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21. 发明授权

US07384633B2 Human type antihuman IgE receptor antibody and fragment 失效
标题翻译：人类抗人IgE受体抗体和片段
公开(公告)号：US07384633B2
公开(公告)日：2008-06-10
申请号：US10484206
申请日：2002-07-18
申请人： Kazuhisa Sugimura , Toshihiro Nakashima , Masaharu Torikai
发明人： Kazuhisa Sugimura , Toshihiro Nakashima , Masaharu Torikai
IPC分类号： A61K39/395
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/622 , Y10S424/805
摘要： An antibody or an antibody fragment is provided that is efficacious for treating allergic diseases in which IgE is involved. A human antibody and a fragment thereof to a receptor (FcεRI) having high affinity to Fc portion of IgE was obtained using phage antibody display technique. The human anti-IgE receptor antibody and a fragment thereof of the invention has an activity to inhibit the binding between IgE and IgE receptor and hence is expected to be useful as a medicament for treating allergic diseases caused by the binding between IgE and IgE receptor.
摘要翻译：提供抗体或抗体片段，其对于治疗涉及IgE的过敏性疾病是有效的。使用噬菌体抗体展示技术，获得对IgE的Fc部分具有高亲和力的受体（FcepsilonRI）的人抗体及其片段。本发明的人抗IgE受体抗体及其片段具有抑制IgE和IgE受体之间结合的活性，因此预期可用作治疗由IgE和IgE受体结合引起的过敏性疾病的药物。

22. 发明申请

US20080131422A1 Human Anti-Amyloid Beta Peptide Antibody And Fragment Of Said Antibody 失效
标题翻译：所述抗体的人抗淀粉样蛋白β肽抗体和片段
公开(公告)号：US20080131422A1
公开(公告)日：2008-06-05
申请号：US11579072
申请日：2005-04-21
申请人： Kazuhisa Sugimura , Toshihiro Nakashima
发明人： Kazuhisa Sugimura , Toshihiro Nakashima
IPC分类号： A61K39/00 , C07K16/00 , C07H21/04 , C12N15/00 , A61P43/00 , C12N5/00 , C12P21/04 , G01N33/53
CPC分类号： G01N33/6896 , A61K31/7088 , A61K48/00 , C07K16/18 , C07K2317/21 , C07K2317/622 , G01N2333/4709 , G01N2800/2821
摘要： A human anti-amyloid β peptide (hereinafter referred to as “Aβ”) antibody that binds to Aβ to thereby inhibit aggregation of Aβ molecules, and a fragment of said antibody are provided. The antibody and a fragment thereof according to the present invention, comprising a variable region of a human-derived anti-Aβ antibody, strongly reacts with Aβ to thereby inhibit its aggregation and hence may be used as a medicament for the prophylaxis and treatment of Alzheimer dementia.
摘要翻译：提供了与Abeta结合从而抑制Abeta分子聚集的人抗淀粉样蛋白β肽（以下称为“Abeta”）抗体和所述抗体的片段。包含人源抗Abeta抗体的可变区的本发明的抗体及其片段与Abeta强烈反应从而抑制其聚集，因此可用作预防和治疗阿尔茨海默病的药物痴呆。

23. 发明授权

US5946962A Method for manufacturing a turbine shell 失效
标题翻译：涡轮壳体的制造方法
公开(公告)号：US5946962A
公开(公告)日：1999-09-07
申请号：US136422
申请日：1998-08-20
申请人： Toshikazu Fukuda , Toshihiro Nakashima
发明人： Toshikazu Fukuda , Toshihiro Nakashima
IPC分类号： B21D53/78 , B21D53/84 , B23P15/00 , F16H41/28 , B21D28/30
CPC分类号： F16H41/28 , B21D53/78 , B21D53/84 , B23P15/00 , Y10T29/4933
摘要： According to the present invention, a turbine shell is manufactured by a method which includes the steps of preparing a planar blank, simultaneously forming a plurality of blade fixture slits 32A, 32B and 32C in the blank 40, and deforming the blank 40 into a curved concave shape by effecting drawing work.
摘要翻译：根据本发明，通过一种方法制造涡轮壳体，该方法包括以下步骤：制备平面坯料，同时在坯料40中形成多个刀片固定缝32A，32B和32C，并将坯料40变形成弯曲通过进行绘图工作，形成凹形。

24. 发明授权

US5623602A Data transmission confirmation by sending frame with command to change transmitter's resend counter when receiver's buffer is full 失效
标题翻译：通过发送帧的数据传输确认，当接收机的缓冲区已满时，用命令改变发射机的重发计数器
公开(公告)号：US5623602A
公开(公告)日：1997-04-22
申请号：US44485
申请日：1993-04-09
申请人： Toshihiro Nakashima
发明人： Toshihiro Nakashima
IPC分类号： G06F13/00 , H04L12/28 , H04L29/06 , H04L29/08 , G06F13/12 , G06F13/42
CPC分类号： H04L47/10 , H04L29/06 , H04L47/32 , H04L69/324
摘要： A computer network system includes a plurality of computers and a network connected to the computers for allowing them to interchange data. Each computer has a data send module and a data receive module. The data send module is made up of a means for sending a data frame to the network in response to a send request, a resend number storing means for storing the number of times that the data frame is to be resent, and a means for updating the content of the resend number storing means upon receiving a frame for changing the number of times that the data frame is to be resent from the network. The data receive module includes a receive buffer for storing the data frame received from the network, and a means for sending, when the receive buffer is full, the frame for changing the number of times that the data frame is to be resent to the network.
摘要翻译：计算机网络系统包括多个计算机和连接到计算机以允许它们互换数据的网络。每台计算机都有一个数据发送模块和一个数据接收模块。数据发送模块由用于响应于发送请求向网络发送数据帧的装置，用于存储要重发数据帧的次数的重发数量存储装置和用于更新的装置在接收到用于改变要从网络重新发送数据帧的次数的帧时，重发数存储装置的内容。数据接收模块包括用于存储从网络接收的数据帧的接收缓冲器，以及用于当接收缓冲器满时发送用于将数据帧重新发送到网络的次数发送的帧的装置。

25. 发明授权

US09873730B2 Method for improving antibody 有权
公开(公告)号：US09873730B2
公开(公告)日：2018-01-23
申请号：US11815838
申请日：2006-02-07
申请人： Masaharu Torikai , Toshihiro Nakashima
发明人： Masaharu Torikai , Toshihiro Nakashima
IPC分类号： C07K16/00 , C07K16/12 , C07K16/28
CPC分类号： C07K16/00 , C07K16/1271 , C07K16/2818 , C07K2317/21 , C07K2317/24 , C07K2317/567 , C07K2317/94
摘要： The present invention provides for a method for improving properties of an antibody such as an expression level and stability. A method for obtaining an antibody with an improved expression level and/or stability by modifying a human antibody or a humanized antibody, characterized by that at least any one of the amino acid residues at position 8, 12, 15 or 18 (according to Kabat numbering) in a light chain variable region (hereinafter referred to as “VL chain”) of a human antibody or a humanized antibody is substituted with a different amino acid other than proline or cysteine, and a human antibody or a humanized antibody or a human antibody fragment or a humanized antibody fragment with an improved expression level and/or stability which are obtained by said method.

26. 发明授权

US08715655B2 Human anti-α9 integrin antibody 有权
标题翻译：人抗α9整联蛋白抗体
公开(公告)号：US08715655B2
公开(公告)日：2014-05-06
申请号：US12810939
申请日：2008-12-26
申请人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
IPC分类号： A61K39/395 , C07K16/00 , C07K16/46 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译：本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段，编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗-α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎其含有抗体或抗体片段。

27. 外观设计

USD669533S1 Electronic whiteboard 有权
标题翻译：电子白板
公开(公告)号：USD669533S1
公开(公告)日：2012-10-23
申请号：US29416904
申请日：2012-03-28
申请人： Keiichi Okabe , Toshihiro Nakashima , Atsushi Tani
设计人： Keiichi Okabe , Toshihiro Nakashima , Atsushi Tani

28. 发明授权

US07947290B2 Protease-resistant modified SEB and vaccine containing the same 有权
标题翻译：蛋白酶抗性修饰SEB和含有相同的疫苗
公开(公告)号：US07947290B2
公开(公告)日：2011-05-24
申请号：US12644952
申请日：2009-12-22
申请人： Toshihiro Nakashima , Takumi Sasaki , Tsukasa Nishihara , Sumiyo Takemoto , Atsuko Sakata , Masao Ohkuchi , Tomoyuki Koshi , Toshiyuki Edano
发明人： Toshihiro Nakashima , Takumi Sasaki , Tsukasa Nishihara , Sumiyo Takemoto , Atsuko Sakata , Masao Ohkuchi , Tomoyuki Koshi , Toshiyuki Edano
IPC分类号： A61K39/085 , A61K39/09 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/31 , A61K39/00
摘要： A modified Staphylococcal enterotoxin B (SEB) having resistance to a protease and a reduced toxicity and a vaccine comprising said modified SEB are provided. A modified SEB which has an amino acid sequence as set forth in SEQ ID NO: 1 wherein each of the lysine at 97-position and the lysine at 98-position are substituted with any other amino acid, or a derivative thereof and a vaccine comprising said modified SEB or a derivative thereof.
摘要翻译：提供了具有对蛋白酶的抗性和毒性降低的改良的葡萄球菌肠毒素B（SEB）和包含所述修饰的SEB的疫苗。具有如SEQ ID NO：1所示的氨基酸序列的修饰的SEB，其中97位的赖氨酸和98位的赖氨酸都被任何其它氨基酸或其衍生物和包含所述修饰的SEB或其衍生物。

29. 发明申请

US20110059077A1 HUMANIZED ANTI-HUMAN ALPHA 9-INTEGRIN ANTIBODY 有权
标题翻译：人类抗人ALPHA 9整合抗体
公开(公告)号：US20110059077A1
公开(公告)日：2011-03-10
申请号：US12812341
申请日：2009-01-09
申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
IPC分类号： C07K16/28 , C12N15/13 , C12N15/70 , C12N1/21 , C12P21/08 , A61K39/395
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
摘要翻译：本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体由由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含由SEQ ID NO：17所示的重链可变区组成的人源化抗人α9整联蛋白抗体由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及用于预防或治疗涉及人α9整数的各种疾病的手段 rin在发病机制中，其使用抗体。

30. 发明申请

US20110014193A1 HUMANIZED ANTI-HUMAN ALPHA 9-INTEGRIN ANTIBODY 审中-公开
标题翻译：人类抗人ALPHA 9整合抗体
公开(公告)号：US20110014193A1
公开(公告)日：2011-01-20
申请号：US12812368
申请日：2009-07-09
申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06 , A61P19/02
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human α9 integrin in their pathogenesis, which uses the antibody.
摘要翻译：本发明提供了与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即人源化抗人α9整联蛋白抗体，其包含由以下组成的重链可变区： SEQ ID NO：1所示的氨基酸序列或SEQ ID NO：1所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及由氨基酸组成的轻链可变区 SEQ ID NO：61所示的酸序列或SEQ ID NO：61所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及用于预防或治疗涉及人α9整合素在其发病机制中，其使用抗体。

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