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1. 发明授权

KR790001459B1 PROCESS FOR PREPARING HEXEHYDRO-1H-INDENO(1,2-B) PYRIDINES 失效
公开(公告)号：KR790001459B1
公开(公告)日：1979-10-20
申请号：KR750002012
申请日：1975-09-10
申请人： HOECHST AG
发明人： RUDOLF KUNSTMANN , HERMANN GERHARDS , ULRICH LERCH
IPC分类号： A61K31/445 , C07D221/16
摘要： Title compds. (I; R1,R2 = H, halogen, hydroxy C1-C6 alkyl, C1-C6 alkoxy, R3 = halogen, hydroxy, nitro, amino etc. R4 = H, aliphatic etc.), useful as psychotropics, were prepd. by hydrogenation of compd. II with LiAlH4 or diisobutrylaluminiumhydride in inert solvent e.g., diethylether, tetrahydrofuran or their mixture.

2. 发明专利

ZA8702975B NOVEL BENZOTHIAZINONE DERIVATIVES,PROCESSES FOR THEIR PREPARATION,MEDICAMENTS CONTAINING THEM AND THEIR USE 未知
公开(公告)号：ZA8702975B
公开(公告)日：1987-11-25
申请号：ZA8702975
申请日：1987-04-27
申请人： HOECHST AG
发明人： LERCH ULRICH , ULRICH LERCH , HENNING RAINER , RAINER HENNING , KAISER JOACHIM , JOACHIM KAISER
IPC分类号： A61K31/54 , A61K31/5415 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , C07D279/16 , C07D , A61K
CPC分类号： C07D279/16

3. 发明专利

ZA7507872B NOVEL PROSTAGLANDIN ANALOGOUS COMPOUNDS AND PROCESS FOR PREPARING THEM 未知
公开(公告)号：ZA7507872B
公开(公告)日：1976-11-24
申请号：ZA7507872
申请日：1975-12-19
申请人： HOECHST AG
发明人： BECK GERHARD , GERHARD BECK , LERCH ULRICH , ULRICH LERCH , SEEGER KARL , KARL SEEGER , TEUFEL HERMANN , HERMANN TEUFEL
IPC分类号： C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/38 , C07F9/40 , C07C , A61K
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12 , C07F9/4006

4. 发明专利

ZA896717B PIPERAZINEDIONES HAVING A PSYCHOTROPIC ACTION 未知
公开(公告)号：ZA896717B
公开(公告)日：1990-05-30
申请号：ZA896717
申请日：1989-09-01
申请人： HOECHST AG
发明人： NICKEL WOLF-ULRICH , WOLF-ULRICH NICKEL , HENNING RAINER , RAINER HENNING , RUEGER WOLFGANG , WOLFGANG RUEGER , LERCH ULRICH , ULRICH LERCH , URBACH HANSJOERG , HANSJOERG URBACH , HOCK FRANZ , FRANZ HOCK , WIEMER GABRIELE , GABRIELE WIEMER
IPC分类号： A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06 , C07D , C07K , A61K
摘要： The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.

5. 发明专利

ZA872975B NOVEL BENZOTHIAZINONE DERIVATIVES,PROCESSES FOR THEIR PREPARATION,MEDICAMENTS CONTAINING THEM AND THEIR USE 未知
公开(公告)号：ZA872975B
公开(公告)日：1987-11-25
申请号：ZA872975
申请日：1987-04-27
申请人： HOECHST AG
发明人： LERCH ULRICH , ULRICH LERCH , HENNING RAINER , RAINER HENNING , KAISER JOACHIM , JOACHIM KAISER
IPC分类号： A61K31/54 , A61K31/5415 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , C07D279/16 , C07D , A61K
摘要： Benzothiazinone derivatives I (I) with R1 and R4 being H, alkyl, alkoxy, Hal, CF3, NO2, OH, acetamido or amino, R2 being H, (cyclo)alk(en)yl, cycloalkylakyl, phenyl or phenylalkyl, A being (CH2)mO(CH2)n, (CH2)p-CH(OH)-CH2)q, (CH2)p-CH(OCH3)-(CH2)q, or (CH2)rOCH2-CO- and (CH2)s-CO-, R5 being NR(6)R(7) or certain cyclic amines, show a calcium-antagonistic action. They are obtained, inter alia, from II (II) by reaction with III IIIa IIIb IIIc IIId IIIe A and B are same or different and are lower alkylene having 1 to 6 carbon atoms; and n is 3 to 4.

6. 发明专利

ZA8702972B BENZOTHIAZINONE DERIVATIVES,PROCESSES FOR THEIR PREPARATION,MEDICAMENTS CONTAINING THEM AND THEIR USE 未知
公开(公告)号：ZA8702972B
公开(公告)日：1987-11-25
申请号：ZA8702972
申请日：1987-04-27
申请人： HOECHST AG
发明人： LERCH ULRICH , ULRICH LERCH , HENNING RAINER , RAINER HENNING , KAISER JOACHIM , JOACHIM KAISER
IPC分类号： A61K31/54 , A61K31/5415 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , C07D279/16 , C07D417/12 , C07D , A61K
CPC分类号： C07D417/12 , C07D279/16

7. 发明专利

ZA757872B NOVEL PROSTAGLANDIN ANALOGOUS COMPOUNDS AND PROCESS FOR PREPARING THEM 未知
公开(公告)号：ZA757872B
公开(公告)日：1976-11-24
申请号：ZA757872
申请日：1975-12-19
申请人： HOECHST AG
发明人： BECK GERHARD , GERHARD BECK , LERCH ULRICH , ULRICH LERCH , SEEGER KARL , KARL SEEGER , TEUFEL HERMANN , HERMANN TEUFEL
IPC分类号： C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/38 , C07F9/40 , C07C , A61K
摘要： Prostaglandin analogues of formula (I) in the natural, optically active configuration or as racemic cpds.: (where R1 + R2 is O, or one of R1 and R2 is H and the other is OH; one of R3 and R4 is H and the other is OH; is 1-5C straight or branched alkyl, or phenyl or benzyl opt. mono- di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy; R5, when X is 1-5C alkyl, is a diphenyl ether gp. opt. mono- di- or tri-substd. in either or both nuclei by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy or a phenoxy-(2-5 C straight chain or 3-6C branched chain alkyl) opt. mono-di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy, or, when X is opt. substd. phenyl, a benzyl residue opt. mono- di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy, or, when X is opt. substd. benzyl, a phenyl residue opt. mono-, di- or tri-substd. by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy; and the C-atoms in the 5- and 6-positions and the 13- and 14-positions are all linked by single bonds or all linked by double bonds), e.g. 9-oxo-11 alpha, 15-dihydroxy-16-methyl-16-(3-chloro-4-(4-chlorophenoxy)-phenoxy)-- 5-cis-13-trans-tetranorprostadienoci acid, their physiologically tolerable salts with organic and inorganic bases, and their esters with 1-8C aliphatic, cycloaliphatic and araliphatic alcohols are new. (I) can be used as pharmaceuticals with hypotensive, diuretic, antithrombotic labour-inducing, abortifacient, contraceptive, gastric secretion inhibiting, antiulcer and antiasthmatic activity. They are particularly useful as contraceptives for use in humans and as agents for synchronising oestrus in various animal species. They are more potent and longer-acting than natural prostaglandins.

8. 发明专利

ZA903224B SUBSTITUTED BIPHENYLCARBOXYLIC ACIDS,A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES 未知
公开(公告)号：ZA903224B
公开(公告)日：1991-01-30
申请号：ZA903224
申请日：1990-04-27
申请人： HOECHST AG
发明人： LERCH ULRICH , ULRICH LERCH
IPC分类号： C07C51/06 , C07C63/70 , C07C63/72 , C07C65/24 , C07D263/10 , C07D263/14 , C07C , C07D
摘要： Novel biphenylcarboxylic acids of the formula I in which R has the meanings given and a process for their preparation are described.

9. 发明专利

ZA9003224B SUBSTITUTED BIPHENYLCARBOXYLIC ACIDS,A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES 未知
公开(公告)号：ZA9003224B
公开(公告)日：1991-01-30
申请号：ZA9003224
申请日：1990-04-27
申请人： HOECHST AG
发明人： LERCH ULRICH , ULRICH LERCH
IPC分类号： C07C51/06 , C07C63/70 , C07C63/72 , C07C65/24 , C07D263/10 , C07D263/14 , C07C , C07D
CPC分类号： C07D263/10 , C07C63/72 , C07C65/24

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