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1. 发明申请

US20230033101A1 METHOD AND DEVICE FOR ANALYSIS OF LIQUID SAMPLES 有权
公开(公告)号：US20230033101A1
公开(公告)日：2023-02-02
申请号：US17785517
申请日：2020-12-21
申请人： QLIFE APS
发明人： Peter WARTHOE , Ebbe FINDING , Robert ELKÆR
IPC分类号： G01N1/40 , G01N1/38 , G01N33/72 , G01N21/31 , G01N21/64
摘要： The present invention relates to a method and a device for quantitatively detecting the presence or absence of an analyte in a liquid sample, comprising the steps of providing a set of parts comprising a container for collecting a liquid sample material, and a filter material and a detection device comprising a reaction liquid, thereafter adding a metered amount of liquid sample material to the container, thereafter transferring the metered amount of liquid sample material from the container to the filter material, thereafter contacting the filter material containing the metered amount of sample material with the reaction liquid and mixing the reaction liquid and the filter material, thereby obtaining a detection liquid, thereafter measuring the transmission of electromagnetic radiation at one or more wavelengths through the detection liquid and/or the emission of electromagnetic radiation at one or more wavelengths from the detection liquid and detecting the amount of analyte in the sample by comparing the results obtained in step e. with an internal standard, the method being characterised in that the metered amount of sample is transferred from the container to the filter material by use of capillary forces.

2. 发明授权

US11549134B2 Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same 有权
公开(公告)号：US11549134B2
公开(公告)日：2023-01-10
申请号：US16832712
申请日：2020-03-27
申请人： Kikkoman Corporation
发明人： Yosuke Masakari , Atsushi Ichiyanagi
IPC分类号： C12Q1/26 , C12N9/06 , G01N33/72
摘要： Provided is a composition by which glycated hemoglobin can be measured even in the presence of a stronger surfactant than a conventional case. Also provided is a buffer and/or stabilizer which maintains the residual activity of an amadoriase or lowers a reduction of residual activity. The present invention provides a composition for use in measuring glycated hemoglobin containing an amadoriase having substitution of one or more amino acid residues at a position(s) corresponding to an amino acid(s) selected from the group consisting of position 262, position 257, position 249, position 253, position 337, position 340, position 232, position 129, position 132, position 133, position 44, position 256, position 231 and position 81 of an amadoriase derived from the genus Coniochaeta and represented by SEQ ID No: 1 or 3, and having residual activity even in the presence of a surfactant. The present invention also provides a composition and kit for use in measuring glycated hemoglobin, comprising a specific stabilizer and/or a buffer. The present invention can provide an enzyme and a composition for use in measuring glycated hemoglobin, excellent in storage stability even if they are exposed to a surfactant.

3. 发明授权

US11543419B2 Measurement sample dilution liquid, kit, and measurement method 有权
公开(公告)号：US11543419B2
公开(公告)日：2023-01-03
申请号：US16961096
申请日：2018-12-27
申请人： TOYOBO CO., LTD.
发明人： Jun Okamoto , Keizo Yoneda
IPC分类号： G01N33/72 , G01N1/38 , G01N21/29 , G01N33/538 , G01N33/548 , G01N33/543
摘要： Provided are a measurement sample diluent that enables the measurement of the proportion of HbA1c in the total Hb molecules in a measurement sample (HbA1c (%)), with high sensitivity, high accuracy, and high correlation with HPLC without being affected by the length of time required to mix a measurement sample with the measurement sample diluent and to drop the mixture onto an immunochromatographic specimen for measuring HbA1c; and a kit containing the measurement sample diluent. The present invention relates to a measurement sample diluent for immunochromatography for quantifying the proportion of hemoglobin A1c in the total hemoglobin molecules in a measurement sample (hemoglobin A1c (%)); and the measurement sample diluent is an aqueous solution that contains a non-ionic surfactant, an anionic surfactant, and a buffer.

4. 发明申请

US20220411874A1 METHODS FOR DIAGNOSING AND EVALUATING NON-ALCOHOLIC STEATOHEPATITIS 有权
公开(公告)号：US20220411874A1
公开(公告)日：2022-12-29
申请号：US17849161
申请日：2022-06-24
申请人： Genfit
发明人： Raphaël Darteil , Geneviève Cordonnier , John Brozek , Emilie Praca , Fouad Ben Sudrik
IPC分类号： C12Q1/6883 , G01N33/72 , G01N33/66 , A61P1/16 , A61K31/192 , G01N33/68
摘要： The invention relates to a method for the diagnosis of non-alcoholic steatohepatitis (NASH), for determining the activity, the stage, or the severity of NASH or for classifying a subject as a potential receiver or non receiver of a treatment of NASH using circulating miRNAs and other blood circulating markers of liver damage, e.g. alpha 2 macroglobulin, HbA1c, N-terminal pro-peptide of collagen type III, miR-34 and miR-200. It also relates to a kit for implementing the method of the invention, and the compounds for use in a method for the treatment of NASH, wherein the subject to be treated is identified, evaluated or classified according to the method of the invention.

5. 发明申请

US20220373564A1 METHOD FOR STABILIZING HEMOGLOBIN AND REAGENTS FOR PERFORMING THE SAME 有权
公开(公告)号：US20220373564A1
公开(公告)日：2022-11-24
申请号：US17833261
申请日：2022-06-06
申请人： Exact Sciences Corporation
发明人： Keith D. Fourrier , Jacquelyn T. Hennek , Michael J. Domanico , William G. Weisburg , Graham P. Lidgard , Kathleen S. Harings , Daniel J. Simpson
IPC分类号： G01N33/72 , G01N33/50 , G01N33/574 , G01N1/38
摘要： A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin, or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.

6. 发明授权

US11460476B2 Dye-based liquid reagent volume indicator for use in analyte detection assays 有权
公开(公告)号：US11460476B2
公开(公告)日：2022-10-04
申请号：US17435433
申请日：2020-02-26
申请人： Siemens Healthcare Diagnostics Inc.
发明人： Aaron Kauffmann , David Ledden , Chris Zimmerle , Jon Stradinger
IPC分类号： G01N33/72 , G01N33/49 , G01N33/58 , B01L3/00
摘要： Devices, kits, and methods are disclosed for use in detecting a concentration of an analyte of interest in a patient's liquid test sample. The devices, kits, and methods employ the use of one or more solid reagent zones that includes at least one analytical reagent for detection of an analyte of interest. The solid reagent zone(s) also includes at least one dye for determining whether results obtained from the diagnostic assay for the at least one analyte of interest are biased or inaccurate due to a loss of volume of a liquid reagent during the dispensing of the liquid reagent.

7. 发明申请

US20220260554A1 BLOOD ANALYSIS METHOD, CONTROL DEVICE AND BLOOD CELL ANALYZER 有权
公开(公告)号：US20220260554A1
公开(公告)日：2022-08-18
申请号：US17733570
申请日：2022-04-29
申请人： SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
发明人： Wenjun TONG , Yijie YANG , Huaming XU , Xing SHI
IPC分类号： G01N33/50 , G01N1/38 , G01N15/10 , G01N15/14 , G01N33/72 , G01N35/00 , G01N35/10 , G01N1/18
摘要： The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or HGB measurement. A blood sample may be tested in one reaction cell through time-division multiplexing technology to obtain four groups leukocytes classification result and HGB result by single detection channel. Thus, the structure of the analyzer may be greatly simplified on the premise of guaranteeing the performance of the analyzer, the size and cost of the analyzer may reduce and a performance-price ratio of the analyzer may increase.

8. 发明授权

US11415575B2 Sample analyzer and computer program product 有权
公开(公告)号：US11415575B2
公开(公告)日：2022-08-16
申请号：US16180590
申请日：2018-11-05
申请人： SYSMEX CORPORATION
发明人： Takaaki Nagai , Noriyuki Narisada , Daigo Fukuma , Masanori Imazu
IPC分类号： G01N15/12 , G01N15/10 , G01N1/00 , G01N33/50 , G01N15/14 , G01N33/72 , G01N15/00
摘要： A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.

9. 发明申请

US20220252621A1 METHOD AND COMPUTER PROGRAM FOR PREDICTING BILIRUBIN LEVELS IN NEONATES 有权
公开(公告)号：US20220252621A1
公开(公告)日：2022-08-11
申请号：US17695714
申请日：2022-03-15
申请人： UNIVERSITÄT BASEL
发明人： Gilbert KOCH , Sven WELLMANN , Marc PFISTER , Severin KASSER , Melanie WILBAUX
IPC分类号： G01N33/72 , G16H50/20 , G16H10/00 , G06F17/18
摘要： The invention relates to a method and a computer program for estimating a bilirubin level of a neonate, comprising the steps of: Acquiring a series of bilirubin levels estimated at different time points from a sample obtained from a neonate, Acquiring a plurality of covariates from the neonate, each comprising an information about a neonatal property, Providing a pre-defined bilirubin model function, wherein the bilirubin model function is configured to describe a time course of a bilirubin level of a neonate, —Determining a plurality of model parameters of the bilirubin model function, wherein each model parameter is estimated from at least one covariate of the plurality of covariates and an associated population model parameter, Determining from the series of acquired bilirubin levels and the bilirubin model function with the determined model parameters an expected bilirubin level of the neonate for a time particularly later than a lastly acquired bilirubin level of the series of bilirubin levels.

10. 发明申请

US20220244274A1 QUANTITATIVE BIOMARKERS FOR ASSESSING MILD TRAUMATIC BRAIN INJURY AND METHODS OF USE THEREOF 有权
公开(公告)号：US20220244274A1
公开(公告)日：2022-08-04
申请号：US17591521
申请日：2022-02-02
申请人： University of Iowa Research Foundation , UNITED STATES DEPARTMENT OF VETERANS AFFAIRS
发明人： Matthew Harper , Michael Anderson , Kacie Meyer , Laura M. Dutca , John Manohar , Randy Kardon
IPC分类号： G01N33/68 , G01N33/72
摘要： Disclosed here is a method of detecting traumatic brain injury in a subject, comprising collecting a biological sample from the subject; analyzing the biological sample to determine the level of at least one protein selected from ALDOA, PHKB, HBA-A1, DPYSL2, SYN1 and/or CKB; and determining whether the level of the at least one protein exceeds a predetermined threshold. In certain aspects, the method further comprises the step of administering a treatment to the subject if the at least one protein exceeds the predetermined threshold. The disclosed technology relates generally to brain injuries, and in particular to a panel of serum based biomarkers that can identify individuals with mild traumatic brain injury (TBI).

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