：2021-01-14
申请号：US16305172
申请日：2017-06-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Harold A. Chapman , Ying WEI , Bradley J. BACKES
IPC分类号： C07D323/00 , C07D321/10 , C07D273/01
摘要： Provided herein, inter alia, are methods and compounds for treating a pulmonary disease, fibrosis, or cancer.

3. 发明申请

US20200290989A1 CALIXCROWNS AND USES THEREOF 审中-公开
公开(公告)号：US20200290989A1
公开(公告)日：2020-09-17
申请号：US16819916
申请日：2020-03-16
申请人： INNOPHARMASCREEN INC.
发明人： Incheol KANG , Nari LEE
IPC分类号： C07D323/00 , G01N33/553 , G01N33/68
摘要： Provided herein are novel calixcrowns, such as those of Formula I, which are useful for coating a solid substrate such as a protein chip, diagnostic kit or protein separation pack. Also provided herein are methods detecting protein-protein interactions with a solid substrate coated with the calixcrown herein and an immobilized protein.

4. 发明授权

US09938251B2 Cyclic ketone peroxide composition 有权
公开(公告)号：US09938251B2
公开(公告)日：2018-04-10
申请号：US15123418
申请日：2015-03-09
申请人： Akzo Nobel Chemicals International B.V.
发明人： Jan Martijn Van Der Schuur , Johan Nuysink , Renaud Charles Joseph Millet , Bart Fischer
IPC分类号： C07D323/00 , C08K5/14 , C10L1/18
CPC分类号： C07D323/00 , C08K5/14 , C10L1/1811 , C10L2200/0446 , C08L23/12
摘要： A composition comprising at least two trimeric cyclic ketone peroxides: a trimeric cyclic methyl ethyl ketone peroxide (3MEK-cp) of formula (I) and at least one peroxide satisfying formula (II) wherein R1 through R3 are independently selected from alkyl and alkoxyalkyl groups, said groups having 2 to 5 carbon atoms, the total number of carbon plus oxygen atoms of R1−R2+R3 is in the range 7-15, and the molar ratio of 3MEK-cp to the total amount of peroxides satisfying formula (II) being in the range of from 10:90 to 80:20.

5. 发明申请

US20180074068A1 FLUORESCENT PROBES FOR DETECTING HYDROGEN POLYSULFIDES 审中-公开
公开(公告)号：US20180074068A1
公开(公告)日：2018-03-15
申请号：US15704101
申请日：2017-09-14
申请人： Washington State University
发明人： Ming Xian , Wei Chen
IPC分类号： G01N33/58 , C07D493/10 , C07D311/86 , C07D323/00
CPC分类号： G01N33/582 , C07D311/86 , C07D323/00 , C07D493/10
摘要： Reactive sulfur species have been recognized as an important regulator in redox biology, wherein the reactive sulfur species have been shown to be active in tumor suppressors, ion channels, and transcription factors. The disclosed invention is a novel composition of matter that allows for the detection of H2S and H2Sn species in living cells. These novel compositions represent significant progress in the field of chemical, H2S and H2Sn probes as they have both been successfully applied in the visualization sulfur species in living systems.

6. 发明授权

US09670175B2 Protected succinates for enhancing mitochondrial ATP-production 有权
公开(公告)号：US09670175B2
公开(公告)日：2017-06-06
申请号：US14433558
申请日：2013-10-04
申请人： NEUROVIVE PHARMACEUTICALS AB
发明人： Hans Georg Fliri , Rhonan Lee Ford , David Arthur Scowen , Derek Gregory Batcheller , Kari Henrik Johannes Ehinger , Mats Eskil Elmer , Magnus Joakim Hansson , Karl Fredrik Lennart Sjovall
IPC分类号： A01N43/26 , A61K31/335 , C07C69/34 , C07C69/52 , C07D317/34 , C07C69/40 , C07C69/708 , C07D323/00 , C07C235/06
CPC分类号： C07D317/34 , C07C69/40 , C07C69/708 , C07C235/06 , C07D323/00
摘要： Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optionally substituted alkyl group or a group of formula (II) and R2 is independently a group according to formula (II) where formula (II) is as defined 10 herein.

7. 发明授权

US09637773B2 Compounds and methods for detection of enzymes that remove formyl, succinyl, methyl succinyl or myristoyl groups from ε-amino lysine moieties 有权
公开(公告)号：US09637773B2
公开(公告)日：2017-05-02
申请号：US12930693
申请日：2011-01-13
申请人： Konrad T. Howitz , Zhongda Zhang , Anne Kisielewski , Elizabeth Dale , Wayne Forrest Patton
发明人： Konrad T. Howitz , Zhongda Zhang , Anne Kisielewski , Elizabeth Dale , Wayne Forrest Patton
IPC分类号： C07D407/00 , C07D493/00 , C07D319/00 , C07D323/00 , C07D305/14 , C07D307/94 , C07D311/96 , C07D313/06 , C07D313/20 , C07D317/72 , C07D311/02 , C12Q1/34 , C07D311/16 , C07D493/10
CPC分类号： C12Q1/34 , C07D311/16 , C07D493/10 , C12Y305/01098 , G01N2333/98
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.

8. 发明申请

US20160368891A1 Cyclic Ketone Peroxide Composition 有权
标题翻译：环状酮过氧化物组成
公开(公告)号：US20160368891A1
公开(公告)日：2016-12-22
申请号：US15123418
申请日：2015-03-09
申请人： AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
发明人： Jan Martijn Van Der Schuur , Johan Nuysink , Renaud Charles Joseph Millet , Bart Fischer
IPC分类号： C07D323/00 , C08K5/14 , C10L1/18
CPC分类号： C07D323/00 , C08K5/14 , C10L1/1811 , C10L2200/0446 , C08L23/12
摘要： A composition comprising at least two trimeric cyclic ketone peroxides: a trimeric cyclic methyl ethyl ketone peroxide (3MEK-cp) of formula (I) and at least one peroxide satisfying formula (II) wherein R1 through R3 are independently selected from alkyl and alkoxyalkyl groups, said groups having 2 to 5 carbon atoms, the total number of carbon plus oxygen atoms of R1−R2+R3 is in the range 7-15, and the molar ratio of 3MEK-cp to the total amount of peroxides satisfying formula (II) being in the range of from 10:90 to 80:20.
摘要翻译：包含至少两种三聚环酮过氧化物的组合物：式（I）的三聚环状甲基乙基酮过氧化物（3MEK-cp）和满足式（II）的至少一种过氧化物，其中R 1至R 3独立地选自烷基和烷氧基烷基，所述具有2-5个碳原子的基团，R1 + R2 + R3的碳加氧原子的总数在7-15范围内，并且3MEK-cp与满足式（II）的过氧化物总量的摩尔比）在10:90至80:20的范围内。

9. 发明授权

US09469651B2 Halichondrin B analogs 有权
公开(公告)号：US09469651B2
公开(公告)日：2016-10-18
申请号：US14707763
申请日：2015-05-08
申请人： Eisai R&D Management Co., Ltd.
发明人： Yongbo Hu
IPC分类号： C07D323/00 , C07D493/22
CPC分类号： C07D493/22 , C07B2200/13
摘要： The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.

10. 发明授权

US09440944B2 Production of cyclic acetals or ketals using solid acid catalysts 有权
标题翻译：使用固体酸催化剂制备环状缩醛或缩酮
公开(公告)号：US09440944B2
公开(公告)日：2016-09-13
申请号：US14337544
申请日：2014-07-22
申请人： Eastman Chemical Company
发明人： Daniel Latham Terrill , Brian David McMurray , Damon Ray Billodeaux , James Lon Little , Adam Scott Howard
IPC分类号： C07D323/00 , C07D321/06 , C07D319/12 , C07D317/12 , C07D321/08
CPC分类号： C07D323/00 , C07D317/12 , C07D319/12 , C07D321/06 , C07D321/08
摘要： A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.
摘要翻译：通过将醛或酮化合物和多羟基化合物以多羟基化合物与醛或酮化合物的摩尔比至少为3:1的比例将醛或酮化合物和多羟基化合物进料到反应区中来制备环状化合物如环缩醛或环酮的方法，使这些化合物在固体酸如酸性离子交换树脂的存在，以便在反应混合物中形成液体反应混合物而不从反应混合物中分离出水，以液体产物的形式从反应区抽出液体反应混合物流，并将液体反应产物流进料到蒸馏塔中以从未反应的多羟基化合物中分离出环状缩醛化合物，并任选地将未反应的多羟基化合物回收到反应区。该方法产生环状缩醛化合物，产率至少为90％，催化剂寿命长。该方法也适用于由酮化合物制备环状缩酮。

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