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41. 发明授权

US08509031B2 H-bridge pulse generator 失效
标题翻译： H桥脉冲发生器
公开(公告)号：US08509031B2
公开(公告)日：2013-08-13
申请号：US12800945
申请日：2010-05-26
申请人： Stephen Smith
发明人： Stephen Smith
IPC分类号： H04B1/02
CPC分类号： B06B1/0269 , B06B1/0215
摘要： Circuitry for high-power, high-frequency excitation of electromagnetic acoustic transducers (EMAT) without the use of a matching transformer is described. This circuit contains at least 4 switching devices, arranged in an H-Bridge configuration to drive EMATs over a range of frequencies. The switching devices can be connected in parallel with respect to the H-Bridge and switched in sequence for greater power output and variety of wave forms including, Churp, Hemming window tone burst, rectangular tone burst and Barker Code wave forms. A circuit for driving sensor coils of an EMAT to correct the disadvantages of conventional pulsers. A plurality of switching devices are connected in parallel and augmented with support circuitry to provide increased power output, stability, reduced noise and complex output wave forms. This design provides for the application of modulated pulses such as multi-pulse, multi-frequency bursts with peak power outputs over 20,000 watts and frequencies over 10,000 Hertz.
摘要翻译：描述了不使用匹配变压器的电磁声换能器（EMAT）的高功率，高频激励电路。该电路包含至少4个开关器件，以H桥配置布置，以在一定频率范围内驱动EMAT。开关设备可以相对于H桥并联连接并且按顺序交换以获得更大的功率输出和各种波形，包括Churp，Hemming窗口音突发，矩形色调和Barker码波形。用于驱动EMAT的传感器线圈以校正传统脉冲发生器的缺点的电路。多个开关装置并联连接并用支持电路增加以提供增加的功率输出，稳定性，降低的噪声和复杂的输出波形。该设计提供了调制脉冲的应用，例如多脉冲，多频突发，峰值功率输出超过20,000瓦，频率超过10,000赫兹。

42. 发明授权

US08192410B2 Control device for surgical stoma 失效
标题翻译：手术造口用控制装置
公开(公告)号：US08192410B2
公开(公告)日：2012-06-05
申请号：US12540110
申请日：2009-08-12
申请人： Stephen Smith , Deborah Smith
发明人： Stephen Smith , Deborah Smith
IPC分类号： A61M1/00
CPC分类号： A61F5/445
摘要： A control device for controlling drainage of waste from a surgical stoma of a human body. The control device comprises a first cylindrical hollow body member, a drain tube extending from the first cylindrical hollow body member, a second cylindrical hollow body member rotatably coupled to the first cylindrical hollow body member and a knob configured on the second cylindrical hollow body member. The first cylindrical hollow body member comprises a skirt portion extending radially outward for being removably attached to a surface surrounding the surgical stoma of the human body. The second cylindrical hollow body member comprises an aperture configured on the second sidewall. A rotation of the knob is capable of aligning the aperture of the second cylindrical hollow body member with the drain tube of the first cylindrical hollow body member thereby forming a passage for draining the waste.
摘要翻译：一种用于控制来自人体手术造口的废物排出的控制装置。控制装置包括第一圆柱形中空本体构件，从第一圆柱形中空本体构件延伸的排水管，可旋转地联接到第一圆柱形中空本体构件的第二圆柱形中空本体构件和构造在第二圆柱形中空本体构件上的旋钮。第一圆柱形中空本体构件包括径向向外延伸的裙部，用于可拆卸地附接到围绕人体手术造口的表面。第二圆柱形中空本体构件包括构造在第二侧壁上的孔。旋钮的旋转能够使第二圆柱形中空本体构件的孔与第一圆柱形中空本体构件的排放管对准，从而形成用于排出废物的通道。

43. 发明申请

US20120130568A1 DATA COMMUNICATION SYSTEM FOR A RAIL VEHICLE CONSIST AND METHOD FOR COMMUNICATING DATA WITH A RAIL VEHICLE CONSIST 审中-公开
标题翻译：用于铁路车辆信息的数据通信系统和用于与轨道车辆通信的数据的方法
公开(公告)号：US20120130568A1
公开(公告)日：2012-05-24
申请号：US13046808
申请日：2011-03-14
申请人： Samuel GOLDEN , David Eldredge , Robert Foy , Stephen Smith , John William Brand , Kevin Kapp
发明人： Samuel GOLDEN , David Eldredge , Robert Foy , Stephen Smith , John William Brand , Kevin Kapp
IPC分类号： G05D1/00 , H04Q5/22
CPC分类号： H04Q9/00 , B61L15/0072 , B61L27/0077 , H04Q2209/30 , H04Q2209/47
摘要： A data communication system for a rail vehicle consist includes a data reading device and a processing module. The data reading device is disposed on the consist and is configured to interrogate and read data from a tangible and non-transitory medium that is spaced apart from the data reading device. The processing module is disposed on the rail vehicle consist and is communicatively coupled with the data reading device. The processing module receives the data from the data reading device and uses the data in connection with one or more operations of the rail vehicle consist. A method for communicating data with a rail vehicle consist includes interrogating and reading data from a tangible and non-transitory medium using an electronic reading device while the medium is spaced apart from the reading device and using the data in connection with one or more operations of the rail vehicle consist based on the data.
摘要翻译：轨道车辆组合的数据通信系统包括数据读取装置和处理模块。数据读取装置设置在组合上，并被配置成询问和从与数据读取装置间隔开的有形和非暂时介质读取数据。处理模块设置在轨道车辆组合件上，并且与数据读取装置通信地耦合。处理模块从数据读取装置接收数据，并使用与轨道车辆组合的一个或多个操作有关的数据。用于与轨道车辆组件通信数据的方法包括使用电子读取装置从有形和非暂时介质询问和读取数据，同时介质与读取装置间隔开并且使用与一个或多个操作相关的数据铁路车辆根据数据组成。

44. 发明授权

US07883704B2 Methods for inhibiting the activity of the P40 subunit of human IL-12 有权
标题翻译：抑制人IL-12的P40亚基活性的方法
公开(公告)号：US07883704B2
公开(公告)日：2011-02-08
申请号：US11645287
申请日：2006-12-22
申请人： Jochen G. Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Edward Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Kantor , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen G. Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Edward Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Kantor , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： A61K38/20 , A61K39/395 , C07K16/24 , C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12 ) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译：公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

45. 发明申请

US20100135853A1 AUTOMATIC ISOTHERMAL TITRATION MICROCALORIMETER APPARATUS AND METHOD OF USE 有权
标题翻译：自动同位素微量滴定仪装置及其使用方法
公开(公告)号：US20100135853A1
公开(公告)日：2010-06-03
申请号：US12326300
申请日：2008-12-02
申请人： MARTIN BROGA , Phillip Price , Stephen Smith
发明人： MARTIN BROGA , Phillip Price , Stephen Smith
IPC分类号： G01N25/20
CPC分类号： G01N25/4873 , B01L3/02 , G01K17/006 , G01N1/14 , G01N25/20 , G01N25/48 , G01N25/4813 , G01N25/4866 , G01N35/00584 , G01N35/0092 , G01N35/1002
摘要： Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.
摘要翻译：自动等温滴定微量热法（ITC）系统，其包括具有样品池和参比细胞的微量热计，样品池可通过样品细胞茎进行，参考细胞可通过参考细胞茎进入。所述系统还包括自动移液管组件，其包括具有滴定针的注射器，所述滴定针被布置成插入到所述样品池中用于供应滴定剂，所述移液管组件包括用于驱动所述注射器中的柱塞的活化剂，支持所述移液管组件的移液管平移单元，布置成将移液管放置在适当位置用于滴定，洗涤和灌装操作，用于滴定针的洗涤台，以及细胞制备单元，其被配置为当移液管放置在另一位置时执行替换样品池中的样品液体的操作，滴定的位置。

46. 发明申请

US20090220371A1 METHODS FOR DIMENSIONAL RESTORATION OF ROOTS TYPE BLOWER ROTORS, RESTORED ROTORS, AND APPARATUS HAVING RESTORED ROTOR 审中-公开
标题翻译：用于尺寸恢复的类型的鼓风机，恢复的转子和具有恢复的转子的装置的方法
公开(公告)号：US20090220371A1
公开(公告)日：2009-09-03
申请号：US12040207
申请日：2008-02-29
申请人： Alistair Jeffrey Smith , Stephen Smith
发明人： Alistair Jeffrey Smith , Stephen Smith
IPC分类号： B23P6/00 , F04C18/18 , F04C27/00
CPC分类号： B23P6/00 , F04C18/126 , F04C2230/602 , F04C2230/80 , F04C2230/91 , Y10T29/49721 , Y10T29/49723 , Y10T29/49746
摘要： Method includes applying additive material to a pre-selected region of a rotor for use in a Roots type blower assembly. The additive material restores structural dimension to provide measured rotor-to-rotor clearance and/or rotor-to-case clearance within the predetermined clearance range. The additive material may be an epoxy paint material or a plating material. The method includes measuring the clearances, preparing the rotor surface, applying the additive material, and re-measuring the clearance. The restored rotor may be returned to service, for example, in a locomotive diesel. The disclosure also provides a restored rotor including at least one region comprising the additive material. Additionally, the disclosure provides an apparatus including a dimensionally restored rotor.
摘要翻译：方法包括将添加剂材料施加到用于罗茨式鼓风机组件的转子的预选区域。添加剂材料恢复结构尺寸以在预定间隙范围内提供测量的转子间转子间隙和/或转子间隙。添加剂材料可以是环氧漆材料或电镀材料。该方法包括测量间隙，制备转子表面，施加添加剂材料，并重新测量间隙。恢复的转子可以例如在机车柴油中恢复使用。本公开还提供了一种还原的转子，其包括至少一个包含添加剂材料的区域。另外，本公开提供了一种包括尺寸恢复的转子的装置。

47. 发明授权

US07504485B2 Human antibodies that bind human IL-12 有权
标题翻译：结合人IL-12的人抗体
公开(公告)号：US07504485B2
公开(公告)日：2009-03-17
申请号：US10884830
申请日：2004-07-01
申请人： Jochen G. Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Edward Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine J. Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen G. Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Edward Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine J. Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译：公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

48. 发明申请

US20080066450A1 System and Method for Controlling Valve Timing of an Engine with Cylinder Deactivation 有权
标题翻译：用于控制气缸停用的发动机气门正时控制系统和方法
公开(公告)号：US20080066450A1
公开(公告)日：2008-03-20
申请号：US11872150
申请日：2007-10-15
申请人： Gopichandra Surnilla , Christian Goralski , Stephen Smith
发明人： Gopichandra Surnilla , Christian Goralski , Stephen Smith
IPC分类号： F01N3/18
CPC分类号： F02D41/0082 , F01N3/101 , F01N13/011 , F01N2430/02 , F02B17/005 , F02B2075/125 , F02D13/0219 , F02D13/06 , F02D17/02 , F02D41/0032 , F02D41/0087 , F02M25/089 , Y02A50/2324 , Y02T10/123 , Y02T10/18 , Y02T10/22
摘要： Various systems and methods are disclosed for carrying out combustion in a fuel-cut operation in some or all of the engine cylinders of a vehicle. Further, various subsystems are considered, such as fuel vapor purging, air-fuel ratio control, engine torque control, catalyst design, and exhaust system design.
摘要翻译：公开了用于在车辆的一些或所有发动机气缸中的燃料切断操作中进行燃烧的各种系统和方法。此外，考虑了各种子系统，例如燃料蒸气吹扫，空燃比控制，发动机转矩控制，催化剂设计和排气系统设计。

49. 发明申请

US20080008285A1 Carrier phase synchronization system for improved amplitude modulation and television broadcast reception 失效
标题翻译：载波相位同步系统，用于改进幅度调制和电视广播接收
公开(公告)号：US20080008285A1
公开(公告)日：2008-01-10
申请号：US11803712
申请日：2007-05-14
申请人： Stephen Smith , James Moore
发明人： Stephen Smith , James Moore
IPC分类号： H04L7/033 , H03D3/24
CPC分类号： H04L27/0014 , H03D3/248 , H04H20/12 , H04H20/49 , H04H20/67 , H04L27/06
摘要： Systems and methods are described for carrier phase synchronization for improved AM and TV broadcast reception. A method includes synchronizing the phase of a carrier frequency of a broadcast signal with the phase of a remote reference frequency. An apparatus includes a receiver to detect the phase of a reference signal; a phase comparator coupled to the reference signal-phase receiver; a voltage controlled oscillator coupled to the phase comparator; and a phase-controlled radio frequency output coupled to the voltage controlled oscillator.
摘要翻译：描述了用于载波相位同步以改进AM和TV广播接收的系统和方法。一种方法包括使广播信号的载波频率的相位与远程参考频率的相位同步。一种装置，包括：检测参考信号的相位的接收器; 相位比较器，耦合到参考信号相位接收器; 耦合到相位比较器的压控振荡器; 以及耦合到压控振荡器的相位控制射频输出。

50. 发明申请

US20070170083A1 Stand-up packaging 审中-公开
标题翻译：立式包装
公开(公告)号：US20070170083A1
公开(公告)日：2007-07-26
申请号：US11336589
申请日：2006-01-20
申请人： Stephen Smith , Ayberk Abayhan
发明人： Stephen Smith , Ayberk Abayhan
IPC分类号： B65D21/00 , B65D65/00
CPC分类号： B65D61/00 , B65D71/066
摘要： Stand-up packaging is disclosed. The stand-up packaging has a cradle, and an object or a plurality of stacked and nested objects. The cradle fits against a bottom portion of a profile of the object or the stacked objects. The object or stack of objects and the cradle may be wrapped within a retaining member, such as a clear polymeric film.
摘要翻译：公开了立式包装。立式包装具有支架，物体或多个堆叠和嵌套的物体。托架装配在物体或堆叠物体的轮廓的底部。物体和物体的堆叠物和托架可以包裹在保持构件内，例如透明的聚合物膜。

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