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1. 发明授权

US09173890B2 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US09173890B2
公开(公告)日：2015-11-03
申请号：US11946028
申请日：2007-11-27
申请人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
发明人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
IPC分类号： A61K38/00 , A61K31/661 , A61K9/14 , A61K38/10 , A61K38/17 , A61P3/00 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51
CPC分类号： A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

2. 发明授权

US08961589B2 Bioabsorbable coating with tunable hydrophobicity 有权
公开(公告)号：US08961589B2
公开(公告)日：2015-02-24
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
IPC分类号： A61F2/82 , A61L31/16 , A61L31/10 , A61L31/14
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.

3. 发明授权

US08500687B2 Stent delivery system having a fibrous matrix covering with improved stent retention 失效
标题翻译：支架输送系统具有纤维基质覆盖，具有改善的支架保留
公开(公告)号：US08500687B2
公开(公告)日：2013-08-06
申请号：US13069020
申请日：2011-03-22
申请人： Kevin J. Ehrenreich , Richard Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9583 , A61L29/16 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： The present invention provides an intraluminal stent delivery catheter device having improved stent retention. Particularly, the present invention is directed to a catheter having an expandable member and a fibrous matrix positioned over the expandable member and a stent mounted on the outer surface of the fibrous matrix. The fibrous matrix provides mechanical interface for improved stent retention, delivery and deployment.
摘要翻译：本发明提供了具有改善的支架保留的管腔内支架输送导管装置。特别地，本发明涉及一种导管，其具有位于可扩张部件上方的可扩张部件和纤维矩阵，以及安装在纤维基质外表面上的支架。纤维基质提供机械界面，用于改进支架保留，递送和部署。

4. 发明申请

US20120276152A1 SYSTEMS AND METHODS OF USING ZINC-CHELATOR TO TREAT MYOCARDIAL INFARCTION 审中-公开
标题翻译：使用锌化合物治疗心肌梗塞的系统和方法
公开(公告)号：US20120276152A1
公开(公告)日：2012-11-01
申请号：US13366841
申请日：2012-02-06
申请人： Syed Hossainy , John Stankus , Mikael Trollsas , Dariush Davalian
发明人： Syed Hossainy , John Stankus , Mikael Trollsas , Dariush Davalian
IPC分类号： A61K9/00 , A61K31/351 , A61K31/4412 , A61K31/44 , A61K38/02 , A61K31/734 , A61K31/045 , A61K33/26 , A61K31/04 , A61K31/519 , A61K31/4985 , A61K31/352 , A61K38/22 , A61K31/198 , A61K33/00 , A61K31/502 , A61K47/30 , A61P9/10 , A61K31/16
CPC分类号： A61K31/16 , A61K31/04 , A61K31/045 , A61K31/198 , A61K31/351 , A61K31/352 , A61K31/44 , A61K31/4412 , A61K31/4985 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： Methods and systems for treating an infarct by delivery of zinc chelator to modulate tissue.
摘要翻译：通过递送锌螯合剂来调节组织来治疗梗死的方法和系统。

5. 发明申请

US20120252089A1 CYTOCOMPATIBLE ALGINATE GELS 有权
公开(公告)号：US20120252089A1
公开(公告)日：2012-10-04
申请号：US13525165
申请日：2012-06-15
申请人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jingping Wan , John Stankus
发明人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jingping Wan , John Stankus
IPC分类号： C12N11/04
CPC分类号： A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
摘要： The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.

6. 发明申请

US20120064141A1 Drug-Coated Balloon With Location-Specific Plasma Treatment 有权
标题翻译：具有位置特异性等离子体处理的药物涂层气球
公开(公告)号：US20120064141A1
公开(公告)日：2012-03-15
申请号：US12883024
申请日：2010-09-15
申请人： Anthony S. Andreacchi , Stephen D. Pacetti , John Stankus , Victoria M. Gong , Michael J. Leonard , Binh Nguyen
发明人： Anthony S. Andreacchi , Stephen D. Pacetti , John Stankus , Victoria M. Gong , Michael J. Leonard , Binh Nguyen
IPC分类号： A61F2/00 , B05D3/06 , C23C14/02
CPC分类号： B05D3/144 , A61F2/82 , B05D7/02 , C08J7/123
摘要： Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.
摘要翻译：涂覆可膨胀构件的方法，例如气囊，所述方法包括提供具有外表面的可扩张构件。该方法包括在可扩张构件的外表面的至少一部分上进行气体供应的等离子体处理。在执行等离子体处理之后，至少在可膨胀构件的外表面的等离子体处理部分上施加治疗剂。等离子体处理可以降低治疗剂对可扩张构件表面的粘附。还提供了通过所公开的方法制造的医疗装置。

7. 发明申请

US20100266349A1 Impact Resistant Lagging, Method For Designing Impact Resistant Lagging, and Apparatus for Testing Impact Resistant Lagging 有权
标题翻译：抗冲击滞后设计方法，耐冲击阻尼设计方法，耐冲击阻尼试验装置
公开(公告)号：US20100266349A1
公开(公告)日：2010-10-21
申请号：US12714139
申请日：2010-02-26
申请人： Kevin Jinrong Ma , John Stankus , Robert McGinnis , Dakota Faulkner , Demrey Brandon , John Feyrer
发明人： Kevin Jinrong Ma , John Stankus , Robert McGinnis , Dakota Faulkner , Demrey Brandon , John Feyrer
IPC分类号： E21D23/04 , E21D5/00 , G01N3/30
CPC分类号： G01N3/30 , E21D11/18 , E21D11/28
摘要： A steel set assembly includes a first pair of legs and a second pair of legs with the first pair of legs being spaced from and positioned opposite the second pair of legs. First and second beams are provided with the first beam being secured to one leg of the first pair of legs and one leg of the second pair of legs. The second beam is secured to the other leg of the first pair of legs and the other leg of the second pair of legs. A panel is secured to the first and second beams and includes a base having a top surface and a bottom surface, a block having a top surface and a bottom surface, and a pad. The block is secured to the base and the pad is positioned between the top surface of the base and the bottom surface of the block.
摘要翻译：钢组件包括第一对腿和第二对腿，其中第一对腿与第二对腿分开并与第二对腿相对定位。第一和第二梁设置有第一梁被固定到第一对腿的一条腿和第二对腿的一条腿。第二梁被固定到第一对腿的另一条腿和第二对腿的另一条腿。面板被固定到第一和第二梁上并且包括具有顶表面和底表面的基部，具有顶表面和底表面的块以及垫。块被固定到基部，并且垫位于基部的顶表面和块的底表面之间。

8. 发明申请

US20100226955A1 POLYMER FOR CREATING HEMOCOMPATIBLE SURFACE 有权
标题翻译：聚合物用于制造易爆表面
公开(公告)号：US20100226955A1
公开(公告)日：2010-09-09
申请号：US12397154
申请日：2009-03-03
申请人： Florian N. Ludwig , John Stankus , Mikael Trollsas
发明人： Florian N. Ludwig , John Stankus , Mikael Trollsas
IPC分类号： A61F2/04 , C08F30/02 , C08L89/00 , A61K9/127 , C08L53/00 , A61K31/436 , C09D135/02
CPC分类号： A61L31/10 , A61K31/436 , A61K47/32 , A61L29/085 , A61L31/16 , A61L33/06 , C08F220/28 , Y10T428/31935
摘要： A polymer comprising a phosphoryl choline moiety(ies), a composition comprising the polymer and optionally a bioactive agent, an implantable device such as a DES or a non-implantable device such as an angioplasty balloon comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.
摘要翻译：包含磷酰胆碱部分的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置例如DES或非可植入装置，例如血管成形术球囊，其上包括包含聚合物的涂层和任选的提供了生物活性剂，以及使用该装置来治疗人的病症的方法。

9. 发明申请

US20100076401A1 Expandable Member Having A Covering Formed Of A Fibrous Matrix For Intraluminal Drug Delivery 有权
标题翻译：具有用于腔内药物递送的纤维基质覆盖物的可膨胀构件
公开(公告)号：US20100076401A1
公开(公告)日：2010-03-25
申请号：US12237998
申请日：2008-09-25
申请人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
发明人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
IPC分类号： A61M25/10 , B23P11/00 , B29C47/00
CPC分类号： A61M25/10 , A61F2/958 , A61F2002/9583 , A61L29/085 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088 , Y10T29/49826
摘要： The present invention generally relates to an intraluminal catheter device for use in angioplasty and delivery of a therapeutic agent. Particularly, the present invention is directed to a catheter having an expandable member having a therapeutic agent disposed thereon and a fibrous matrix covering for delivering a therapeutic agent and methods of using the same.
摘要翻译：本发明一般涉及用于血管成形术和治疗剂递送的管腔内导管装置。特别地，本发明涉及具有设置在其上的治疗剂的可膨胀构件的导管和用于递送治疗剂的纤维基质覆盖物及其使用方法。

10. 发明申请

US20070076887A1 Double phase encoding quantum key distribution 审中-公开
标题翻译：双相编码量子密钥分配
公开(公告)号：US20070076887A1
公开(公告)日：2007-04-05
申请号：US11241164
申请日：2005-09-30
申请人： Randy Kuang , Guo Wang , John Stankus
发明人： Randy Kuang , Guo Wang , John Stankus
IPC分类号： H04L9/00
CPC分类号： H04L9/0858
摘要： A laser pulse representing a bit of a quantum key is split into two pulses. In addition to known round trip phase encoding schema, a secret phase key is modulated into one of the two pulses: P1 and P2. The secret phase key is used to identify whether the returning pulses originated from the sender, i.e., whether the key distribution has been attacked by an eavesdropper. A secret key phase modulator randomly modulates pulse P1. An attenuator then reduces the average photon number of the modulated pulse P1 to a selected level greater than one to increase the likelihood of efficient, successful transmission while reducing the possibility of eavesdropping, e.g., μ=10. Both pulses P1 and P2 are sent to the intended recipient and reflected to the sender. Pulse P2 is modulated upon return to the sender using the same secret phase key previously modulated into pulse P1. Therefore, when both pulses meet together at a coupler/beamsplitter of the sender, both pulses should contain the same secret key in their phase and therefore exhibit no resulting phase difference if the photon pulse is the same pulse originated by the sender. If the returning pulse is not the pulse originated by the sender then phase differences indicative of a so-called intercept-resend attack applied by an eavesdropper EVE are indicated by a large quantum bit error rate (“QBER”) will be detectable. If EVE applies photon-split attack, the secret phase key modulated by the sender prevents Eve from knowing the encoded key information in the photon(s). Therefore, double phase encoding QKD enables use of multi-photon pulses without unacceptable loss of security, thereby enhancing QKD bit rate.
摘要翻译：表示量子键位的激光脉冲被分成两个脉冲。除了已知的往返相位编码模式之外，秘密相位键被调制成两个脉冲之一：P 1和P 2。秘密相位键用于识别来自发送者的返回脉冲是否是密钥分发是否已被窃听者攻击。秘密密钥相位调制器随机调制脉冲P 1。然后，衰减器将调制脉冲P 1的平均光子数减小到大于1的选定电平，以增加有效成功传输的可能性，同时降低窃听的可能性，例如，μ= 10。两个脉冲P 1和P 2被发送到预期的接收者并被反射到发送者。在使用预先调制到脉冲P 1中的相同秘密相位键返回发送器时，脉冲P 2被调制。因此，当两个脉冲在发送器的耦合器/分束器处相遇在一起时，两个脉冲在它们的相位中应该包含相同的秘密密钥，因此如果光子脉冲是由发送器产生的相同的脉冲，则不会产生相位差。如果返回的脉冲不是由发送器产生的脉冲，则指示由窃听者EVE施加的所谓的截距重发攻击的相位差由大量子比特误码率（“QBER”）指示。如果EVE应用光子分裂攻击，则由发送者调制的秘密相位键防止Eve知道光子中的编码密钥信息。因此，双相编码QKD使得能够使用多光子脉冲而不会无法接受的安全损失，从而提高QKD比特率。

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