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1. 发明授权

US11708516B2 1,2,3,3,3-pentafluropropene production processes 有权
公开(公告)号：US11708516B2
公开(公告)日：2023-07-25
申请号：US17336575
申请日：2021-06-02
申请人： THE CHEMOURS COMPANY FC, LLC
发明人： Velliyur Nott Mallikarjuna Rao , Mario Joseph Nappa , Allen Capron Sievert
IPC分类号： C07K5/04 , C09K5/04 , C07C17/00 , C07C17/087 , C07C17/20 , C07C17/23 , C07C17/354 , C07C19/08 , C07C19/10
CPC分类号： C09K5/045 , C07C17/00 , C07C17/087 , C07C17/206 , C07C17/23 , C07C17/354 , C07C19/08 , C07C19/10 , C07C17/00 , C07C21/18 , C07C17/00 , C07C19/08 , C07C17/087 , C07C19/10 , C07C17/206 , C07C19/10 , C07C17/23 , C07C21/18 , C07C17/23 , C07C19/08 , C07C17/354 , C07C19/08
摘要： A process is disclosed for making CF3CF═CHF. The process involves reacting CF3CClFCCl2F with H2 in a reaction zone in the presence of a catalyst to produce a product mixture comprising CF3CF═CHF. The catalyst has a catalytically effective amount of palladium supported on a support selected from the group consisting of alumina, fluorided alumina, aluminum fluoride and mixtures thereof and the mole ratio of H2 to CF3CClFCCl2F fed to the reaction zone is between about 1:1 and about 5:1. Also disclosed are azeotropic compositions of CF3CClFCCl2F and HF and azeotropic composition of CF3CHFCH2F and HF.

2. 发明授权

US08354499B2 Cyanine-based probe\tag-peptide pair fluorescence protein imaging and fluorescence protein imaging methods 有权
$Cyanine-based probe\tag-peptide pair fluorescence protein imaging and fluorescence protein imaging methods$
标题翻译：基于花青的探针\标签肽对荧光蛋白成像和荧光蛋白成像方法
公开(公告)号：US08354499B2
公开(公告)日：2013-01-15
申请号：US12773707
申请日：2010-05-04
申请人： M. Uljana Mayer-Cumblidge , Haishi Cao
发明人： M. Uljana Mayer-Cumblidge , Haishi Cao
IPC分类号： C07K7/06 , C07K5/04
CPC分类号： C09B23/06 , C07K1/13 , C07K7/06 , C09B23/0075 , C09B23/083 , C09B23/086 , G01N33/582 , Y10T436/13
摘要： A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having a second formula. A method of labeling a peptide includes providing a peptide comprising a tag sequence and contacting the peptide with a biarsenical molecular probe. A complex is formed comprising the tag sequence and the molecular probe. A method of studying a peptide includes providing a mixture containing a peptide comprising a peptide tag sequence, adding a biarsenical probe to the mixture, and monitoring the fluorescence of the mixture.
摘要翻译：分子探针包含两个砷原子和至少一个基于花青的部分。制备分子探针的方法包括提供具有第一式的分子，用HgOAc处理分子，随后用AsCl 3进行金属化。 As被配体化为乙二硫醇以产生具有第二式的探针。标记肽的方法包括提供包含标签序列的肽并使肽与双链分子探针接触。形成包含标签序列和分子探针的复合物。一种研究肽的方法包括提供含有肽标签序列的肽的混合物，向该混合物中加入双缩醛探针，并监测该混合物的荧光。

3. 发明申请

US20110092668A1 AZIDE FUNCTIONALIZED PEPTIDE TARGETING GROUPS 有权
标题翻译： AZIDE功能性肽肽靶向组
公开(公告)号：US20110092668A1
公开(公告)日：2011-04-21
申请号：US12961918
申请日：2010-12-07
申请人： Kurt Breitenkamp , Kevin N. Sill , Habib Skaff , Rebecca Breitenkamp
发明人： Kurt Breitenkamp , Kevin N. Sill , Habib Skaff , Rebecca Breitenkamp
IPC分类号： C07K5/04 , C07D475/00
CPC分类号： A61K47/34 , A61K9/1075 , A61K9/19 , A61K47/551 , A61K47/62 , A61K47/6907 , C08G69/40 , C08G73/028 , C12N15/88
摘要： The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
摘要翻译：本发明涉及聚合物化学领域，更具体地涉及包含其的多嵌段共聚物和胶束。

4. 发明授权

US07842782B2 Heparanase-derived peptides for vaccination of tumor patients 失效
标题翻译：肝素酶衍生肽用于疫苗接种肿瘤患者
公开(公告)号：US07842782B2
公开(公告)日：2010-11-30
申请号：US10557249
申请日：2004-05-18
申请人： Volker Schirrmacher , Philipp Beckhove , Nora Sommerfeldt
发明人： Volker Schirrmacher , Philipp Beckhove , Nora Sommerfeldt
IPC分类号： C07K5/04
CPC分类号： C12Y302/01166 , A61K39/0005 , A61K39/0008 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , C12N9/2402 , G01N33/574 , G01N2333/924
摘要： Disclosed is a vaccine against diseases, particularly tumor diseases, being associated with an enhanced heparanase expression and/or activity, wherein the vaccine contains a heparanase peptide, which binds to a HLA molecule.
摘要翻译：公开了一种针对疾病特别是肿瘤疾病的疫苗，其与增强的乙酰肝素酶表达和/或活性相关，其中所述疫苗含有结合HLA分子的乙酰肝素酶。

5. 发明申请

US20070191284A1 Compounds for enzyme inhibition 有权
公开(公告)号：US20070191284A1
公开(公告)日：2007-08-16
申请号：US11786217
申请日：2007-04-11
申请人： Mark Smyth , Guy Laidig , Ronald Borchardt , Barry Bunin , Craig Crews , John Musser
发明人： Mark Smyth , Guy Laidig , Ronald Borchardt , Barry Bunin , Craig Crews , John Musser
IPC分类号： A61K38/04 , C07K5/04
CPC分类号： C07K5/1016 , A61K38/00 , A61K38/07 , C07K5/0812 , C07K5/1008 , C07K5/1024
摘要： Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

6. 发明申请

US20070106086A1 PROCESS FOR THE PREPARATION OF 3,3-DIMETHYLBUTANAL 有权
标题翻译：制备3,3-二甲基吡啶的方法
公开(公告)号：US20070106086A1
公开(公告)日：2007-05-10
申请号：US11552395
申请日：2006-10-24
申请人： Jerry Ebner , Zhi Guo , Arnold Hershman , Loraine Klein , William McGhee , Mark Paster , Indra Prakash
发明人： Jerry Ebner , Zhi Guo , Arnold Hershman , Loraine Klein , William McGhee , Mark Paster , Indra Prakash
IPC分类号： C07C45/29 , C07K5/04
CPC分类号： C07C303/24 , C07C17/275 , C07C29/095 , C07C29/12 , C07C29/124 , C07C29/132 , C07C29/147 , C07C29/149 , C07C45/002 , C07C45/38 , C07C47/02 , C07K5/06113 , Y02P20/127 , C07C19/01 , C07C305/08 , C07C31/125
摘要： 3,3-Dimethylbutanal is prepared from 3,3-dimethylbutanol. Intermediate 3,3-dimethylbutanol is obtained by reacting ethylene, isopropylene and a mineral acid to produce a 3,3-dimethylbutyl ester which is hydrolyzed to the alcohol. The hydrolysis step is effectively carried out by reactive distillation. Alternatively, 3,3-dimethylbutanal is prepared from 3,3-dimethylbutanol obtained by reduction of the corresponding carboxylic acid or 1,2-epoxy-3,3-dimethylbutane, or by hydrolysis of 1-halo-3,3-dimethylbutane. Fixed bed gas phase and stirred tank liquid phase processes are provided for converted 3,3-dimethylbutanol to 3,3-dimethylbutanal by catalytic dehydrogenation.
摘要翻译： 3,3-二甲基丁醛由3,3-二甲基丁醇制备。中间体3,3-二甲基丁醇通过使乙烯，异丙烯和无机酸反应得到3,3-二甲基丁酯，将其水解成醇。水解步骤通过反应蒸馏有效地进行。或者，通过还原相应的羧酸或1,2-环氧-3,3-二甲基丁烷或通过1-卤代-3,3-二甲基丁烷的水解得到的3,3-二甲基丁醇制备3,3-二甲基丁醛。提供固定床气相和搅拌釜液相方法，通过催化脱氢将3,3-二甲基丁醇转化为3,3-二甲基丁醛。

7. 发明授权

US07179792B2 Combination product of a 1,4-benzothiepine 1,1-dioxide compound with at least one other active ingredient and the use of the product 有权
标题翻译： 1,4-苯并噻吩1,1-二氧化物化合物与至少一种其它活性成分的组合产物和产物的用途
公开(公告)号：US07179792B2
公开(公告)日：2007-02-20
申请号：US10699967
申请日：2003-11-03
申请人： Heiner Glombik , Wendelin Frick , Hans-Ludwig Schaefer , Werner Kramer
发明人： Heiner Glombik , Wendelin Frick , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K38/06 , A61K38/05 , A61K38/04 , C07K5/06 , C07K5/04
CPC分类号： A61K45/06 , A61K31/395 , A61K31/55 , A61K2300/00
摘要： The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically functional derivative thereof, with at least one other active ingredient, or a pharmaceutically acceptable salt or physiologically functional derivative thereof. The invention is also directed to the use of the combination product, pharmaceutical composition comprising the combination product and method for preparing the pharmaceutical composition.
摘要翻译：本发明涉及其中基团具有本文定义的含义，或其药学上可接受的盐或生理功能衍生物的式I的1,4-苯并硫代1,1-二氧化物化合物与至少一种其它活性成分，或其药学上可接受的盐或生理功能衍生物。本发明还涉及组合产品，包含组合产品和方法的药物组合物用于制备药物组合物的用途。

8. 发明申请

US20070037753A1 Inhibitors of cancer cell, T-cell and keratinocyte proliferation 失效
标题翻译：癌细胞抑制剂，T细胞和角化细胞增殖
公开(公告)号：US20070037753A1
公开(公告)日：2007-02-15
申请号：US11501722
申请日：2006-08-10
申请人： Johann Leban , Martin Kralik
发明人： Johann Leban , Martin Kralik
IPC分类号： A61K38/05 , A61K38/04 , C07K5/04 , C07D403/02
CPC分类号： C07D233/72 , A61K38/00 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/14 , C07K5/0205 , C07K5/06078 , C07K5/06191 , Y02A50/409
摘要： The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y is —NRaRb, —NRcC═ONRaRb, —NRcC═SNRaRb, —NRcC═NRdNaRb, heterocycle, —C═ONRaRb, heterocycle, or aryl; n is 0 to 8; m is 0, or 1; r is 0 to 3; t is 0 to 3; X is O or N; Z is CH2, C═O, C═S or a single bond; Z1 is CO—R2, CS—R2, (CH2)t—R2 or the side-chain of a naturally occuring amino acid;, Z2 is CO—R2, CS—R2 or (CH2)t—R3 or the side-chain of a naturally occuring amino acid; Z3 is CO—R2, CS—R2 or (CH2)t—R4 or the side-chain of a naturally occuring amino acid; Z4 is H, alkyl, alkoxy, or cycloalkyl; R1, R2, R3, and R4 are independently from each other H, OH, SH, NH2, CN, NO2, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl, alkylthio, haloalkyloxy, hydroxyalkyl, hydroxyalkylamino, alkylamino, alkylaryl, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxyalkyl, alkoxy, aryloxy, heteroaryl, aryl, or halogen.
摘要翻译：本发明涉及通式（I）的化合物及其盐和生理功能衍生物，其中Y是-NR a，R b， C-ON＆lt; b＆gt; b＆lt;＆lt;＆lt; C＆gt; C-SNR＆lt; b＆gt; b C 1 -C 6卤代烷基，杂环基，C 1 -C 6 - 杂环或芳基;杂环或芳基; n为0〜8; m为0或1; r为0〜3; t为0〜3; X是O或N; Z是CH 2，C-O，C-S或单键; Z 1是CO-R 2，CS-R 2，（CH 2）2， / SUB> -R 2或天然存在的氨基酸的侧链; Z 2是CO-R 2，CS- R 2或（CH 2）2 -TH 3或天然存在的氨基酸的侧链 ; Z 3是CO-R 2，CS-R 2或（CH 2 CH 2） / SUB→4或天然存在的氨基酸的侧链; Z 4是H，烷基，烷氧基或环烷基; R 1，R 2，R 3和R 4彼此独立地为H，OH，SH ，NH 2，CN，NO 2，烷基，环烷基，杂环烷基，卤代烷基，烷硫基，卤代烷氧基，羟烷基，羟烷基氨基，烷基氨基，烷基芳基，烷基亚磺酰基，烷基磺酰基，烷硫基烷基，烷基亚磺酰基烷基烷基磺酰基烷基，烷氧基烷基，烷氧基，芳氧基，杂芳基，芳基或卤素。

9. 发明申请

US20070015716A1 Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs 失效
标题翻译：用于增强口服吸收和药物全身生物利用度的胆汁酸衍生化合物
公开(公告)号：US20070015716A1
公开(公告)日：2007-01-18
申请号：US11483770
申请日：2006-07-11
申请人： Mark Gallop , Kenneth Cundy
发明人： Mark Gallop , Kenneth Cundy
IPC分类号： A61K38/04 , C07K5/04 , C07J41/00 , C07J43/00 , A61K31/66 , A61K31/58 , A61K31/56
CPC分类号： C07K5/0205 , A61K38/00 , A61K47/54 , A61K47/554 , A61K47/64 , A61K47/65
摘要： Disclosed are methods for providing enhanced systemic blood concentrations of orally delivered drugs that are incompletely translocated across the intestinal wall of an animal. Also disclosed are methods for the sustained release of drugs, whether poorly or readily bioavailable via oral delivery to animals. Still further, disclosed are compounds and pharmaceutical compositions that are used in such methods.
摘要翻译：公开了用于提供不完全易位穿过动物肠壁的口服递送药物的增强的全身血液浓度的方法。还公开了用于药物持续释放的方法，无论是通过口服递送给动物还是很少或容易生物利用。此外，还公开了用于这些方法的化合物和药物组合物。

10. 发明申请

US20070004642A1 Oxadiazole derivatives and drugs containing these derivatives as the active ingredient 审中-公开
标题翻译：恶二唑衍生物和含有这些衍生物的药物作为活性成分
公开(公告)号：US20070004642A1
公开(公告)日：2007-01-04
申请号：US11488782
申请日：2006-07-19
申请人： Kazuyuki Ohmoto , Iori Itagaki
发明人： Kazuyuki Ohmoto , Iori Itagaki
IPC分类号： A61K38/05 , A61K38/04 , C07K5/06 , C07K5/04 , C07D413/02
CPC分类号： C07D271/07 , A61K38/00 , C07D271/113 , C07D413/06 , C07D413/12 , C07K5/06043 , C07K5/06139
摘要： An oxadiazole derivative of formula (I) and a non-toxic salt thereof, wherein R is hydrogen, alkyl, CycA, etc.; AA1 is a single bond, amino acid residue, etc.; AA2 is a single bond, amino acid residue, etc.; R7 and R8 are hydrogen, alkyl, etc.; R9 is hydrogen, alkyl, etc.; R10 is hydrogen, alkyl, etc.). The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation system disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.
摘要翻译：式（I）的恶二唑衍生物及其无毒盐，其中R为氢，烷基，CycA等; AA 1是单键，氨基酸残基等; AA 2是单键，氨基酸残基等; R 7和R 8是氢，烷基等; R 9为氢，烷基等; R 10是氢，烷基等）。式（I）化合物对半胱氨酸蛋白酶具有抑制活性，因此可用作预防和/或治疗炎性疾病，由凋亡诱导的疾病，由免疫应答障碍引起的疾病，自身免疫性疾病，疾病由构成有机体的蛋白质，休克，循环系统疾病，凝血系统疾病，恶性肿瘤，获得性免疫缺陷综合征（AIDS）和AIDS相关复合物（ARC），寄生虫病，神经变性疾病，肺功能障碍，骨骼吸收疾病，内分泌等

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