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    • 54. 发明申请
    • TOOL TO DETECT STRUCTURAL INTEGRITY OF IMPLANT
    • 检测植入物的结构完整性的工具
    • WO2006119243A3
    • 2009-04-16
    • PCT/US2006016728
    • 2006-05-01
    • UNIV RICE WILLIAM MLIEBSCHNER MICHAEL
    • LIEBSCHNER MICHAEL
    • G01M7/02G01N24/00
    • A61B5/4312A61B5/0051A61B5/4851A61B9/00A61B2562/0219
    • Disclosed within are embodiments of the present invention directed toward methods and apparatus for detecting the structural integrity of a fluid-filled implant (200), and, more specifically, a silicone gel-filled breast implant (200) while it is implanted in the patient. A mechanical action or S vibration is applied to the implant in vivo in a safe and noninvasive manner, and a response is measured and analyzed. The measured response may be compared to a predetermined baseline, and the comparison used to indicate the structural integrity of the implant. The severity and location of any rupture may also be indicated. The measured dynamic response, which is a direct mechanical measurement, may be used to more accurately determine the structural integrity of the implant than 10 conventional imaging techniques.
    • 在本发明的实施例中公开了针对用于检测流体填充的植入物(200)的结构完整性的方法和装置,更具体地说,是将硅胶填充的乳房植入物(200)植入患者体内 。 在体内以安全和无创的方式对植入物施加机械作用或S振动,并测量和分析响应。 测量的响应可以与预定基线进行比较,并且比较用于指示植入物的结构完整性。 也可以指出任何破裂的严重程度和位置。 测量的动态响应(其是直接机械测量)可以用于比10种常规成像技术更准确地确定植入物的结构完整性。
    • 58. 发明申请
    • NANORICE PARTICLES: HYBRID PLASMONIC NANOSTRUCTURES
    • 纳米颗粒:混合等离子体纳米结构
    • WO2007103802A3
    • 2007-11-22
    • PCT/US2007063201
    • 2007-03-02
    • UNIV RICE WILLIAM MLE FEIWANG HUIBRANDL DANIELNORDLANDER PETERHALAS NAOMI J
    • WANG HUIBRANDL DANIELNORDLANDER PETERHALAS NAOMI J
    • G01N21/55
    • B82B1/00B82B3/00B82Y30/00B82Y40/00Y10T428/2991Y10T428/2993
    • A new hybrid nanoparticle, i.e., a nanorice particle, which combines the intense local fields of nanorods with the highly tunable plasmon resonances of nanoshells, is described herein. This geometry possesses far greater structural tunability than previous nanoparticle geometries, along with much larger local field enhancements and far greater sensitivity as a surface plasmon resonance (SPR) nanosensor than presently known dielectric-conductive material nanostructures. In an embodiment, a nanoparticle comprises a prolate spheroid-shaped core having a first aspect ratio. The nanoparticle also comprises at least one conductive shell surrounding said prolate spheroid-shaped core. The nanoparticle has a surface plasmon resonance sensitivity of at least 600 nm RIU -1 . Methods of making the disclosed nanorice particles are also described herein.
    • 本文描述了将纳米棒的强局部场与纳米壳的高度可调谐等离子体共振组合的新的混合纳米颗粒,即纳米颗粒。 该几何具有比以前的纳米颗粒几何形状更大的结构可调性,以及比目前已知的介电导电材料纳米结构更大的局部场增强和比表面等离子体共振(SPR)纳米传感器更大的灵敏度。 在一个实施方案中,纳米颗粒包含具有第一纵横比的扁球状球形芯。 纳米颗粒还包括围绕所述扁球状球形芯的至少一个导电壳。 纳米颗粒的表面等离子体共振灵敏度至少为600nm RIU -1。 本文还描述了制备所公开的纳米微粒的方法。