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21. 发明申请

US20070072858A1 Process for the stereoselective preparation of (-)-halofenate and derivatives thereof 失效
标题翻译：（ - ） - 卤代苯甲酸酯及其衍生物的立体选择性制备方法
公开(公告)号：US20070072858A1
公开(公告)日：2007-03-29
申请号：US11525200
申请日：2006-09-20
申请人： Yan Zhu , Peng Cheng , Xin Chen , Jingyuan Ma , Zuchun Zhao
发明人： Yan Zhu , Peng Cheng , Xin Chen , Jingyuan Ma , Zuchun Zhao
IPC分类号： A61K31/5375 , A61K31/495 , A61K31/4025 , A61K31/401
CPC分类号： C07D295/185
摘要： The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1-C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4)aminoalkyl, amido, (C1-C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds
摘要翻译：本发明提供式（IV）化合物及其制备下式的α-（苯氧基）苯乙酸化合物的方法：其中R 1是选自以下的成员：各 R 2是独立地选自（C 1 -C 4 -C 4）烷基，卤素，（C 1 -C 4）烷基的成员， C 1 -C 4卤代烷基，氨基，（C 1 -C 4）氨基烷基，酰氨基，（C 1 H 4）（C 1 -C 4）磺酰基烷基，（C 1 -C 4）磺酰基烷基，（C 1 -C 4 - C 1 -C 4亚磺酰基烷基，（C 1 -C 4 -C 4）烷氧基，（C 1 -C 3 - 亚磺酰基烷基） > 4个）杂烷基，羧基和硝基; 当R 1具有式（a）或（b）时，下标n为1，当R 1具有式（c）或（d））时，下标n为1。下标m为0〜3的整数; *表示富含一种立体异构构型的碳; 波浪线表示R 1的连接点; 和化合物

22. 发明申请

US20070037813A1 Serine Protease Inhibitors 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂
公开(公告)号：US20070037813A1
公开(公告)日：2007-02-15
申请号：US11537482
申请日：2006-09-29
申请人： Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
发明人： Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
IPC分类号： A61K31/50 , A61K31/44 , A61K31/165 , C07D237/02
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要： Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
摘要翻译：具有如下结构的化合物可用于抑制丝氨酸蛋白酶，例如TF /因子VIIa，因子Xa，凝血酶和激肽释放酶。这些化合物可用于预防和/或治疗凝血障碍的方法。

23. 发明申请

US20060014809A1 Substituted triazoles as modulators of PPAR and methods of their preparation 有权
标题翻译：取代三唑作为PPAR的调节剂及其制备方法
公开(公告)号：US20060014809A1
公开(公告)日：2006-01-19
申请号：US11137678
申请日：2005-05-24
申请人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
发明人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
IPC分类号： A61K31/4192 , C07D249/04
CPC分类号： C07D249/06 , C07D409/10
摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
摘要翻译：本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

24. 发明授权

US06919369B2 Serine protease inhibitors 失效
标题翻译：丝氨酸蛋白酶抑制剂
公开(公告)号：US06919369B2
公开(公告)日：2005-07-19
申请号：US10224114
申请日：2002-08-19
申请人： Ignacio Aliagas-Martin , Dean R. Artis , Michael S. Dina , John A. Flygare , Richard A. Goldsmith , Regina A. Munroe , Alan G. Olivero , Richard Pastor , Thomas E. Rawson , Kirk D. Robarge , Daniel P. Sutherlin , Kenneth J. Weese , Aihe Zhou , Yan Zhu
发明人： Ignacio Aliagas-Martin , Dean R. Artis , Michael S. Dina , John A. Flygare , Richard A. Goldsmith , Regina A. Munroe , Alan G. Olivero , Richard Pastor , Thomas E. Rawson , Kirk D. Robarge , Daniel P. Sutherlin , Kenneth J. Weese , Aihe Zhou , Yan Zhu
IPC分类号： C07D333/34 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/381 , A61P7/02 , A61P9/10 , C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要： Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
摘要翻译：具有如下结构的化合物可用于抑制丝氨酸蛋白酶，例如TF /因子VIIa，因子Xa，凝血酶和激肽释放酶。这些化合物可用于预防和/或治疗凝血障碍的方法。

25. 发明授权

US08975258B2 Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的杂环受体激动剂
公开(公告)号：US08975258B2
公开(公告)日：2015-03-10
申请号：US13612451
申请日：2012-09-12
申请人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： A61K31/50 , C07D413/04 , C07D401/04 , C07D401/14 , C07D417/14 , C07D413/14 , C07D417/04
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

26. 发明申请

US20140024830A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：用于治疗糖尿病和代谢障碍的异位受体激动剂
公开(公告)号：US20140024830A1
公开(公告)日：2014-01-23
申请号：US13612451
申请日：2012-09-12
申请人： Xin Chen , Peng Cheng , L. Edwards Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jaingao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edwards Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jaingao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： C07D413/04 , C07D413/14
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

27. 发明授权

US08434544B2 Die casting process incorporating computerized pattern recognition techniques 有权
标题翻译：包含计算机化模式识别技术的压铸工艺
公开(公告)号：US08434544B2
公开(公告)日：2013-05-07
申请号：US13442628
申请日：2012-04-09
申请人： Arnie Fulton , Yan Zhu , Michael Bomar
发明人： Arnie Fulton , Yan Zhu , Michael Bomar
IPC分类号： B22D46/00
CPC分类号： B22D17/32 , B22D46/00
摘要： A die casting process using pattern recognition techniques to identify those die castings manufactured under conditions likely to produce a die casting which would subsequently prove unacceptable for use. By promptly identifying such die castings, they may be discarded before being shipped to a remote facility for further processing. As a result, the rejection rate of die castings at the remote facility may be reduced and the raw materials used to form the discarded die castings may be more readily recycled.
摘要翻译：使用模式识别技术的压铸方法来识别在可能产生压铸件的条件下制造的那些压铸件，随后将被证明是不可接受的。通过及时识别这种压铸件，在运送到远程设备进行进一步处理之前，可将其丢弃。结果，可以减少远程设备的压铸件的排出率，并且用于形成废弃压铸件的原材料可以更容易地再循环。

28. 发明授权

US08344931B2 N-bits successive approximation register analog-to-digital converting circuit 有权
标题翻译： N位逐次逼近寄存器模数转换电路
公开(公告)号：US08344931B2
公开(公告)日：2013-01-01
申请号：US13150508
申请日：2011-06-01
申请人： Yan Zhu , Chi-Hang Chan , U-Fat Chio , Sai-Weng Sin , Seng-Pan U , Rui Paulo Da Silva Martins , Franco Maloberti
发明人： Yan Zhu , Chi-Hang Chan , U-Fat Chio , Sai-Weng Sin , Seng-Pan U , Rui Paulo Da Silva Martins , Franco Maloberti
IPC分类号： H03M1/12
CPC分类号： H03M1/002 , H03M1/466
摘要： The present invention provides an n-bits successive approximation register (SAR) analog-to-digital converting (ADC) circuit, comprising: an n-bits SAR control logic, a p-type capacitor network including a DACp array and a sampling capacitor CSp, an n-type capacitor network including a DACn array and a sampling capacitor CSn; and a comparator for comparing outputs from the p-type capacitor network and the n-type capacitor network, wherein a power supply and ground are directly connected to the p-type capacitor network and the n-type capacitor network without using reference voltages produced by a reference voltage generator. The n-bits SAR control logic comprises n shift registers, n bit registers, and a switching logic. The comparator comprises a first pre-amplifier, a second pre-amplifier and a dynamic latch. Alternative, the comparator comprises a four-input pre-amplifier and a dynamic latch.
摘要翻译：本发明提供一种n位逐次逼近寄存器（SAR）模数转换（ADC）电路，包括：n位SAR控制逻辑，包括DACp阵列和采样电容器CSp的p型电容器网络包括DACn阵列和采样电容器CSn的n型电容器网络; 以及用于比较来自p型电容器网络和n型电容器网络的输出的比较器，其中电源和接地直接连接到p型电容器网络和n型电容器网络，而不使用由p型电容器网络和n型电容器网络产生的参考电压参考电压发生器。 n位SAR控制逻辑包括n个移位寄存器，n个位寄存器和一个开关逻辑。比较器包括第一前置放大器，第二前置放大器和动态锁存器。替代方案，比较器包括四输入前置放大器和动态锁存器。

29. 发明授权

US08183381B2 N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的N-连接的杂环受体激动剂
公开(公告)号：US08183381B2
公开(公告)日：2012-05-22
申请号：US12171209
申请日：2008-07-10
申请人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号： C07D401/00
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。

30. 发明授权

US08167022B2 Die casting process incorporating computerized pattern recognition techniques 有权
标题翻译：包含计算机化模式识别技术的压铸工艺
公开(公告)号：US08167022B2
公开(公告)日：2012-05-01
申请号：US13100778
申请日：2011-05-04
申请人： Arnie Fulton , Yan Zhu , Michael Bomar
发明人： Arnie Fulton , Yan Zhu , Michael Bomar
IPC分类号： B22D46/00
CPC分类号： B22D17/32 , B22D46/00
摘要： A die casting process using pattern recognition techniques to identify those die castings manufactured under conditions likely to produce a die casting which would subsequently prove unacceptable for use. By promptly identifying such die castings, they may be discarded before being shipped to a remote facility for further processing. As a result, the rejection rate of die castings at the remote facility may be reduced and the raw materials used to form the discarded die castings may be more readily recycled.
摘要翻译：使用模式识别技术的压铸方法来识别在可能产生压铸件的条件下制造的那些压铸件，随后将被证明是不可接受的。通过及时识别这种压铸件，在运送到远程设备进行进一步处理之前，可将其丢弃。结果，可以减少远程设备的压铸件的排出率，并且用于形成废弃压铸件的原材料可以更容易地再循环。

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