专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180371012A1 QUINSTATIN COMPOUNDS 审中-公开
公开(公告)号：US20180371012A1
公开(公告)日：2018-12-27
申请号：US15747077
申请日：2016-07-22
申请人： George Robert Pettit , Noeleen Melody
发明人： George Robert Pettit , Noeleen Melody
IPC分类号： C07K5/02 , A61P35/00
CPC分类号： C07K5/0205 , A61K38/00 , A61P35/00 , C07K5/06043 , C07K7/02
摘要： The present disclosure relates to Quinstatin compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or pharmaceutical compositions.

2. 发明申请

US20180318425A1 Bortezomib Conjugates and Methods Using Same 审中-公开
公开(公告)号：US20180318425A1
公开(公告)日：2018-11-08
申请号：US15772910
申请日：2016-11-02
申请人： University of Rochester
发明人： Frank Ebetino , Robert Boeckman , Lianping Xing , Lifeng Xiao , Brendan Boyce
IPC分类号： A61K47/54 , A61K31/69 , A61P19/00 , A61P35/00
CPC分类号： A61K47/548 , A61K31/69 , A61K49/0032 , A61K49/0052 , A61P19/00 , A61P35/00 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07K5/06043 , C07K5/06139 , C07K5/06191
摘要： The present invention provides compositions and methods for providing controllable local delivery of a conjugate of bortezomib (Btz) and a bisphosphonate to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with diseases and disorders characterized by bone loss.

3. 发明申请

US20180009845A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES 审中-公开
公开(公告)号：US20180009845A1
公开(公告)日：2018-01-11
申请号：US15702682
申请日：2017-09-12
申请人： Ambrx, Inc.
发明人： Zhenwei Maio , Kyle Atkinson , Sandra Biroc , Timothy Buss , Melissa Neal , Vadim Kraynov , Robin Marsden , Jaosn Pinkstaff , Lillian Skidmore , Ying Sun , Agnieszka Szydlik , Delia Lanina Lopez De Valenta
IPC分类号： C07K5/103 , C07K5/02 , C07D401/12 , C07D207/08 , A61K38/07 , C07D417/12 , C07K5/062
CPC分类号： C07K5/101 , A61K38/07 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6855 , A61K47/6861 , C07D207/08 , C07D401/12 , C07D417/12 , C07K5/0205 , C07K5/06043
摘要： Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.

4. 发明申请

US20170321187A1 BIOLOGICALLY ACTIVE C-TERMINAL ARGININE-CONTAINING PEPTIDES 审中-公开
公开(公告)号：US20170321187A1
公开(公告)日：2017-11-09
申请号：US15655279
申请日：2017-07-20
申请人： GENENTECH, INC.
发明人： James Wilkins , Masaru Ken Shiratori , Tim Breece
IPC分类号： C12N5/00 , C07K1/20 , C07K5/093 , C07K5/087 , C07K5/083 , C07K5/072 , C07K1/16 , C07K5/065 , C07K5/062
CPC分类号： C12N5/0018 , C07K1/16 , C07K1/20 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0819 , C12N2501/998 , C12N2510/02
摘要： The present invention concerns the separation, identification and characterization of active peptide fragments from peptones.

5. 发明授权

US09783574B2 Cardiovascular therapeutics 有权
公开(公告)号：US09783574B2
公开(公告)日：2017-10-10
申请号：US13589082
申请日：2012-08-17
申请人： Christopher Joseph Pemberton , Arthur Mark Richards , Christopher John Charles , Maithri Siriwardena
发明人： Christopher Joseph Pemberton , Arthur Mark Richards , Christopher John Charles , Maithri Siriwardena
IPC分类号： C07K7/06 , C07K5/083 , C07K5/103 , C07K5/062 , A61K38/08 , A61K38/22
CPC分类号： C07K7/06 , A61K38/08 , A61K38/2242 , C07K5/06043 , C07K5/0808 , C07K5/101
摘要： Compounds and compositions comprising a B-type natriuretic signal peptide fragment agent, and methods of use thereof, are provided for the treatment or prevention of cardiovascular diseases, disorders, and conditions.

6. 发明申请

US20170210778A1 NOVEL COMPOUNDS 审中-公开
公开(公告)号：US20170210778A1
公开(公告)日：2017-07-27
申请号：US15326534
申请日：2015-07-15
申请人： The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Hol , INVIVOGEN SAS
发明人： Kingston Mills , Patrick Kelly , Jean-Gerard Tiraby , Thierry Lioux , Eric Perouzel
IPC分类号： C07K5/062 , A61K38/00 , C07C237/22 , C07C323/59 , C07C237/12
CPC分类号： C07K5/06026 , A61K38/00 , C07C237/12 , C07C237/22 , C07C323/59 , C07K5/0215 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/06078
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, (formula 1) wherein R1, R2, R3, R4, R5, X, m and n are defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.

7. 发明授权

US09481709B2 Boropeptide inhibitors of enteropeptidase and their uses in treatment of obesity, overweight and/or diseases associated with an abnormal fat metabolism 有权
标题翻译：肠肽酶的硼肽抑制剂及其在治疗与异常脂肪代谢相关的肥胖，超重和/或疾病中的用途
公开(公告)号：US09481709B2
公开(公告)日：2016-11-01
申请号：US14107855
申请日：2013-12-16
申请人： OBE THERAPY BIOTECHNOLOGY
发明人： Itzik Harosh , Sandrine Braud , Marco A. Ciufolini
IPC分类号： C07D345/00 , C07D517/00 , C07K5/08 , C07K5/062 , C07K5/065 , C07K5/072 , C07K5/083 , C07K5/087 , C07K5/09 , A61K38/05 , A61K38/06 , C07K5/06 , A61K38/00
CPC分类号： C07K5/08 , A61K38/00 , A61K38/005 , A61K38/05 , A61K38/06 , C07K5/06 , C07K5/06026 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06095 , C07K5/06104 , C07K5/06191 , C07K5/0806 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0827
摘要： Novel compounds, particularly derivatives of boroarginine, boroornithine and borolysine that selectively modulate, regulate, and/or inhibit enteropeptidase. Compositions, particularly pharmaceutical compositions, as well as methods to treat excess weight, obesity and diseases associated with an abnormal fat metabolism.
摘要翻译：选择性调节，调控和/或抑制肠肽酶的新型化合物，特别是硼精氨酸衍生物，硼代鸟氨酸和硼氢化钠。组合物，特别是药物组合物，以及治疗过量体重，肥胖和与异常脂肪代谢相关的疾病的方法。

8. 发明申请

US20160272582A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERGLYCEMIA AND METABOLIC SYNDROME 审中-公开
标题翻译：用于治疗高血压和代谢综合征的组合物和方法
公开(公告)号：US20160272582A1
公开(公告)日：2016-09-22
申请号：US15159832
申请日：2016-05-20
申请人： Mohan Murali Alapati
发明人： Mohan Murali Alapati
IPC分类号： C07C279/26 , C07C57/04 , C07C237/12
CPC分类号： C07C279/265 , C07C57/03 , C07C57/04 , C07C237/12 , C07C279/26 , C07K5/06043
摘要： The invention relates to the compounds and compositions of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprises a salt of metformin and the methods for treating or preventing metabolic syndrome, prediabetes and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
摘要翻译：本发明涉及式I，式II，式III，式IV，式V，式VI或其药学上可接受的多晶型物，溶剂合物，对映异构体，立体异构体和水合物的化合物和组合物。药物组合物包含二甲双胍的盐，并且可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射的治疗或预防代谢综合征的方法。这些组合物可用于治疗糖尿病，肥胖症，脂质疾病，高甘油三酯血症，高血糖症，高胰岛素血症和胰岛素抵抗。

9. 发明授权

US09441012B2 Fluorinated epoxyketone-based compounds and uses thereof as proteasome inhibitors 有权
标题翻译：氟化环氧酮类化合物及其作为蛋白酶体抑制剂的用途
公开(公告)号：US09441012B2
公开(公告)日：2016-09-13
申请号：US14420817
申请日：2013-08-13
申请人： FLUORINOV PHARMA INC.
发明人： Abdelmalik Slassi , Peter Dove
IPC分类号： A61K38/06 , C07K5/08 , C07K5/06 , C07K5/062 , C07K5/065 , A61K38/00
CPC分类号： C07K5/0827 , A61K38/00 , A61K38/06 , C07K5/06008 , C07K5/06043 , C07K5/06078
摘要： The present application relates to novel fluorinated epoxyketone-based compounds, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions mediated by proteasome inhibition, in particular, the present application includes compounds of Formula I, and compositions and uses thereof.

10. 发明授权

US09371276B1 Compositions and methods for the treatment of hyperglycemia and metabolic syndrome 有权
标题翻译：用于治疗高血糖症和代谢综合症的组合物和方法
公开(公告)号：US09371276B1
公开(公告)日：2016-06-21
申请号：US14938185
申请日：2015-11-11
申请人： Mohan Murali Alapati
发明人： Mohan Murali Alapati
IPC分类号： C07C279/26
CPC分类号： C07C279/265 , C07C57/03 , C07C57/04 , C07C237/12 , C07C279/26 , C07K5/06043
摘要： The invention relates to the compounds and compositions of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprises a salt of metformin and the methods for treating or preventing metabolic syndrome, prediabetes and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
摘要翻译：本发明涉及式I，式II，式III，式IV，式V，式VI或其药学上可接受的多晶型物，溶剂合物，对映异构体，立体异构体和水合物的化合物和组合物。药物组合物包含二甲双胍的盐，并且可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射的治疗或预防代谢综合征的方法。这些组合物可用于治疗糖尿病，肥胖症，脂质疾病，高甘油三酯血症，高血糖症，高胰岛素血症和胰岛素抵抗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式