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1. 发明申请

WO2019051335A1 METHODS OF IDENTIFYING CELLULAR ATTRIBUTES RELATED TO OUTCOMES ASSOCIATED WITH CELL THERAPY 审中-公开
公开(公告)号：WO2019051335A1
公开(公告)日：2019-03-14
申请号：PCT/US2018/050114
申请日：2018-09-07
申请人： JUNO THERAPEUTICS, INC.
发明人： HAUSE, Ronald James Jr. , LEVITSKY, Hyam I. , CLOUSER, Christopher R. , JOHNSTONE, Timothy G.
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/505 , G01N33/6854
摘要： Provided herein are methods for tracking certain cells associated with a cell therapy, such as from a starting cell composition or a sample prior to administration to a subject and from a sample following administration to a subject. In some aspects, the methods include assessing one or more parameters or attributes of such cells and methods of identifying cellular attributes associated with particular desired cells. The provided methods can be used in connection with cell therapy including adoptive transfer of engineered T cells or T cell precursors.

2. 发明申请

WO2017214211A1 METHODS FOR IDENTIFYING A HIGH AFFINITY ANTIBODY 审中-公开
标题翻译：鉴定高亲和力抗体的方法
公开(公告)号：WO2017214211A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036235
申请日：2017-06-07
申请人： IGC BIO, INC.
发明人： SCHINDLER, Daniel
IPC分类号： C12N15/10 , G01N33/68 , C07K16/28
CPC分类号： G01N33/68 , C07K16/00 , C07K2317/622 , G01N33/6854
摘要： The invention relates to methods for identifying an antibody having a high binding affinity for an antigen. Specifically, the invention relates to determining a frequency of occurrence with respect to binding to an antigen, in order to identify an antibody having a high binding affinity for an antigen.
摘要翻译：本发明涉及鉴定对抗原具有高结合亲和力的抗体的方法。具体而言，本发明涉及确定与抗原结合的发生频率，以鉴定对抗原具有高结合亲和力的抗体。

3. 发明申请

WO2017144900A1 MASS SPECTROMETRY KIT 审中-公开
标题翻译：质谱分析套件
公开(公告)号：WO2017144900A1
公开(公告)日：2017-08-31
申请号：PCT/GB2017/050489
申请日：2017-02-24
申请人： THE BINDING SITE GROUP LIMITED , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： MURRAY, David L. , HARDING, Stephen , BARNIDGE, David R. , WALLIS, Gregg , MILLS, John , ASHBY, Jamie
IPC分类号： G01N33/68 , C07K16/00
CPC分类号： G01N33/6854 , C07K16/00 , G01N33/6893 , G01N2800/24
摘要： An anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof. A method purifying an anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof. A method of quantifying an amount of a subject analyte, or a fragment of an analyte in a sample from the subject comprising: (i) adding to the sample a predetermined amount of one or more control analytes or fragments thereof, which are distinguishable from the equivalent subject analyte or fragment; (ii) measuring the relative amount of the subject analyte or fragment and the amount of the control analyte or fragment in the sample; and (iii) comparing the relative amount of subject analyte or fragment to the relative amount of control analyte or fragment, to quantify the amount of analyte or fragment in the original subject sample.
摘要翻译：抗免疫球蛋白特异性抗体（或其片段），其特征在于所述抗体或其片段在至少一个重链或其片段与至少一个重链或其片段之间包含一个或多个非二硫键交联轻链或其抗体片段或其片段。纯化抗免疫球蛋白特异性抗体（或其片段）的方法，其特征在于所述抗体或其片段包含至少一个重链或其片段与至少一个轻链或其片段之间的一个或多个非二硫键交联的抗体或其片段。一种量化来自受试者的样品中的受试者分析物或分析物片段的量的方法，包括：（i）向样品中加入预定量的一种或多种控制分析物或其片段，其可与等效的主题分析物或片段; （ii）测量主题分析物或片段的相对量以及样品中对照分析物或片段的量; （iii）将主题分析物或片段的相对量与对照分析物或片段的相对量进行比较，以量化原始主题样品中的分析物或片段的量。

4. 发明申请

WO2017134274A1 NEW STREPTOCOCCAL PROTEASES 审中-公开
标题翻译：新的链球菌蛋白酶
公开(公告)号：WO2017134274A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052463
申请日：2017-02-03
申请人： VON PAWEL-RAMMINGEN, Ulrich , SPOERRY, Christian
发明人： VON PAWEL-RAMMINGEN, Ulrich , SPOERRY, Christian
IPC分类号： C07K14/36 , C12N9/52 , C12N9/64
CPC分类号： C12Q1/37 , C12N9/641 , G01N33/6854
摘要： The invention relates to new Streptococcal proteases designated IgdE which display IgG degrading cysteine protease activity. The invention further relates to in vitro methods of cleaving IgG using the described Streptococcal proteases, using the methods to generate Fc and Fab fragments, and using the methods to detect IgG.
摘要翻译：本发明涉及显示IgG降解半胱氨酸蛋白酶活性的称为IgdE的新型链球菌蛋白酶。本发明进一步涉及使用所述链球菌蛋白酶切割IgG的体外方法，使用产生Fc和Fab片段的方法，并使用所述方法来检测IgG。

5. 发明申请

WO2017112707A1 COMPOSITIONS, DEVICES, AND METHODS OF MIGRAINE HEADACHE FOOD SENSITIVITY TESTING 审中-公开
标题翻译：偏头痛食物敏感性试验的组合物，装置和方法
公开(公告)号：WO2017112707A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067873
申请日：2016-12-20
申请人： BIOMERICA, INC.
发明人： IRANI-COHEN, Zackary , LADERMAN, Elisabeth
IPC分类号： G01N33/536 , G01N33/68
CPC分类号： G01N33/6854
摘要： Contemplated test kits and methods for food sensitivity are based on rational-based selection of food preparations with established discriminatory p-value. Exemplary kits include those with a minimum number of food preparations that have an average discriminatory p-value of ≤ 0.07 as determined by their raw p-value or an average discriminatory p-value of ≤ 0.10 as determined by FDR multiplicity adjusted p-value. In further contemplated aspects, compositions and methods for food sensitivity are also stratified by gender to further enhance predictive value.
摘要翻译：预期的食品敏感试验试剂盒和方法是基于基于理性的选择具有确定的歧视性p值的食品制剂。示例性试剂盒包括具有通过其原始p值或通过FDR多重性调节的p值确定的≤0.10的平均鉴别p值具有≤0.07的平均鉴别性p值的食品制剂的最小数量的那些。在进一步考虑的方面，用于食物敏感性的组合物和方法也按性别分层以进一步增强预测值。

6. 发明申请

WO2017087634A1 NOVEL MULTIPLEX ASSAYS TO DIAGNOSE OR EVALUATE DISEASES OR DISORDERS IN MAMMALS 审中-公开
标题翻译：用于诊断或评估哺乳动物疾病或病症的新型多重检测试剂
公开(公告)号：WO2017087634A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062469
申请日：2016-11-17
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： YU, Liping , REWERS, Marian , MICHELS, Aaron
IPC分类号： G01N33/68 , G01N33/53 , G01N33/566
CPC分类号： G01N33/6854 , G01N33/54306 , G01N33/564
摘要： The invention includes methods and kits that can be used to simultaneously determine whether an antibody out of a plurality of antibodies is present in a sample. In certain embodiments, at least one of the antibodies comprises an autoantibody. In other embodiments, the methods and kits of the invention can be used to simultaneously determine if a subject is likely to develop or has developed each one of a plurality of diseases or disorders.
摘要翻译：本发明包括可用于同时确定样品中是否存在多种抗体中的抗体的方法和试剂盒。在某些实施方案中，至少一种抗体包含自身抗体。在其他实施方案中，本发明的方法和试剂盒可用于同时确定受试者是否可能发展或已经发展多种疾病或病症中的每一种。

7. 发明申请

WO2017083681A1 OPTIMIZED CROSSLINKERS FOR TRAPPING A TARGET ON A SUBSTRATE 审中-公开
标题翻译：优化的交联剂用于在基材上俘获目标
公开(公告)号：WO2017083681A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061574
申请日：2016-11-11
申请人： THE UNIVERSITY OR NORTH CAROLINA AT CHAPEL HILL
发明人： LAI, Samuel , FOREST, Gregory , HENRY, Christine , WESSLER, Timothy , CHEN, Alexander , SCHILLER, Jennifer , NEWBY, Jay
IPC分类号： G01N33/566 , G01N33/569 , G01N33/557 , G01N33/558 , C07K16/08 , C07K16/12 , C07K16/14 , C07K16/18 , A61K39/395 , A61P15/18 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , G06F19/18
CPC分类号： G01N33/557 , C07K16/44 , G01N33/54346 , G01N33/56983 , G01N33/6854 , G01N2333/16 , G01N2333/4725
摘要： The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest.
摘要翻译：目前公开的主题涉及用于将感兴趣的靶标捕获在感兴趣的基底上的交联剂，组合物和方法。该方法可用于抑制和治疗病原体感染并提供避孕。这些方法可用于捕获或分离颗粒和其他物质。该主题还涉及识别和制备用于操纵感兴趣的目标的最佳交联剂和方法的方法。

8. 发明申请

WO2017053677A1 ADENO-ASSOCIATED VIRUS FACTOR VIII VECTORS, ASSOCIATED VIRAL PARTICLES AND THERAPEUTIC FORMULATIONS COMPRISING THE SAME 审中-公开
标题翻译： ADENO相关病毒因子VIII载体，相关病毒颗粒和包含其的治疗方案
公开(公告)号：WO2017053677A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/053269
申请日：2016-09-23
申请人： BIOMARIN PHARMACEUTICAL INC.
发明人： BUNTING, Stuart , COLOSI, Peter, Cameron , PUNGOR, Erno
IPC分类号： A61K39/12 , C07K14/755
CPC分类号： A61K38/37 , A61K39/12 , A61K47/02 , A61K47/10 , A61K47/26 , A61K48/0008 , A61K48/0075 , C07K14/755 , C12N7/00 , C12N2710/16044 , C12N2750/14121 , C12N2750/14141 , C12N2750/14143 , G01N33/6854 , G01N2333/015
摘要： The invention provides adeno-associated virus (AAV) Factor VIII (FVIII)- encoding/expressing vectors and virus, including AAV FVIII vectors with high expression activity and AAV FVIII vectors that express full-length or truncated functional FVIII protein. The invention also relates to methods of making the herein described AAV FVIII vectors, recombinant AAV FVIII virus particles comprising or expressing such vectors, associated pharmaceutical formulations comprising the same and therapeutic uses thereof.
摘要翻译：本发明提供编码/表达载体和病毒的腺相关病毒（AAV）因子VIII（FVIII） - 包括具有高表达活性的AAV FVIII载体和表达全长或截短的功能性FVIII蛋白的AAV FVIII载体。本发明还涉及制备本文描述的AAV FVIII载体，包含或表达此类载体的重组AAV FVIII病毒颗粒的方法，其包含相同的药物制剂及其治疗用途。

9. 发明申请

WO2017025954A1 METHODS FOR DETERMINING THE RISK OF A SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENT TO DEVELOP NEUROPSYCHIATRIC SYNDROMES 审中-公开
标题翻译：确定系统性红斑狼疮（SLE）患者发展神经缺血综合征风险的方法
公开(公告)号：WO2017025954A1
公开(公告)日：2017-02-16
申请号：PCT/IL2016/050859
申请日：2016-08-07
申请人： IMMUNARRAY LTD
发明人： JAKOB, Keren , REINER-BENAIM, Anat
IPC分类号： G01N33/564 , G06F19/20 , G06F19/24
CPC分类号： G01N33/564 , G01N33/6854 , G01N2800/28 , G01N2800/30 , G06F19/18 , G06F19/24
摘要： Methods and kits are provided for diagnosing of neuropsychiatric syndromes concurrent with SLE (NPSLE) and for determining whether an SLE subject is at risk of developing a neuropsychiatric disease.
摘要翻译：提供方法和试剂盒用于诊断与SLE（NPSLE）并发症的神经精神综合征，并确定SLE受试者是否处于发展神经精神疾病的风险。

10. 发明申请

WO2016202414A1 ANTIBODY 审中-公开
标题翻译：抗体
公开(公告)号：WO2016202414A1
公开(公告)日：2016-12-22
申请号：PCT/EP2015/074527
申请日：2015-10-22
申请人： UCB BIOPHARMA SPRL
发明人： O'CONNELL, James Philip , PORTER, John Robert , LAWSON, Alastair , LIGHTWOOD, Daniel John , WOOTTON, Rebecca Jayne
IPC分类号： G01N33/68 , C07K14/705 , C07K14/525 , C07D401/14 , C07D471/00 , C07K16/24
CPC分类号： G01N33/6863 , A61K47/6425 , C07D213/72 , C07D235/04 , C07D239/26 , C07D401/14 , C07D471/00 , C07D471/04 , C07K14/525 , C07K14/70575 , C07K16/241 , C07K2317/55 , C07K2317/92 , G01N33/6845 , G01N33/6854 , G01N2333/525 , G01N2500/02
摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
摘要翻译：已经证明某些化合物结合TNF并稳定结合TNF受体的三聚体TNF的构象。公开了选择性地结合这些化合物与TNF超家族成员的复合物的抗体。这些抗体可用于检测具有相同活性的其它化合物以及靶标接合生物标志物。

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