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91. 发明专利

AU2047376A PYRROLIDONES 未知
公开(公告)号：AU2047376A
公开(公告)日：1978-06-15
申请号：AU2047376
申请日：1976-12-10
申请人： HOECHST AG
发明人： BARTMANN WILHELM , KUNSTMANN RUDOLF , LERCH ULRICH , SCHOLKENS BERNWARD
IPC分类号： C07D207/27 , A61K31/40 , A61K31/4015 , A61P43/00 , C07D207/26 , C07D405/06 , C07D405/08 , C07D405/12 , C07D409/06 , C07D409/08 , C07D409/12

92. 发明专利

AU1517776A PYRROLIDONES 未知
公开(公告)号：AU1517776A
公开(公告)日：1978-01-05
申请号：AU1517776
申请日：1976-06-23
申请人： HOECHST AG
发明人： REUSCHLING DIETER-BERND , KUHLEIN KLAUS , SCHOLKENS BERNWARD , KUNSTMANN RUDOLF , LERCH ULRICH , BARTMANN WILHELM , TEUFEL HERMANN , BECK GERHARD
IPC分类号： C07D207/26 , C07D207/27 , C07D405/12 , C07D405/06 , A61K31/40
摘要： The present invention relates to pyrrolidones which are analogues of prostaglandins and to a process for their manufacture. The compounds of the invention have prostaglandin-like pharmacological properties and can therefore be used as pharmaceutical compositions.

93. 发明专利

AU8243975A CYCLOPENTANE DERIVATIVES 未知
公开(公告)号：AU8243975A
公开(公告)日：1977-01-06
申请号：AU8243975
申请日：1975-06-25
申请人： HOECHST AG
发明人： BECK GERHARD , LERCH ULRICH , TEUFEL HERMANN
IPC分类号： C07D409/06 , C07C49/395 , C07D317/72 , C07D319/08 , C07D339/06 , C07D339/08 , C07D493/10 , C07D409/08 , C07C69/74 , C07C121/46 , C07C121/48

94. 发明专利

AU8178975A NEW CYCLOPENTANE DERIVATIVES FOR THEIR MANUFACTURE 未知
公开(公告)号：AU8178975A
公开(公告)日：1976-12-09
申请号：AU8178975
申请日：1975-06-03
申请人： HOECHST AG
发明人： LERCH ULRICH , BABEJ MILOS , BARTMANN WILHELM , KUNSTMANN RUDOLF
IPC分类号： A61K31/21 , C07C67/00 , C07C401/00 , C07C405/00 , C07C177/00 , C07D307/20 , C07D309/12 , C07D313/18
摘要： The present invention relates to new cyclopentane derivatives having the formula I and to a process for their manufacture. The compounds can be used as medicaments due to their antiprostaglandin effect.

95. 发明专利

ZA7507872B NOVEL PROSTAGLANDIN ANALOGOUS COMPOUNDS AND PROCESS FOR PREPARING THEM 未知
公开(公告)号：ZA7507872B
公开(公告)日：1976-11-24
申请号：ZA7507872
申请日：1975-12-19
申请人： HOECHST AG
发明人： BECK GERHARD , GERHARD BECK , LERCH ULRICH , ULRICH LERCH , SEEGER KARL , KARL SEEGER , TEUFEL HERMANN , HERMANN TEUFEL
IPC分类号： C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/38 , C07F9/40 , C07C , A61K
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12 , C07F9/4006

96. 发明专利

FI101963B1 未知
公开(公告)号：FI101963B1
公开(公告)日：1998-09-30
申请号：FI920269
申请日：1992-01-22
申请人： HOECHST AG
发明人： KAMMERMEIER BERNHARD , LERCH ULRICH
IPC分类号： C07D217/26
摘要： A process for the preparation of racemic and optically active 1,2.3,4-tetrahydroisoquinoline-3-carboxylic acid is described, in which dihalo-o-xylylenes are cyclized to dicarboxylic acid esters in basic medium using dialkyl N-acylamidomalonates of the formula (CO2R1)2CHNHCOR2, in which R1 is (C1-C4)-alkyl and R2 is H, (C1-C4)-alkyl or (C6-C12)-aryl, decarboxylated by basic hydrolysis and subsequent acid work-up and then reacted in acid medium to give (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, or dihalo-o-xylylenes are cyclized in basic medium to give the dicarboxylic acid esters and these are reacted directly without isolation in a one-pot process to give (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, if desired the racemic 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is reacted with (-)menthol and p-toluenesulfonic acid to give (-)menthyl (D)- or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate, then the diastereomers are separated by column chromatography and subjected to basic hydrolysis to give (D)-or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, or (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is esterified by means of benzyl alcohol and p-toluenesulfonic acid, reacted with D(-)mandelic acid to give benzyl (D)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (D)-mandelate and benzyl (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (D)-mandelate or with L(+)mandelic acid to give benzyl (D)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (L)-mandelate and benzyl (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (L)-mandelate and then the compounds obtained are separated into the optical antipodes by fractional crystallization in an inert solvent and the enantiomers (D)- or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid are liberated by basic hydrolysis, the chiral auxiliary reagent being recovered.

97. 发明专利

FI91876C Menetelmä nootrooppisen vaikutuksen omaavien aminohappojohdannaisten valmistamiseksi 未知
公开(公告)号：FI91876C
公开(公告)日：1994-08-25
申请号：FI871304
申请日：1987-03-25
申请人： HOECHST AG
发明人： HOCK FRANZ , SCHOLTHOLT JOSEF , URBACH HANSJOERG , HENNING RAINER , LERCH ULRICH , NICKEL WOLF-ULRICH , RUEGER WOLFGANG
IPC分类号： C07K14/81 , A61K38/00 , A61P9/12 , A61P25/28 , C07C235/02 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07D209/52

98. 发明专利

NZ228825A ESTERS OF AMINOACYL CYCLIC AMINO ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS 未知
公开(公告)号：NZ228825A
公开(公告)日：1993-11-25
申请号：NZ22882589
申请日：1989-04-20
申请人： HOECHST AG
发明人： HOCK FRANZ , SCHOLTHOLT JOSEF , URBACH HANSJORG , HENNING RAINER , LERCH ULRICH , NICKEL WOLF-ULRICH , RUGER WOLFGANG
IPC分类号： A61K38/00 , A61P25/28 , C07K1/02 , C07K1/06 , C07C219/02 , C07K1/113 , C07K5/02 , C07K5/06 , A61K37/02
摘要： The invention relates to esters of amino acids, of the formula I in which n is 2 and R, R , R , R , R and R have the meaning indicated in the description, to a process and intermediates for the preparation thereof, to agents containing them and to the use thereof.

99. 发明专利

DK163819C 未知
公开(公告)号：DK163819C
公开(公告)日：1992-09-07
申请号：DK602084
申请日：1984-12-14
申请人： HOECHST AG
发明人： LERCH ULRICH
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07D209/02 , C07D209/42 , C07D209/44 , C07D209/52
摘要： The invention relates to a process for resolving racemic mixtures of bicyclic imino- alpha -carboxylic acid esters into the components of the formula Ia and Ib in which R1 stands for an aliphatic, cycloaliphatic, aromatic or araliphatic radical, A denotes hydrogen and B and C together form a carbon chain or C denotes hydrogen and A and B together form a carbon chain, by crystallizing diastereoisomeric salts, which comprises preparing the salts of the racemic esters with optically active O,O-diacyltartaric acids in a suitable solvent in which only one of the two diastereoisomeric salts crystallizes in optically pure form, if desired purifying the diastereoisomeric salt by recrystallization, reprecipitation or trituration, and finally adding basec to the salt to cleave it into the pure enantiomer of the formula Ia or Ib. The invention also relates to diastereoisomeric salts of an ester of the formula Ia or Ib and a diacyltartaric acid.

100. 发明专利

AU627491B2 PIPERAZINEDIONES HAVING A PSYCHOTROPIC ACTION 未知
公开(公告)号：AU627491B2
公开(公告)日：1992-08-27
申请号：AU4095789
申请日：1989-09-01
申请人： HOECHST AG
发明人： NICKEL WOLF-ULRICH , HENNING RAINER , RUGER WOLFGANG , LERCH ULRICH , URBACH HANSJORG , HOCK FRANZ , WIEMER GABRIELE
IPC分类号： A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06
摘要： The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.

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