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1. 发明申请

WO2019109330A1 ROBOT OF SCARA TYPE AND METHOD FOR MANUFACTURING THE ROBOT 审中-公开
公开(公告)号：WO2019109330A1
公开(公告)日：2019-06-13
申请号：PCT/CN2017/115197
申请日：2017-12-08
申请人： ABB SCHWEIZ AG , WANG, Luoluo , CAO, Xiaodong , YU, Hui , ZHU, Zhu
发明人： WANG, Luoluo , CAO, Xiaodong , YU, Hui , ZHU, Zhu
IPC分类号： B25J9/00 , B25J18/00
摘要： A robot (100) of SCARA type comprises: a base (101); a first arm (102) coupled to the base (101), the first arm (102) being rotatable about a first axis (X1) relative to the base (101) when driven by a first motor (201) arranged in the base (101) via a first transmission mechanism (221); a second arm (103) coupled to the first arm (102), the second arm (103) being rotatable about a second axis (X2) relative to the first arm (102) when driven by a second motor (202) via a second transmission mechanism (222), wherein the second motor (202) is arranged in the base (101) or the first arm (102), and the second axis (X2) is substantially parallel to the first axis (X1); and an operating unit (104) arranged in the second arm (103) and including an operating shaft (801), wherein the operating shaft (801) is movable along a third axis (X3) relative to the second arm (103) when driven by a third motor (203) arranged in the base (101) or the first arm (102) via a third transmission mechanism (223), wherein the third axis (X3) is substantially parallel to the first and second axes (X1, X2), and wherein the operating shaft (801) is rotatable about the third axis (X3) relative to the second arm (103) when driven by a fourth motor (204) arranged in the base (101) or the first arm (102) via a fourth transmission mechanism (224). The load of the robot (100) around the first and second axes (X1, X2) may be reduced, and the heat generated by the motors can be dissipated into the floor or working table quickly.

2. 发明申请

WO2022193060A1 PRESSURE RELIEF COMPONENT, GEARBOX AND ROBOT 审中-公开
公开(公告)号：WO2022193060A1
公开(公告)日：2022-09-22
申请号：PCT/CN2021/080761
申请日：2021-03-15
申请人： ABB SCHWEIZ AG , CAO, Xiaodong , HA, Yun , YU, Hui
发明人： CAO, Xiaodong , HA, Yun , YU, Hui
IPC分类号： F16H57/02 , F16H57/04
摘要： A pressure relief component, a gearbox and a robot. The pressure relief component (100) for a gearbox (200) comprises: a body (101) arranged to close an internal chamber (201) of the gearbox (200) and comprising a groove (1011), the groove (1011) formed on a side of the body (101) adjacent to the internal chamber (201) to form a cavity (1013) in the body (101), wherein the cavity (1013) is in fluid communication with a pressure source providing a predetermined pressure; and an elastic member (102) arranged at an opening of the groove (1011) to isolate the cavity (1013) from the internal chamber (201), the elastic member (102) adapted to deform in response to a pressure difference between the cavity (1013) and the internal chamber(201). With the pressure relief component (100), when the pressure within the internal chamber (201) is increased during the operation of the gearbox (200), the elastic member (102) will deform towards the cavity (1013) because the pressure within the cavity (1013) remains basically constant. The deformation of the elastic member (102) towards the cavity (1013) will increase the volume of the internal chamber (201) and thus reduce the pressure within the internal chamber (201) according to the relationship between the volume and pressure. In this way, the pressure relief component (100) can efficiently reduce the pressure within the internal chamber (201), thereby improve the sealing performance.

3. 发明申请

WO2023049475A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF 审中-公开
公开(公告)号：WO2023049475A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/044765
申请日：2022-09-26
申请人： WAVE LIFE SCIENCES LTD. , MONIAN, Prashant , SHIVALILA, Chikdu Shakti , LU, Genliang , VARGEESE, Chandra , GIANGRANDE, Paloma Hoban , KANDASAMY, Pachamuthu , IWAMOTO, Naoki , SHIMIZU, Mamoru , YU, Hui , YANG, Hailin , LAMORE, Sarah Diane , ZHANG, Fengjiao , NARAYANAN, Padmakumar
发明人： MONIAN, Prashant , SHIVALILA, Chikdu Shakti , LU, Genliang , VARGEESE, Chandra , GIANGRANDE, Paloma Hoban , KANDASAMY, Pachamuthu , IWAMOTO, Naoki , SHIMIZU, Mamoru , YU, Hui , YANG, Hailin , LAMORE, Sarah Diane , ZHANG, Fengjiao , NARAYANAN, Padmakumar
IPC分类号： C12N15/113 , A61K31/7088 , A61P1/16 , A61P11/00
摘要： Among other things, the present disclosure provides designed oligonucleotides and compositions thereof. In some embodiments, oligonucleotides and compositions of the present disclosure can provide high levels of adenosine editing. In some embodiments, oligonucleotides and compositions of the present disclosure are useful for treating various conditions, disorders or diseases, e.g., alpha- 1 antitrypsin deficiency. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine editing.

4. 发明申请

WO2022046667A1 CELLS AND NON-HUMAN ANIMALS ENGINEERED TO EXPRESS ADAR1 AND USES THEREOF 审中-公开
公开(公告)号：WO2022046667A1
公开(公告)日：2022-03-03
申请号：PCT/US2021/047205
申请日：2021-08-23
申请人： WAVE LIFE SCIENCES LTD. , YANG, Hailin , MONIAN, Prashant , SHIVALILA, Chikdu Shakti , MARAPPAN, Subramanian , VARGEESE, Chandra , KANDASAMY, Pachamuthu , LU, Genliang , YU, Hui , BUTLER, David, Charles, Donnell , APPONI, Luciano, Henrique , SHIMIZU, Mamoru , STANDLEY, Stephany, Michelle , BOULAY, David, John , GODFREY, Jack, David , IWAMOTO, Naoki
发明人： YANG, Hailin , MONIAN, Prashant , SHIVALILA, Chikdu Shakti , MARAPPAN, Subramanian , VARGEESE, Chandra , KANDASAMY, Pachamuthu , LU, Genliang , YU, Hui , BUTLER, David, Charles, Donnell , APPONI, Luciano, Henrique , SHIMIZU, Mamoru , STANDLEY, Stephany, Michelle , BOULAY, David, John , GODFREY, Jack, David , IWAMOTO, Naoki
IPC分类号： A61K38/50 , A61K47/60 , C07K14/47
摘要： Among other things, the present disclosure provides cells and non-human animals engineered to express an ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, the present disclosure provides cells and non-human animals engineered to express a human ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, non-human animals are genetically modified rodents such as mice, rat, etc. In some embodiments, non-human animals are mice. In some embodiments, the present disclosure provides technologies for assessing an agent comprising administering the agent to a cell or non-human animal engineered to express an ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, such a cell or non-human animal is engineered to express a human ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, an agent is a pharmaceutical agent. In some embodiments, an agent is or comprises an oligonucleotide.

5. 发明申请

WO2013176699A1 FUNCTIONAL NORBORNANYL ESTER DERIVATIVES, POLYMERS AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：功能诺贝恩酯衍生物，聚合物及其制备方法
公开(公告)号：WO2013176699A1
公开(公告)日：2013-11-28
申请号：PCT/US2012/062343
申请日：2012-10-28
申请人： YU, Hui
发明人： YU, Hui
IPC分类号： C07C69/52 , C07C69/34 , C08G63/123
CPC分类号： C08G63/137 , C07C67/08 , C07C69/734 , C07C69/753 , C07C69/757 , C07C2602/42 , C08F222/10 , C08F232/08
摘要： This invention relates to the new functional norbornanyl ester derivative and/or polymer compositions which are easily obtainable by reacting the Diels-Alder adduct of appropriate dienes and dienophiles with carboxylic acids. In particular, this invention relates to a new process for making cyclic chemical raw materials suitable for production coating, ink, adhesive, plasticizer, thermoplastic or thermosetting plastic and functional polymers.
摘要翻译：本发明涉及新的功能性降冰片烷基酯衍生物和/或聚合物组合物，其可通过使适当的二烯和亲双烯体的狄尔斯 - 阿尔德加合物与羧酸反应而容易地获得。特别地，本发明涉及适用于生产涂料，油墨，粘合剂，增塑剂，热塑性或热固性塑料和功能性聚合物的循环化学原料的新方法。

6. 发明申请

WO2023049477A2 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF 审中-公开
公开(公告)号：WO2023049477A2
公开(公告)日：2023-03-30
申请号：PCT/US2022/044767
申请日：2022-09-26
申请人： WAVE LIFE SCIENCES LTD. , ACKER, Christopher Michael , CHIVATAKARN, Onanong , MONIAN, Prashant , SHIVALILA, Chikdu Shakti , MARAPPAN, Subramanian , VARGEESE, Chandra , KANDASAMY, Pachamuthu , LU, Genliang , YU, Hui , BUTLER, David Charles Donnell , APPONI, Luciano Henrique , SHIMIZU, Mamoru , STANDLEY, Stephany Michelle , BOULAY, David John , HOSS, Andrew Guzior , DESAI, Jigar , GODFREY, Jack David , YANG, Hailin , IWAMOTO, Naoki , KUMARASAMY, Jayakanthan , LAMATTINA, Anthony , HARDING, Ian Chandler , TURNER, Jesse
发明人： ACKER, Christopher Michael , CHIVATAKARN, Onanong , MONIAN, Prashant , SHIVALILA, Chikdu Shakti , MARAPPAN, Subramanian , VARGEESE, Chandra , KANDASAMY, Pachamuthu , LU, Genliang , YU, Hui , BUTLER, David Charles Donnell , APPONI, Luciano Henrique , SHIMIZU, Mamoru , STANDLEY, Stephany Michelle , BOULAY, David John , HOSS, Andrew Guzior , DESAI, Jigar , GODFREY, Jack David , YANG, Hailin , IWAMOTO, Naoki , KUMARASAMY, Jayakanthan , LAMATTINA, Anthony , HARDING, Ian Chandler , TURNER, Jesse
IPC分类号： C07H21/02 , A61K31/712
摘要： Among other things, the present disclosure provides oligonucleotides, compositions and methods thereof that can bring about specific editing of a target adenosine in a target RNA molecule. Such oligonucleotides, compositions and methods are useful to treat, prevent, or ameliorate MECP2 associated disorders, diseases and syndromes that can benefit from adenosine modification.

7. 发明申请

WO2022099159A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF 审中-公开
公开(公告)号：WO2022099159A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/058495
申请日：2021-11-08
申请人： WAVE LIFE SCIENCES LTD. , MONIAN, Prashant , SHIVALILA, Chikdu Shakti , MARAPPAN, Subramanian , VARGEESE, Chandra , KANDASAMY, Pachamuthu , LU, Genliang , YU, Hui , BUTLER, David Charles Donnell , APPONI, Luciano Henrique , SHIMIZU, Mamoru , STANDLEY, Stephany Michelle , BOULAY, David John , HOSS, Andrew Guzior , DESAI, Jigar , GODFREY, Jack David , YANG, Hailin , IWAMOTO, Naoki , KUMARASAMY, Jayakanthan , LAMATTINA, Anthony , PU, Tom Liantang
发明人： MONIAN, Prashant , SHIVALILA, Chikdu Shakti , MARAPPAN, Subramanian , VARGEESE, Chandra , KANDASAMY, Pachamuthu , LU, Genliang , YU, Hui , BUTLER, David Charles Donnell , APPONI, Luciano Henrique , SHIMIZU, Mamoru , STANDLEY, Stephany Michelle , BOULAY, David John , HOSS, Andrew Guzior , DESAI, Jigar , GODFREY, Jack David , YANG, Hailin , IWAMOTO, Naoki , KUMARASAMY, Jayakanthan , LAMATTINA, Anthony , PU, Tom Liantang
IPC分类号： C12N15/11 , C12N9/22 , C07H21/02
摘要： Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.

8. 发明申请

WO2014179186A1 ALDOSTERONE SYNTHASE INHIBITORS 审中-公开
公开(公告)号：WO2014179186A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/035596
申请日：2014-04-28
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BALESTRA, Michael , BURKE, Jennifer , CHEN, Zhidong , COGAN, Derek , FADER, Lee , GUO, Xin , MCKIBBEN, Bryan , MARSHALL, Daniel Richard , NEMOTO, Peter Allen , YU, Hui
发明人： BALESTRA, Michael , BURKE, Jennifer , CHEN, Zhidong , COGAN, Derek , FADER, Lee , GUO, Xin , MCKIBBEN, Bryan , MARSHALL, Daniel Richard , NEMOTO, Peter Allen , YU, Hui
IPC分类号： C07D471/04 , A61K31/444 , C07D498/04 , A61P9/00
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I): I and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R3, R4, R5, R 6 , R 7 , W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of a variety of diseases that are mediated or sustained by aldosterone activity, including renal disease, diabetic nephropathy, cardiovascular diseases and fibrotic disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物：I及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，W，Y，本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗由醛固酮活性介导或维持的各种疾病的方法，包括肾脏疾病，糖尿病性肾病，心血管疾病和纤维化疾病，制备这些化合物的方法在这些方法中有用的化合物和中间体。

9. 发明申请

WO2006107923A1 SUBSTITUTED BENZYLIMIDAZOLES USEFUL FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗炎症性疾病的替代苄基咪唑
公开(公告)号：WO2006107923A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/012431
申请日：2006-04-04
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , KIM, Jin, Mi , LEMIEUX, Rene, Marc , MCKIBBEN, Bryan , TSCHANTZ, Matt, Aaron , YU, Hui
发明人： KIM, Jin, Mi , LEMIEUX, Rene, Marc , MCKIBBEN, Bryan , TSCHANTZ, Matt, Aaron , YU, Hui
IPC分类号： C07D401/12 , C07D401/14 , C07D233/54 , C07D233/88 , C07D233/70 , A61K31/415 , A61K31/454 , A61P29/00
CPC分类号： C07D233/64 , C07D233/70 , C07D233/88 , C07D401/12 , C07D401/14
摘要： The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory conditions.
摘要翻译：本发明包括一类式（I）的取代苄基咪唑衍生物及其制备方法。这些化合物可用于治疗炎性病症。

10. 发明申请

WO2021071858A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021071858A1
公开(公告)日：2021-04-15
申请号：PCT/US2020/054436
申请日：2020-10-06
申请人： WAVE LIFE SCIENCES LTD. , MONIAN, Prashant , SHIVALILA, Chikdu Shakti , MARAPPAN, Subramanian , VARGEESE, Chandra , KANDASAMY, Pachamuthu , LU, Genliang , YU, Hui , BUTLER, David Charles Donnell , APPONI, Luciano Henrique , SHIMIZU, Mamoru , STANDLEY, Stephany Michelle , BOULAY, David John , HOSS, Andrew Guzior , DESAI, Jigar , GODFREY, Jack David , YANG, Hailin , IWAMOTO, Naoki
发明人： MONIAN, Prashant , SHIVALILA, Chikdu Shakti , MARAPPAN, Subramanian , VARGEESE, Chandra , KANDASAMY, Pachamuthu , LU, Genliang , YU, Hui , BUTLER, David Charles Donnell , APPONI, Luciano Henrique , SHIMIZU, Mamoru , STANDLEY, Stephany Michelle , BOULAY, David John , HOSS, Andrew Guzior , DESAI, Jigar , GODFREY, Jack David , YANG, Hailin , IWAMOTO, Naoki
IPC分类号： C12N15/11
摘要： Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.

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