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1. 发明申请

WO2004058052A8 GENETIC POLYMORPHISMS ASSOCIATED WITH MYOCARDIAL INFARCTION, METHODS OF DETECTION AND USES THEREOF 审中-公开
标题翻译：与心肌梗塞相关的遗传多态性，检测方法及其用途
公开(公告)号：WO2004058052A8
公开(公告)日：2011-11-10
申请号：PCT/US0340978
申请日：2003-12-22
申请人： APPLERA CORP , CARGILL MICHELE , DEVLIN JAMES J , IAKOUBOVA OLGA
发明人： CARGILL MICHELE , DEVLIN JAMES J , IAKOUBOVA OLGA
IPC分类号： C12Q1/68 , A61B20060101 , C07H21/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C12N15/12 , C12P19/34 , C12Q1/44 , C12Q1/48 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. Figure 1 provides a diagrammatic representation of a computer-based discovery system containing the SNP information of the present invention in computer readable form.
摘要翻译：本发明基于与心肌梗塞相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。图1提供了以计算机可读形式包含本发明的SNP信息的基于计算机的发现系统的示意图。

2. 发明申请

WO2004058046A3 FLUID TREATMENT METHOD, APPARATUS AND SYSTEM 审中-公开
标题翻译：流体处理方法，装置和系统
公开(公告)号：WO2004058046A3
公开(公告)日：2009-06-18
申请号：PCT/US0339973
申请日：2003-12-16
申请人： BAXTER INT
发明人： JOHNSON KENNETH M , DAHAN MEIR , SHADMAN SOHAIL , JONES MARK B , WEST RICHARD L , LO YING-CHENG , MUI TAT CHI , AKONUR ALP , YARDIMCI ATIF , DAVIS SHAWN , ZHIZHIN NIKOLAY , KILLE ERIC J , WESTBERG TOM , LABONTE JUDITH , JOHNSTON JOHN F , OTTINO JULIO , LEIBSON ABRAHAM , PENNINGTON DAVID W , PAWLAK KENNETH E , MORIARITY JULIE A , SLEPICKA JANE S
IPC分类号： B01D33/00 , A61B20060101 , A61B19/00 , A61M1/00 , A61M1/02 , A61M5/178 , A61M37/00 , B01D37/00
CPC分类号： A61M1/3692 , A61M1/02 , A61M1/0218 , A61M1/1006 , A61M1/1039 , A61M1/1081 , A61M1/3679 , A61M1/3687 , A61M39/221 , A61M2039/222 , A61M2205/12 , A61M2206/22
摘要： Treatment apparatus, system and method are disclosed for treating a biological fluid, such as blood or blood components. The treatment may include but isnot limited to inactivation of pathogens in red cell concentrate. The system may include a disposable fluid circuit assembly and a reusable controller that controls flow through the fluid circuit for reconstituting, if necessary, a treating agent, combining the treating agent with a biological fluid and mixing the agent and biological fluid. An optional quenching agent may also be used.
摘要翻译：公开了用于处理诸如血液或血液成分的生物流体的处理装置，系统和方法。治疗可能包括但不限于红细胞浓缩物中病原体的灭活。该系统可以包括一次性流体回路组件和可重复使用的控制器，其控制通过流体回路的流动，以便如果需要，重组处理剂，将处理剂与生物流体混合并混合该试剂和生物流体。也可以使用任选的淬火剂。

3. 发明申请

WO2005037080A3 METHOS OF JOINING MATERIALS 审中-公开
标题翻译：接合材料
公开(公告)号：WO2005037080A3
公开(公告)日：2009-06-11
申请号：PCT/US2004034294
申请日：2004-10-15
申请人： TYCO HEALTHCARE , EPSTEIN ADAM S , WIATER STEPHEN J , CRESTON BRIAN
发明人： EPSTEIN ADAM S , WIATER STEPHEN J , CRESTON BRIAN
IPC分类号： A61M29/00 , A61B20060101 , A61L33/00
CPC分类号： A61L31/06 , A61L31/10 , Y10T428/1352 , C08L69/00 , C08L75/04
摘要： Methods of joining two structures made from dissimilar polymeric materials involve applying a coating containing a polymeric resin, such as a polyurethane-based polymer, to at least a portion of the first structure and welding the second structure to the coated portion of the first structure.
摘要翻译：连接由不同聚合物材料制成的两种结构的方法包括将包含聚合树脂（例如基于聚氨酯的聚合物）的涂层施加到第一结构的至少一部分并将第二结构焊接到第一结构的涂覆部分。

4. 发明申请

WO2005053512A3 ANIMAL MODELS OF PANCREATIC ADENOCARCINOMA AND USES THEREFOR 审中-公开
标题翻译：胰腺癌的动物模型及其用途
公开(公告)号：WO2005053512A3
公开(公告)日：2009-05-14
申请号：PCT/US2004039756
申请日：2004-11-24
申请人： DANA FARBER CANCER INST INC , UNIV PENNSYLVANIA , DEPINHO RONALD A , BARDEESY NABEEL , AGUIRRE ANDREW J , TUVESON DAVID A
发明人： DEPINHO RONALD A , BARDEESY NABEEL , AGUIRRE ANDREW J , TUVESON DAVID A
IPC分类号： A01K67/00 , A01K67/027 , A01K67/033 , A61B20060101 , G01N33/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , C07K14/4738 , C07K14/82 , C12N2800/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/16
摘要： The present invention is based, at least in part, on the generation of an animal model of pancreatic adenocarcinoma which recapitulates the genetic and histological features of human pancreatic adenocarcinoma, including the initiation,maintenance, and progression of the disease. Accordingly, the present invention provides animal models of cancer, e.g., pancreatic adenocarcinoma, wherein an activating mutation of Kras has been introduced, and any one or more known or unknown tumor suppressor genes or loci, e.g., Ink4a/Arf, Ink4a, Arf, p53, Smad4/Dpc, Lkb1, Brca2, or Mlh1, have been misexpressed, e.g., have been misexpressed leading to decreased expression or non-expression. The animal models of the invention may be used, for example, to identify biomarkers of pancreatic cancer, to identify agents for the treatment or prevention of pancreatic cancer, and to evaluate the effectiveness of potential therapeutic agents.
摘要翻译：本发明至少部分地基于胰腺腺癌的动物模型的产生，其概括了人胰腺腺癌的遗传和组织学特征，包括疾病的起始，维持和进展。因此，本发明提供了癌症的动物模型，例如胰腺腺癌，其中引入了Kras的活化突变，以及任何一种或多种已知或未知的肿瘤抑制基因或基因座，例如Ink4a / Arf，Ink4a，Arf， p53，Smad4 / Dpc，Lkb1，Brca2或Mlh1已经被错误表达，例如，被错误表达导致表达降低或不表达。本发明的动物模型可以用于例如识别胰腺癌的生物标志物，以鉴别用于治疗或预防胰腺癌的药剂，以及评价潜在治疗剂的有效性。

5. 发明申请

WO2005044075A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，与乳腺特异性基因和蛋白相关的差异变异和方法
公开(公告)号：WO2005044075A3
公开(公告)日：2009-04-02
申请号：PCT/US2004030719
申请日：2004-09-20
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING
IPC分类号： C07H21/02 , A61B20060101 , A61K31/70 , C07H21/04
CPC分类号： C07K14/47 , C12Q1/6876
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

6. 发明申请

WO2004100759A3 ENDO 180 RECEPTOR FOR DIAGNOSIS AND TREATMENT 审中-公开
标题翻译：第180号接受诊断和治疗的受试者
公开(公告)号：WO2004100759A3
公开(公告)日：2009-03-12
申请号：PCT/IL2004000423
申请日：2004-05-18
申请人： QUARK BIOTECH INC , MOR ORNA , FEINSTEIN ELENA , FAERMAN ALEXANDER
发明人： MOR ORNA , FEINSTEIN ELENA , FAERMAN ALEXANDER
IPC分类号： G01N33/53 , A61B20060101 , C07H21/04 , C12P21/06 , G01N33/50 , G01N33/68
CPC分类号： G01N33/5032 , G01N33/6872 , G01N2333/4724 , G01N2333/78
摘要： This application is directed to a process of identifying a compound capable of modulating activity of a human ENDO180 receptor that comprises the steps of measuring the binding of the ENDO180 receptor to an interactor with which the ENDO180 receptor interacts specifically in vivo, in the absence or presence of a compound, and determining whether the binding of the ENDO180 receptor to the interactor is affected by the compound. This application is also directed to use of a compound identified by that process in the preparation of a medicament for therapy of disease, in particular fibrosis. This application also relates to the use of ENDO 180 modulators in treatment of disease.
摘要翻译：本申请涉及鉴定能够调节人ENDO180受体活性的化合物的方法，该方法包括以下步骤：在不存在或存在下测量ENDO180受体与ENDO180受体在体内特异性相互作用的相互作用因子的结合的化合物，并确定ENDO180受体与相互作用体的结合是否受化合物的影响。本申请还涉及通过该方法鉴定的化合物在制备用于治疗疾病，特别是纤维化的药物中的用途。本申请还涉及使用ENDO 180调节剂治疗疾病。

7. 发明申请

WO2004080283A3 TYPE 1 RYANODINE RECEPTOR-BASED METHODS 审中-公开
标题翻译： 1型雷诺孕素受体的方法
公开(公告)号：WO2004080283A3
公开(公告)日：2008-11-13
申请号：PCT/US2004006971
申请日：2004-03-05
申请人： UNIV COLUMBIA
发明人： MARKS ANDREW R
IPC分类号： G01N33/53 , A61B20060101 , A61B1/00 , A61K38/17 , C12Q1/00 , G01N33/567 , G01N33/569
CPC分类号： G01N33/5076 , A61K31/135 , A61K31/403 , A61K49/0008 , G01N33/5061 , G01N33/6872 , G01N2333/705 , G01N2333/99
摘要： This invention provides methods of treating defective skeletal muscle function during heart failure and methods for identifying compounds useful in such treatments.
摘要翻译：本发明提供了在心力衰竭期间治疗缺陷性骨骼肌功能的方法以及用于鉴定在这种治疗中有用的化合物的方法。

8. 发明申请

WO2005034721A8 LANCING DEVICE END CAP WITH BLOOD-DIRECTING CONTACT FACE 审中-公开
标题翻译：带有指向接触面的起吊装置端盖
公开(公告)号：WO2005034721A8
公开(公告)日：2008-03-06
申请号：PCT/US2004024466
申请日：2004-07-28
申请人： FACET TECHNOLOGIES LLC , FLYNN STEPHEN , LEVAUGHN RICHARD W , RUF CHRISTOPHER J , KENNEDY GWENN E , LIPOMA MICHAEL V , SALLERAS JUAN D , HOLZAEPFEL JAC , RAMOS SYLVIA
发明人： FLYNN STEPHEN , LEVAUGHN RICHARD W , RUF CHRISTOPHER J , KENNEDY GWENN E , LIPOMA MICHAEL V , SALLERAS JUAN D , HOLZAEPFEL JAC , RAMOS SYLVIA
IPC分类号： A61B17/14 , A61B20060101 , A61B5/15
CPC分类号： A61B5/150259 , A61B5/150022 , A61B5/150061 , A61B5/150748 , A61B5/15105 , A61B5/15142
摘要： An endcap (10) for a lancing device. The endcap (10) has a substantially planar contact face (20) surrounding an opening (16) for passing a lancet tip. The contact face (20) has a length substantially greater than its with, and at least one side edge along its length. The user tips the lancing device to bring a side edge into contact with the skin several inches from the intended sampling site, draws the contact face (20) along the skin toward the sampling site, and lances the skin to obtain a fluid sample. The contact face (20) can be repeatedly drawn along the skin toward the sampling site to stimulate blood-flow until the desired sample size is obtained.
摘要翻译：一种用于采血装置的端盖（10）。端盖（10）具有围绕用于使刺血针尖端通过的开口（16）的大致平坦的接触面（20）。接触面（20）的长度基本上大于其长度，并且沿其长度具有至少一个侧边缘。用户提示穿刺装置使侧边缘与预期取样部位几英寸处的皮肤接触，沿着皮肤将接触面（20）拉向采样部位，并且将皮肤喷出以获得流体样品。可以将接触面（20）沿着皮肤重复地抽取到采样部位以刺激血流直到获得所需的样本大小。

9. 发明申请

WO2007089846A3 VERTEBRAL STABILIZATION ASSEMBLY AND METHOD 审中-公开
标题翻译： VERTEBRAL STABILIZATION ASSEMBLY和方法
公开(公告)号：WO2007089846A3
公开(公告)日：2008-01-24
申请号：PCT/US2007002648
申请日：2007-01-30
申请人： VAUGHAN MEDICAL TECHNOLOGIES I , VAUGHAN PAUL A
发明人： VAUGHAN PAUL A
IPC分类号： A61B17/70 , A61B20060101 , A61B17/17 , A61B17/56 , A61B17/58 , A61B17/88 , A61B19/00
CPC分类号： A61B17/1757 , A61B17/1735 , A61B17/70 , A61B17/7001 , A61B17/7059 , A61B17/7082 , A61B17/8875 , A61B90/36 , A61B2017/8655
摘要： A vertebral stabilization assembly for stabilizing vertebrae is disclosed. In one exemplary embodiment, the assembly comprises a first vertebral screw having a shaft with a threaded portion and an engaging portion, a second vertebral screw having a shaft with a threaded portion and an engaging portion, a first connecting screw having a first end configured to be engaged by the engaging portion of the first vertebral screw, a second connecting screw having a first end configured to be engaged by the engaging portion of the second vertebral screw, a first horizontal connecting member configured to be coupled to the first vertebral screw and the first connecting screw, a second horizontal connecting member configured to be coupled to the second vertebral screw and the second connecting screw, and a vertical connecting member configured to be coupled to the first horizontal connecting member and the second horizontal connecting member.
摘要翻译：公开了一种用于稳定椎骨的椎骨稳定组件。在一个示例性实施例中，组件包括具有带有螺纹部分和接合部分的轴的第一椎骨螺钉，具有带螺纹部分的轴和接合部分的第二椎骨螺钉，第一连接螺钉，其具有构造成由第一椎骨螺钉的接合部分接合，第二连接螺钉，其具有构造成与第二椎骨螺钉的接合部分接合的第一端;第一水平连接构件，其构造成联接到第一椎骨螺钉，第一连接螺钉，被配置为联接到第二椎骨螺钉和第二连接螺钉的第二水平连接构件，以及构造成联接到第一水平连接构件和第二水平连接构件的垂直连接构件。

10. 发明申请

WO2004058054A3 TRANSDUCER FOR SENSING BODY SOUNDS 审中-公开
标题翻译：用于传感身体的传感器
公开(公告)号：WO2004058054A3
公开(公告)日：2007-12-27
申请号：PCT/US0341422
申请日：2003-12-23
申请人： SMITH CLIVE
发明人： SMITH CLIVE
IPC分类号： A61B7/04 , A61B20060101 , A61B5/02 , A61B5/08 , A61B7/02 , H04R1/46 , H04R19/01
CPC分类号： H04R19/016 , A61B7/04 , A61B2560/0209 , A61B2562/0204 , H04R1/46
摘要： An acoustic-to-electrical transducer (152) for sensing body sounds is disclosed. The transducer (152) comprises a diaphragm (2/202) that can be placed in direct contact with a body, whereby the diaphragm motion directly affects an electromagnetic sensing signal, which is then converted to an electrical signal representation of the diaphragm motion. Such sensing means (70) allows the diaphragm (2/202) to move freely without mechanical coupling to a secondary transducer, while providing a direct and further provides a means for using static diaphragm pressure to control gain and frequency characteristics of the electrical signal. The transducer provides methods for ambient noise reduction or applications such as well as means for simulating sound detection for applications such as medical education and testing. The sensor, circuitry, manufacturing methods and improvements are disclosed.
摘要翻译：公开了一种用于感测身体声音的声 - 电传感器（152）。换能器（152）包括可以放置成与身体直接接触的隔膜（2/202），由此隔膜运动直接影响电磁感测信号，然后电磁感测信号被转换成隔膜运动的电信号表示。这种感测装置（70）允许膜片（2/202）在没有机械耦合到二次换能器的情况下自由移动，同时提供直接并且进一步提供使用静态隔膜压力来控制电信号的增益和频率特性的装置。传感器提供环境降噪或应用的方法，例如用于模拟医学教育和测试等应用的声音检测的手段。公开了传感器，电路，制造方法和改进。

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