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    • 5. 发明申请
    • BIOCIDAL COMPOSITIONS AND METHODS OF USING THE SAME
    • 生物组合物及其使用方法
    • WO2013086181A1
    • 2013-06-13
    • PCT/US2012/068231
    • 2012-12-06
    • ROCHAL INDUSTRIES, LLP
    • SALAMONE, Joseph, C.SALAMONE, Ann, Beal
    • A61K31/155A61K31/045A61K31/74A61P31/02
    • A01N47/44A61K31/155Y02A50/473A01N31/02A01N37/12
    • An antimicrobial composition with synergistic biocidal activity is described which comprises at least one antimicrobial polymeric biguanide and at least one antimicrobial vicinal diol, said vicinal diol comprises at least one monoalkyl glycol, monoalkyl glycerol, or monoacyl glycerol, to diminish or eliminate biofilm communities. Such synergistic interaction is effective in wound treatment, particularly for chronic wounds, burns and battlefield-induced wounds, as well as for disinfecting non-biological surfaces. The antimicrobial composition can also be prepared as viscous solutions or as gels. The antimicrobial composition may be added to a substrate and dried, such as to a catheter, or to a foam, or to a fiber wound dressing, or coated as a viscous solution or gel upon such devices, to provide controlled release antimicrobial activity.
    • 描述了具有协同杀生物活性的抗微生物组合物,其包含至少一种抗微生物聚合双胍和至少一种抗微生物连位二醇,所述连位二醇包含至少一种单烷基二醇,单烷基甘油或单酰基甘油,以减少或消除生物膜群落。 这种协同相互作用在伤口治疗中是有效的,特别是对于慢性伤口,烧伤和战场引起的伤口以及用于消毒非生物表面。 抗微生物组合物也可以制备成粘稠溶液或凝胶。 可以将抗微生物组合物加入到基质中并干燥,例如导管,或泡沫,或纤维伤口敷料,或在这些装置上作为粘性溶液或凝胶涂覆,以提供受控释放的抗微生物活性。