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61. 发明申请

WO2014152789A1 CITRATE CONTAINING BEVERAGE 审中-公开
标题翻译：包含饮料的CITRATE
公开(公告)号：WO2014152789A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027736
申请日：2014-03-14
申请人： NEW YORK UNIVERSITY , GENERAL HOSPITAL CORPORATION , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： GOLDFARB, David, S. , EISNER, Brian , ASPLIN, John , STOLLER, Marshall, L.
IPC分类号： A61P3/02 , A61P3/14 , A23L2/385 , A23L2/52 , A23L1/304 , A61K31/19
CPC分类号： A61K33/08 , A23L2/52 , A23L2/66 , A23L2/68 , A23L33/16 , A23L33/20 , A23V2002/00 , A61K31/194 , A61K31/4415 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may be provided in a concentrate form. Also provided are kits comprising the beverage compositions and methods for treating various conditions using the beverage compositions.
摘要翻译：提供了包含增加尿液的组分和减少尿液的组分的饮料组合物。饮料组合物可以以即饮型形式提供，或者可以浓缩物形式提供。还提供了包含饮料组合物和使用饮料组合物处理各种条件的方法的试剂盒。

62. 发明申请

WO2014127126A1 HANDPHONE 审中-公开
标题翻译：手机
公开(公告)号：WO2014127126A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/016256
申请日：2014-02-13
申请人： NEW YORK UNIVERSITY
发明人： PARK, Tae Hong
IPC分类号： H04R1/20
CPC分类号： H04M1/035 , H04M1/0281 , H04M9/08 , H04R1/345 , H04R1/403 , H04R19/02 , H04R23/002 , H04R2499/11
摘要： A handphone is configured to receive a first audio signal of a telecommunication conversation from a telecommunication device and send a second audio signal of the telecommunication conversation to the telecommunication device. A modulated ultrasound frequency audio signal that is directional is created from the first audio signal of the telecommunication conversation. The modulated ultrasound frequency audio signal is output via a loudspeaker. A direction of the modulated ultrasound frequency audio signal is controlled by a physical object and a location of the loudspeaker.
摘要翻译：手机被配置为从电信设备接收电信会话的第一音频信号，并将电信会话的第二音频信号发送到电信设备。从电信对话的第一音频信号创建定向的调制超声频率音频信号。经调制的超声频率音频信号通过扬声器输出。调制超声频率音频信号的方向由物理对象和扬声器的位置控制。

63. 发明申请

WO2014107484A1 METHODS FOR TREATING INFLAMMATION 审中-公开
标题翻译：治疗炎症的方法
公开(公告)号：WO2014107484A1
公开(公告)日：2014-07-10
申请号：PCT/US2014/010026
申请日：2014-01-02
申请人： NEW YORK UNIVERSITY
发明人： MOORE, Kathryn, J. , FISHER, Edward, A.
IPC分类号： A61K39/395 , A61K48/00 , A61P29/00
CPC分类号： A61K39/395 , A61K31/7088 , A61K31/7105 , A61K38/02 , A61K45/06 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/2803 , C12N15/113 , C12N2310/14 , C12N2320/31
摘要： The invention provides methods and compositions for inhibiting, reducing or slowing inflammation or inflammatory diseases, for reducing sequestration or collecting or localization of macrophages, for treating a disease caused all or in part by or characterized by inflammation such as, for instance, chronic inflammation, for inhibiting, slowing, reversing or preventing atherosclerosis, and for increasing insulin sensitivity, decreasing or inhibiting resistance to insulin, or treating diabetes by inhibiting, inhibiting the biological activity of or antagonizing an axonal guidance protein. The methods may feature administering to a subject a therapeutically effective amount of an agent effective to inhibit or reduce the biological activity of an axonal guidance protein or a receptor of the axonal guidance protein, or an analog, derivative or combination thereof. The disease may be, for instance, one of atherosclerosis, rheumatoid arthritis, tuberculosis, autoimmune syndromes and obesity where macrophage accumulation in adipose tissue is known to promote insulin resistance.
摘要翻译：本发明提供用于抑制，减少或减缓炎症或炎症疾病的方法和组合物，用于减少巨噬细胞的螯合或收集或定位，用于治疗由炎症引起的全部或部分或特征的疾病，例如慢性炎症，用于抑制，减缓，逆转或预防动脉粥样硬化，以及增加胰岛素敏感性，降低或抑制对胰岛素的抵抗，或通过抑制，抑制轴突引导蛋白的生物学活性或拮抗轴索引导蛋白来治疗糖尿病。所述方法可以特征在于向受试者施用治疗有效量的有效抑制轴突引导蛋白或轴突引导蛋白或其类似物，衍生物或组合的轴突引导蛋白或受体的生物学活性的试剂。该疾病可以是例如动脉粥样硬化，类风湿性关节炎，结核病，自身免疫综合征和肥胖之一，其中已知脂肪组织中的巨噬细胞积聚可促进胰岛素抵抗。

64. 发明申请

WO2014070652A1 COLLOIDS WITH VALENCE: FABRICATION, FUNCTIONALIZATION AND DIRECTIONAL BONDING 审中-公开
标题翻译：具有价值的胶合剂：制造，功能化和方向性结合
公开(公告)号：WO2014070652A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/067051
申请日：2013-10-28
申请人： NEW YORK UNIVERSITY
发明人： PINE, David, J. , WANG, Yufeng , WANG, Yu , WECK, Marcus
IPC分类号： B01J13/02 , B01J13/14
CPC分类号： B01J13/00 , B01J13/0039 , B01J13/14 , C08F112/08 , C08F212/08
摘要： A method and articles of manufacture for creating colloidal clusters and functionalized patchy particles. The method includes selecting at least one type of colloidal particle, functionalizing a patch of the colloidal particle and mixing a plurality of the colloidal particles to construct a cluster with particular desired geometries properties based on the bonding of the colloidal particles by virtue of the patch having bond-type characteristic analogous to, but not limited to atomic orbitals and other symmetries.
摘要翻译：用于产生胶体团簇和功能化斑块状颗粒的方法和制造方法。所述方法包括选择至少一种类型的胶体颗粒，功能化胶体颗粒的贴片并混合多个胶体颗粒以构建具有特定期望几何性质的簇，其基于胶体颗粒的粘合，由于具有键型特征类似于但不限于原子轨道和其他对称性。

65. 发明申请

WO2014062681A1 INVERTED ORTHOGONAL SPIN TRANSFER LAYER STACK 审中-公开
标题翻译：反转正交转移层堆叠
公开(公告)号：WO2014062681A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/065055
申请日：2013-10-15
申请人： NEW YORK UNIVERSITY
发明人： KENT, Andrew , BACKES, Dirk
IPC分类号： G11C11/16
CPC分类号： H01L37/00 , B82Y40/00 , G11C11/16 , G11C11/161 , H01F10/3272 , H01F10/3286 , H01F41/307 , H01L43/08
摘要： A magnetic device includes a pinned magnetic layer having a first fixed magnetization vector with a first fixed magnetization direction. The magnetic device also includes a free magnetic layer having a variable magnetization vector having at least a first stable state and a second stable state. The magnetic device also has a first non-magnetic layer and a reference. The first non-magnetic layer spatially separates the pinned magnetic layer and the free magnetic layer. The magnetic device also includes a second non-magnetic layer spatially separating the free magnetic layer and the reference magnetic layer. A magnetic tunnel junction, located below the pinned magnetic layer, is formed by the free magnetic layer, the second non-magnetic layer, and the reference magnetic layer. Application of a current pulse, having either positive or negative polarity and a selected amplitude and duration, through the magnetic device switches the variable magnetization vector.
摘要翻译：磁性装置包括具有第一固定磁化方向的第一固定磁化矢量的钉扎磁性层。磁性装置还包括具有至少第一稳定状态和第二稳定状态的可变磁化矢量的自由磁性层。磁性器件还具有第一非磁性层和参考。第一非磁性层空间分离被钉扎的磁性层和自由磁性层。磁性装置还包括在空间上分离自由磁性层和参考磁性层的第二非磁性层。位于钉扎磁性层下方的磁性隧道结由自由磁性层，第二非磁性层和参考磁性层形成。通过磁性装置施加具有正极性或负极性以及所选择的幅度和持续时间的电流脉冲来切换可变磁化矢量。

66. 发明申请

WO2014062634A1 INCREASED MAGNETORESISTANCE IN AN INVERTED ORTHOGONAL SPIN TRANSFER LAYER STACK 审中-公开
标题翻译：反转正交转移层堆叠中磁化强度的增加
公开(公告)号：WO2014062634A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/064975
申请日：2013-10-15
申请人： NEW YORK UNIVERSITY
发明人： KENT, Andrew , BACKES, Dirk
IPC分类号： G11C11/16
CPC分类号： H01L43/02 , G11C11/16 , G11C11/161 , H01L43/08 , H01L43/10 , H01L43/12
摘要： A magnetic device includes a pinned magnetic layer and a free magnetic layer including a first body-centered cubic material and having a variable magnetization vector that has a first stable state and a second stable state. The magnetic device also includes a first non-magnetic layer and a reference layer. The first non-magnetic layer spatially separates the pinned magnetic layer and the free magnetic layer and includes a second body-centered cubic material that interfaces with the first body-centered cubic material. The magnetic device includes a second non-magnetic layer spatially separating the free magnetic layer and the reference magnetic layer. A magnetic tunnel junction, located below the pinned magnetic layer, is formed by the free magnetic layer, the second non-magnetic layer, and the reference magnetic layer. Application of a current pulse through the magnetic device switches the variable magnetization vector.
摘要翻译：磁性装置包括钉扎磁性层和包含第一体心立方材料并具有可变磁化矢量的自由磁性层，其具有第一稳定状态和第二稳定状态。磁性器件还包括第一非磁性层和参考层。第一非磁性层空间上分离被钉扎的磁性层和自由磁性层，并且包括与第一体心立方体材料相接的第二体心立方体材料。磁性装置包括在空间上分离自由磁性层和参考磁性层的第二非磁性层。位于钉扎磁性层下方的磁性隧道结由自由磁性层，第二非磁性层和参考磁性层形成。通过磁性装置施加电流脉冲切换可变磁化矢量。

67. 发明申请

WO2014055644A2 PHARMACEUTICAL COMPOSITIONS AND TREATMENT OF GENETIC DISEASES ASSOCIATED WITH NONSENSE MEDIATED RNA DECAY 审中-公开
标题翻译：药物组合物和与非神经介导的RNA衰减相关的遗传病的治疗
公开(公告)号：WO2014055644A2
公开(公告)日：2014-04-10
申请号：PCT/US2013/063064
申请日：2013-10-02
申请人： NEW YORK UNIVERSITY , GARDNER, Lawrence, B. , CARDOZO, Timothy, J. , MARTIN, Leenus
发明人： GARDNER, Lawrence, B. , CARDOZO, Timothy, J. , MARTIN, Leenus
CPC分类号： A61K31/53 , A61K31/167 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/4035 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/4184 , A61K31/4192 , A61K31/4245 , A61K31/433 , A61K31/44 , A61K31/445 , A61K31/498 , A61K31/50 , A61K31/513 , A61K31/536 , A61K31/538 , A61K45/06 , G01N33/5023 , G06F19/12 , G06F19/16 , G06F19/706 , Y02A90/26
摘要： The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating a genetic disease caused by premature termination codons, or other conditions that render messenger ribonucleic acid (mRNA) susceptible to nonsense mediated RNA decay, in a subject. Also disclosed is a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy. The present invention also relates to a method of identifying inhibitors of nonsense mediated RNA decay and/or inducing autophagy. The present invention further relates to a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy in a subject.
摘要翻译：本发明涉及包含化合物和药学上可接受的载体的药物组合物。本发明还涉及一种治疗由过早终止密码子引起的遗传疾病的方法或在受试者中使信使核糖核酸（mRNA）易于无义介导的RNA衰变的其它病症。还公开了抑制无义介导的RNA衰变和/或诱导自噬的方法。本发明还涉及鉴定无义介导的RNA衰变和/或诱导自噬的抑制剂的方法。本发明还涉及抑制无症状介导的RNA衰变和/或受试者自噬诱导的方法。

68. 发明申请

WO2014022784A2 HUMANIZED SINGLE-CHAIN ANTIBODY AGAINST BETA 3 INTEGRIN FOR THE TREATMENT AND PREVENTION OF METASTASIS 审中-公开
标题翻译：用于治疗和预防METASTASIS的BETA 3 INTEGRIN的人类单链抗体
公开(公告)号：WO2014022784A2
公开(公告)日：2014-02-06
申请号：PCT/US2013/053447
申请日：2013-08-02
申请人： NEW YORK UNIVERSITY , WISNIEWSKI, Thomas, M. , ZHANG, Wei , DANG, Suying
发明人： WISNIEWSKI, Thomas, M. , ZHANG, Wei , DANG, Suying
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/2848 , A61K2039/505 , C07K2317/622 , C07K2317/73

69. 发明申请

WO2013184960A3 CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE 审中-公开
公开(公告)号：WO2013184960A3
公开(公告)日：2013-12-12
申请号：PCT/US2013/044592
申请日：2013-06-06
申请人： NEW YORK UNIVERSITY , MOHAMMADI, Moosa , GOETZ, Regina
发明人： MOHAMMADI, Moosa , GOETZ, Regina
IPC分类号： A61K38/18 , C12P21/04 , A61K38/00 , A61K38/24 , C07K14/50 , C07K5/00
摘要： The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor ("FGF") and the C-terminus includes a C-terminal portion of an FGF23 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from a disorder, and methods of screening for compounds with enhanced binding affinity for the αKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention.

70. 发明申请

WO2013142278A1 PLASMODIUM VIVAX VACCINE COMPOSITIONS 审中-公开
标题翻译： PLASMODIUM VIVAX VACCINE组合物
公开(公告)号：WO2013142278A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/031663
申请日：2013-03-14
申请人： NEW YORK UNIVERSITY , UNIVERSIDADE DE SAO PAULO , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG , RODRIGUES, Mauricio Martins , TEIXEIRA, Laís Helena , TARARAM, Cibele Aparacida , JAMPAULO, Vander Oliveira
发明人： RODRIGUES, Mauricio Martins , TEIXEIRA, Laís Helena , TARARAM, Cibele Aparacida , JAMPAULO, Vander Oliveira , NUSSENZWEIG, Victor N. , NUSSENZWEIG, Ruth , SOARES, Irene da Silva , ERTL, Hildegund C.J. , LASARO, Marcio de Oliveira , BRUNA-ROMERO, Oscar
IPC分类号： A61K39/002 , A61P33/06 , A61K39/015
CPC分类号： A61K39/015 , A61K2039/5256 , Y02A50/412
摘要： The invention provides P. vivax vaccine compositions.
摘要翻译：本发明提供间日疟原虫疫苗组合物。

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