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1. 发明申请

US20230139883A1 Peptides for Inducing Differentiation 有权
公开(公告)号：US20230139883A1
公开(公告)日：2023-05-04
申请号：US17918105
申请日：2021-04-12
申请人： Shimadzu Corporation , University Public Corporation Osaka
发明人： Hayato Matsui , Junko Enomoto , Masataka Michigami , Ikuo Fujii
IPC分类号： C07K14/00 , C12N5/07
摘要： The present invention chiefly aims to provide a new differentiation inducing agent (peptide) that can solve the previous problems in inducing differentiation of pluripotent stem cells such as ES/iPS cells into somatic cells (e.g., cardiomyocytes).
The present invention can include, for example, a synthetic peptide having, in the molecular structure thereof, an amino acid sequence represented by the following (SEQ ID NO: 1), or an amino acid sequence formed by substitution, deletion and/or addition of one or several amino acid residues in the amino acid sequence. It can also include, for example, a composition for inducing differentiation of pluripotent stem cells into somatic cells, comprising said synthetic peptide. (SEQ ID No. 1) C A X X L X X L X X X L X X L X G X X X X X X X X X X X X X X L X X X L X X L X X A C • • •

2. 发明申请

US20230126097A1 Infrared Transmissive Member and Fourier Transform Infrared Spectroscope 有权
公开(公告)号：US20230126097A1
公开(公告)日：2023-04-27
申请号：US17969650
申请日：2022-10-19
申请人： SHIMADZU CORPORATION
发明人： Shinya WAKUDA
IPC分类号： G02B1/02 , G02B1/10
摘要： An infrared window includes a substrate composed of “KRS-5” as a raw material which is mixed crystal of thallium iodide and thallium bromide and an infrared transmissive coating that covers a surface of the substrate. A raw material for the infrared transmissive coating is parylene. A thickness of the infrared transmissive coating is set to a value at which an infrared absorptance is lower than 3%. The thickness of the infrared transmissive coating is set to a value at which the infrared absorptance is lower than 3%. The thickness of the infrared transmissive coating is set to a value within a range not smaller than 20 nanometers and smaller than 50 nanometers.

3. 发明授权

US11630088B2 Preparative liquid chromatography system 有权
公开(公告)号：US11630088B2
公开(公告)日：2023-04-18
申请号：US17215081
申请日：2021-03-29
申请人： SHIMADZU CORPORATION
发明人： Tomoyuki Yamazaki
IPC分类号： G01N30/06 , G01N35/10 , G01N30/02
摘要： Automation of the collection and reinjection of a sample into a large number of containers is made possible without increasing the size of a liquid handler itself. A preparative liquid chromatography system includes a liquid delivery part (2) that feeds a mobile phase, a separation column (14A; 14B) for separating a sample transported by the mobile phase, a plurality of liquid handlers (6-1 to 6-n), each of which independently including a container arrangement portion (18) in which a plurality of containers for containing a sample are disposed, an injecting part (20A) configured to suck a sample from a container disposed in the container arrangement portion (18) and hold it, and to inject the sample into the mobile phase fed by the liquid delivery part (2) by being interposed between the liquid delivery part (2) and the separation column (14A), and a fractionation part (22) configured to collect a sample eluted from the separation column (14A) so that the sample is fractionated to containers disposed in the container arrangement portion (18), an injection switching part (4) configured to selectively interpose one of the injecting parts (20A) of the plurality of liquid handlers (6-1 to 6-n) between the liquid delivery part (2) and the separation column (14A) by switching connection of channels at a position between the liquid delivery part (2) and the separation column (14A), and a fractionation switching part (12) configured to selectively connect one of the fractionation parts (22) of the plurality of liquid handlers (6-1 to 6-n) to a downstream side of the separation column (14A) by switching connection of channels at a position downstream of the separation column (14A).

4. 发明授权

US11629730B2 Vacuum pump 有权
公开(公告)号：US11629730B2
公开(公告)日：2023-04-18
申请号：US17566843
申请日：2021-12-31
申请人： SHIMADZU CORPORATION
发明人： Hiroaki Kimura
IPC分类号： F04D29/58 , F04D19/04
摘要： A vacuum pump comprises: a cylindrical rotor; multiple heat insulating pins; and a stator having a cylindrical portion arranged with a predetermined gap in an outer peripheral side of the rotor and a fixing portion to be fixed to a pump base through the multiple heat insulating pins. The heat insulating pins have a lower thermal conductivity than those of the stator and the pump base, and support the fixing portion.

5. 发明申请

US20230098252A1 LIQUID FEEDING UNIT, AND LIQUID CHROMATOGRAPHY ANALYSIS SYSTEM AND CONTROL METHOD THEREOF 有权
公开(公告)号：US20230098252A1
公开(公告)日：2023-03-30
申请号：US17866677
申请日：2022-07-18
申请人： Shimadzu Corporation
发明人： Kosuke NAKAJIMA
IPC分类号： G01N30/34 , G01N30/22 , B01D15/16 , G01N30/32 , G01N30/16 , G01N30/02
摘要： A first solution is supplied from a first pump. A second solution is supplied from a second pump. A flow path from the first pump and the second pump to a column is switched between a first flow path and a second flow path. In the first flow path, a first mixer is located upstream of an injection part for a sample, and the second mixer is located downstream of the injection part. In the second flow path, the first mixer and the second mixer are located upstream of the injection part. The first flow path is formed in a first mode in which the sample is diluted before introduction into the column. The second flow path is formed in a second mode in which the sample is not diluted before introduction into the column.

6. 发明申请

US20230097849A1 CREATION METHOD OF TRAINED MODEL, IMAGE GENERATION METHOD, AND IMAGE PROCESSING DEVICE 有权
公开(公告)号：US20230097849A1
公开(公告)日：2023-03-30
申请号：US17802303
申请日：2020-02-26
申请人： SHIMADZU CORPORATION
发明人： Wataru TAKAHASHI , Shota OSHIKAWA , Yuichiro HIRANO , Yohei SUGAWARA , Zhengyan GAO , Kazue MIZUNO
IPC分类号： G06T7/00 , G06T11/00 , G06T5/50 , G06V10/70
摘要： In a creation method of a trained model, a reconstructed image (60) obtained by reconstructing three-dimensional X-ray image data (80) is generated. A projection image (61) is generated from a three-dimensional model of an image element (50) by a simulation. The projection image is superimposed on the reconstructed image to generate a superimposed image (67). A trained model (40) is created by performing machine learning using the superimposed image, and the reconstructed image or the projection image.

7. 发明申请

US20230097148A1 DATA PROCESSING METHOD AND DATA PROCESSING SYSTEM 有权
公开(公告)号：US20230097148A1
公开(公告)日：2023-03-30
申请号：US17888806
申请日：2022-08-16
申请人： SHIMADZU CORPORATION
发明人： Yuichiro FUJITA , Akira NISHIO
IPC分类号： G01N30/86 , G06K9/00 , G06K9/62
摘要： A data processing method includes: a data preparing step of preparing actual data of a three-dimensional chromatogram including a chromatogram and a spectrum acquired by chromatography analysis for a sample containing a plurality of components, and spectral data for the plurality of components in the sample whose peaks overlap each other on the chromatogram of the actual data; a similarity calculating step of calculating, for each wavelength region, a similarity between wavelength regions corresponding to each other in the spectral data for the plurality of components prepared in the data preparing step while comprehensively changing the wavelength regions; a target range setting step of setting a target range by searching for a wavelength region having a similarity lower than an overall similarity between the spectral data for the plurality of components based on a calculation result in the similarity calculating step; and a peak separating step of creating chromatogram data for the plurality of components by performing, using the spectral data for the plurality of components, matrix decomposition of the actual data in the target range set in the target range setting step.

8. 发明申请

US20230082052A1 PHOTOREACTION EVALUATION DEVICE AND PHOTON COUNT CALCULATION METHOD 有权
公开(公告)号：US20230082052A1
公开(公告)日：2023-03-16
申请号：US17792572
申请日：2020-09-28
申请人： SHIMADZU CORPORATION
发明人： Yasuyuki WATANABE , Takahiro TAMAKI
IPC分类号： G01N21/31 , G01N21/64 , G01N21/25
摘要： An intensity distribution acquirer acquires a first detected intensity distribution detected by a detector with a sample position at which a sample is not present irradiated with light by a standard light source, and acquires a second detected intensity distribution detected by the detector with the sample position at which a sample is not present irradiated with light by an irradiation light source during a first measuring work. An irradiation intensity calculator calculates a radiation intensity at each wavelength of irradiation light of the irradiation light source based on the first detected intensity distribution, the second detected intensity distribution and radiation characteristics of the standard light source. An irradiation photon count calculator calculates an irradiation photon count at each wavelength of irradiation light of the irradiation light source based on an irradiation intensity at each wavelength.

9. 发明授权

US11604173B2 Device storage structure for fluid chromatograph 有权
公开(公告)号：US11604173B2
公开(公告)日：2023-03-14
申请号：US17054831
申请日：2019-01-17
申请人： SHIMADZU CORPORATION
发明人： Tomoki Hiraoka
IPC分类号： B01D15/14 , G01N30/60 , G01N30/32 , G01N30/30 , B01D15/40
摘要： A storage container includes a casing and a bi-parting door. The casing has an opening and stores a device to be used in a fluid chromatograph. A door of the bi-parting door includes a frame member and a cover member. The frame member includes an upper frame and a lower frame. The upper frame and the lower frame are provided at the casing to be turnable around a turning axis and be spaced apart from each other on the turning axis. The cover member is configured to be attachable to and detachable from the frame member and partially cover the opening when the door is closed. A space is formed between the upper frame and the lower frame.

10. 发明申请

US20230076477A1 IMAGING DEVICE AND IMAGING METHOD 有权
公开(公告)号：US20230076477A1
公开(公告)日：2023-03-09
申请号：US17467261
申请日：2021-09-05
申请人： SHIMADZU CORPORATION
发明人： Kazuyuki MATSUDA
IPC分类号： A61B5/026 , G06T7/00 , A61B5/00
摘要： An imaging device and a method of imaging accurately decides a cause when pixel values of each pixel in a predetermined region of a fluorescence image varies with time. The imaging device, has an excitation light source, an imaging element that acquires a fluorescence image, an image storing element that stores the fluorescence image with time, a pixel value measurement element an average value calculation element and a first curve generation element that generates showing a time-course change of the average pixel value of the entire fluorescence image, a second curve generation element that generates showing a time-course change of the average pixel value of the region of interest.

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