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1. 发明申请

US20230077828A1 FILTER STACK FOR A THOMSON PARABOLA SPECTROMETER 有权
公开(公告)号：US20230077828A1
公开(公告)日：2023-03-16
申请号：US17941554
申请日：2022-09-09
申请人： Marvel Fusion GmbH
发明人： Vahe Shirvanyan , Marius Schollmeier
IPC分类号： H01J49/06
摘要： A filter stack for a Thomson Parabola spectrometer, the filter stack having at least one filter foil of a filter material, wherein the filter foil is shaped to have stripes of a respective stripe size made of the filter material and gaps of a respective controlled gap size free of the filter material between the stripes or without gaps.

2. 发明授权

US11605532B2 Method and ion guide assembly for modulating a stream of ions 有权
公开(公告)号：US11605532B2
公开(公告)日：2023-03-14
申请号：US17332810
申请日：2021-05-27
申请人： TOFWERK AG
发明人： Stephan Graf , Michael Kamrath , Sebastian Gerber
IPC分类号： H01J49/00 , H01J49/06 , H01J49/02 , G01N27/622
摘要： The invention relates to a method for, in an ion guide (10), modulating a stream of ions according to a modulation function, wherein the stream of ions includes at least N different ion species, wherein N is at least 1. This ion guide (10) forms an ion guide path, wherein the ions of the stream of ions are conveyed along the ion guide path in a conveying direction to form the stream of ions. The ion guide (10) includes an ion gate (12) arranged at an ion gate position on the ion guide path, wherein the ion gate (12) is adapted to provide an open state for allowing the ions passing the ion gate position when being conveyed along the ion guide path and a closed state for preventing the ions from passing the ion gate position. The ion guide (10) further includes a first arrangement (13) of conveying electrodes (230) arranged along the ion guide path, the first arrangement (13) of conveying electrodes (230) extending over a first section of the ion guide path, wherein the first section of the ion guide path reaches from at least the ion gate position downstream to at least a transition position on the ion guide path, wherein the first arrangement (13) of conveying electrodes (230) is adapted for generating first travelling waves having a first travelling wave amplitude and travelling along the first section of the ion guide path at a first travelling wave velocity for conveying the ions along the first section of the ion guide path. Furthermore, the ion guide (10) includes a second arrangement (14) of conveying electrodes (240) arranged along the ion guide path, the second arrangement (14) of conveying electrodes (240) extending over a second section of the ion guide path, wherein the second section of the ion guide path reaches from the transition position downstream, wherein the second arrangement (14) of conveying electrodes (240) is adapted for generating second travelling waves having a second travelling wave amplitude and travelling along the second section of the ion guide path at a second travelling wave velocity for conveying the ions along the second section of the ion guide path. According to the method, the stream of ions is modulated with the ion gate (12) according to the modulation function and AC voltages are applied to the first arrangement (13) of conveying electrodes (230) for generating the first travelling waves and to the second arrangement (14) of conveying electrodes (240) for generating the second travelling waves for conveying the ions downstream of the ion gate (12) along the first section and the second section of the ion guide path in the conveying direction away from the ion gate (12), wherein for each ion species of the at least N different ion species, a ratio A is the average velocity of the ions of the respective ion species in the first section of the ion guide path divided by the first travelling wave velocity, wherein for each ion species of the at least N different ion species, a ratio B is the average velocity of the ions of the respective ion species in the second section of the ion guide path divided by the second travelling wave velocity, wherein the first travelling wave amplitude, the first travelling wave velocity, the second travelling wave amplitude and the second travelling wave velocity are chosen such that for each ion species of the at least N different ion species, the ratio A is larger than the ratio B.

3. 发明申请

US20230059144A1 ION ANALYZER 有权
公开(公告)号：US20230059144A1
公开(公告)日：2023-02-23
申请号：US17839590
申请日：2022-06-14
申请人： SHIMADZU CORPORATION
发明人： Masaru NISHIGUCHI
IPC分类号： H01J49/06 , H01J49/02
摘要： An ion analyzer includes an ion optical element having four rod electrodes around an optical axis, for transferring ions from their surrounding space to the subsequent stage while converging the ions. To create an RF electric field within this space, a voltage supplier applies RF voltages of opposite polarities to two pairs of electrodes facing each other across the axis. The cross-sectional shape of each electrode in a plane orthogonal to the axis has a first side having width w facing the axis and is tangent to a circle of radius r0 around the axis, and two adjacent sides connected to the ends of the first side at an angle determined so that an RF field created by the adjacent sides exerts no influence within the space. The ratio w/r0 is determined so that the amount of dodecapole field component becomes a predetermined value or does not exceed it.

4. 发明授权

US11581179B2 Ion funnels and systems incorporating ion funnels 有权
公开(公告)号：US11581179B2
公开(公告)日：2023-02-14
申请号：US17467033
申请日：2021-09-03
申请人： THERMO FINNIGAN LLC , Thermo Fisher Scientific (Bremen) GmbH
发明人： Joshua A. Silveira , Eloy R. Wouters , Alexander A. Makarov , Mikhail G. Skoblin , Viacheslav I. Kozlovskiy , Christopher Mullen , Brian D. Adamson
IPC分类号： H01J49/06
摘要： A method of reducing fragmentation of ions generated from a sample during transport of the ions through an ion transport apparatus that comprises an ion funnel portion, comprises: applying a selected DC potential difference between an outlet end of the ion transport apparatus and an exit ion lens that is disposed adjacent to the outlet end, wherein a sign of the selected DC potential difference is chosen so as to accelerate the ions from the outlet end of the ion transport apparatus towards and through the exit ion lens.

5. 发明申请

US20230039701A1 CHARGE FILTER ARRANGEMENT AND APPLICATIONS THEREOF 有权
公开(公告)号：US20230039701A1
公开(公告)日：2023-02-09
申请号：US17781485
申请日：2020-12-16
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： Martin F. JARROLD , David E. CLEMMER
IPC分类号： H01J49/42 , H01J49/06
摘要： A charge filter instrument includes a field-free drift region, a plurality of charge detection cylinders in the drift region through which ions drifting axially therethrough pass, a plurality of charge sensitive amplifiers each coupled to at least one charge detection cylinder and configured to produce a charge detection signal corresponding to a charge of one or more of ions passing therethrough, a single inlet, single outlet charge deflector or a single inlet, multiple outlet charge steering device coupled to the outlet end of the drift region, means for determining charge magnitudes or charge states of ions drifting axially through the drift region based on the charge detection signals, and means for controlling the charge deflector or the charge steering device to pass through the single outlet or through a specified one of the multiple outlets only ions having a specified charge magnitude or charge state.

6. 发明授权

US11567087B2 Method of fragmenting and charge reducing biomolecules 有权
公开(公告)号：US11567087B2
公开(公告)日：2023-01-31
申请号：US16604947
申请日：2018-04-13
申请人： Micromass UK Limited
发明人： Steven Bajic , Jeffrey Mark Brown
IPC分类号： G01N33/68 , G01N30/72 , H01J49/00 , H01J49/16 , H01J49/06 , H01J49/04
摘要： A method of ionising a sample is disclosed comprising nebulising a sample which includes monoclonal antibody (“mAb”) molecules. A stream of monoclonal antibody droplets or charged droplets is directed so as to impact upon a target or electrode so as to form intact parent monoclonal antibody ions, intact minus light chain parent monoclonal antibody ions or light chain (“LC”) fragment monoclonal antibody ions.

7. 发明申请

US20230005729A1 DEVICE FOR RAPID EXCHANGE OF ION SOURCES AND ION TRANSMISSION DEVICES 有权
公开(公告)号：US20230005729A1
公开(公告)日：2023-01-05
申请号：US17930116
申请日：2022-09-07
申请人： Micromass UK Limited
发明人： Paul Murray , Mark Towers , Andrew Whatley , Matthew Henderson , Philippa Hart , Emmanuelle Claude , Richard Jarrold , Jeff Brown , Steve Brace , Edward Scott
IPC分类号： H01J49/06 , G01N27/622 , H01J49/00 , H01J49/04 , H01J49/24 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a rotatable isolation valve 1 having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide 2 is positioned so as to extend within a swept volume of the isolation valve 1 enabling the ion guide 2 to be positioned close to a second downstream ion guide 3 and for ions to be transmitted from the first 2 ion guide to the second ion guide 3 with high ion transmission efficiency.

8. 发明授权

US11532471B2 Instrument for separating ions including an interface for transporting generated ions thereto 有权
公开(公告)号：US11532471B2
公开(公告)日：2022-12-20
申请号：US17468738
申请日：2021-09-08
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： Martin F. Jarrold , Staci N. Anthony , Benjamin E. Draper
IPC分类号： H01J49/06 , H01J49/02 , H01J49/24 , H01J49/42
摘要： An instrument for separating ions may include an ion source in a first pressure environment at a first pressure and configured to generate ions from a sample, an ion separation instrument, controlled to an instrument pressure that is less than the first pressure, and configured to separate ions as a function of at least one molecular characteristic and an interface, controlled to a second pressure less than the first pressure and greater than the instrument pressure, for transporting the generated ions from the first pressure environment into the ion separation instrument operating at the instrument pressure. The interface may include a sealed ion funnel defining an axial passageway therethrough, and an ion carpet sealed to the first ion funnel. A portion of the axial passageway tapers from a first cross-sectional area to a reduced cross-sectional area such that the tapered axial passageway defining a virtual jet disrupter therein.

9. 发明授权

US11527395B2 Ion entry/exit device 有权
公开(公告)号：US11527395B2
公开(公告)日：2022-12-13
申请号：US17130636
申请日：2020-12-22
申请人： Micromass UK Limited
发明人： Kevin Giles , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/06 , G01N27/622 , H01J49/42 , H01J49/00 , H01J49/40
摘要： A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

10. 发明授权

US11527394B2 Methods and apparatus for determining interference in MS scan data, filtering ions and performing mass spectrometry analysis on a sample 有权
公开(公告)号：US11527394B2
公开(公告)日：2022-12-13
申请号：US17243464
申请日：2021-04-28
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Christian Thoeing , Anastassios Giannakopulos
IPC分类号： H01J49/00 , H01J49/06
摘要： A method of determining one or more interference parameters for a particular peak of an isotopic distribution corresponding to a precursor molecule in MS scan data is provided. The MS scan data comprises a plurality of peaks. Each peak has a mass-to-charge ratio and a relative abundance. The isotopic distribution comprises a subset of the plurality of peaks. The one or more interference parameters comprises a peak purity, pi, for the particular peak. The method comprises determining that there are no interfering peaks relevant to the isotopic distribution and determining that the peak purity, pi, for the particular peak should be a maximum purity value. Alternatively, the method comprises identifying one or more interfering peaks from the MS scan data, wherein the one or more interfering peaks do not belong to the subset of peaks of the isotopic distribution, and determining the peak purity, pi, for the particular peak based on: the relative abundance, Ii, of the particular peak, and the relative abundance of the one or more interfering peaks.

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