化感作用相关的专利数据

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
181	COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PATHOGENIC BACTERIAL INFECTION BASED ON THE ESSENTIAL ROLE OF DNA METHYLATION IN BACTERIAL VIRULENCE	PCT/US0002866	2000-02-02	WO0045840A8	2001-03-22	MAHAN MICHAEL J; HEITHOFF DOUGLAS M; LOW DAVID A; SINSHEIMER ROBERT L
The present invention is directed towards vaccine compositions containing pathogenic bacteria such as Salmonella having non-reverting genetic mutations which alter activity of DNA adenine methylase (Dam) and methods using these compositions to elicit an immune response. The invention also provides methods for preparing vaccines as well as screening methods to identify agents which may have anti-bacterial activity.
182	USE OF RIFABUTIN AND A COMBINATION OF RIFABUTIN ANUSE OF RIFABUTIN AND A COMBINATION OF RIFABUTIN AND ATOVAQUONE IN THE TREATMENT OF PNEUMOCYSTIS CARID ATOVAQUONE IN THE TREATMENT OF PNEUMOCYSTIS CARINII INFECTIONS NII INFECTIONS	PCT/GB9502790	1995-11-29	WO9616652A3	1996-08-15	COMLEY JOHN CHARLES WILLIAM
The invention relates to combinations of atovaquone and rifabutin, their use in the treatment and prophylaxis of infections caused by P.carinii and their use in the manufacture of medicaments for the treatment and/or prophylaxis of such infections. The combinations can conveniently be administered in a single pharmaceutical formulation. Preferably, atovaquone and rifabutin are administered in a potentiating ratio so that they act in synergy.
183	USE OF PEUMUS BOLDUS EXTRACT OBTAINED BY MEANS OF IN VIVO CULTURE AND HAVING ANTI-BOTRYTIS, ALLELOPATHIC AND ANTIOXIDANT ACTIVITY	EP12794850.3	2012-10-19	EP2783693A1	2014-10-01	ZUÑIGA, Gustavo
Use of a Peumus Boldus extract obtained by in vitro culture, with antibotricide, allelochemical and antioxidant capacity.
184	USE OF A CHEMOTHERAPEUTIC AGENT IN THE PREPARATION OF A MEDICAMENT FOR TREATING OR AMELIORATING AN ADVERSE SIDE EFFECT ASSOCIATED WITH ONCOLYTIC VIRAL THERAPY	PCT/US2008008832	2008-07-18	WO2009011924A1	2009-01-22	YU YONG A
Gemcitabine, irinotecan, doxorubicin and cisplatin are chemotherapeutic agents shown to inhibit the growth of an oncolytic vaccinia virus. As such, they can control viral titer- in a subject. These compounds i can be used for the treatment or amelioration of side affects associated with oncolytic virus therapy, or for controlling' the oncolytic virus load in a subject.
185	COMBINED PREPARATION OF ANTI-INFECTIOUSLY ACTIVE COMPOUNDS WHICH INHIBIT THE 2-C-METHYLERYTHROSE-4 METABOLIC PATHWAY, AND INHIBITORS OF LIPID METABOLISM	PCT/EP1999/004360	1999-06-23	WO99066875A2	1999-12-29
The invention relates to a combined preparation which, as an active ingredient, contains at least one anti-infectiously active compound that inhibits the 2-C-methylerythrose-4 metabolic pathway, and which contains at least one lipid metabolism inhibitor. The combined preparation is used in infectious processes, especially in infections in humans and animals and as a herbicide in plants. It is shown that the build-up of resistance against the inventive combined preparation is largely reduced compared to the build-up of resistance against the individual components.
186	COMBINED PREPARATION OF ANTI-INFECTIOUSLY ACTIVE COMPOUNDS WHICH INHIBIT THE 2-C-METHYLERYTHROSE-4 METABOLIC PATHWAY, AND INHIBITORS OF LIPID METABOLISM	PCT/EP9904360	1999-06-23	WO9966875A3	2000-09-14	JOMAA HASSAN
The invention relates to a combined preparation which, as an active ingredient, contains at least one anti-infectiously active compound that inhibits the 2-C-methylerythrose-4 metabolic pathway, and which contains at least one lipid metabolism inhibitor. The combined preparation is used in infectious processes, especially in infections in humans and animals and as a herbicide in plants. It is shown that the build-up of resistance against the inventive combined preparation is largely reduced compared to the build-up of resistance against the individual components.
187	Positive-working radiation sensitive mixtures and articles containing alkali-soluble binder, o-quinonediazide photoactive compound and BLANKOPHOR FBW acting dye	US891011	1992-06-01	US5275909A	1994-01-04	Tripunithura V. Jayaraman; David J. Brzozowy
A radiation-sensitive composition comprising an admixture in a solvent of: at least one alkali-soluble binder resin, at least one photoactive compound and an effective absorbance increasing amount of BLANKOPHOR FBW actinic dye; the amount of said binder resin being about 60 to 95% by weight, the amount of said photoactive component being about 5% to about 40% by weight, based on the total solids content of said radiation-sensitive composition.
188	COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PATHOGENIC BACTERIAL INFECTION BASED ON THE ESSENTIAL ROLE OF DNA METHYLATION IN BACTERIAL VIRULENCE	EP00910070.2	2000-02-02	EP1150711A1	2001-11-07	MAHAN, Michael, J.; HEITHOFF, Douglas, M.; LOW, David, A.; SINSHEIMER, Robert, L.
The present invention is directed towards vaccine compositions containing pathogenic bacteria such as Salmonella having non-reverting genetic mutations which alter activity of DNA adenine methylase (Dam) and methods using these compositions to elicit an immune response. The invention also provides methods for preparing vaccines as well as screening methods to identify agents which may have anti-bacterial activity.
189	Linear magnetization mover motor due to linear force resulting from the interaction between magnetostatic induction element and electromagnetic coil	US909668	1992-07-07	US5302872A	1994-04-12	Yasutsugu Ohki; Shin-ichi Hase; Hiroyasu Toda; Kouichi Matsuoka; Tetsuo Uzuka
A linear motor has a mover that is a magnetostatic induction element and is relatively movable through electromagnetic coils or the like. The mover has a length of a magnetic path which derives attraction from the coil in regard to the length of the electromagnetic coil. As the magnetostatic induction element proceeds through the electromagnetic coils, the electromagnetic coils are energized while the magnetic field created thereby exert forward attractive force on the magnetostatic induction element, and disenergized before the traction in a reverse direction is exerted on the magnetostatic induction element.
190	KOMBINATIONSPRÄPARAT VON ANTIINFEKTIÖS WIRKENDEN VERBINDUNGEN, DIE DEN 2-C-METHYLERYTHROSE-4-STOFFWECHSELWEG HEMMEN, UND HEMMERN DES FETTSTOFFWECHSELS	EP99929309.5	1999-06-23	EP1100510A2	2001-05-23	Jomaa, Hassan
The invention relates to a combined preparation which, as an active ingredient, contains at least one anti-infectiously active compound that inhibits the 2-C-methylerythrose-4 metabolic pathway, and which contains at least one lipid metabolism inhibitor. The combined preparation is used in infectious processes, especially in infections in humans and animals and as a herbicide in plants. It is shown that the build-up of resistance against the inventive combined preparation is largely reduced compared to the build-up of resistance against the individual components.
191	Silver halide photographic light-sensitive material suitable for a rapid processing and capable of obtaining dye images excellent in fastness against light	EP87107975.2	1987-06-02	EP0252288A2	1988-01-13	Sasaki, Masao; Onodera, Kaoru
A silver halide color photographic light-sensitive material is disclosed, which has excellent rapid processability and is remarkably improved in spectral absorption characteristics and fastness against light of magent images. The photographic material omprising a support bearing at least one silver halide emulsion layer thereon, and the silver halide emulsion layer contains silver halide grains each containing silver chloride in an amount of not less than 80 mol%, and at least one couplers selected from the group consisting of the couplers represented by the following General Formulas (a), (b) and (c), respectively, or a polymer coupler comprising said coupler, and an anti-discoloring agent , each dispersed in the silver halide emulsion layer by making use of a high boiling organic solvent, provided that a proportion of said high boiling organic solvent to said coupler is not less than 0.6 by weight. General Formula
192	Biosensor for detecting or measuring a substance that interacts with a physiologically active substance comprising a polysaccharide capable of chemically immobilizing physiologically active subtances	EP06023147.9	2006-11-07	EP1783493A1	2007-05-09	Kuruma, Koji; Ezoe, Toshihide
An object of the present invention is to provide a biosensor that is capable of immobilizing large quantities of physiologically active substances thereon. The present invention provides a biosensor comprising a substrate having on its surface a polysaccharide capable of chemically immobilizing physiologically active substances, wherein the polysaccharide is a linear polysaccharide or a polysaccharide having 0.3 to 2 primary alcohol groups per unit.
193	MAGENSAFTRESISTENTE FORMULIERUNGEN ZUR APPLIKATION VON ANTIINFEKTIÖS WIRKENDEN VERBINDUNGEN, DIE DEN 2-C-METHYLERYTHROSE-4-STOFFWECHSELWEG HEMMEN, SOWIE IHREN SALZEN UND ESTERN	PCT/EP2002/003109	2002-03-20	WO2002078714A1	2002-10-10	JOMAA, Hassan; WOLF, Oliver
Magensaftresistente Formulierungen von antiinfektiös wirkenden Verbindungen, die den 2-C-Methylerythrose-4-Stoffwechselweg hemmen, sowie ihren Salzen und Estern, als Applikationsform zur Behandlung von Infektionen bei Mensch und Tier verursacht durch Viren, Bakterien und Parasiten. Es zeigt sich, dass die zu verabreichende Wirkstoffdosis durch den Einsatz von magensaftresistenten Formulierungen stark reduziert werden kann ohne die Wirksamkeit zu beeinflussen.
194	Method and apparatus for determining exposure to an oxidation-type sterilant using a non-pH-sensitive, bleachable metallic azo dye as chemical indicator	EP98309091.1	1998-11-06	EP0914833B1	2005-03-02	Antonoplos, Patricia A.; Hui, Henry K.; Ebrahim, Alireza; Feldman, Leslie A.; Kohli, Nitu

195	Chemical indicator for oxidative sterilization processes using bleachable dyes	EP98309091.1	1998-11-06	EP0914833A2	1999-05-12	Antonoplos, Patricia A.; Hui, Henry K.; Ebrahim, Alireza; Feldman, Leslie A.; Kohli, Nitu
A method and apparatus for detecting exposure to an oxidation-type sterilant using a chemical indicator comprising bleachable dye is disclosed. Using the method and apparatus disclosed, a bleachable azo dye is incorporated with an anodized aluminum or chromate conversion coated surface and exposed to an oxidation-type sterilant, such as hydrogen peroxide, and inspected upon completion of the sterilization process for color change. If exposed to sterilant for an appropriate amount of time the bleachable dye changes color thereby indicating adequate sterilization. The surface incorporating bleachable dye may be made to change color after a predetermined number of exposures to a oxidation-type sterilant.
196	THE USE OF COMPOUNDS SHOWING HEAT SHOCK PROTEIN (HSP) CO-INDUCING PROPERTIES TO ENHANCE THE INSULIN SENSITIZING EFFECT IN THE TREATMENT OF TYPE 2 DIABETES	PCT/IB2013/056254	2013-07-30	WO2015015248A1	2015-02-05	DR. PATONAY, Tamás 15 %; DR. SZILVÁSSY, Zoltán 11 %; DR. PEITL, Barna 11 %; DR. VÍGH, László 11 %; DR. TÖRÖK, Zsolt 11 %; DR. BERÉNYI, Sándor 10 %; DR. HORVÁTH, Ibolya 6 %; BALOGH, Gábor 5 %; DR. SOMSÁK, László 5 %; DR. KISS, Attila 5 %; DR. DRIMBA, László Péter 5 %; MOLNÁRNÉ HATVANI, Ilona 5 %
The invention relates to the use of compounds showing heat shock protein (HSP) co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes. The invention furthermore relates to a pharmaceutical preparation containing compounds showing HSP co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes.
197	METHOD FOR QUANTITATIVELY SENSING AND EFFECTIVELY MARKING INTERACTION WITH TARGET MATERIAL BY USING ENERGY TRANSFER AND SIGNAL CHANGE BASED ON HIGH-DENSITY DISPLAY OF MATERIAL	US14237840	2012-08-10	US20140309132A1	2014-10-16	Tae Kook Kim
The present invention relates to methods of quantitatively analyzing and detecting interactions, which effectively occur between detector materials displayed on a nano-assembly matrix at high density, and sensitively labeling and isolating a target material that effectively interacts with the detector materials, by the use of energy transfer and signal changes that effectively occur in label molecules displayed at high density. Specifically, the present invention relates to a method of quantitatively detecting the interactions between various bioactive materials, which occur in vitro or in vivo, based on high-density displays of molecules, and to a method of sensitively labeling a target material that interacts with these bioactive materials.
198	Method for preventing nonspecific adsorption of fluorescent intercalator to solid phase surface, hybridization detection method using the method, and substrate for bioassay	JP2004149226	2004-05-19	JP2005331334A	2005-12-02	MATSUMOTO SAYOKO; YAMASHITA YUKIISA; ONISHI MICHIHIRO; SATO KAZUMASA
PROBLEM TO BE SOLVED: To prevent effectively nonspecific adsorption of an intercalator onto the solid state surface. SOLUTION: The solid state surface f for detecting hybridization between a nucleic acid D for detection and a target nucleic acid T is covered with a material to be positively charged such as avidin or modified with a functional group to be positively charged resulting from a silane coupling agent, to thereby prevent nonspecific adsorption of the fluorescent intercalator I onto the solid state surface f. Thus this method is especially useful when detecting hybridization on the solid state surface f by using the fluorescent intercalator I. COPYRIGHT: (C)2006,JPO&NCIPI
199	A MAGNETIC MEASUREMENT SYSTEM BASED ON AN ULTRASENSITIVE PLANAR HALL MAGNETORESISTIVE BIOSENSOR (PHR) AND A METHOD FOR MEASURING LOW SPECIFIC BIOPARTICLES CONCENTRATIONS AND QUANTIFYING BIO-PARTICLES INTERACTIONS	EP16305639.3	2016-06-02	EP3252461A1	2017-12-06	TRAN, Quang Hung; TERKI, Ferial; KAMARA, Souleymane; FELIX, Gautier; KIM, CheolGi; KIM, KunWoo; KIM, SungJoon; RAMULU, Torati Sri
A magnetic measurement system (2) for measuring a concentration of specific bio-particles through a sensitive detection of magnetic particle labels comprises an aptamer-based magnetic hybrid AMR/PHR sensor (12) having an active surface (22) on which at least one magnetic particle (28) is ready to be or is closely bound through a sandwich-type aptamer structure that includes a captured unitary bio-particle. The magnetic measurement system is characterized in that an actual amplitude of an applied DC constant magnetic field onto the magnetic track (24) of the sensor (12) is closely located in a vicinity of an optimum amplitude of the permanent DC magnetic field comprised in a set of two optimum values H1, H2 of the permanent DC magnetic field, each optimum value H1, H2 maximizing locally the absolute value of a first quantity $H \cdot \frac{\partial V_{MR}}{\partial H},$ where H is the amplitude of the applied magnetic field and $\frac{\partial V_{MR}}{\partial H}$ is the derivate of the differential voltage with respect to the magnetic field at the applied field H.
200	Positive acting composition yielding pre-development high visibility image after radiation exposure comprising acid free novolak, diazo oxide and acid sensitive dyestuff	US273819	1981-06-15	US4348471A	1982-09-07	James Shelnut; Richard J. Cohen
A colored, positive-acting, radiation-sensitive composition whose color is extinguished or greatly decreased in intensity upon irradiation comprising at least one acid-free resin, at least one acid-sensitive dyestuff and at least one positive-acting component which yields an acidic product upon irradiation; positive-acting elements comprising suitable support materials at least one surface of which has been coated with the above composition and lithographic printing plates comprising the above elements, wherein the support materials are lithographically suitable support materials, which have been imagewise exposed to radiation wherein there is a high contrast, before development, between the colored image areas and less intensely colored or colorless non-image areas, the image areas of said plates being additionally highly stable against aqueous alkaline developers after development to remove the exposed non-image areas of the composition and more highly colored than the non-image areas of the revealed substrate surface.

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