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11. 发明申请

US20070280991A1 Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug 有权
标题翻译：用于可控释放亲水药物和疏水性药物的可植入医疗器械的涂层
公开(公告)号：US20070280991A1
公开(公告)日：2007-12-06
申请号：US11447551
申请日：2006-06-05
申请人： Thierry Glauser , Irina Astafieva , Syed Faiyaz Ahmed Hossainy
发明人： Thierry Glauser , Irina Astafieva , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61F2/02 , A61K31/4745 , C08G63/91
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/25 , A61L2300/416 , A61L2300/45 , A61L2300/602 , C08L75/04 , C08L33/14
摘要： Provided herein is a coating that includes cRGD for endothelial cells and methods of making and using the same.
摘要翻译：本文提供了包含内皮细胞的cRGD及其制备和使用方法的涂层。

12. 发明授权

US08735344B2 Sustained release of APO A-I mimetic peptides and methods of treatment 有权
标题翻译： APO A-I模拟肽的持续释放和治疗方法
公开(公告)号：US08735344B2
公开(公告)日：2014-05-27
申请号：US13177476
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。

13. 发明申请

US20110263497A1 APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
标题翻译： APO A-I MIME技术和治疗方法
公开(公告)号：US20110263497A1
公开(公告)日：2011-10-27
申请号：US13177473
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
IPC分类号： A61K38/10 , A61P9/10
CPC分类号： A61K38/17 , A61K31/661 , A61K38/10 , A61K38/1709
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与内源性Apo AI相关肽的顺序相反的顺序。一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

14. 发明申请

US20090081298A1 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
公开(公告)号：US20090081298A1
公开(公告)日：2009-03-26
申请号：US11946026
申请日：2007-11-27
申请人： Katsuyuki Murase , Syed F. A. Hossainy , Irina Astafieva , Li Zhao , Hong Ma
发明人： Katsuyuki Murase , Syed F. A. Hossainy , Irina Astafieva , Li Zhao , Hong Ma
IPC分类号： A61K9/14 , A61K38/02 , A61K38/10 , A61K38/17 , C07K14/775 , C07K7/08
CPC分类号： C07K7/08 , A61F2/95 , A61K9/1075 , A61K9/127 , A61K38/00 , A61L29/16 , A61L2300/25 , A61L2300/802 , A61M25/1011 , A61M2025/0086 , A61M2025/105 , A61M2025/1075 , C07K7/06 , C07K14/775
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

15. 发明授权

US08101565B2 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US08101565B2
公开(公告)日：2012-01-24
申请号：US11946026
申请日：2007-11-27
申请人： Katsuyuki Murase , Syed F. A. Hossainy , Irina Astafieva , Li Zhao , Hong Ma
发明人： Katsuyuki Murase , Syed F. A. Hossainy , Irina Astafieva , Li Zhao , Hong Ma
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K7/08 , A61F2/95 , A61K9/1075 , A61K9/127 , A61K38/00 , A61L29/16 , A61L2300/25 , A61L2300/802 , A61M25/1011 , A61M2025/0086 , A61M2025/105 , A61M2025/1075 , C07K7/06 , C07K14/775
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

16. 发明授权

US07985727B1 Apo A-I mimetic peptides and methods of treatment 有权
标题翻译： Apo A-I模拟肽和治疗方法
公开(公告)号：US07985727B1
公开(公告)日：2011-07-26
申请号：US11858851
申请日：2007-09-20
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
IPC分类号： A61K38/10 , A61K31/661
CPC分类号： A61K38/17 , A61K31/661 , A61K38/10 , A61K38/1709
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与内源性Apo AI相关肽的顺序相反的顺序。一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

17. 发明授权

US08383592B2 Apo A-I mimetic peptides and methods of treatment 有权
标题翻译： Apo A-I模拟肽和治疗方法
公开(公告)号：US08383592B2
公开(公告)日：2013-02-26
申请号：US13177473
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
IPC分类号： C07K7/00 , C07K14/00
CPC分类号： A61K38/17 , A61K31/661 , A61K38/10 , A61K38/1709
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与内源性Apo AI相关肽的顺序相反的顺序。一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

18. 发明授权

US07985728B1 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US07985728B1
公开(公告)日：2011-07-26
申请号：US11858862
申请日：2007-09-20
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。

19. 发明授权

US09594171B2 Detector for radiation, particularly high energy electromagnetic radiation 有权
标题翻译：辐射检测器，特别是高能量电磁辐射
公开(公告)号：US09594171B2
公开(公告)日：2017-03-14
申请号：US14403707
申请日：2012-06-08
申请人： Irina Astafieva , Oliver Heid , Timothy Hughes
发明人： Irina Astafieva , Oliver Heid , Timothy Hughes
IPC分类号： G01V5/04 , G01T1/185 , H01J47/02 , G01T1/20
CPC分类号： G01T1/185 , G01T1/2006 , H01J47/02 , H01J47/024
摘要： A detector for radiation, particularly high energy electromagnetic radiation is provided. The detector includes a converting section including a cathode for converting the radiation incident on the converting section in electrons by the photoelectric effect. The detector further includes a gas electron multiplier for generating an electron avalanche from electrons which are generated by the converting section and enter the gas electron multiplier, the gas electron multiplier including a first electrode, a dielectric layer and a second electrode, the first electrode being disposed at a first side of the dielectric layer adjacent to the converting section and the second electrode being disposed at a second side of the dielectric layer opposite to the first side. The gas electron multiplier includes a number of holes filled with gas, the holes extending through the first electrode, the dielectric layer and the second electrode.
摘要翻译：提供了用于辐射的检测器，特别是高能量的电磁辐射。检测器包括转换部分，其包括用于通过光电效应将入射在转换部分上的辐射转换为电子的阴极。检测器还包括气体电子倍增器，用于从由转换部分产生并进入气体电子倍增器的电子产生电子雪崩，气体电子倍增器包括第一电极，电介质层和第二电极，第一电极为设置在与转换部相邻的电介质层的第一侧，第二电极设置在与第一侧相反的电介质层的第二侧。气体电子倍增器包括填充有气体的多个孔，所述孔延伸穿过第一电极，电介质层和第二电极。

20. 发明授权

US07087600B2 Peptidyl prodrugs and linkers and stabilizers useful therefor 有权
公开(公告)号：US07087600B2
公开(公告)日：2006-08-08
申请号：US10161234
申请日：2002-05-31
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
IPC分类号： A61K31/535 , A61K31/407 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

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