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1. 发明申请

WO2019157156A1 MEDICAL DEVICE DELIVERY SYSTEM WITH ALIGNMENT FEATURE 审中-公开
公开(公告)号：WO2019157156A1
公开(公告)日：2019-08-15
申请号：PCT/US2019/017015
申请日：2019-02-07
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： FITTERER, Mimi Trinh , INO, Takashi H. , ESCALONA, Floriza Q. , ZUNIGA, Leticia Marquez
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B2017/00243 , A61B2017/00867 , A61B2017/0088 , A61F2/2412 , A61F2/2436 , A61F2/2439 , A61F2230/0091
摘要： A delivery system for delivering an implantable heart valve includes an outer shaft and an inner shaft that is slidingly disposable within an outer shaft lumen, the inner shaft including a distal end region. A plurality of fingers extend distally relative to the distal end region of the inner shaft and are adapted to releasably engage an implantable heart valve. A plurality of looped sheathing aids extend distally from the distal region of an inner shaft lumen and are adapted to guide the implantable heart valve back into the outer shaft lumen when the implantable heart valve is pulled back into the outer shaft lumen. Each of the plurality of looped sheathing aids include a distal petal adapted to engage tissue adjacent a native valve annulus in order to limit distal advancement of the implantable heart valve during deployment of the implantable heart valve.

2. 发明申请

WO2019154927A1 A HEART VALVE THERAPEUTIC DEVICE 审中-公开
公开(公告)号：WO2019154927A1
公开(公告)日：2019-08-15
申请号：PCT/EP2019/053038
申请日：2019-02-07
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
发明人： HENEGHAN, Paul , MURPHY, Bruce , O'KEEFFE, Lucy , QUINN, Martin , QUINN, Conor
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2466
摘要： A heart valve therapeutic device (1) comprises a coaptation assist valve (20) comprising a conduit (2) with an outer surface (3) for coaption with the native leaflets, and a prosthetic flow valve (5) mounted within the conduit (2) to allow one-way flow through the conduit (2). Support for the coaptation assist valve (20) is provided by a support (10) for positioning the conduit (2) across the native leaflets, and connectors (15) attaching the conduit (2) to the support (10).

3. 发明申请

WO2019129636A1 MEDICAL IMPLANT PREFORM PRODUCED USING AN INSIDE OUT FLIPPING METHOD 审中-公开
公开(公告)号：WO2019129636A1
公开(公告)日：2019-07-04
申请号：PCT/EP2018/086166
申请日：2018-12-20
申请人： XELTIS, BV
发明人： MIEDEMA, Jurgen , COX, Martijn Antonius Johannes , NAZ, Christophe Pierre Edouard
IPC分类号： D01D5/00 , A61F2/24
CPC分类号： D01D5/0076 , A61F2/06 , A61F2/2412 , A61F2/2415 , D01D5/0007
摘要： A method of making a medical implant is provided by electrospinning a polymer solution to form a preform around a mandrel. The formed preform distinguishes an inner surface and an outer surface. The formed preform is removed from the mandrel and flipped inside-out resulting in the inner surface of the formed preform becoming the outer surface of the inside-out flipped preform, and the outer surface of the formed preform becoming the inner surface of the inside- out flipped preform. At least part of the inside-out flipped preform forms the medical implant such as e.g. an artificial heart valve, an artificial leaflet, an artificial graft, or an artificial vessel. The products made according to the method of this invention greatly improve the performance and durability of the medical implant.

4. 发明申请

WO2019094342A1 SEGMENTED, GROWTH-ACCOMMODATING, ARTIFICIAL VALVE 审中-公开
公开(公告)号：WO2019094342A1
公开(公告)日：2019-05-16
申请号：PCT/US2018/059281
申请日：2018-11-05
申请人： THE CHARLES STARK DRAPER LABORATORY, INC.
发明人： CARR, Jesse M. , WILLIAMS, Corin
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2250/001 , A61F2250/0082
摘要： According to various aspects and embodiments, a prosthetic valve assembly for controlling fluid flow in an annulus is provided. The prosthetic valve assembly includes a suture ring formed from two or more segments, where each segment is configured to attach to the annulus, and a leaflet subassembly that attaches to an inner portion of at least one segment of the suture ring. The leaflet subassembly includes at least one leaflet configured for controlling a flow of fluid through the prosthetic valve assembly.

5. 发明申请

WO2017201082A1 THIN-FILM TRANSCATHETER HEART VALVE 审中-公开
标题翻译：薄膜传感器心脏瓣膜
公开(公告)号：WO2017201082A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/032958
申请日：2017-05-16
申请人： NSVASCULAR, INC.
发明人： KEALEY, Colin , GUPTA, Vikas , COOK, Ian
IPC分类号： A61F2/00 , A61F2/02 , A61F2/07 , A61F2/24 , A61F2/82 , A61L27/00
CPC分类号： A61F2/2415 , A61F2/2412 , A61L27/06 , A61L27/3604 , A61L27/507
摘要： A thin-film transcatheter heart valve includes a stent support structure extending along a longitudinal axis and having a circular cross-section and a fenestrated thin-film mesh cover having a circular cross-section and attached to the stent support structure. The thin-film transcatheter heart valve may further include a bioprosthetic valve and/or a polymer outer covering. The fenestrated thin-film mesh cover may be formed by deep reactive ion etching a pattern of grooves on a surface of a substrate, the grooves corresponding to fenestrations in a desired Nitinol structure, depositing a lift-off layer on the grooved substrate surface, depositing a first Nitinol layer over the lift-off layer, lifting off the fenestrated thin-film sheet by etching, wherein the etching removes the lift-off layer, and expanding the fenestrated thin-film sheet to expand the fenestrations.
摘要翻译：薄膜经导管心脏瓣膜包括沿着纵向轴线延伸并具有圆形横截面的支架支撑结构以及具有圆形横截面并且附接到该孔的开窗薄膜网罩，支架支撑结构。薄膜经导管心脏瓣膜可进一步包括生物人造瓣膜和/或聚合物外覆层。有孔薄膜网罩可以通过深反应离子蚀刻在衬底表面上的凹槽图案来形成，所述凹槽对应于期望的镍钛诺结构中的窗孔，在带槽衬底表面上沉积剥离层，沉积在剥离层上方的第一镍钛诺层，通过蚀刻剥离开窗薄膜片，其中蚀刻除去剥离层，并且扩张开窗薄膜片以扩展开窗。

6. 发明申请

WO2017151292A1 TRANSCATHETER CORONARY SINUS MITRAL VALVE ANNULOPLASTY PROCEDURE AND CORONARY ARTERY AND MYOCARDIAL PROTECTION DEVICE 审中-公开
标题翻译：经导管冠状动脉鼻窦二尖瓣全长瓣膜置换术及冠状动脉和心肌保护装置
公开(公告)号：WO2017151292A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/017367
申请日：2017-02-10
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： KIM, June-Hong , LEDERMAN, Robert, J. , KOCATURK, Ozgur
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/2412 , A61F2250/006
摘要： Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. A protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.
摘要翻译：公开了用于治疗或修复诸如二尖瓣的反流心脏瓣膜的装置和方法。可以在冠状窦中放置瓣环成形术装置以重塑二尖瓣并减少二尖瓣反流。可以在瓣环成形术装置和下面的冠状动脉之间放置保护装置，以抑制冠状窦中的瓣环成形术装置压缩下面的冠状动脉。此外，保护装置可以抑制冠状动脉从心脏内部的压缩，例如从向冠状动脉施加径向外部压力的假体二尖瓣的压缩。瓣环成形术装置还可以形成突出到天然二尖瓣区域中的人造内脊或保持特征以帮助固定假体二尖瓣。

7. 发明申请

WO2017120351A3 BIOROSTHETIC TISSUE REPAIR AND REINFORCEMENT 审中-公开
标题翻译：生物组织修复与增强
公开(公告)号：WO2017120351A3
公开(公告)日：2017-08-17
申请号：PCT/US2017012354
申请日：2017-01-05
申请人： MEDTRONIC VASCULAR INC
发明人： TIEN TRACEY , EBERHARDT CAROL , GARDE KSHITIJA , WONG BENJAMIN , WANG WEI , HOWARD ELLIOT , MCLINLEY LAURA , OLNEY KARL , WINTERS TAYLOR
IPC分类号： A61F2/24 , A61L24/04 , A61L24/10 , A61L27/26 , A61L27/36 , A61L27/50
CPC分类号： A61F2/2415 , A61B2017/0065 , A61F2/2409 , A61F2/2412 , A61F2220/005 , A61F2220/0075 , A61L24/06 , A61L24/108 , A61L27/26 , A61L27/3625 , A61L27/50 , A61L27/507 , A61L2430/20 , A61L2430/40 , C09J4/00 , C09J189/00 , C08L35/04
摘要： A method of reinforcing or repairing a bioprosthetic tissue for use as a prosthetic valve leaflet. The method includes evaluating a bioprosthetic tissue, identifying a defect in the bioprosthetic tissue, and selectively applying an adhesive to a surface of the bioprosthetic tissue at the defect prior to implantation in a patient. A valve assembly comprising a frame and valve leaflets formed of bioprosthetic tissue reinforced selectively applying an adhesive to its surface at a defect. A method of manufacturing a prosthetic heart valve assembling bioprosthetic tissue leaflets to a frame by suturing and reinforcing the suturing lines by applying an additive compound at the suturing holes.
摘要翻译：增强或修复用作人工瓣膜小叶的生物假体组织的方法。该方法包括评估生物假体组织，识别生物假体组织中的缺陷，以及在植入患者体内之前选择性地将粘合剂施加到缺损处的生物假体组织表面。一种瓣膜组件，包括由生物假体组织形成的框架和瓣膜小叶，所述瓣膜小叶在缺陷处选择性地将粘合剂施加到其表面。一种制造假体心脏瓣膜的方法，其通过在缝合孔处施加添加剂化合物来缝合和增强缝合线，从而将生物假体组织小叶组装到框架上。

8. 发明申请

WO2017120404A1 PROSTHETIC VALVE WITH FLOW DIRECTOR 审中-公开
标题翻译：带流动导向器的假体阀
公开(公告)号：WO2017120404A1
公开(公告)日：2017-07-13
申请号：PCT/US2017/012429
申请日：2017-01-06
申请人： MEDTRONIC VASCULAR INC.
发明人： SHEAHAN, Edmond , DUFFY, Niall
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2002/068
摘要： A prosthetic valve comprising a stent frame, a valve structure, and a baffle structure. The stent frame defines a lumen. The valve structure is disposed within the lumen, and defines an inflow side and an outflow side. An outflow track is established within the lumen downstream of the outflow side and along which fluid flow from the valve structure progresses. The baffle structure is connected to the stent frame downstream of the outflow side. In some embodiments, the baffle structure directs blood flow into designated areas to encourage laminar flow and eliminate or reduce turbulence.
摘要翻译：人造瓣膜包括支架框架，瓣膜结构和挡板结构。支架框架限定内腔。阀结构设置在内腔内，并限定流入侧和流出侧。流出路径在流出侧下游的内腔内建立，并且来自阀结构的流体流沿着该流出路径前进。挡板结构连接到流出侧下游的支架框架。在一些实施例中，挡板结构将血流引导到指定区域以促进层流并消除或减少湍流。

9. 发明申请

WO2017106052A1 DELIVERY SYSTEM HAVING RETRACTABLE WIRES AS A COUPLING MECHANISM AND A DEPLOYMENT MECHANISM FOR A SELF-EXPANDING PROSTHESIS 审中-公开
标题翻译：具有可伸缩线的输送系统作为自扩展假体的联接机构和展开机构
公开(公告)号：WO2017106052A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/065983
申请日：2016-12-09
申请人： MEDTRONIC INC.
发明人： ROTHSTEIN, Paul , KEOGH, James, R.
IPC分类号： A61F2/24 , A61F2/966
CPC分类号： A61F2/2439 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/2469 , A61F2/966 , A61F2002/826 , A61F2002/9665 , A61F2230/0006 , A61F2230/0069 , A61F2250/006
摘要： A delivery system for transcatheter implantation of a heart valve prosthesis. The delivery system includes an outer sheath component (106) defining a lumen therethrough, an elongate tube (136) having at least two flat wires (146) longitudinally extending from a distal end thereof, and self-expanding first and second frames (102, 104) disposed in series within a distal portion of the outer sheath component and held in a compressed delivery configuration therein. The elongate tube and the at least two flat wires are slidably disposed within the lumen of the outer sheath component. In the compressed delivery configuration the at least two flat wires longitudinally extend along exterior portions of the first and second frames and are woven through adjacent ends of the first and second frames to releasably couple them to each other. Proximal retraction of the at least two flat wires from the first and second frames releases at least the first frame from the delivery system.
摘要翻译：一种用于心脏瓣膜假体的经导管植入的输送系统。输送系统包括限定穿过其中的内腔的外护套部件（106），具有从其远端纵向延伸的至少两根扁线（146）的细长管（136），以及自扩张的第一和第二框架（102,104）串联设置在外部护套部件的远侧部分内并且保持在其中的压缩输送构型中。细长管和至少两根扁线可滑动地设置在外部护套部件的内腔内。在压缩输送构造中，至少两根扁平线沿着第一和第二框架的外部纵向延伸，并且编织穿过第一和第二框架的相邻端部以将它们可释放地联接到彼此。至少两根扁线从第一和第二框架向近侧缩回至少从输送系统释放第一框架。

10. 发明申请

WO2017083381A8 ENGINEERED POLYMERIC VALVES AND SYSTEMS, METHODS FOR GENERATING THE SAME, AND USES OF THE SAME 审中-公开
标题翻译：工程聚合物阀门及系统，产生该聚合物阀门的系统及其使用方法
公开(公告)号：WO2017083381A8
公开(公告)日：2017-06-22
申请号：PCT/US2016061129
申请日：2016-11-09
申请人： HARVARD COLLEGE
发明人： CAPULLI ANDREW K , PARKER KEVIN KIT
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/2412 , A61L27/14 , A61L27/50 , A61L2400/12 , A61L2430/20
摘要： The present invention provides engineered valves comprising oriented polymeric fibers, e.g., nanofibers, methods of fabricating such structures, and systems and devices for fabricating such structures. Such valve scaffolds are fabricated using a multi-part mandrel assembly upon which micron, submicron, and nanometer dimension polymer fibers are collected. The valve scaffolds include one or more sinuses corresponding to at least one leaflet within the valve scaffold.
摘要翻译：本发明提供包含取向聚合物纤维（例如纳米纤维）的工程阀，制造这种结构的方法以及用于制造这种结构的系统和装置。这种瓣膜支架使用其上收集有微米，亚微米和纳米尺寸聚合物纤维的多部分心轴组件制造。瓣膜支架包括对应于瓣膜支架内的至少一个小叶的一个或多个窦。

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