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    • 10. 发明申请
    • PROCESS FOR COATING A PERFORATED SUBSTRATE
    • 涂覆执行基材的方法
    • WO00065143A1
    • 2000-11-02
    • PCT/GB2000/001415
    • 2000-04-13
    • A61F13/00B32B5/24C08J5/24D06M15/643D06N3/00D06N7/00A61L15/00
    • A61L15/425D06M15/263D06M15/285D06M15/3566D06M23/00D06N3/0097D06N3/045D06N3/047D06N3/125D06N3/128D06N2211/18D06N2213/04Y10T442/172Y10T442/2525
    • A process for coating a perforated substrate with a gel (e.g. a polymerised acrylate hydrogel or a xerogel) without substantial occlusion of the perforations comprises (i) forming a layer of a liquid pregel mixture, comprising one or more monomers, on a web coated with a silicone, polyethylene, Teflon (R) or other coating having a surface energy less than the surface energy of the liquid pregel mixture; (ii) contacting the perforated substrate with the liquid pregel mixture; and (iii) curing the liquid pregel mixture. Preferably at least part of the curing takes place while the liquid pregel mixture is in contact with both the perforated substrate and the web. The process is especially applicable to the manufacture of attachment tabs for wigs and toupees, wound dressings, patches for transdermal drug delivery, therapeutic patches or biomedical skin electrodes.
    • 使用凝胶(例如,聚合的丙烯酸酯水凝胶或干凝胶)涂覆多孔基材的方法而没有实质上阻塞穿孔的步骤包括(i)在涂覆有纤维网的网上形成一层包含一种或多种单体的液体预凝胶混合物层 硅氧烷,聚乙烯,特氟隆或其表面能低于液体预凝胶混合物的表面能的其他涂层; (ii)使穿孔基材与液体预凝胶混合物接触; 和(iii)固化液体预凝胶混合物。 优选地,当液体预凝胶混合物与多孔基材和网状物接触时,至少部分固化发生。 该方法特别适用于制造用于假发和硬币,伤口敷料,透皮药物递送贴剂,治疗贴剂或生物医学皮肤电极的附接片。