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1. 发明授权

US11525765B2 Particle detection device and particle detection method 有权
公开(公告)号：US11525765B2
公开(公告)日：2022-12-13
申请号：US16484964
申请日：2018-02-13
申请人： TOSOH CORPORATION , NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Kazuki Iijima , Toshinobu Toyoshima , Kotohiro Furukawa , Koji Katayama , Naotaka Jin , Minoru Seki
IPC分类号： G01N15/12 , G01N15/00 , G01N15/10
摘要： The objective of the present invention is to provide a particle detection device and a particle detection method that can individually and continuously detect a wide range of particles. The objective is achieved by a particle detection device including: a particle separation channel through which particles are separated according to particle sizes in a perpendicular direction to the flow of fluid; and two or more particle recovery channels that are connected to and branched from the particle separation channel, in which each of the particle recovery channels includes a particle detection unit that includes an aperture and an electric detector.

2. 发明申请

US20220317016A1 Sensor for Particle Identification, Measurement Instrument, Computer Device, and System 有权
公开(公告)号：US20220317016A1
公开(公告)日：2022-10-06
申请号：US17629219
申请日：2019-10-11
申请人： Aipore Inc.
发明人： Norihiko Naono
IPC分类号： G01N15/12
摘要： A sensor for particle identification, the sensor comprising: a first chamber configured to be filled with an electrolytic solution; a first electrode provided inside the first chamber and configured to be connected to an external power supply for applying a voltage; a second chamber configured to be filled with the electrolytic solution; a second electrode provided inside the second chamber and configured to be connected to the external power supply; a data output means configured to output measurement data expressing an ion current generated between the first electrode and the second electrode; a partition separating the first chamber and the second chamber; and a presentation means for providing a unique identifier to an external computer device over a network. The partition includes a pore connecting the first chamber and the second chamber, a physical property of the sensor is associated with the unique identifier, the sensor is configured such that when a particle passes through the pore, a transient change dependent on at least a physical property of the pore and a physical property of the particle occurs in the ion current generated between the first electrode and the second electrode, and the unique identifier is configured to cause the external computer device receiving the unique identifier to perform a process of identifying the particle according to the physical property of the sensor associated with the unique identifier. The physical property of the sensor at least includes a physical property of the pore.

3. 发明申请

US20220170912A1 SAMPLE ANALYZER AND COMPUTER PROGRAM PRODUCT 有权
公开(公告)号：US20220170912A1
公开(公告)日：2022-06-02
申请号：US17675759
申请日：2022-02-18
申请人： SYSMEX CORPORATION
发明人： Takaaki NAGAI , Noriyuki NARISADA , Daigo FUKUMA , Masanori IMAZU
IPC分类号： G01N33/50 , G01N15/12 , G01N15/14 , G01N33/72
摘要： A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.

4. 发明授权

US11213818B2 Systems and devices for microfluidic instrumentation 有权
公开(公告)号：US11213818B2
公开(公告)日：2022-01-04
申请号：US15778180
申请日：2016-11-22
申请人： SPECTRADYNE LLC
发明人： Andrew N. Cleland , Jean-Luc Fraikin , Peter Meinhold , Franklin Monzon
IPC分类号： B01L3/00 , B01L9/00 , C12Q1/00 , C12M1/00 , C40B60/00 , G01N15/10 , G01N15/12 , G01N15/00
摘要： Various embodiments herein disclose a device, comprising one or more fluid interfacing components and a cartridge holder, wherein the one or more fluid interfacing components are fixed while the cartridge holder moves along a linear guide. Also disclosed herein are methods of using the device to analyze a sample containing particles, and methods of diagnosing a disease in a subject by using the device.

5. 发明申请

US20210372987A1 METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER 有权
公开(公告)号：US20210372987A1
公开(公告)日：2021-12-02
申请号：US17445180
申请日：2021-08-16
申请人： Roche Sequencing Solutions, Inc.
发明人： Roger J.A. Chen , Randall Davis
IPC分类号： G01N33/487 , G01N15/12 , B81B1/00 , G01N33/483
摘要： A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.

6. 发明申请

US20210293780A1 METHOD OF CONTROLLING A BLOOD ANALYZER FOR MEASURING PLATELETS 有权
公开(公告)号：US20210293780A1
公开(公告)日：2021-09-23
申请号：US17338280
申请日：2021-06-03
申请人： Sysmex Corporation
发明人： Jo LINSSEN , Pieter STEENHUIS
IPC分类号： G01N33/49 , G01N15/14 , G01N15/12 , G01N35/00
摘要： A method of controlling a blood analyzer for measuring platelets is provided. The method comprises: determining a relationship between at least one first measurement value obtained by detecting platelets in at least one previous test by an electrical type detector of the blood analyzer and at least one second measurement value obtained by detecting the platelets in the at least one previous test by an optical type detector of the blood analyzer, and controlling the blood analyzer to prepare the first and/or second measurement sample for a current test according to the determined relationship.

7. 发明申请

US20210285863A1 PARTICLE DETECTION DEVICE AND PARTICLE DETECTION METHOD 有权
公开(公告)号：US20210285863A1
公开(公告)日：2021-09-16
申请号：US16484964
申请日：2018-02-13
申请人： TOSOH CORPORATION , NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Kazuki IIJIMA , Toshinobu TOYOSHIMA , Kotohiro FURUKAWA , Koji KATAYAMA , Naotaka JIN , Minoru SEKI
IPC分类号： G01N15/12
摘要： The objective of the present invention is to provide a particle detection device and a particle detection method that can individually and continuously detect a wide range of particles. The objective is achieved by a particle detection device including: a particle separation channel through which particles are separated according to particle sizes in a perpendicular direction to the flow of fluid; and two or more particle recovery channels that are connected to and branched from the particle separation channel, in which each of the particle recovery channels includes a particle detection unit that includes an aperture and an electric detector.

8. 发明授权

US10859591B2 Method and apparatus for analyzing blood 有权
公开(公告)号：US10859591B2
公开(公告)日：2020-12-08
申请号：US15740110
申请日：2016-06-21
申请人： NIHON KOHDEN CORPORATION
发明人： Koji Masuda , Hyuga Masu , Satoshi Suzuki , Rikiya Tanabe
IPC分类号： G01N35/10 , G01N33/49 , G01N15/12 , G01N35/00 , G01N15/14
摘要： A blood analyzing method for detecting a short sample of blood in a suction tube, when blood is sucked by the suction tube constituting a blood analyzing apparatus, includes measuring a first blood parameter by using blood that is present in a first area of a blood analysis area, blood in the blood analysis area being used to analyze the blood in the suction tube, measuring a second blood parameter by using blood that is present in a second area of the blood analysis area, the second area being different from the first area, and detecting the short sample of blood based on the first blood parameter and the second blood parameter.

9. 发明申请

US20200216892A1 FORCE BASED SEQUENCING OF BIOPOLYMERS 审中-公开
公开(公告)号：US20200216892A1
公开(公告)日：2020-07-09
申请号：US16735551
申请日：2020-01-06
申请人： Lab79 Technologies, Inc.
发明人： Jason Paul CLEVELAND , Allison Beth CHURNSIDE , Jan Håkan HOH
IPC分类号： C12Q1/6869 , G01N15/12 , G01N33/487
摘要： Method and apparatus for determining internal structural properties of a polymer molecule by measuring the force required to translocate the molecule through the interface between two fluids. In some cases, the fluid interface may have a well-defined curvature, which may be held constant or otherwise controlled during translocation. In some cases, the translocating force may be modulated at one or more frequencies. In some cases, attachment of the molecule to a manipulator may be detected before or during translocation.

10. 发明授权

US10564089B2 Cross-instrument method and system for cell population discrimination 有权
公开(公告)号：US10564089B2
公开(公告)日：2020-02-18
申请号：US15263133
申请日：2016-09-12
申请人： Beckman Coulter, Inc.
发明人： William H. Gutierrez , Cheng Qian , John S. Riley
IPC分类号： G01N15/14 , G01N15/12 , G01N15/00 , G01N15/10
摘要： The present invention provides methods and systems to combine the capabilities of a hematology analyzer with those of a flow cytometer to yield a far more powerful analytical system than either device alone. In one embodiment, a method of analyzing a cell sample includes receiving a first data generated by an analysis of a first aliquot of the sample on a first particle analyzer having a fluorescence measurement device such as a flow cytometer, detecting at least one unresolved cell population in the first data, and accessing a second data stored on a storage device wherein the second data was previously generated by interrogating a second aliquot of the sample using at least one of a cell volume measurement device and a cell conductivity measurement device in a second particle analyzer such as a hematology analyzer. The unresolved cell population in the first data is then resolved using the second data. Corresponding system embodiments are also disclosed.

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