The invention discloses a high-sensitivity micro-pressure sensor based on a dual pressure film and a weak coupling resonance system. The sensor comprises a pressure film layer and a quartz resonance layer. The pressure film layer is provided with two pressure films and two offset bosses and used to transmit pressure to be measured. The quartz resonance layer is provided with a weak coupling resonance system and a pair of excitation and detection electrodes. The weak coupling resonance system comprises two double-ended fixed support quartz beams and a weak coupling beam. The anchor points on both ends of the first double-ended fixed support quartz beam are engaged with the offset bosses on the pressure film layer, and are used to withstand compressive stress caused by the pressure to be measured. The excitation and detection electrodes are used to drive two double-ended fixed support quartz beams to resonate. The modal localization effect caused by the vibration imbalance of two quartzbeams is used, and the amplitude ratio of two quartz beams is detected as the output to acquire the pressure value to be measured. The sensor provided by the invention solves the problem of low sensitivity of micro pressure measurement of a traditional resonance pressure sensor, and has the advantages of high sensitivity and strong anti-interference ability.