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    • 1. 发明申请
    • IMPROVEMENTS IN PARASITE TREATMENTS
    • 在寄生虫治疗中的改进
    • WO2018038623A1
    • 2018-03-01
    • PCT/NZ2017/050111
    • 2017-08-17
    • DONAGHYS LIMITED
    • YERITSYAN, Karen
    • A61K31/429A61P3/10A61K31/365A01N43/90A01N43/74
    • A01N43/74A01N43/90A61K31/365A61K31/4184A61K31/429A61K31/7048A61P3/10A01N53/00A01N59/02A61K2300/00
    • Described herein are formulations and methods of manufacture providing levamisole in a salt form with an additional anthelmintic having a different class of activity. The formulation uses a multi- solvent system to produce a topically applied formulation with all compounds in solution. In one aspect a formulation is described comprising in solution a mixture of a therapeutically effective amount of levamisole salt dissolved in at least one inorganic solvent; and a therapeutically effective amount of at least one additional anthelmintic compound with a different class of activity to levamisole, the at least one additional anthelmintic compound being substantially lipophilic and being dissolved in at least one organic solvent. A related veterinary medicament and method of treatment of parasites are also described.
    • 本文描述了制备方法和制备方法,提供盐形式的左旋咪唑与具有不同类别活性的另外的驱虫药。 该配方使用多溶剂体系来生产溶液中所有化合物的局部应用配方。 一方面,描述了一种制剂,其包含在溶液中的治疗有效量的溶解在至少一种无机溶剂中的左旋咪唑盐的混合物; 和治疗有效量的至少一种具有与左旋咪唑不同类别活性的另外的驱蠕虫化合物,所述至少一种另外的驱蠕虫化合物基本上是亲脂性的并且溶解在至少一种有机溶剂中。 还描述了一种相关的兽医药物和治疗寄生虫的方法。