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91. 发明授权

US11319591B2 Core transcriptional circuitry in human cells and methods of use thereof 有权
公开(公告)号：US11319591B2
公开(公告)日：2022-05-03
申请号：US15390275
申请日：2016-12-23
申请人： Whitehead institute for Biomedical Research
发明人： Violaine Saint-Andre , Brian J. Abraham , Zi Peng Fan , Tong Ihn Lee , Richard A. Young
IPC分类号： C12Q1/68 , C12Q1/6883
摘要： Disclosed are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.

92. 发明授权

US11293922B2 Sequential lateral flow device 有权
公开(公告)号：US11293922B2
公开(公告)日：2022-04-05
申请号：US16047980
申请日：2018-07-27
申请人： Verax Biomedical Incorporated
发明人： Yli Remo Vallejo , Gregory M. Lawrence , Adam P. Lousararian , Lisa Shinefeld
IPC分类号： G01N33/566 , G01N33/543 , G01N33/53 , B01L3/00 , G01N33/577 , G01N33/569 , G01N33/558
摘要： The present disclosure provides methods and lateral flow devices for detecting a plurality of target analytes in a liquid sample. In some implementations, the disclosed lateral flow device comprises a housing unit, a capillary flow bed, a sample-receiving zone, a buffer-receiving zone, and a capture zone. The device is configured to control the flow of the sample and reagent buffer in a sequential manner with minimal mixing. In some implementations, the disclosed method is capable of detecting a plurality of target analytes in an assay by applying the binding agents and the signaling agents in separate or sequential steps.

93. 发明授权

US11269611B2 Data interface processing method, device, server and medium 有权
公开(公告)号：US11269611B2
公开(公告)日：2022-03-08
申请号：US16314138
申请日：2018-04-12
申请人： BEIJING INTERNETWARE LIMITED COMPANY
发明人： Ying Zhang , Zhen Huang , Xing Su , Gang Huang , Wei Yao
IPC分类号： G06F8/65 , G06F9/54
摘要： A data interface processing method, device, server and medium are disclosed. The method includes: loading a configuration file when installing the user application, where the configuration file includes a configuration file of a combination relationship between at least one third-party application programming interface and at least one connector, and the connector is used to implement different data conversions between the third-party application programming interfaces. The combination relationship is set according to the requirements of the user application; obtaining, through the user application, user inputs as input parameters; converting, by the user application, the input parameters according to the combination relationship defined in the configuration file and outputting the converted input parameters.

94. 发明授权

US11255094B2 Expanding foam insulating system and method 有权
公开(公告)号：US11255094B2
公开(公告)日：2022-02-22
申请号：US16703448
申请日：2019-12-04
申请人： Sperry Product Innovation, Inc.
发明人： Anthony O. Davlin , Brian A. Murch , Marc B. Laverdiere
IPC分类号： E04B1/74 , E04F21/08 , E04B1/76 , E04B1/66
摘要： A method and system for the application of foam insulation onto a surface or into a cavity include a sheet with an aperture, where the sheet covers or partially covers the surface or a cavity with the aperture adjacent to the surface or cavity. A pressure-activated foam generator which generates foam is coupled with the sheet. The pressure-activated foam generator includes a frangible output seal with a ruptured position. The pressure-activated foam generator is positioned so that in the ruptured position the foam has a path from the frangible output seal through the aperture and onto the surface or into the cavity. The sheet is connected to cover or partially cover the surface or cavity, and the pressure-activated foam generator is activated and the foam flows onto the surface or into the cavity.

95. 发明授权

US11145391B1 Longitudinal condition tracking system and method 有权
公开(公告)号：US11145391B1
公开(公告)日：2021-10-12
申请号：US16518403
申请日：2019-07-22
申请人： Health Vector LLC
发明人： Dan M. Mirica
IPC分类号： G16H10/20 , G16H50/20 , H04L9/06 , G06F16/182 , G16H10/60
摘要： A system and method for coordinating cooperative diagnosis construction, decreasing diagnostic error, reducing delays and repetition in performing tasks, and improving application of data gathering devices through structured data tracking of symptoms, diagnoses, conditions and records using encrypted, event-based blockchain ledgers distributed throughout a network of processors. Symptom and diagnosis devices are used to collect participant data. Data is encrypted and used to generate a secure chain of decentralized ledger blocks. The secure chain is stored in a network of secure processing devices. Data access is controlled by a gatekeeper. Structured data blocks are integrated, creating a comprehensive digital record that may be shared without sacrificing control. Pathology collections are generated from integrated data. Interfaces are used to provide reports and directives to allow participants to leverage data and perform tasks that were heretofore unavailable while simultaneously improving privacy, security, usability and accessibility of participant conditions, events and data.

96. 发明授权

US11144861B1 System and method for modeling endorsement of skills of an individual in a skills map 有权
公开(公告)号：US11144861B1
公开(公告)日：2021-10-12
申请号：US16460657
申请日：2019-07-02
申请人： Vega Factor Inc.
发明人： Lindsay E. McGregor , Neel J. Doshi , Mary W. Miller
IPC分类号： G06Q10/06 , G06N5/02
摘要： The present invention relates to a system and method suitable for objectively evaluating individuals within an organization. In particular, the present invention relates to a system and method for objectively and consistently evaluating individuals for knowledge, training, and compensation within an organization, and across industries. Further the system and method provides models that enable individuals to identify skill that can be altered in a manner that dictates a desired career path and compensation range for the individual.

97. 发明授权

US11136585B2 UTRs increasing the translation efficiency of RNA molecules 有权
公开(公告)号：US11136585B2
公开(公告)日：2021-10-05
申请号：US15739147
申请日：2016-06-30
申请人： Ethris GmbH
发明人： Carsten Rudolph , Manish Kumar Aneja , Mehrije Ferizi , Johannes Geiger
IPC分类号： C07H21/04 , C12N15/67 , C07K14/47 , A61K38/00
摘要： Described is an RNA molecule comprising (a) a coding region coding for a polypeptide; and (b) upstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:1 or a sequence which shows 1 to 4 substitutions in comparison to SEQ ID NO:1 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:1; and/or (c) downstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:2 or a sequence which shows 1 to 7 substitutions in comparison to SEQ ID NO:2 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:2; wherein said polypeptide encoded by said coding region is not a cytochrome b-245 alpha polypeptide (CYBA). Moreover, described is a nucleic acid molecule encoding the RNA molecule according to the present invention. Further, described is a vector comprising the nucleic acid molecule according to the present invention and to a host cell comprising the vector according to the present invention. Further, described is a pharmaceutical composition comprising the RNA molecule according to the present invention and optionally a pharmaceutically acceptable carrier. Moreover, described is a kit comprising the RNA molecule according to the present invention. Finally, described is the use of one or more UTR(s) as defined in (b) and/or one or more UTR(s) as defined in (c) for increasing the efficiency of translating a coding region of an RNA molecule into a polypeptide or a protein encoded by said coding region.

98. 外观设计

USD926665S1 Set of aircraft canards 有权
公开(公告)号：USD926665S1
公开(公告)日：2021-08-03
申请号：US29692499
申请日：2019-05-24
申请人： Alakai Technologies Corporation
设计人： Brian D. Morrison , Andre H. De Salis , Martti J. Lampela , Adil M. Ali , Peter F. Falt

99. 发明授权

US11078463B2 SC-beta cells and compositions and methods for generating the same 有权
公开(公告)号：US11078463B2
公开(公告)日：2021-08-03
申请号：US16934333
申请日：2020-07-21
申请人： President and Fellows of Harvard College
发明人： Quinn P. Peterson , Felicia J. Pagliuca , Douglas A. Melton , Jeffrey R. Millman , Michael Saris Segel , Mads Gurtler
IPC分类号： C12N5/071 , C12N5/0735 , C12N5/074
摘要： Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.

100. 发明授权

US11017697B2 Visual display device with bead transport control 有权
公开(公告)号：US11017697B2
公开(公告)日：2021-05-25
申请号：US16560925
申请日：2019-09-04
申请人： Gordon Sharp
发明人： Gordon Sharp
IPC分类号： G09F19/12 , G10K15/04 , G09F27/00
摘要： A visual display device creating various visual and audible effects from the motion of light particulate matter, such as beads of expanded polystyrene, comprising a chamber through which a stream of air flow is configured to agitate, fluidize, suspend, or float at least some of the beads. The device also includes a bead transport control subsystem to control the flow of some beads through a conduit from one region of a chamber in the device to another different region in the chamber of the visual display device. The bead transport control subsystem comprises the conduit and a second stream of airflow into or out of a portion of the conduit through a screened opening to prevent or create fluid-like flow of the beads through the conduit that is controlled at least partially independently from the first stream of airflow.

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