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1. 发明申请

WO2019036403A1 COMPOSITIONS AND METHODS FOR ISOLATING AND ENRICHING IGM-PRODUCING CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2019036403A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/046597
申请日：2018-08-14
申请人： TRUSTEES OF BOSTON UNIVERSITY , BOSTON MEDICAL CENTER CORPORATION
发明人： ZHONG, Xuemei , WONG, Joyce
IPC分类号： G01N33/50 , A61B5/05 , A61K9/51 , A61K35/14 , A61K35/15 , A61K45/06
CPC分类号： A61K35/17 , A61K47/24 , A61K47/6929 , A61P35/00 , A61P35/02 , B82Y5/00 , C07K16/00 , C07K16/30 , C07K2317/52 , C12N5/0635 , C12N5/0693 , C12N5/163 , C12N2529/00
摘要： The technology described herein relates, at least in part, to compositions comprising and methods for isolating and enriching natural IgM-producing phagocytic B (NIMPAB) cells and methods of producing IgM antibodies using such cells, as well as uses of the antibodies produced by the methods for the prevention and treatment of diseases wherein immunotherapy with such natural IgM antibodies and their derivatives can be useful.

2. 发明申请

WO2019036030A1 LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS 审中-公开
公开(公告)号：WO2019036030A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/000317
申请日：2018-08-17
申请人： ACUITAS THERAPEUTICS, INC.
发明人： DU, Xinyao
IPC分类号： C07C229/16 , C07C229/24 , A61K9/127 , A61K9/51 , A61K47/54 , A61K47/69
CPC分类号： C07C229/16 , A61K9/1271 , A61K9/5123 , A61K47/543 , A61K47/6929 , C07C229/24
摘要： Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein X, Y, L 1 , L 2 , L 3 , G 1 , G 2 and G 3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

3. 发明申请

WO2019036028A1 LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS 审中-公开
公开(公告)号：WO2019036028A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/000315
申请日：2018-08-17
申请人： ACUITAS THERAPEUTICS, INC.
发明人： DU, Xinyao
IPC分类号： C07C229/16 , C07C229/24 , A61K9/127 , A61K9/51 , A61K47/54 , A61K47/69
CPC分类号： C07C229/16 , A61K9/1271 , A61K9/1272 , A61K9/5123 , A61K47/183 , A61K47/543 , A61K47/6929 , C07C229/24 , C12N15/88
摘要： Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein G 1 , G 1' , G 2 , G 2' , G 3 , L 1 , L 1' , L 2 , L 2' , X, X', Y and Y' are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

4. 发明申请

WO2018118567A1 DELIVERY OF ANTIVIRAL THERAPIES 审中-公开
公开(公告)号：WO2018118567A1
公开(公告)日：2018-06-28
申请号：PCT/US2017/066049
申请日：2017-12-13
申请人： AGENOVIR CORPORATION
发明人： SLOAN, Derek, D. , XIONG, Xin, Cindy
IPC分类号： A61K38/40 , A61K38/16 , A61K9/50 , A61K9/51 , C12N9/16 , B82Y5/00
CPC分类号： A61K47/549 , A61K9/0014 , A61K9/127 , A61K9/141 , A61K9/5184 , A61K38/465 , A61K47/6929 , B82Y5/00 , C07K2319/01 , C07K2319/10 , C12N9/22 , C12N15/111 , C12N2320/32
摘要： Compositions and methods for treating viral infections use a programmable nuclease programmed to digest a viral genome and a delivery agent that promotes penetration of the composition from a site of topical delivery, through tissue or cells, and into infected cells. Compositions may include a programmable nuclease such as a Cas endonuclease that may be delivered as an active ribonucleoprotein (RNP) or a messenger RNA (mRNA) encoding the nuclease preferably packed within a nanoparticle such as a lipid nanoparticle.

5. 发明申请

WO2018064350A1 APO-E MODIFIED LIPID NANOPARTICLES FOR DRUG DELIVERY TO TARGETED TISSUES AND THERAPEUTIC METHODS 审中-公开
标题翻译： APO-E修饰的脂质纳米粒子用于靶向组织的药物递送和治疗方法
公开(公告)号：WO2018064350A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/054045
申请日：2017-09-28
申请人： ERIOCHEM USA, LLC
发明人： NUNEZ, Jose, Lucio , SELENSCIG, Dante , RAMIREZ, Maria, de los Angeles
IPC分类号： A61K9/127 , A61K9/19 , A61K9/26
CPC分类号： A61K9/1275 , A61K9/1277 , A61K9/19 , A61K31/337 , A61K47/548 , A61K47/62 , A61K47/6929 , A61P35/00
摘要： Lipid nanoparticles and methods of making and using the same, including pharmaceutical compositions and kits, and the targeted delivery of drugs in various treatment methods. The nanoparticle formulation includes phospholipids, triglycerides, cholesterol, cholesteryl ester, apolipoprotein E3 (ApoE3), and a lipophilic therapeutic agent.
摘要翻译：脂质纳米粒子及其制备和使用方法，包括药物组合物和试剂盒，以及各种治疗方法中药物的靶向递送。纳米颗粒制剂包括磷脂，甘油三酯，胆固醇，胆固醇酯，载脂蛋白E3（ApoE3）和亲脂性治疗剂。

6. 发明申请

WO2017223492A1 MICRO-RNA DELIVERY COMPOSITIONS, DEVICES, AND METHODS 审中-公开
标题翻译：微RNA输送组合物，装置和方法
公开(公告)号：WO2017223492A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039072
申请日：2017-06-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RAMOT AT TEL-AVIV UNIVERSITY LTD
发明人： ARTZI, Natalie , CONDE, João Diogo , SHOMRON, Noam , GILAM, Avital
IPC分类号： C12N15/63 , C12N5/071 , C12N15/113 , C12N15/115 , C12N15/85 , A61K9/51 , A61K31/713 , A61K9/16 , A61K45/06
CPC分类号： C12N15/113 , A61K9/06 , A61K31/713 , A61K33/243 , A61K45/06 , A61K47/59 , A61K47/61 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K47/6931 , A61M5/19 , A61P35/04 , B82Y5/00 , C12N15/111 , C12N15/85 , C12N2310/141 , C12N2310/351 , C12N2310/3513 , C12N2320/32 , C12N2740/15043
摘要： Provided herein are compositions that include a metal nanoparticle functionalized with a miRNA and a targeting biomolecule. The compositions may be used to prevent or reduce the rate of metastasis of cancer cells. The compositions also may include a drug, such as a chemotherapeutic agent. The compositions also may include a hydrogel in which the metal nanoparticles are dispersed. Methods of miRNA and/or drug delivery and kits also are provided.
摘要翻译：本文提供了包含用miRNA和靶向生物分子功能化的金属纳米颗粒的组合物。该组合物可用于预防或降低癌细胞转移的速率。该组合物还可以包含药物，例如化学治疗剂。该组合物还可以包括其中分散有金属纳米颗粒的水凝胶。还提供了miRNA和/或药物递送的方法和试剂盒。

7. 发明申请

WO2017214261A1 NANOCARRIERS FOR INTRACELLULAR DELIVERY 审中-公开
标题翻译：用于细胞内递送的纳米载体
公开(公告)号：WO2017214261A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036331
申请日：2017-06-07
申请人： GEORGIA TECH RESEARCH CORPORATION
发明人： CHAMPION, Julie , LIM, Sung In
IPC分类号： A61K39/385 , A61K39/00 , A61K39/395 , A61K9/127 , A61K49/00 , C12P21/08
CPC分类号： A61K47/6455 , A61K9/127 , A61K31/713 , A61K39/385 , A61K47/62 , A61K47/65 , A61K47/6849 , A61K47/6919 , A61K47/6929 , C07K16/18
摘要： An embodiment of the present disclosure can include a nanocarrier for delivering a cargo to a cell comprising: a bundle domain and a binding domain, the binding domain configured to bind to the cargo. An embodiment of the present disclosure can include a method for delivering a cargo to a cell comprising: introducing an amino-acid based nanocarrier to the cell, the nanocarrier can comprise an alpha-helical protein bundle domain and a binding domain, the cargo can bound to the binding domain and the cargo can be a therapeutic cargo.
摘要翻译：本公开的一个实施方案可以包括用于将货物递送至细胞的纳米载体，所述纳米载体包含：束域和结合域，所述结合域被配置成结合货物。本公开的实施方案可以包括用于将货物递送至细胞的方法，其包括：将基于氨基酸的纳米载体引入细胞，纳米载体可以包含α-螺旋蛋白质束域和结合域，货物可以结合到结合域，货物可以是治疗性货物。

8. 发明申请

WO2017197133A1 FUNCTIONALIZED NANOPARTICLES AND COMPOSITIONS FOR CANCER TREATMENT AND METHODS 审中-公开
标题翻译：功能化纳米粒子和癌症治疗组合物及方法
公开(公告)号：WO2017197133A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/032192
申请日：2017-05-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ARTZI, Natalie , CONDE, Joao , OLIVA, Nuria
IPC分类号： A61K47/62 , A61K47/69
CPC分类号： A61K47/6929 , A61K31/713 , A61K39/44 , A61K41/0042 , A61K47/60 , A61K47/62 , A61K47/6845 , A61K47/6903 , A61K47/6923 , A61M5/19 , A61N5/062 , A61P35/00 , B82Y5/00 , C07K16/22 , C07K2317/24 , C07K2317/76 , C12N15/1135 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , C12N2760/16122
摘要： Provided herein are functionalized nanoparticles and compositions containing functionalized nanoparticles. The functionalized nanoparticles include a first metal nanoparticle functionalized with a drug and a targeting biomolecule, and a second metal nanoparticle functionalized with an siRNA and a targeting biomolecule. The compositions include the first metal nanoparticle and the second metal nanoparticle. Kits and methods of drug delivery also are provided.
摘要翻译：本文提供官能化纳米粒子和含有官能化纳米粒子的组合物。官能化的纳米粒子包括用药物和靶向生物分子官能化的第一金属纳米粒子和用siRNA和靶向生物分子官能化的第二金属纳米粒子。该组合物包含第一金属纳米颗粒和第二金属纳米颗粒。还提供了药物递送的试剂盒和方法。

9. 发明申请

WO2017172881A1 THERMOGENIC COMPOSITIONS AND METHODS 审中-公开
标题翻译：致炎组合物和方法
公开(公告)号：WO2017172881A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024701
申请日：2017-03-29
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： ZIOUZENKOVA, Ouliana , PARQUETTE, Jonathan, R.
IPC分类号： A61K35/35 , A61K38/10
CPC分类号： A61K38/1808 , A61K9/0019 , A61K38/185 , A61K38/1883 , A61K38/19 , A61K38/30 , A61K38/43 , A61K45/06 , A61K47/64 , A61K47/6919 , A61K47/6929 , A61K47/6949 , A61K2300/00
摘要： Thermogenic molecules and methods of using these molecules for treating or preventing a condition in a subject selected from the group consisting of visceral fat accumulation (e.g., Crohn's disease associated with visceral fat accumulation), obesity, diabetes, pre-diabetes, hypothermia, and chronic inflammation are disclosed. Also disclosed is a method for promoting glucose uptake in peripheral tissues (e.g., adipocytes and muscles) of a subject, enhancing nerve innervation in a subject, activating PI3 kinase in cell, and inducing leptin secretion by an adipocyte. Also disclosed are inhibitors of thermogenic molecules and methods of using these inhibitors to decrease thermogenesis of adipocytes in a subject. Also disclosed are self-assembled, biocompatible nanostructure non-covalently associated with a therapeutic or diagnostic peptide or peptidomimetic.
摘要翻译：使用这些分子治疗或预防选自由内脏脂肪积聚（例如，与内脏脂肪积累相关的克罗恩病），肥胖症，糖尿病，前驱糖尿病，低体温和慢性炎症。还公开了用于促进受试者的外周组织（例如，脂肪细胞和肌肉）中的葡萄糖摄取，增强受试者中的神经支配，激活细胞中的PI3激酶和诱导脂肪细胞分泌瘦素的方法。还公开了产热分子的抑制剂和使用这些抑制剂来减少受试者中脂肪细胞的产热的方法。还公开了与治疗或诊断肽或肽模拟物非共价缔合的自组装，生物相容性纳米结构。

10. 发明申请

WO2017129365A1 FUNKTIONALISIERTE METALLISCHE NANOPARTIKEL 审中-公开
标题翻译：功能化金属纳米粒子
公开(公告)号：WO2017129365A1
公开(公告)日：2017-08-03
申请号：PCT/EP2017/000097
申请日：2017-01-27
申请人： FRIZ BIOCHEM GESELLSCHAFT FÜR BIOANALYTIK MBH
发明人： HARTWICH, Gerhard
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K47/6923 , A61K47/6929 , B82Y5/00
摘要： Die Erfindung betrifft ein vorfunktionalisiertes metallisches Nanopartikel (10) als standardisierter Grundbaustein biofunktionalisierter Nanopartikel (40), mit einem thiolreaktiven metallischen Nanopartikel (12), das durch ein bifunktionelles Molekül (20) vorfunktionalisiert ist, welches aus einem Ankerbestandteil (22) und einem kurzen Weiterfunktionalisierungsstummel (24) besteht. Dabei ist vorgesehen, dass der Ankerbestandteil (22) eine oder mehrere Dithiol-Phosphat-Gruppen umfasst, und der kurze Weiterfunktionalisierungsstummel (24) für die Anbindung einer gewünschten Biofunktionalisierung (30) eingerichtet ist und ausgewählt ist aus der Gruppe bestehend aus i) einem unmodifizierten standardisierten Oligonukleotid-Strang (26) mit 2 bis 18 Basen zur Weiterfunktionalisierung mit Biomolekülen (30) mit einem terminalen komplementären Gegenstrang (36) des standardisierten Oligonukleotid-Strangs (26), und ii) einem 2 bis 18 Basen langen Oligonukleotid-Strang (50; 60), der mit einer terminalen reaktiven Gruppe (52; 62) für Biomoleküle modifiziert ist.
摘要翻译：
本发明涉及一种vorfunktionalisiertes金属纳米粒子（10），其为标准化的基本元件生物功能化的纳米颗粒（40），具有一个巯基反应性的金属纳米粒子（12）通过一个双功能分子导航用途是vorfunktionalisiert升（20），其由一个锚定组件（22）和一个短的Weiterfunktionalisierungsstummel（24）组成。它被提供，该电枢组件（22）包括一个或多个二硫醇 - 磷酸基团，和短Weiterfunktionalisierungsstummel（24）的F导航用途R A重量导航用途的nschten生物功能化的连接件（30）被布置和AUML拾取;选自HLT （包括i）为2〜18个碱基对Weiterfunktionalisierung与生物分子导航用途LEN（30）与末端补体＆AUML未修饰的标准寡核苷酸链26）;标准化寡核苷酸链（26）的任链（36），和ii）一用生物分子的末端反应基团（52; 62）修饰的2至18个碱基的寡核苷酸链（50; 60）。

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