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    • 14. 发明授权
    • Anti-diabetic extract isolated from rauvolfia vomitoria and citrus aurantium, and methods of using same
    • 从狂犬病和柑橘中分离的抗糖尿病提取物及其使用方法
    • US07579025B2
    • 2009-08-25
    • US12240913
    • 2008-09-29
    • Joan Campbell-Tofte
    • Joan Campbell-Tofte
    • A61K36/00A61K131/00A61K135/00A61K127/00
    • A61K36/24A61K31/4745A61K36/752A61K2300/00
    • This invention provides a process for extracting a pharmaceutically active fraction from the foliage (leaves and stems) and/or roots of Rauvolfia vomitoria and the fruit of Citrus aurantium. In one aspect, the process requires extracting from a boiled tea of Rauvolfia vomitoria foliage and/or roots and Citrus aurantium fruit an active fraction made by filtering the boiled tea and concentrating the supernatant. In one embodiment, the fraction is concentrated by freeze drying the supernatant. The fraction is useful to treat a disorder associated with abnormally elevated glucose levels in a subject by administering to the subject a therapeutically effective amount of the extract or a pharmaceutical composition containing the extract. Such conditions include, but are not limited to the diabetes Type II, abnormal steraroyl-CoA desaturase activity, hyperphagia, abnormal lipid mobilization, abnormal fatty acid profile from the eye of the subject, ulcers and a glucosuria.
    • 本发明提供了一种从萝卜(Vauvolfia vomitoria)的叶子(叶和茎)和/或根和柑橘的果实中提取药物活性成分的方法。 在一个方面,该方法需要从萝卜茶叶和/或根的煮沸茶和柑橘ium汁中提取通过过滤煮沸的茶并浓缩上清液而制成的活性级分。 在一个实施方案中,通过冷冻干燥上清液来浓缩级分。 通过向受试者施用治疗有效量的提取物或含有提取物的药物组合物,该级分可用于治疗与受试者异常升高的葡萄糖水平相关的病症。 这些病症包括但不限于糖尿病II型,异硬脂酰辅酶A去饱和酶活性,食欲不振,异常脂质动员,来自受试者眼睛的异常脂肪酸谱,溃疡和葡萄糖尿症。
    • 19. 发明申请
    • Method for producing grape extract with high ORAC value, and grape extract so proudced
    • 葡萄提取物生产ORAC值高,葡萄提取物骄傲的方法
    • US20110250344A1
    • 2011-10-13
    • US13134692
    • 2011-06-14
    • Weichao YingXiaoyan XiongJiaomei ChenJianying Yang
    • Weichao YingXiaoyan XiongJiaomei ChenJianying Yang
    • A23L1/29A61K131/00
    • A61K36/87A23L33/105A23V2002/00A23V2200/02A23V2250/21166
    • Grape material is processed to yield a grape extract high in concentrated polyphenols, with ORAC values exceeding at least about 10,000 μmol TE/g. The grape material is dried, and soaked in ethanol to commence desired concentrate extraction. Following ethanol removal, inactive residue is at least partially separated from the desired concentrate solution, which passes through a macroporous absorption resin that absorbs desired active ingredients. Ethanol resin washing yields an intermediate extraction solution. After ethanol removal, the intermediate extract solution with the mixed active ingredients is refined. During refinement, high concentration of polyphenols and monomeric phenols are separated, and collected. These collected materials yield a desired high ORAC extract solution. Further drying yields the desired material, which is tested and packaged. This material exhibits good water solubility, mild flavor, and can be added to foodstuffs and nutritional supplements as a beneficial antioxidant.
    • 处理葡萄材料以产生高浓度多酚的葡萄提取物,ORAC值超过至少约10,000μmolTE / g。 将葡萄原料干燥并浸泡在乙醇中以开始所需的浓缩物萃取。 除去乙醇后,惰性残余物至少部分地从所需的浓缩液中分离出来,该浓缩液通过吸收所需活性成分的大孔吸收树脂。 乙醇树脂洗涤产生中间提取溶液。 乙醇除去后,将具有混合活性成分的中间体提取液精制。 在精制过程中,高浓度的多酚和单体苯酚被分离并收集。 这些收集的材料产生期望的高ORAC提取物溶液。 进一步的干燥产生所需的材料,其被测试和包装。 该材料具有良好的水溶性,温和的味道,可作为有益的抗氧化剂添加到食品和营养补充剂中。
    • 20. 发明申请
    • METHODS AND COMPOSITIONS FOR WEIGHT LOSS USING GARCINIA INDICA FRUIT PUREE
    • 使用GARCINIA INDICA FRUIT PUREE的重量损失的方法和组合
    • US20100233306A1
    • 2010-09-16
    • US12405045
    • 2009-03-16
    • Sevanti Mehta
    • Sevanti Mehta
    • A61K36/38A61K31/194A61P3/04A61K131/00
    • A61K36/38A61K31/194
    • Methods for increasing weight loss in a mammal in need thereof are provided. In one embodiment the method comprises administering to a mammal a weight loss effective amount of Garcinia indica fruit purée. In another embodiment of the present invention, a method of administering to a mammal a weight loss effective amount of naturally occurring HCA, cyanidin-3-sambubioside and cyanidine 3-glucoside from Garcinia indica fruit purée is provided. In another embodiment, a method for providing a stabilized hydroxycitric acid composition comprising hydroxycitric acid and anthocyanins to provide a very pure, stabilized preparation that is substantially tasteless for optimal use in a variety of foods items which includes treating an aqueous extract of Garcinia indica fruit with a liquid quaternizing agent such as a trialkylamine in which the alkyl groups are octyl, caprylyl, isooctyl, lauryl or decyl.
    • 提供了有需要的哺乳动物增加体重减轻的方法。 在一个实施方案中,该方法包括向哺乳动物施用减肥有效量的藤黄果实果肉。 在本发明的另一个实施方案中,提供了一种向哺乳动物施用减肥有效量的来自藤黄果的天然存在的HCA,花青素-3-三聚苷和氰胺3-葡萄糖苷的方法。 在另一个实施方案中,提供包含羟基柠檬酸和花青素的稳定的羟基柠檬酸组合物的方法,以提供非常纯的,稳定的制剂,其在各种食品中的最佳用途基本上是无味的,其包括用 诸如三烷基胺的液体季铵化剂,其中烷基是辛基,辛酰基,异辛基,月桂基或癸基。