专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2019100686A1 区分免疫和感染动物H5亚型禽流感疫苗株及其制备方法和应用审中-公开
公开(公告)号：WO2019100686A1
公开(公告)日：2019-05-31
申请号：PCT/CN2018/089519
申请日：2018-06-01
申请人：宋家升
发明人：宋家升
IPC分类号： C12N15/62 , C07K19/00 , C12N7/01 , C12N15/87 , A61K39/145 , A61P31/16
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/552 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N7/00 , C12N15/87 , C12N2760/16221 , C12N2760/16222 , C12N2760/16234
摘要：提供了一种区分免疫和感染动物H5亚型禽流感疫苗株及其制备方法和应用。所述疫苗株用B型流感的NA蛋白作为标签，对H5亚型禽流感的防控和净化具有应用价值和公共卫生学意义。

2. 发明申请

WO2018049037A1 DEVICE FOR MANUFACTURE OF T-CELLS FOR AUTOLOGOUS CELL THERAPY 审中-公开
标题翻译：用于自体细胞疗法的T细胞制造装置
公开(公告)号：WO2018049037A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050493
申请日：2017-09-07
申请人： NDSU RESEARCH FOUNDATION
发明人： NAWARTHNA, Dharmakeerthi , VELMANICKAM, Logeeshan , JAYASOORIYA, Vidura
IPC分类号： C12Q1/68 , C12M1/34 , C12M1/00 , B01J19/00 , B01L3/00 , G01N33/50 , G01N33/48
CPC分类号： C12M23/34 , B01J19/087 , C12M35/02 , C12N5/0636 , C12N13/00 , C12N15/00 , C12N15/87 , C12N2501/515 , C12N2501/599 , C12N2510/00
摘要： The present invention relates to a new device for a scalable, biomanufacturing platform for the production of CAR-modified T-cells while eliminating on-target/off-tumor toxicity and decreasing the current production cost by 500 times (per treatment). The invention relates to a device to produce modified T-cells comprising a first chamber for proliferating a population of T-cells and a second chamber for modifying the T-cells to express a desired T-cell receptor antigen.
摘要翻译：本发明涉及一种用于生产CAR-修饰的T细胞的可扩展的生物制造平台的新设备，同时消除了靶标上/肿瘤外毒性并将当前生产成本降低了500 次（每次治疗）。本发明涉及生产改良T细胞的装置，其包含用于增殖T细胞群的第一室和用于修饰T细胞以表达期望的T细胞受体抗原的第二室。

3. 发明申请

WO2018047149A1 CELL FILTRATION AS A MEANS OF INTRODUCING EXOGENOUS MATERIAL INTO A CELL 审中-公开
标题翻译：细胞过滤作为将外源物质引入细胞的手段
公开(公告)号：WO2018047149A1
公开(公告)日：2018-03-15
申请号：PCT/IB2017/055502
申请日：2017-09-12
申请人： TEXAS CHILDREN'S HOSPITAL
发明人： ANNAPRAGADA, Ananth , PATEL, Chandreshkumar
IPC分类号： C12N5/07 , C12N15/87 , G01N1/30
CPC分类号： C12N15/87 , C12N15/88 , G01N1/30
摘要： Disclosed are methods of delivering substances into cells by passing cells through porous membranes. Disclosed embodiments include methods of delivering a substance into cells by providing a cell suspension, passing the cell suspension through a porous membrane, and exposing the cells to the substance to be delivered into the cells.
摘要翻译：公开了通过使细胞穿过多孔膜将物质递送到细胞中的方法。公开的实施方案包括通过提供细胞悬浮液，使细胞悬浮液通过多孔膜，并将细胞暴露于待递送到细胞中的物质，将物质递送到细胞中的方法。

4. 发明申请

WO2018035435A1 NON-VIRAL DELIVERY AGENTS FROM POLYELECTROLYTES BASED ON CYCLOPROPENIUM IONS, THEIR SYNTHESES, AND USES THEREOF 审中-公开
标题翻译：基于环丙基芘离子聚合物的非病毒递送药物及其合成及其应用
公开(公告)号：WO2018035435A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047562
申请日：2017-08-18
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： CAMPOS, Luis M. , LAMBERT, Tristan Hayes , FREYER, Jessica L. , BRUCKS, Spencer C.
IPC分类号： C08F212/08 , C08F112/32 , C08G77/388
CPC分类号： C08F8/30 , C08F8/12 , C08F12/22 , C08F12/26 , C08F293/005 , C08F2438/01 , C12N15/87
摘要： Non-viral gene delivery agents can be provided comprising a polyamine comprising a polymer containing a secondary amine, wherein the polyamine and a derivative of a cyclopropenium ion that are covalently attached. The non-viral gene delivery agents can be formed by a click reaction combining a polyamine polymer precursor backbone with a trisaminocyclopropenium polymer. The non-viral gene delivery agents can be used to deliver genetic material to cells in mammals or other organisms as part of gene therapy.
摘要翻译：可以提供非病毒基因递送剂，其包含含有含仲胺的聚合物的多胺，其中共价连接的多胺和环丙烯鎓离子的衍生物。非病毒基因递送剂可通过将多胺聚合物前体骨架与三氨基环丙烯鎓聚合物组合的点击反应形成。作为基因治疗的一部分，非病毒基因递送剂可用于将遗传物质递送至哺乳动物或其他生物体中的细胞。

5. 发明申请

WO2017191096A1 METHOD FOR INTRODUCING NUCLEIC ACIDS INTO A CELL 审中-公开
标题翻译：将核酸引入细胞的方法
公开(公告)号：WO2017191096A1
公开(公告)日：2017-11-09
申请号：PCT/EP2017/060345
申请日：2017-05-02
申请人： MILTENYI BIOTEC GMBH
发明人： JURK, Marion , WILD, Stefan , BOSIO, Andreas
IPC分类号： C12N15/87
CPC分类号： C12N15/87 , C07K14/4703
摘要： The present invention provides the use of a nucleic acid encoding SOCS1 for enhancing the efficacy of introducing at least one nucleic acid of interest into a cell; a method of repeated transfection of a cell with at least one nucleic acid of interest comprising the steps of adding a) nucleic acid encoding SOCS1, and simultaneously or subsequently b) at least one nucleic acid of interest encoding at least one polypeptide of interest, wherein at least step b) is repeated at least once; and a method of electroporation of a cell with at least one nucleic acid of interest comprising the steps of adding to the cell a) a nucleic acid encoding SOCS1, and simultaneously or subsequently b) said at least one nucleic of interest. The at least one nucleic acid of interest and the nucleic acid encoding SOCS1 may be mRNAs, wherein each of said mRNAs has a poly(A) tail at its 3' end comprising at least 200 adenines.
摘要翻译：本发明提供编码SOCS1的核酸用于增强将至少一种感兴趣的核酸导入细胞的功效的用途; 用至少一种目标核酸重复转染细胞的方法，包括以下步骤：添加a）编码SOCS1的核酸，并且同时或随后b）编码至少一种目的多肽的至少一种感兴趣的核酸，其中至少步骤b）重复至少一次; 以及用至少一种感兴趣的核酸对细胞进行电穿孔的方法，所述方法包括以下步骤：向细胞中加入a）编码SOCS1的核酸，并且同时或随后b）所述至少一种感兴趣的核酸。至少一种目标核酸和编码SOCS1的核酸可以是mRNA，其中每种所述mRNA在其3'末端具有包含至少200个腺嘌呤的聚（A）尾巴。

6. 发明申请

WO2017168428A1 TREATMENTS UTILIZING A POLYMER-PROTEIN CONJUGATE 审中-公开
公开(公告)号：WO2017168428A1
公开(公告)日：2017-10-05
申请号：PCT/IL2017/050397
申请日：2017-03-30
申请人： REGENTIS BIOMATERIALS LTD.
发明人： SHACHAF, Yonatan , WECHSLER, Aharon
IPC分类号： A61K47/60 , A61K47/64 , A61K47/69 , A61K47/59 , A61L27/18 , A61L27/22 , A61L27/52 , C12N15/87 , A61K31/728 , A61K35/16 , A61K45/06 , A61P19/02
CPC分类号： A61K47/6435 , A61K9/0019 , A61K9/08 , A61K31/728 , A61K45/06 , A61K47/59 , A61K47/60 , A61K47/6903 , A61L27/18 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2430/02 , A61L2430/06 , A61P19/02 , A61P19/04 , C12N15/87 , A61K2300/00 , C08L71/02
摘要： A composition for use in treating a condition associated with degeneration of articular cartilage and/or with subchondral bone loss is disclosed herein. The composition comprises a conjugate which comprises a polypeptide having attached thereto at least two polymeric moieties, at least one of the polymeric moieties exhibiting a reverse thermal gelation. Further disclosed is a composition comprising the aforementioned conjugate along with a hyaluronic acid, an anti-inflammatory agent, an analgesic, a growth factor, a blood fraction, a nucleic acid, and/or a cell, the composition being an aqueous composition which forms a hydrogel at a temperature in a range of from 32 °C to 37 °C, as well as a method utilizing such a composition comprising a nucleic acid for effecting gene delivery. In an embodiment, the composition comprises a conjugate of fibrinogen to F127 poloxamer diacrylate.

7. 发明申请

WO2017160662A1 BIODEGRADABLE VECTORS FOR EFFICIENT RNA DELIVERY 审中-公开
标题翻译：可生物降解的载体有效地提供RNA
公开(公告)号：WO2017160662A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/021978
申请日：2017-03-10
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： GUAN, Zhibin , OLDENHUIS, Nathan
IPC分类号： C08G75/14 , C12N15/11 , C12N15/113 , C12N15/87
CPC分类号： A61K47/6455 , C08G75/14 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/20 , C12N2320/32
摘要： The disclosure provides for vectors, and methods of using the vectors to efficiently deliver mRNA and/or ssRNA into cells.
摘要翻译：本公开提供了载体和使用载体将mRNA和/或ssRNA有效递送到细胞中的方法。

8. 发明申请

WO2017156252A1 BIOSYNTHETIC MODULES 审中-公开
标题翻译：生物合成模块
公开(公告)号：WO2017156252A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021546
申请日：2017-03-09
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , DANA-FARBER CANCER INSTITUTE, INC.
发明人： SHIH, William, M. , CHOU, Leo , SORENSEN, Rasmus , HAHN, Jaeseung
IPC分类号： A61K9/51 , A61K31/711 , A61K47/48 , C07H21/04
CPC分类号： A61K31/711 , A61K9/0019 , A61K9/5068 , A61K9/5153 , A61K31/7105 , A61K31/713 , B82Y5/00 , C12N9/1241 , C12N15/00 , C12N15/10 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2320/32 , C12Y207/07006 , C12Y207/07007 , C12N2310/531
摘要： The present disclosure provides, in some aspects, nucleic acid-based biosynthetic modules for the production of ribonucleic acid (RNA) and other biopolymers.
摘要翻译：在一些方面，本公开内容提供了用于生产核糖核酸（RNA）和其他生物聚合物的基于核酸的生物合成模块。

9. 发明申请

WO2017124022A2 METHODS FOR PRODUCING HYPO-ALLERGENIC CATS USING GENE EDITING TECHNOLOGY 审中-公开
标题翻译：使用基因编辑技术生产低变应原猫的方法
公开(公告)号：WO2017124022A2
公开(公告)日：2017-07-20
申请号：PCT/US2017/013540
申请日：2017-01-13
申请人： FELIX PETS, LLC
发明人： AVNER, David, B. , BOCKLANDT, Sven , KEHLER, James
IPC分类号： A01K67/027 , C12N5/073
CPC分类号： C12N5/0696 , A01K67/0275 , A01K2217/00 , A01K2227/10 , A01K2267/02 , C12N15/87
摘要： A genetically modified cat produced through gene editing with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the genetically modified cat by targeting either the gene sequence of the Fel d I locus or sequences flanking the coding sequence of the two contiguous Fel d I genes with specialized gene editing constructs. The genotype and phenotype of the genetically modified cat is transmissible to its offspring.
摘要翻译：通过基因编辑产生的遗传修饰的猫具有表征，其特征在于主要猫过敏原Fel d I基本上不存在。该表型在基因修饰的猫中通过靶向 Fel d I基因座或两个连续的Fel d I基因的编码序列侧翼的序列与专门的基因编辑构建体结合。转基因猫的基因型和表型可传递给后代。

10. 发明申请

WO2017115220A1 METHOD FOR THE OPTOINJECTION OF EXOGENOUS MATERIAL INTO A BIOLOGICAL CELL 审中-公开
标题翻译：将外源材料插入生物细胞的方法
公开(公告)号：WO2017115220A1
公开(公告)日：2017-07-06
申请号：PCT/IB2016/057829
申请日：2016-12-20
申请人： FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
发明人： DIFATO, Francesco , SOLOPERTO, Alessandro , PALAZZOLO, Gemma
IPC分类号： C12N15/87 , C12N13/00 , C12M1/42 , B23K26/00
CPC分类号： C12N13/00 , B23K26/00 , C12M35/02 , C12N15/87
摘要： Method for the optoinjection of exogenous material in a recipient biological cell enclosed by a membrane, which comprises: placing a biological cell on a planar surface of a substrate, transmitting a sub-ns pulsed laser beam through a variable convergence/divergence collimator, the collimator comprising a lens with focal length tunable by means of a variable amplitude control electrical signal; focusing the laser beam in a focal spot positioned along an axial direction substantially perpendicular to the substrate; moving the focal spot towards the cell along the axial direction by continuously varying the electric control signal from a first amplitude value corresponding to a first axial position zi of the focal spot above the apical surface of the cell to a second amplitude value, the second amplitude value defining a second focal length corresponding to a second axial position Zf of the focal spot, wherein the second amplitude value of the control signal is selected such that the second axial position is positioned inside the cell, at a second axial distance from the planar surface of the substrate, such that the focal spot traverses the membrane of the cell during the descent of the focal spot towards the cell producing a pore in the membrane, which allows the fluid solution containing exogenous material to enter the cell.
摘要翻译：用于在由膜包封的受体生物细胞中光注射外源性物质的方法，该方法包括：将生物细胞放置在基底的平坦表面上，将亚ns脉冲激光束透射通过可变会聚/发散准直器，所述准直器包括焦距可借助于可变幅度控制电信号调谐的透镜; 将激光束聚焦在沿基本上垂直于衬底的轴向定位的焦点上; 通过连续地将电控制信号从对应于细胞顶点表面上方的焦点的第一轴向位置zi的第一幅度值改变为第二幅度值，将焦点沿着轴向方向移动到细胞，第二幅度其定义对应于所述焦斑的第二轴向位置Zf的第二焦距，其中所述控制信号的所述第二幅值被选择为使得所述第二轴向位置位于所述单元内部，距离所述平坦表面使得焦斑在焦斑下降过程中穿过细胞膜朝向在细胞膜中产生孔的细胞，这允许含有外源性物质的流体溶液进入细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式