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1. 发明授权

US09259398B1 Bioactive agent-loaded targeting micelles 有权
标题翻译：生物活性剂负载靶向胶束
公开(公告)号：US09259398B1
公开(公告)日：2016-02-16
申请号：US12324618
申请日：2008-11-26
申请人： Kyle Klein , Katsuyuki Murase , Jinping Wan , Dariush Davalian
发明人： Kyle Klein , Katsuyuki Murase , Jinping Wan , Dariush Davalian
IPC分类号： A61K9/50 , A61K51/00 , A01N25/28 , A61K31/00 , A61K38/00 , A61K39/44
CPC分类号： A61K31/00 , A61K9/1075 , A61K38/00 , A61K39/44 , A61K47/183
摘要： A composition of bioactive agent-loaded micelles with tissue-targeting properties and methods of using the same are disclosed.
摘要翻译：公开了具有组织靶向特性的生物活性剂负载胶束的组合物及其使用方法。

2. 发明申请

US20100104506A1 Nanoparticle-Coated Medical Devices And Formulations For Treating Vascular Disease 审中-公开
标题翻译：纳米颗粒涂层医疗器械和治疗血管疾病的配方
公开(公告)号：US20100104506A1
公开(公告)日：2010-04-29
申请号：US12652668
申请日：2010-01-05
申请人： Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Katsuyuki Murase , Li Zhao , Irina Astafieva
发明人： Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Katsuyuki Murase , Li Zhao , Irina Astafieva
IPC分类号： A61K51/00 , A61K9/00 , A61K31/56 , A61K31/4353 , A61K31/337 , A61K31/66 , A61K38/16 , A61K49/00 , A61K49/06 , A61K49/22 , A61K49/04 , A61P9/00
CPC分类号： A61L31/10 , A61K9/1075 , A61K9/127 , A61K9/51 , A61L31/16 , A61L2300/624 , A61L2300/626 , A61L2400/12
摘要： Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The medical device includes a coating that comprises a plurality of nanoparticles, wherein the nanoparticles comprise one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles and further comprise one or more contrast enhancing agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles.
摘要翻译：公开了纳米颗粒涂覆的医疗装置，含纳米颗粒的制剂和用于治疗血管疾病的方法。医疗装置包括包含多个纳米颗粒的涂层，其中所述纳米颗粒包含一种或多种包封在其内，附着于纳米颗粒结构的表面或整合到纳米颗粒的结构中的生物活性剂，还包含一种或多种包封在其内的对比增强剂，粘附到纳米颗粒的结构的表面或整合到纳米颗粒的结构中。

3. 发明授权

US09173890B2 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US09173890B2
公开(公告)日：2015-11-03
申请号：US11946028
申请日：2007-11-27
申请人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
发明人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
IPC分类号： A61K38/00 , A61K31/661 , A61K9/14 , A61K38/10 , A61K38/17 , A61P3/00 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51
CPC分类号： A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

4. 发明申请

US20120061067A1 Heat sink 审中-公开
标题翻译：散热器
公开(公告)号：US20120061067A1
公开(公告)日：2012-03-15
申请号：US13199948
申请日：2011-09-13
申请人： Motonori Tominaga , Tsutomu Kamizono , Masanobu Katou , Katsuyuki Murase
发明人： Motonori Tominaga , Tsutomu Kamizono , Masanobu Katou , Katsuyuki Murase
IPC分类号： F28F7/00
CPC分类号： H01L23/3672 , F21V29/77 , F21V29/773 , F21W2102/00 , F21Y2115/10 , H01L2924/0002 , H01L2924/00
摘要： A heat sink includes a pillar member, to which a device that generates heat is to be mounted, and a plurality of heat-dissipating fins arranged on a side surface of the pillar member to dissipate the heat generated by the device. The heat sink further includes a ring-shaped holding member that has a plurality of grooves formed therein. The holding member is mounted to a longitudinal end of the pillar member and has each of the heat-dissipating fins inserted in a corresponding one of the grooves of the holding member, thereby holding the heat-dissipating fins to the pillar member. Each of the heat-dissipating fins has a detachment prevention portion that prevents the heat-dissipating fin from being detached from the pillar member in a direction perpendicular to the longitudinal direction of the pillar member.
摘要翻译：散热器包括：要安装发热装置的柱构件;以及布置在柱构件的侧表面上以散发由装置产生的热的多个散热翅片。散热器还包括形成有多个槽的环状保持构件。保持构件被安装到柱构件的纵向端部，并且每个散热翅片插入到保持构件的相应的一个槽中，从而将散热翅片保持在柱构件上。每个散热片具有防止散热片沿与柱构件的纵向方向垂直的方向从柱构件分离的防脱部。

5. 发明申请

US20100104653A1 Nanoparticle-Coated Medical Devices And Formulations For Treating Vascular Disease 审中-公开
标题翻译：纳米颗粒涂层医疗器械和治疗血管疾病的配方
公开(公告)号：US20100104653A1
公开(公告)日：2010-04-29
申请号：US12652697
申请日：2010-01-05
申请人： Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Katsuyuki Murase , Li Zhao , Irina Astafieva
发明人： Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Katsuyuki Murase , Li Zhao , Irina Astafieva
IPC分类号： A61K9/16
CPC分类号： A61L31/10 , A61K9/1075 , A61K9/127 , A61K9/51 , A61L31/16 , A61L2300/624 , A61L2300/626 , A61L2400/12
摘要： Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The method for treating a vascular disease includes providing a formulation comprising a plurality of nanoparticles having a density different from that of blood and further comprising one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles; and administering a therapeutically effective amount of the formulation to a vascular disease locale in a patient.
摘要翻译：公开了纳米颗粒涂覆的医疗装置，含纳米颗粒的制剂和用于治疗血管疾病的方法。用于治疗血管疾病的方法包括提供包含多个密度不同于血液的密度的纳米颗粒的制剂，并且进一步包含一种或多种包封在其内，附着于纳米颗粒的结构表面或整合到纳米颗粒结构中的生物活性剂; 以及将治疗有效量的制剂施用于患者的血管疾病区域。

6. 发明申请

US20090081299A1 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
公开(公告)号：US20090081299A1
公开(公告)日：2009-03-26
申请号：US11946029
申请日：2007-11-27
申请人： Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
发明人： Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
IPC分类号： A61K9/14 , A61K38/00 , A61K38/10 , A61P3/00 , A61K38/17 , A61K31/661
CPC分类号： A61K31/661 , A61K9/1647 , A61K9/5084 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

7. 发明授权

US08735344B2 Sustained release of APO A-I mimetic peptides and methods of treatment 有权
标题翻译： APO A-I模拟肽的持续释放和治疗方法
公开(公告)号：US08735344B2
公开(公告)日：2014-05-27
申请号：US13177476
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。

8. 发明申请

US20110263497A1 APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
标题翻译： APO A-I MIME技术和治疗方法
公开(公告)号：US20110263497A1
公开(公告)日：2011-10-27
申请号：US13177473
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
IPC分类号： A61K38/10 , A61P9/10
CPC分类号： A61K38/17 , A61K31/661 , A61K38/10 , A61K38/1709
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与内源性Apo AI相关肽的顺序相反的顺序。一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

9. 发明申请

US20110262530A1 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
标题翻译：可持续发布的APO A-I型胶原蛋白和治疗方法
公开(公告)号：US20110262530A1
公开(公告)日：2011-10-27
申请号：US13177476
申请日：2011-07-06
申请人： KATSUYUKI MURASE , LI ZHAO , IRINA ASTAFIEVA , PAUL M. CONSIGNY , STEPHEN D. PACETTI , DARIUSH DAVALIAN , SYED FAYAIZ AHMED HOSSAINY , FLORIAN N. LUDWIG , JINPING WAN , JOHN STANKUS , RACHEL BRIGHT
发明人： KATSUYUKI MURASE , LI ZHAO , IRINA ASTAFIEVA , PAUL M. CONSIGNY , STEPHEN D. PACETTI , DARIUSH DAVALIAN , SYED FAYAIZ AHMED HOSSAINY , FLORIAN N. LUDWIG , JINPING WAN , JOHN STANKUS , RACHEL BRIGHT
IPC分类号： A61K38/16 , A61K38/10 , A61K9/127 , A61K9/14 , A61K9/00 , A61P9/10 , B82Y5/00
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。

10. 发明授权

US08044021B2 Sustained release of apo A-I mimetic peptides and methods of treatment 有权
标题翻译：载脂蛋白A-I模拟肽的持续释放和治疗方法
公开(公告)号：US08044021B2
公开(公告)日：2011-10-25
申请号：US11946029
申请日：2007-11-27
申请人： Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
发明人： Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： A61K31/661 , A61K9/1647 , A61K9/5084 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

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