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1. 发明申请

WO2019115670A1 WEARABLE OR INSERTABLE DEVICES WITH MICRONEEDLES THAT INCLUDE MECHANICALLY-RESPONSIVE MATERIAL 审中-公开
公开(公告)号：WO2019115670A1
公开(公告)日：2019-06-20
申请号：PCT/EP2018/084686
申请日：2018-12-13
申请人： KONINKLIJKE PHILIPS N.V.
发明人： ESPINA PEREZ, Javier , WORTELBOER, Pippinus, Maarten, Robertus , GERHARDT, Lutz, Christian , VAN LIESHOUT, Ron, Martinus, Laurentius , JOHNSON, Mark, Thomas
IPC分类号： A61B5/15 , A61B5/155 , A61B5/157 , A61B5/145 , A61M37/00
CPC分类号： A61B5/150022 , A61B5/0051 , A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150076 , A61B5/150083 , A61B5/150091 , A61B5/150099 , A61B5/150389 , A61B5/150511 , A61B5/150755 , A61B5/150862 , A61B5/150877 , A61B5/150946 , A61B5/150969 , A61B5/150984 , A61B5/155 , A61B5/157 , A61B5/6802 , A61B5/7475 , A61M2037/003
摘要： The present disclosure is directed to wearable or insertable devices that allow for ongoing sampling and analysis of biomarkers and self-cleaning. In various embodiments, an apparatus may include a base (102) defining at least one reservoir (104), and at least one microneedle (106, 306, 406, 506, 606, 706, 806, 906) extending from the base. The at least one microneedle may define an inner lumen (409, 509, 609, 709, 809, 909) that fluidly couples the at least one reservoir with tissue of the patient. A mechanically responsive material (670, 770, 870) on an inner surface of the at least one microneedle defining the inner lumen may be reactive to various stimuli to undergo various mechanical responses, such as one mechanical response that purges fluid from the inner lumen of the at least one microneedle and another mechanical response that draws fluid into the inner lumen of the at least one microneedle.

2. 发明申请

WO2016200757A1 METHODS AND DEVICES TO DECREASE TISSUE TRAUMA DURING SURGERY 审中-公开
标题翻译：在手术期间减少组织病变的方法和装置
公开(公告)号：WO2016200757A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036130
申请日：2016-06-07
申请人： PHYSCIENT, INC.
发明人： CRENSHAW, Hugh Charles , PELL, Charles Anthony , WILLIAMS, Jeffrey P.
IPC分类号： A61B17/02 , A61B5/00 , A61B7/00 , A61B17/12 , A61B90/00
CPC分类号： A61B17/0218 , A61B5/0051 , A61B5/442 , A61B5/7239 , A61B7/00 , A61B17/02 , A61B17/0206 , A61B17/025 , A61B17/0293 , A61B17/12136 , A61B90/03 , A61B2017/00022 , A61B2017/00172 , A61B2017/00181 , A61B2017/00314 , A61B2017/00323 , A61B2017/00398 , A61B2017/00539 , A61B2017/00544 , A61B2017/00557 , A61B2017/00734 , A61B2017/0225 , A61B2017/0256 , A61B2017/0262 , A61B2090/064 , A61B2090/065 , A61B2090/0809 , A61B2562/0219 , A61M25/104
摘要： Methods and devices are disclosed to reduce tissue trauma when a physician retracts a patient's tissues for surgery. In one part, methods and devices are disclosed for controlling retraction force and pace. In another part, methods and devices are disclosed for oscillating force when opening. In another part, methods and devices are disclosed for detecting trauma during retraction. In another part, methods and devices are disclosed for balancing forces on multiple retraction elements. In another part, methods and devices are disclosed for reducing forces in multiple dimensions. In another part, methods and devices are disclosed for engaging ribs. In another part, methods and devices are disclosed to compensate for deformation of a retractor under load. In another part, methods and devices are disclosed that combine these methods and devices. In another part, methods and devices are disclosed for controlling pressure inside inf1atable devices used for deforming biological tissues.
摘要翻译：公开了一种方法和装置，用于当医师缩回患者组织进行手术时减少组织损伤。一方面，公开了用于控制收缩力和速度的方法和装置。在另一部分中，当打开时公开了振荡力的方法和装置。在另一部分中，公开了用于在收缩期间检测创伤的方法和装置。在另一部分中，公开了用于在多个回缩元件上平衡力的方法和装置。在另一部分中，公开了用于减少多个维度的力的方法和装置。在另一部分中，公开了用于接合肋的方法和装置。在另一部分中，公开了用于补偿牵引器在负载下的变形的方法和装置。另一方面，公开了组合这些方法和装置的方法和装置。另一方面，公开了用于控制用于使生物组织变形的可充电装置内的压力的方法和装置。

3. 发明申请

WO2016200432A1 SYSTEMS AND METHODS FOR DELIVERING BONE CONDUCTION STIMULI TO AND FOR MEASURING GRAVITATION RECEPTOR FUNCTIONS OF THE INNER EAR 审中-公开
标题翻译：用于传递骨诱导刺激和测量内耳的诱导受体功能的系统和方法
公开(公告)号：WO2016200432A1
公开(公告)日：2016-12-15
申请号：PCT/US2015/064333
申请日：2015-12-07
申请人： EAR AND SKULL BASE CENTER, P.C.
发明人： WACKYM, Phillip, Ashley , WACKYM, Ashton, Rhys
IPC分类号： A61B5/12 , A61B5/00 , A61B3/113 , A61B3/14
CPC分类号： A61B5/12 , A61B3/113 , A61B5/0051 , A61B5/0057 , A61B5/4023
摘要： Disclosed herein are apparatus and methods for delivering bone conduction stimuli for measuring the gravitation receptor functions of the inner ear. In some embodiments, a system may include (i) an impactor operatively linked to a guide disposed within a housing and (ii) an electrically driven actuator enclosed within the housing. The electrically driven actuator may be configured to cause the impactor to (i) travel to a striking point to deliver a mechanical bone conduction stimulus for transmission to a skull bone and (ii) controllably decelerate prior to the instance of stimuli delivery. The system may also include an oculometric response monitoring system including a video camera for capturing video of motion of one or more eyes of the patient.
摘要翻译：本文公开了用于输送用于测量内耳的引力受体功能的骨传导刺激的装置和方法。在一些实施例中，系统可以包括（i）可操作地连接到设置在壳体内的引导件的冲击器和（ii）封闭在壳体内的电驱动致动器。电驱动致动器可以被配置为使得冲击器（i）行进到击打点以递送机械骨传导刺激以传输到颅骨，并且（ii）在刺激传递之前可控制地减速。该系统还可以包括眼睛响应监测系统，其包括用于捕获患者的一只或多只眼睛的运动的视频的摄像机。

4. 发明申请

WO2015175904A1 MULTISENSOR PHYSIOLOGICAL MONITORING SYSTEMS AND METHODS 审中-公开
标题翻译：多传感器生理监测系统和方法
公开(公告)号：WO2015175904A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/031021
申请日：2015-05-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MAHAJAN, Aman , KAISER, William
IPC分类号： A61B5/02 , A61B5/08 , A61B5/00
CPC分类号： A61B5/0205 , A61B5/0051 , A61B5/04012 , A61B5/0404 , A61B5/0456 , A61B5/0803 , A61B5/091 , A61B5/1135 , A61B5/6823 , A61B5/6831 , A61B5/7267 , A61B7/00 , A61B7/003 , A61B7/04 , A61B2562/0204 , A61B2562/04 , A61B2562/06
摘要： An integrated cardio-respiratory system that fuses continuously recorded data from multiple physiological sensor sources to acquire signals representative of acoustic events caused by physiological phenomena occurring in the cardiac and/or arterial structures underneath particular areas of the chest and/or neck to monitor cardiac and respiratory conditions.
摘要翻译：一种整合的心肺呼吸系统，其将来自多个生理传感器源的连续记录的数据融合，以获取表示在胸部和/或颈部的特定区域下方的心脏和/或动脉结构中发生的生理现象引起的声学事件的信号，以监测心脏和/ 呼吸状况。

5. 发明申请

WO2014169217A3 SYSTEMS AND METHODS FOR ESTABLISHING THE STIFFNESS OF A BONE USING MECHANICAL RESPONSE TISSUE ANALYSIS 审中-公开
标题翻译：使用机械响应组织分析建立骨骼硬度的系统和方法
公开(公告)号：WO2014169217A3
公开(公告)日：2015-11-05
申请号：PCT/US2014033816
申请日：2014-04-11
申请人： UNIV OHIO
发明人： BOWMAN LYN , ARNOLD PATRICIA A , ELLERBROCK EMILY R
IPC分类号： A61B8/00 , A61B8/14 , G01S15/89 , G09B23/30
CPC分类号： A61B5/4509 , A61B5/0051 , A61B5/442 , A61B5/4504 , A61B5/6824 , A61B5/6831 , A61B5/7242 , A61B5/7246 , A61B5/7253 , A61B5/7278 , A61B2560/0475 , A61B2562/0219 , A61B2562/0252 , A61B2562/14
摘要： Parametric model based computer implemented methods for determining the stiffness of a bone, systems for estimating the stiffness of a bone in vivo, and methods for determining the stiffness of a bone. The computer implemented methods include determining a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f) and fitting a parametric mathematical model to Y(f) and to H(f). The systems include a device for measuring the stiffness of the bone in vivo and a data analyzer to determine a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f). The methods for determining the stiffness include fitting a parametric model to stiffness of the skin-bone complex as a function of frequency H(f) and the compliance of the skin-bone complex as a function of frequency Y(f).
摘要翻译：用于确定骨骼刚度的参数模型计算机实现方法，用于估计体内骨骼刚度的系统以及用于确定骨骼刚度的方法。计算机实现的方法包括确定复杂符合频率响应函数Y（f）和相关联的复刚度频率响应函数H（f），并将参数数学模型拟合为Y（f）和H（f）。该系统包括用于测量体内骨骼刚度的装置和用于确定复合顺应性频率响应函数Y（f）和相关联的复刚度频率响应函数H（f）的数据分析器。用于确定刚度的方法包括将参数模型拟合为皮肤 - 骨骼复合体的刚度，作为频率H（f）的函数以及作为频率Y（f）的函数的皮肤 - 骨骼复合物的顺应性。

6. 发明申请

WO2015144811A1 RHEOLOGY SYSTEM AND MR RHEOLOGY SYSTEM WITH RHEOLOGY SENSOR FEEDBACK CONTROL 审中-公开
标题翻译：流变学系统与流变学流变学系统与传感器反馈控制
公开(公告)号：WO2015144811A1
公开(公告)日：2015-10-01
申请号：PCT/EP2015/056526
申请日：2015-03-26
申请人： KONINKLIJKE PHILIPS N.V.
发明人： WIRTZ, Daniel , LEUSSLER, Christoph , MAZURKEWITZ, Peter
IPC分类号： G01R33/563 , A61B5/00
CPC分类号： A61B5/055 , A61B5/0051 , G01R33/30 , G01R33/56358
摘要： The present invention provides a rheology system (202) comprising a rheology transducer device (204) for introducing mechanical waves into a subject of interest (120), whereby the rheology transducer device (204) comprises multiple transducers (212), a driving device (206) for driving the rheology transducer device (204), a sensor device (208) for sensing mechanical waves at the subject of interest (120), and a control device (210) for receiving input from the sensor device (208) and for controlling the driving device (206) based on the received input from the sensor device (208). The present invention further provides a MR rheology system (200) comprising a MR imaging system (110), and the above rheology system (202), whereby the MR imaging system (110) is adapted to control the rheology system (200). Still further, the present invention provides a rheology method comprising the steps of providing a rheology system (202) with its rheology transducer device (204) and its sensor device (208) in contact to a subject of interest (120), driving the rheology transducer device (204) to introduce mechanical waves into the subject of interest (120), sensing mechanical waves at the subject of interest (120) using the sensor device (208), and performing feedback control for driving the rheology transducer device (204) based on the mechanical waves sensed using the sensor device (208). The invention also provides MR rheology method based on the above rheology method with and without real-time feedback control.
摘要翻译：本发明提供一种流变系统（202），其包括用于将机械波引入感兴趣的对象（120）的流变学换能器装置（204），由此流变学换能器装置（204）包括多个换能器（212），驱动装置 206），用于驱动所述流变换能器装置（204）的传感器装置（208），用于感测感兴趣对象（120）的机械波的传感器装置（208）和用于接收来自传感器装置（208）的输入的控制装置基于从所述传感器装置（208）接收到的输入来控制所述驱动装置（206）。本发明还提供了一种MR流变系统（200），其包括MR成像系统（110）和上述流变系统（202），由此MR成像系统（110）适于控制流变系统（200）。此外，本发明提供一种流变学方法，其包括以下步骤：提供其流变学系统（202）与其流变学换能器装置（204）及其传感器装置（208）接触感兴趣的对象（120），驱动流变学传感器装置（204），以将机械波引入感兴趣的对象（120）中，使用传感器装置（208）感测感兴趣对象（120）上的机械波，以及执行用于驱动流变换能器装置（204）的反馈控制，基于使用传感器装置（208）感测的机械波。本发明还提供了基于上述具有和不具有实时反馈控制的流变学方法的MR流变学方法。

7. 发明申请

WO2015077086A3 SYSTEM AND METHOD FOR ANALYZING TISSUE USING SHEAR WAVES 审中-公开
标题翻译：使用剪切波分析组织的系统和方法
公开(公告)号：WO2015077086A3
公开(公告)日：2015-07-16
申请号：PCT/US2014064992
申请日：2014-11-11
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： HAUPT ROBERT W
IPC分类号： A61B8/08 , A61B5/00 , G01N29/11 , G01N29/24 , G01N29/34 , G01S7/52
CPC分类号： A61B8/0808 , A61B5/0051 , A61B5/0059 , A61B5/055 , A61B8/08 , A61B8/085 , A61B8/0858 , A61B8/0875 , A61B8/485 , A61B8/488 , A61B8/5215 , A61B8/5223 , G01N29/0654 , G01N29/11 , G01N29/346 , G01N2291/02475 , G01N2291/02491 , G01N2291/02827 , G01N2291/0422 , G01S7/52042 , G01S7/52047 , G01S15/8913 , G01S15/8915
摘要： A system and method for determining tissue changes. Shear waves are transmitted across the tissue in response to an ultrasonic signal input exterior to the tissue surface. Adaptive beam forming signal processing is applied to signal returns and arrivals to remove distortions by targeting velocity contrasts. Shear-wave dispersion, such as due to viscosity and mass changes in the tissue, are then estimated and compared to reference data to determine tissue health.
摘要翻译：一种确定组织变化的系统和方法。响应于组织表面外部的超声信号输入，剪切波传输穿过组织。自适应波束形成信号处理被应用于信号返回和到达以通过瞄准速度对比来去除失真。然后估计剪波分散，例如由于组织中的粘度和质量变化，并与参考数据比较以确定组织健康。

8. 发明申请

WO2014208199A1 超音波観測システム、超音波観測システムの作動方法审中-公开
标题翻译：超声观察系统及超声观察系统的运行方法
公开(公告)号：WO2014208199A1
公开(公告)日：2014-12-31
申请号：PCT/JP2014/062101
申请日：2014-05-01
申请人：オリンパスメディカルシステムズ株式会社
发明人：三宅　達也
IPC分类号： A61B8/12 , A61B8/08
CPC分类号： A61B8/485 , A61B5/0051 , A61B5/0053 , A61B5/0402 , A61B8/02 , A61B8/12 , A61B8/461 , A61B8/463 , A61B8/467 , A61B8/488 , A61B8/5223 , A61B8/5276 , A61B8/5284 , A61B8/54 , A61B8/543
摘要：　被検体へ超音波を送受信して超音波信号を生成する超音波振動子（１１）と、被検体に押圧力を加えて加圧変位を発生させる第１自動加圧機構（１２）と、超音波信号に基づき被検体の画像用変位量を計測する弾性画像生成用変位計測回路（２８）と、画像用変位量に基づき被検体の弾性率を演算する弾性率演算回路（２９）と、被検体の変位に基づく信号の波形を解析して変位の極大点および変位周期を取得する信号波形解析回路（３１）と、信号波形解析結果に基づき変位周期に同期して変位の極大点と同一のタイミングで第１自動加圧機構（１２）に加圧を行わせる加圧機構制御回路（３２）と、を備えた超音波観測システム（１）。
摘要翻译：一种超声波观测系统（1），具备：超声波换能器（11），用于向被摄体发送超声波并从对象接收超声波，并产生超声波信号; 第一自动加压机构（12），用于对受试者施加压力以产生加压位移; 用于弹性成像图像生成的位移测量电路（28），所述电路基于所述超声信号测量所述被摄体成像的位移量; 弹性计算电路（29），用于基于成像位移量计算被检者的弹性; 信号波形分析电路（31），用于分析基于被摄体的位移的信号波形，以获得位移最大和位移周期; 以及加压机构控制电路（32），用于使第一自动加压机构（12）基于信号波形分析结果与位移周期同步地进行加压，同时作为位移最大值。

9. 发明申请

WO2014180825A2 DEVICE AND METHOD FOR CONTINUOUS DETECTION OF CHANGES OF DENSITY IN FLUIDS AND SOLIDS AS WELL AS USE OF THE DEVICE 审中-公开
标题翻译：用于连续检测流体和固体中密度变化的装置和方法以及如何使用装置
公开(公告)号：WO2014180825A2
公开(公告)日：2014-11-13
申请号：PCT/EP2014059204
申请日：2014-05-06
申请人： MECSENSE AS
发明人： ELLINGSEN OLAV , ELLINGSEN BJARTE SØREBØ
IPC分类号： A61B5/145
CPC分类号： G01N9/00 , A61B5/0051 , A61B5/14532 , A61B5/14546 , A61B5/4875 , A61B8/08 , G01N29/032 , G01N29/245 , G01N29/343 , G01N2291/012 , G01N2291/02818
摘要： The present invention relates to a sensor for continuous detection of minute changes of density in fluids and biological fluids, solids and semisolid bodies by use of a transducer. The invention also relates to a method for continuous detection of changes of density of fluids or solids as well as use of the device.
摘要翻译：本发明涉及一种传感器，用于通过使用传感器来连续检测流体和生物流体，固体和半固体中的密度的微小变化。本发明还涉及用于连续检测流体或固体的密度变化以及使用该装置的方法。

10. 发明申请

WO2014169217A2 SYSTEMS AND METHODS FOR ESTABLISHING THE STIFFNESS OF A BONE USING MECHANICAL RESPONSE TISSUE ANALYSIS 审中-公开
标题翻译：使用机械响应组织分析建立骨骼硬度的系统和方法
公开(公告)号：WO2014169217A2
公开(公告)日：2014-10-16
申请号：PCT/US2014/033816
申请日：2014-04-11
申请人： OHIO UNIVERSITY
发明人： BOWMAN, Lyn , ARNOLD, Patricia, A. , ELLERBROCK, Emily, R.
IPC分类号： G06F19/00
CPC分类号： A61B5/4509 , A61B5/0051 , A61B5/442 , A61B5/4504 , A61B5/6824 , A61B5/6831 , A61B5/7242 , A61B5/7246 , A61B5/7253 , A61B5/7278 , A61B2560/0475 , A61B2562/0219 , A61B2562/0252 , A61B2562/14
摘要： Parametric model based computer implemented methods for determining the stiffness of a bone, systems for estimating the stiffness of a bone in vivo, and methods for determining the stiffness of a bone. The computer implemented methods include determining a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f) and fitting a parametric mathematical model to Y(f) and to H(f). The systems include a device for measuring the stiffness of the bone in vivo and a data analyzer to determine a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f). The methods for determining the stiffness include fitting a parametric model to stiffness of the skin-bone complex as a function of frequency H(f) and the compliance of the skin-bone complex as a function of frequency Y(f).
摘要翻译：用于确定骨骼刚度的参数模型计算机实现方法，用于估计体内骨骼刚度的系统以及用于确定骨骼刚度的方法。计算机实现的方法包括确定复杂符合频率响应函数Y（f）和相关联的复刚度频率响应函数H（f），并将参数数学模型拟合为Y（f）和H（f）。该系统包括用于测量体内骨骼刚度的装置和用于确定复合顺应性频率响应函数Y（f）和相关联的复刚度频率响应函数H（f）的数据分析器。用于确定刚度的方法包括将参数模型拟合为皮肤 - 骨骼复合体的刚度，作为频率H（f）的函数以及作为频率Y（f）的函数的皮肤 - 骨骼复合物的顺应性。

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