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1. 发明申请

WO2019152691A1 WOVEN GRAFT COMPOSITE WITH VARIED DENSITY 审中-公开
公开(公告)号：WO2019152691A1
公开(公告)日：2019-08-08
申请号：PCT/US2019/016118
申请日：2019-01-31
申请人： THE SECANT GROUP, LLC
发明人： WINNER, Seth A. , WEBER, Amanda , METZGER, Andrew , REED, Stephanie , SMOOT, Carissa
IPC分类号： D03D1/00 , A61F2/00
CPC分类号： A61F2/07 , A61F2/0077 , A61F2/06 , A61F2002/072 , A61F2240/001 , A61F2250/0017 , A61F2250/0023 , D03D1/00 , D10B2509/06
摘要： The disclosure describes textiles for endovascular and other medical applications having a low-profile and varying density. The textiles are woven and are formed of a uniform or non-uniform weaving pattern. The resulting textiles have a low profile and areas of targeted density to enhance ingrowth of regenerative tissue.

2. 发明申请

WO2019043721A1 SCAFFOLD GRAFT AND METHOD OF MANUFACTURING THEREOF 审中-公开
公开(公告)号：WO2019043721A1
公开(公告)日：2019-03-07
申请号：PCT/IN2017/050476
申请日：2017-10-17
申请人： MERIL LIFE SCIENCES PVT LTD
发明人： KOTHWALA, Deveshkumar Mahendralal , VYAS, Rajnikant Gandalal , MINOCHA, Pramodkumar
IPC分类号： A61F2/07 , A61F2/88
CPC分类号： A61F2/915 , A61F2/07 , A61F2002/91558 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L2/0035 , A61L2/007 , A61L2202/21
摘要： A scaffold graft used for treatment of treatment of arterial perforations and/or condition of aneurysm. The scaffold may be made of a biodegradable material. The scaffold is coated with a biodegradable layer of polymer on an outer surface. The biodegradable scaffold is made of poly- L-lactic acid (PLLA). The biodegradable graft may be made of poly-L-lactide-co-caprolactone (PLCL), polycaprolactone (PCL), poly-dl-lactic acid, (PDLLA), polyglycerol sebacate (PGS), Poly L- lactide (PLLA), Poly(glycolic acid) (PGA), Poly L-lactide co-glycolic acid (PLGA) or a mixture thereof. Additionally, the scaffold graft is coated with an antiproliferative drug formulation.

3. 发明申请

WO2019042202A1 覆膜支架审中-公开
公开(公告)号：WO2019042202A1
公开(公告)日：2019-03-07
申请号：PCT/CN2018/101759
申请日：2018-08-22
申请人：先健科技(深圳)有限公司
发明人：肖本好 , 王逸斐
IPC分类号： A61F2/07 , A61F2/90 , A61F2/966
CPC分类号： A61F2/07 , A61F2/90 , A61F2/966
摘要：一种覆膜支架，包括裸支架及与所述裸支架连接的覆膜，所述覆膜包括第一膜片及与所述第一膜片贴合的第二膜片，所述裸支架包括多个沿轴向分布的波圈，所述波圈包括多个波峰、多个波谷及连接相邻所述波峰及所述波谷的多个杆体，所述第二膜片覆盖至少一所述杆体，并裸露出所述波峰及所述波谷，且所述第二膜片在被覆盖的所述杆体位置处的延伸方向与所述覆膜支架的轴向方向之间的夹角不大于75°。

4. 发明申请

WO2018209259A1 INTRAVASCULAR RETRIEVABLE CELL DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2018209259A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/032354
申请日：2018-05-11
申请人： NORTHWESTERN UNIVERSITY
发明人： AMEER, Guillermo, A. , PUGLISI, Paul, D.
IPC分类号： A61F2/02 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2/82 , A61L27/00
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/07 , A61F2250/0039 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/52 , A61L27/54 , A61L2300/64 , A61L2400/06 , C12N5/0677
摘要： Provided herein are intravascular retrievable cell delivery systems and methods of use thereof for cell transplantation.

5. 发明申请

WO2018200972A1 COMPLIANT AORTIC STENT GRAFTS AND RELATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2018200972A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/029820
申请日：2018-04-27
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： FAIZER, Rumi , BAROCAS, Victor , COLETTI, Filippo , KIZILSKI, Shannen, B. , DATTA, Ankurita , AMILI, Omid
IPC分类号： A61F2/02 , A61F2/06 , A61F2/07 , A61F2/82
CPC分类号： A61F2/07 , A61F2002/077 , A61F2250/0003
摘要： A vascular implant for an endoluminal stent or blood vessel, the stent or blood vessel defining a lumen for the passage of blood. The liner can comprise a flexible bladder arrangeable within the lumen, which can be fillable with a compressible fluid. The liner can define an inner lumen for the passage of blood. The liner and the fluid are conformable in response to a pulsatile pressure wave of the blood in the blood vessel such that the pressure within the blood vessel is reduced.

6. 发明申请

WO2018036434A1 一种植入式完全生物可吸收血管聚合物支架审中-公开
公开(公告)号：WO2018036434A1
公开(公告)日：2018-03-01
申请号：PCT/CN2017/098108
申请日：2017-08-18
申请人：深圳市信立泰生物医疗工程有限公司
发明人：陈泳 , 胡晓露 , 高康荣 , 申峰
IPC分类号： A61F2/07 , A61F2/915 , A61F2/89
CPC分类号： A61F2/07 , A61F2/89 , A61F2/915
摘要：一种植入式完全生物可吸收血管聚合物支架，包括五个以上的环状波形支撑杆（1），以及间隔连接于该支撑杆（1）之间的连接杆（2），该支撑杆（1）由类"Ω"形波（3）和类"m"形波（4）交替连接而成，其中，类"Ω"形波（3）和类"m"形波（4）分别由两组正"s"和倒"s"连接构成，相邻两个支撑杆（1）之间的连接是由连接杆（2）在类"Ω"形波（3）顶和类"m"形波（4）底连接起来。该支架兼顾了径向支撑力、壁厚与柔顺性，拥有良好的通过性能，也能在损伤愈合的特定时间内给予病变段足够的机械支撑，并且在损伤愈合后逐步被机体吸收，内皮化良好，有效地降低支架再狭窄率和晚期支架内血栓的风险。

7. 发明申请

WO2017200866A1 APPARATUS FOR BLOCKING BLOODFLOW THROUGH A DISSECTED AORTA 审中-公开
标题翻译：通过被隔离的AORTA阻止血流的装置
公开(公告)号：WO2017200866A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/032377
申请日：2017-05-12
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： ROSELLI, Eric E.
IPC分类号： A61B17/12
CPC分类号： A61B17/12109 , A61B17/12036 , A61B17/12136 , A61B17/12172 , A61B17/12177 , A61B2017/00597 , A61B2017/00867 , A61B2017/00893 , A61B2017/1205 , A61F2/07 , A61F2210/0014
摘要： An implantable expandable device includes an occluding surface oriented substantially in a transverse plane. The occluding surface is bounded by a lateral occluding surface edge and a medial occluding surface edge. The occluding surface has an occluding surface body located transversely between the lateral and medial occluding surface edges. A supporting structure is located entirely inferiorly to the occluding surface. The supporting surface includes a plurality of struts extending substantially in the superior-inferior direction. At least a first one of the struts is a full-height strut and spans substantially a full superior-inferior height of the device. At least a second one of the struts is a reduced-height strut and spans substantially less than a full superior-inferior height of the device. The occluding surface substantially occludes a transverse cross-section of the false lumen to substantially block bloodflow in the superior-inferior direction within the false lumen.
摘要翻译：可植入式可扩张装置包括基本上在横向平面中定向的闭塞表面。闭塞表面由外侧闭塞表面边缘和内侧闭塞表面边缘界定。闭塞表面具有在横向和内侧闭塞表面边缘之间横向定位的闭塞表面体。支撑结构完全位于闭塞表面的下方。支撑表面包括基本沿上下方向延伸的多个支柱。至少第一个支柱是全高支柱并基本上跨越该装置的完全上 - 下高度。支柱中的至少第二个支柱是高度减小的支柱并且跨越该设备的完全上 - 下高度的实质上小于该高度。闭塞表面基本上闭塞了假腔的横截面，以基本上阻止假腔内上下方向的血液流动。

8. 发明申请

WO2017165833A1 THIN WALL CONSTRUCTIONS FOR VASCULAR FLOW DIVERSION 审中-公开
标题翻译：薄壁结构用于血管分流
公开(公告)号：WO2017165833A1
公开(公告)日：2017-09-28
申请号：PCT/US2017/024119
申请日：2017-03-24
申请人： COVIDIEN LP
发明人： CHOUBEY, Animesh
IPC分类号： A61F2/07 , A61F2/92 , A61F2/82 , A61F2/91
CPC分类号： A61B17/12172 , A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12113 , A61B17/12118 , A61B2017/00592 , A61F2/07 , A61F2/91 , A61F2/92 , A61F2002/823
摘要： Devices that can be delivered into a vascular system to divert flow are disclosed herein. According to some embodiments, devices are provided for treating aneurysms by diverting flow. A flow-diverting device can comprise, for example, a frame and mesh immovably attached to and extending over a portion of the frame. The mesh can include a plurality of pores that are sized to inhibit the flow of blood through the frame into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the device is positioned in a blood vessel and adjacent to the aneurysm.
摘要翻译：本文公开了可被递送到血管系统中以转移血流的装置。根据一些实施例，提供了用于通过转向流动来治疗动脉瘤的装置。流动转向装置可以包括例如框架和不可移动地连接到框架的一部分上并在其上延伸的网。所述网状物可以包括多个孔，所述孔的大小被设定为当装置位于血管中并且与动脉瘤相邻时，所述孔的大小被设置成抑制血液通过框架流入动脉瘤至足以导致血栓形成和动脉瘤愈合的程度

9. 发明申请

WO2017139545A1 STENT GRAFT WITH EXTERNAL SCAFFOLDING AND METHOD 审中-公开
标题翻译：带外部支架和方法的支架移植
公开(公告)号：WO2017139545A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/017327
申请日：2017-02-10
申请人： MEDTRONIC VASCULAR INC.
发明人： PERKINS, Keith , ARGENTINE, Jeffery , PETRUSKA, Matt , ROBAINA, Samuel , GALLIGAN, Darren , RADHAKRISHNAN, Rajesh
IPC分类号： A61F2/07 , A61F2/00
CPC分类号： A61F2/07 , A61F2/0077 , A61F2002/065 , A61F2002/068 , A61F2002/075 , A61F2002/077 , A61F2210/0061 , A61F2230/0065 , A61F2250/0051 , A61F2250/0056 , A61F2310/00023
摘要： A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.
摘要翻译：脚手架支架移植物包括具有内表面和外表面的移植物材料。内表面限定移植物材料内的内腔。脚手架覆膜支架还包括支架，该支架包括在外表面处与移植物材料偶联的网。支架构造成促进其中的组织向内生长。以这种方式，支架增强组织整合到脚手架支架 - 移植物中。组织整合增强了支架支架移植物在血管中的生物固定，从而最大限度地减少了内漏和迁移的可能性。

10. 发明申请

WO2017081679A1 STENT-GRAFTS SYSTEMS WITH SKIRT 审中-公开
标题翻译：带裙边的扶手系统
公开(公告)号：WO2017081679A1
公开(公告)日：2017-05-18
申请号：PCT/IL2016/051207
申请日：2016-11-09
申请人： ENDOSPAN LTD.
发明人： ZIGELBOIM, Or , MARMUR, Yaniv , SHALEV, Alon
IPC分类号： A61F2/07 , A61F2/962 , A61F2/06
CPC分类号： A61F2/07 , A61F2/962 , A61F2002/061 , A61F2002/075 , A61F2002/077 , A61F2230/0093 , A61F2250/0039
摘要： An endovascular prosthesis (200) includes a stent-graft (240) and an external coagulation inducer (750). The stent-graft (240) includes a first portion (734A) of structural strut members (730) and a first portion (736A) of a graft member (732), which, when the endovascular prosthesis (200) is unconstrained in a radially-expanded state, together are shaped so as to define a blood-carrying tubular structure defining a lumen. The external coagulation inducer (750) includes an extra-luminal skirt (760), which includes a second portion (734B) of the structural strut members (730) and a second portion (736B) of the graft member (732), and is configured to assume: (i) when the endovascular prosthesis (200) is removably disposed in a delivery sheath, a radially- compressed delivery state, in which the structural strut members (730) of the first portion (734A) do not coincide with the structural stent members (730) of the second portion (734B), and (ii) when the endovascular prosthesis (200) is unconstrained, a radially- expanded state, in which the extra-luminal skirt extends (760) radially outward from an external surface (252) of the stent-graft (240).
摘要翻译：血管内假体（200）包括支架移植物（240）和外部凝血诱导物（750）。支架移植物（240）包括结构支柱构件（730）的第一部分（734A）和移植物构件（732）的第一部分（736A），当血管内假体（200）不径向约束时膨胀状态一起成形为限定限定内腔的携血管状结构。外部凝血诱导器750包括包括结构支柱构件730的第二部分734B和移植构件732的第二部分736B的外腔裙部760，被构造成假设：（i）当血管内假体（200）被可移除地设置在输送护套中时，径向压缩输送状态，其中第一部分（734A）的结构支柱构件（730）不与当所述血管内假体（200）不受约束时，所述第二部分（734B）的结构支架构件（730）和所述血管外假体（200）不受约束的径向扩张状态（其中所述腔外裙部从外部支架移植物（240）的表面（252）。

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