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1. 发明申请

WO2016065046A9 TRIPLE TRANSGENIC PIGS SUITABLE FOR XENOGRAFT 审中-公开
标题翻译：适用于异体移植的三联转基因猪
公开(公告)号：WO2016065046A9
公开(公告)日：2017-06-29
申请号：PCT/US2015056730
申请日：2015-10-21
申请人： UNIV INDIANA RES & TECH CORP
发明人： TECTOR III A JOSEPH
IPC分类号： A61K35/12 , A01K67/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2217/15 , A01K2227/108 , A01K2267/025 , A61K35/12 , A61K35/22 , A61K35/407 , C12N2517/02
摘要： The application provides methods of improving a rejection related symptom, reducing premature separation and methods of producing a compound of interest with an altered epitope profile are provided. Knockout pigs with a disrupted gene or genes, and porcine organs, tissues, and cells therefrom are provided.
摘要翻译：本申请提供了改善排斥相关症状，减少过早分离的方法以及产生具有改变的表位谱的感兴趣的化合物的方法。提供具有破坏的基因或基因的敲除猪，以及猪的器官，组织和细胞。

2. 发明申请

WO2016210280A1 TRANSGENIC PIGS WITH GENETIC MODIFICATIONS OF SLA 审中-公开
标题翻译：具有SLA遗传修饰的转基因小鼠
公开(公告)号：WO2016210280A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039279
申请日：2016-06-24
申请人： INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION
发明人： TECTOR III, A., Joseph
IPC分类号： A01K67/027 , A61K35/407 , C12N9/26 , C12N9/40 , C12N15/85 , C12N15/877
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/075 , A01K2227/108 , A01K2267/025 , A61K35/407 , A61K35/44 , C07K14/705 , C12N15/8509 , C12N15/877
摘要： The application provides methods of improving a rejection related symptom, reducing premature separation and methods of producing a compound of interest with an altered epitope profile are provided. Transgenic pigs with a disrupted gene or genes, and porcine organs, tissues, and cells therefrom are provided.
摘要翻译：本申请提供了改进排斥相关症状，减少过早分离的方法和提供具有改变的表位分布的感兴趣的化合物的方法。提供了具有破坏性基因或基因的转基因猪，以及猪器官，组织和细胞。

3. 发明申请

WO2016065046A1 TRIPLE TRANSGENIC PIGS SUITABLE FOR XENOGRAFT 审中-公开
标题翻译：适用于XENOGRAFT的三重转基因小鼠
公开(公告)号：WO2016065046A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/056730
申请日：2015-10-21
申请人： INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION
发明人： TECTOR, Joseph, A.
IPC分类号： A61K35/12 , A01K67/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2217/15 , A01K2227/108 , A01K2267/025 , A61K35/12 , A61K35/22 , A61K35/407 , C12N2517/02
摘要： [0146] The application provides methods of improving a rejection related symptom, reducing premature separation and methods of producing a compound of interest with an altered epitope profile are provided. Knockout pigs with a disrupted gene or genes, and porcine organs, tissues, and cells therefrom are provided.
摘要翻译：本申请提供了改进排斥相关症状，减少过早分离的方法和提供具有改变的表位图谱的感兴趣的化合物的方法。提供具有破坏性基因或基因的敲除猪，以及猪器官，组织和细胞。

4. 发明申请

WO2015066768A1 COMPOSITIONS AND METHODS FOR PRODUCING GENETICALLY MODIFIED ANIMALS 审中-公开
标题翻译：用于生产基因改良动物的组合物和方法
公开(公告)号：WO2015066768A1
公开(公告)日：2015-05-14
申请号：PCT/AU2014/050339
申请日：2014-11-07
申请人： OZGENE HOLDINGS PTY LTD
发明人： KOENTGEN, Frank
IPC分类号： C12N15/877 , C12N5/10 , A01K67/027
CPC分类号： A01K67/0276 , A01K67/0271 , A01K2207/12 , A01K2217/075 , A01K2227/105 , A01K2267/025 , C12N5/0606 , C12N15/8509 , C12N2510/00 , C12N2800/30
摘要： Methods, compositions and non-human animals and parts thereof are disclosed for improving germ line transmission of genetic modifications. More particular, the present invention discloses methods and compositions for producing non-human embryos with a disrupted or disruptable fertility gene, which can be used as hosts for the development of donor pluripotent cells, including genetically modified donor pluripotent cells, into germ cells and gametes. Also disclosed are methods and compositions for producing from such embryos chimeric non-human animals with a disrupted fertility gene and for breeding the chimeric non-human animals with cognate non-human animals that comprise a fertility gene that lacks a disruption to produce non-human animals having substantially all gametes and/or germ cells derived from the donor pluripotent cells. The present invention also discloses non-human gametes, germ cells, embryos and animals for use in the subject methods.
摘要翻译：公开了用于改善遗传修饰的种系传播的方法，组合物和非人动物及其部分。更具体地，本发明公开了用于产生具有破坏或破坏性生育基因的非人胚胎的方法和组合物，其可以用作供体多能细胞（包括遗传修饰的供体多能细胞）发育成生殖细胞和配子的宿主。还公开了用于从具有破坏的生殖力基因的这种胚胎嵌合非人动物中产生的方法和组合物，并且用包含缺乏破坏以产生非人类的生育基因的同源非人动物来繁殖嵌合非人动物具有基本上所有来自供体多能细胞的配子和/或生殖细胞的动物。本发明还公开了用于本发明方法的非人配子，生殖细胞，胚胎和动物。

5. 发明申请

WO2013057164A1 PRODUCTION OF A HUMAN BETA CELL LINE FROM AN EARLY POST NATAL PANCREAS 审中-公开
标题翻译：从早期的NATO PANCREAS生产人类细胞系
公开(公告)号：WO2013057164A1
公开(公告)日：2013-04-25
申请号：PCT/EP2012/070612
申请日：2012-10-18
申请人： SARL ENDOCELLS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： CZERNICHOW, Paul , RAVASSARD, Philippe , SCHARFMANN, Raphael
IPC分类号： C12N5/10 , A01K67/027 , C12N5/071
CPC分类号： C12N5/0676 , A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/025 , A01K2267/0362 , C12N5/0677 , C12N5/0693 , C12N2501/33 , C12N2501/734 , C12N2503/00 , C12N2510/04 , G01N33/5023 , G01N33/56966
摘要： The present invention relates to a method for preparing commercial scale quantities of human functional beta cells and to the establishment of cell lines from non- foetal pancreatic tissues. It also relates to a method of diagnosis using beta cell tumors or cells derived thereof. The method comprises sub-transplantation procedure to enrich the graft in proliferating beta cells, allowing to generate human Beta cell lines. Such lines express, produce and secrete insulin upon glucose stimulation. They have a gene expression profile that resembles to adult beta cells. In addition, the human beta cell lines are able to normalize glycemia of diabetic mice when transplanted, demonstrating their insulin secretion capabilities.
摘要翻译：本发明涉及一种制备商业规模量的人功能性β细胞的方法以及从非胎儿胰腺组织建立细胞系的方法。它还涉及使用β细胞肿瘤或其衍生细胞的诊断方法。该方法包括亚细胞移植过程，以在增殖的β细胞中富集移植物，允许产生人β细胞系。这样的线在葡萄糖刺激时表达，产生和分泌胰岛素。它们具有类似于成体β细胞的基因表达谱。此外，人类β细胞系能够在移植时使糖尿病小鼠的血糖正常化，从而证明其胰岛素分泌能力。

6. 发明申请

WO2011139488A3 METHODS AND MATERIALS FOR REDUCING CARDIAC XENOGRAFT REJECTION 审中-公开
标题翻译：减少心脏XENOGRAFT抑制剂的方法和材料
公开(公告)号：WO2011139488A3
公开(公告)日：2012-02-23
申请号：PCT/US2011031976
申请日：2011-04-11
申请人： MAYO FOUNDATION , MCGREGOR CHRISTOPHER G A , BYRNE GUERARD W
发明人： MCGREGOR CHRISTOPHER G A , BYRNE GUERARD W
IPC分类号： A01K67/027 , A61F2/02 , A61K38/17 , A61P37/06
CPC分类号： A61K39/001 , A01K67/0276 , A01K2207/30 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A61K35/34 , A61K38/00 , C12N15/8509
摘要： This document provides methods and materials involved in reducing cardiac xenograft rejection. For example, methods and materials for preparing transgenic pigs expressing reduced or no endogenous Sda or SDa-like glycans derived from the porcine ß1,4 N-acetyl-galactosaminyl transferase 2 (B4GALNT2) glycosyltransferase and/or reduced or no endogenous a-Gal antigens, methods and materials for modifying the xenograft recipient's immunological response to non-Gal antigens (e.g. CD46, CD59, CD9, PROCR, and ANXA2) to reduce cardiac xenograft rejection, and methods and materials for monitoring the progress of xenotransplant immunologic rejection are provided.
摘要翻译：本文档提供了减少心脏异种移植排斥反应的方法和材料。例如，用于制备表达来源于猪β1,4N-乙酰半乳糖胺基转移酶2（B4GALNT2）糖基转移酶和/或还原或没有内源性α-Gal抗原的内源性Sda或SDa样聚糖的转基因猪的方法和材料提供了用于修饰异种移植受体对非Gal抗原（例如CD46，CD59，CD9，PROCR和ANXA2）的免疫应答以减少心脏异种移植物排斥的方法和材料，以及用于监测异种移植免疫排斥进展的方法和材料。

7. 发明申请

WO2011111588A1 METHOD OF INDUCING THE DIFFERENTIATION OF GERMLINE STEM CELLS, METHOD OF EXPANDING THE CELLS, AND CULTURE MEDIA THEREFOR 审中-公开
标题翻译：诱导GERMLINE干细胞分化的方法，扩增细胞的方法及其培养基
公开(公告)号：WO2011111588A1
公开(公告)日：2011-09-15
申请号：PCT/JP2011/054828
申请日：2011-02-24
申请人： Kyoto University , YAMANAKA, Shinya , NOCE, Toshiaki , IMAMURA, Masanori
发明人： YAMANAKA, Shinya , NOCE, Toshiaki , IMAMURA, Masanori
IPC分类号： C12N5/00 , A01K67/027 , A61K35/48 , A61P15/08 , C07K14/47 , C07K14/475 , C07K14/485 , C07K14/51 , C12N5/0735
CPC分类号： C12N5/0611 , A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A61K35/12 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/125 , C12N2501/13 , C12N2501/155 , C12N2502/99 , C12N2506/45
摘要： Provided are a method of inducing the differentiation of germline stem cells possessing the capabilities of self-regeneration and spermiogenesis from pluripotent stem cells such as iPS cells, a method of maintaining and expanding the germline stem cells, and culture media therefor. Specifically provided are a method of producing Oct4-positive Vasa-positive germline stem cells (GR cells), comprising culturing pluripotent stem cells in the presence of (a) bone morphogenetic protein 4 (BMP4) and (b) one or more growth factors selected from among glial cell-derived neurotrophic factor (GDNF), epithelial cell growth factor (EGF) and stem cell factor (SCF), and a method of expanding GR cells, comprising culturing GR cells in the presence of GDNF, EGF, SCF and basic fibroblast growth factor (bFGF).
摘要翻译：本发明提供诱导具有自身再生和精子发生能力的种系干细胞分化的方法，所述多能干细胞如iPS细胞，维持和扩大种系干细胞的方法及其培养基。具体提供的是产生Oct4阳性Vasa阳性生殖系干细胞（GR细胞）的方法，包括在（a）骨形态发生蛋白4（BMP4）和（b）选择的一种或多种生长因子存在下培养多能干细胞来自神经胶质细胞衍生的神经营养因子（GDNF），上皮细胞生长因子（EGF）和干细胞因子（SCF），以及扩增GR细胞的方法，包括在存在GDNF，EGF，SCF和碱性成纤维细胞生长因子（bFGF）。

8. 发明申请

WO2007035213A3 TRANSGENIC UNGULATES EXPRESSING CTLA4-IG AND USES THEREOF 审中-公开
标题翻译：表达CTLA4-IG的转基因载体及其用途
公开(公告)号：WO2007035213A3
公开(公告)日：2007-10-11
申请号：PCT/US2006030842
申请日：2006-08-09
申请人： REVIVICOR INC , AYARES DAVID LEE , COOPER DAVID K C
发明人： AYARES DAVID LEE , COOPER DAVID K C
IPC分类号： C12N5/08 , A01N63/00
CPC分类号： A61K38/1774 , A01K2217/05 , A01K2227/108 , A01K2267/02 , A01K2267/025 , C07K14/70521 , C07K2319/30 , C12N15/85 , C12N15/8509 , C12N2830/008
摘要： The present invention provides ungulates, including pigs, expressing CTLA4-Ig, as well as tissue, organs, cells and cell lines derived from such animals. Such animals, tissues, organs and cells can be used in research and medical therapy, including xenotransplanation. In addition, methods are provided to prepare organs, tissues and cells expressing the CTLA4-Ig for use in xenotransplantation, and nucleic acid constructs and vectors useful therein.
摘要翻译：本发明提供了包括猪，表达CTLA4-Ig以及来自这些动物的组织，器官，细胞和细胞系的有蹄类动物。这些动物，组织，器官和细胞可用于研究和药物治疗，包括异种移植。此外，提供了用于制备用于异种移植的表达CTLA4-Ig的器官，组织和细胞的方法，以及用于其中的核酸构建体和载体。

9. 发明申请

WO2006036975A2 METHODS OF EMBRYO TRANSFER 审中-公开
标题翻译：胚胎转移方法
公开(公告)号：WO2006036975A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034641
申请日：2005-09-28
申请人： VIAGEN, INC. , DAVIS, Scott, K. , WALKER, Shawn , POLEJAEVA, Irina
发明人： DAVIS, Scott, K. , WALKER, Shawn , POLEJAEVA, Irina
IPC分类号： A01K67/027
CPC分类号： A01K67/0273 , A01K2227/108 , A01K2267/02 , A01K2267/025 , C12N15/8778
摘要： Methods for the efficient production of cloned porcine fetuses/piglets following the production of cloned embryos, including culture of the embryos for extended periods prior to transfer of the embryos into the uterus of the recipient. Transfer can be accomplished surgically or through less-invasive laparoscopic or non-surgical transfer.
摘要翻译：在克隆胚胎生产之后有效生产克隆的猪胎儿/仔猪的方法，包括在将胚胎转移到接受者的子宫之前将胚胎长时间培养。转移可以通过手术或通过较少侵入性的腹腔镜或非手术转移来完成。

10. 发明申请

WO2005030928A2 PORCINE INVARIANT CHAIN PROTEIN, FULL LENGTH cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION 审中-公开
标题翻译： PORCINE INVARIAIN CHAIN蛋白，全长cDNA，基因组织和调控区
公开(公告)号：WO2005030928A2
公开(公告)日：2005-04-07
申请号：PCT/US2004/031154
申请日：2004-09-23
申请人： KOIKE, Chihiro
发明人： KOIKE, Chihiro
IPC分类号： C12N
CPC分类号： C07K14/70503 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , C07K14/70539 , C12N15/8509
摘要： The present invention provides the complete porcine invariant chain protein, full length cDNA, genomic organization, and regulatory region. Methods are provided to prepare organs, tissues, cells and animals lacking the porcine invariant chain gene for use in xenotransplantation.
摘要翻译：本发明提供了完整的猪不变链链蛋白，全长cDNA，基因组组织和调节区。提供了用于准备用于异种移植的缺乏猪不变链基因的器官，组织，细胞和动物的方法。

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