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11. 发明授权

US08784633B2 Automatic positioning and sensing microelectrode arrays 有权
标题翻译：自动定位和感应微电极阵列
公开(公告)号：US08784633B2
公开(公告)日：2014-07-22
申请号：US12667507
申请日：2007-07-04
申请人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
发明人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N33/4836 , B01J2219/00653 , B01J2219/00743 , B01L3/502707 , B01L2300/0645 , B01L2400/0421 , B01L2400/0424
摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.
摘要翻译：微电极感测装置包括基板和微电极传感器阵列。每个传感器包括至少部分地导电的第一导电层。第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。每个传感器还包括至少部分地传导电的第二导电层。第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

12. 发明申请

US20070299007A1 Muteins OF Fibroblast Growth Factor 21 有权
标题翻译：成纤维细胞生长因子的突变蛋白21
公开(公告)号：US20070299007A1
公开(公告)日：2007-12-27
申请号：US11571933
申请日：2005-08-25
申请人： Christopher Frye , Lihua Huang , Radmila Micanovic
发明人： Christopher Frye , Lihua Huang , Radmila Micanovic
IPC分类号： C07K14/50 , A61K38/18 , A61P3/04 , C07K7/00 , A61P3/10
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to novel muteins of human fibroblast growth factor-21 with reduced susceptibility for proteolytic degradation when expressed in yeast. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome. X-16816
摘要翻译：本发明涉及当在酵母中表达时具有降低的蛋白水解降解易感性的人成纤维细胞生长因子-21的新颖突变蛋白。公开了蛋白质和各自编码的核酸物质。本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。还公开了治疗2型糖尿病，肥胖症或代谢综合征的方法。 X-16816

13. 发明申请

US20070293430A1 Muteins of Fibroblast Growth Factor 21 失效
标题翻译：成纤维细胞生长因子的突变蛋白21
公开(公告)号：US20070293430A1
公开(公告)日：2007-12-20
申请号：US11718636
申请日：2005-12-07
申请人： Christopher Frye , Lihua Huang , Radmila Micanovic
发明人： Christopher Frye , Lihua Huang , Radmila Micanovic
IPC分类号： A61K38/18 , A61P3/00 , A61P3/04 , A61P3/10 , C07K14/475
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with reduced deamidation compared to wild-type human FGF-21. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.
摘要翻译：本发明涉及与野生型人FGF-21相比，减少脱酰胺的人成纤维细胞生长因子21的新颖突变蛋白。公开了蛋白质和各自编码的核酸物质。本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。还公开了治疗2型糖尿病，肥胖症或代谢综合征的方法。

14. 外观设计

USD927249S1 Cup lid 有权
公开(公告)号：USD927249S1
公开(公告)日：2021-08-10
申请号：US29743783
申请日：2020-07-24
申请人： Lihua Huang
设计人： Lihua Huang

15. 外观设计

USD889114S1 Water bottle 有权
公开(公告)号：USD889114S1
公开(公告)日：2020-07-07
申请号：US29659141
申请日：2018-08-07
申请人： Lihua Huang
设计人： Lihua Huang

16. 发明授权

US07622445B2 Muteins of fibroblast growth factor 21 有权
标题翻译：成纤维细胞生长因子21的突变蛋白
公开(公告)号：US07622445B2
公开(公告)日：2009-11-24
申请号：US11571933
申请日：2005-08-25
申请人： Christopher Carl Frye , Lihua Huang , Radmila Micanovic
发明人： Christopher Carl Frye , Lihua Huang , Radmila Micanovic
IPC分类号： C07K14/50 , A61K38/18
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to novel muteins of human fibroblast growth factor-21 with reduced susceptibility for proteolytic degradation when expressed in yeast. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.
摘要翻译：本发明涉及当在酵母中表达时具有降低的蛋白水解降解易感性的人成纤维细胞生长因子-21的新颖突变蛋白。公开了蛋白质和各自编码的核酸物质。本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。还公开了治疗2型糖尿病，肥胖症或代谢综合征的方法。

17. 发明授权

US07582607B2 Muteins of fibroblast growth factor 21 有权
标题翻译：成纤维细胞生长因子21的突变蛋白
公开(公告)号：US07582607B2
公开(公告)日：2009-09-01
申请号：US11574332
申请日：2005-07-26
申请人： Christopher Carl Frye , Lihua Huang , Radmila Micanovic
发明人： Christopher Carl Frye , Lihua Huang , Radmila Micanovic
IPC分类号： A61K38/18 , C07K14/50
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with reduced capacity of O-glycosylation when expressed in yeast compared to wild-type human FGF-21. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.
摘要翻译：本发明涉及当与野生型人FGF-21相比时在酵母中表达时O-糖基化能力降低的人成纤维细胞生长因子21的新颖突变蛋白。公开了蛋白质和各自编码的核酸物质。本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。还公开了治疗2型糖尿病，肥胖症或代谢综合征的方法。

18. 发明申请

US20080103096A1 Muteins of Fibroblast Growth Factor 21 有权
标题翻译：成纤维细胞生长因子的突变蛋白21
公开(公告)号：US20080103096A1
公开(公告)日：2008-05-01
申请号：US11574332
申请日：2005-07-26
申请人： Christopher Carl Frye , Lihua Huang , Radmila Micanovic
发明人： Christopher Carl Frye , Lihua Huang , Radmila Micanovic
IPC分类号： A61K38/18
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with reduced capacity of O-glycosylation when expressed in yeast compared to wild-type human FGF-21. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.
摘要翻译：本发明涉及当与野生型人FGF-21相比时在酵母中表达时O-糖基化能力降低的人成纤维细胞生长因子21的新颖突变蛋白。公开了蛋白质和各自编码的核酸物质。本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。还公开了治疗2型糖尿病，肥胖症或代谢综合征的方法。

19. 发明申请

US20060189162A1 Adhesion improvement for low k dielectrics 有权
公开(公告)号：US20060189162A1
公开(公告)日：2006-08-24
申请号：US11405852
申请日：2006-04-18
申请人： Lihua Huang , Tzu-Fang Huang , Dian Sugiarto , Jerry Sugiarto , Li-qun Xia , Peter Lee , Hichem M'Saad , Zhenjiang Cui , Sohyun Park
发明人： Lihua Huang , Tzu-Fang Huang , Dian Sugiarto , Jerry Sugiarto , Li-qun Xia , Peter Lee , Hichem M'Saad , Zhenjiang Cui , Sohyun Park
IPC分类号： H01L21/31 , H01L21/469
CPC分类号： H01L21/31633 , C23C16/02 , C23C16/325 , C23C16/401 , H01L21/02126 , H01L21/02274 , H01L21/02304 , H01L21/76801 , H01L21/7681 , H01L21/76826 , H01L21/76832
摘要： Methods are provided for processing a substrate for depositing an adhesion layer having a low dielectric constant between two low k dielectric layers. In one aspect, the invention provides a method for processing a substrate including introducing an organosilicon compound and an oxidizing gas at a first ratio of organosilicon compound to oxidizing gas into the processing chamber, generating a plasma of the oxidizing gas and the organosilicon compound to form an initiation layer on a barrier layer comprising at least silicon and carbon, introducing the organosilicon compound and the oxidizing gas at a second ratio of organosilicon compound to oxidizing gas greater than the first ratio into the processing chamber, and depositing a first dielectric layer adjacent the dielectric initiation layer.

20. 发明申请

US20060162661A1 Mixing energized and non-energized gases for silicon nitride deposition 审中-公开
标题翻译：混合通电和无能气体用于氮化硅沉积
公开(公告)号：US20060162661A1
公开(公告)日：2006-07-27
申请号：US11040712
申请日：2005-01-22
申请人： Kee Jung , Dale Du Bois , Lun Tsuei , Lihua Huang , Martin Seamons , Soovo Sen , Reza Arghavani , Michael Kwan
发明人： Kee Jung , Dale Du Bois , Lun Tsuei , Lihua Huang , Martin Seamons , Soovo Sen , Reza Arghavani , Michael Kwan
IPC分类号： H05H1/24 , C23C16/00 , H01L21/306 , C23F1/00 , B08B6/00
CPC分类号： C23C16/45574 , C23C16/345 , C23C16/452 , C23C16/45565 , C23C16/50 , H01J37/3244 , H01L21/0217 , H01L21/3185
摘要： A dual channel gas distributor can simultaneously distribute plasma species of an first process gas and a non-plasma second process gas into a process zone of a substrate processing chamber. The gas distributor has a localized plasma box with a first inlet to receive a first process gas, and opposing top and bottom plates that are capable of being electrically biased relative to one another to define a localized plasma zone in which a plasma of the first process gas can be formed. The top plate has a plurality of spaced apart gas spreading holes to spread the first process gas across the localized plasma zone, and the bottom plate has a plurality of first outlets to distribute plasma species of the plasma of the first process gas into the process zone. A plasma isolated gas feed has a second inlet to receive the second process gas and a plurality of second outlets to pass the second process gas into the process zone. A plasma isolator is between the second inlet and second outlets to prevent formation of a plasma of the second process gas in the plasma isolated gas feed.
摘要翻译：双通道气体分配器可以将第一工艺气体和非等离子体第二工艺气体的等离子体种类同时分配到衬底处理室的工艺区域中。气体分配器具有局部等离子体盒，其具有第一入口以接收第一工艺气体，以及相对的顶板和底板，其能够相对于彼此电偏置以限定局部等离子体区，其中第一工艺的等离子体可以形成气体。顶板具有多个间隔开的气体扩散孔，以将第一处理气体扩散通过局部等离子体区域，并且底板具有多个第一出口，用于将第一处理气体的等离子体的等离子体物质分配到处理区。等离子体隔离气体进料具有用于接收第二处理气体的第二入口和多个第二出口以将第二处理气体通入处理区。等离子体隔离器位于第二入口和第二出口之间，以防止在等离子体隔离气体进料中形成第二工艺气体的等离子体。

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