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1. 发明申请

US20160297854A1 COMPOSITIONS AND METHODS FOR LONG ACTING MOLECULES 审中-公开
标题翻译：组合物和长期作用分子的方法
公开(公告)号：US20160297854A1
公开(公告)日：2016-10-13
申请号：US15186025
申请日：2016-06-17
申请人： Joy GHOSH , Michael ROGUSKA , Andrew Anh NGUYEN , Thomas PIETZONKA , Matthias MACHACEK , Andrei GOLOSOV
发明人： Joy GHOSH , Michael ROGUSKA , Andrew Anh NGUYEN , Thomas PIETZONKA , Matthias MACHACEK , Andrei GOLOSOV
IPC分类号： C07K14/00 , A61K31/713 , A61K47/48 , C07K16/22 , C12N15/115
CPC分类号： C07K14/00 , A61K31/713 , A61K38/00 , A61K39/3955 , A61K47/42 , A61K47/64 , C07K14/4718 , C07K16/22 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/20 , C07K2319/31 , C07K2319/33 , C12N15/115 , C12N2310/16 , C12N2310/3513 , C12N2320/32
摘要： The invention relates, in part, to compositions and methods that utilize a peptide tag that binds to hemagglutanin (HA). The HA tag can be linked to a molecule such as a protein or nucleic acid which, when administered to the eye, results in an increase in ocular half-life and/or mean residence time, and or a decrease in ocular clearance of the protein or nucleic acid. The invention also encompasses methods for treating ocular disease, including retinal vascular disease, by administering a protein or nucleic acid linked to an HA peptide tag.
摘要翻译：本发明部分地涉及利用结合血凝素（HA）的肽标签的组合物和方法。 HA标签可以连接到分子，例如蛋白质或核酸，当被施用于眼睛时，导致眼半衰期和/或平均停留时间的增加和/或蛋白质的眼清除率的降低或核酸。本发明还包括通过施用与HA肽标签连接的蛋白质或核酸来治疗眼部疾病（包括视网膜血管疾病）的方法。

2. 发明授权

US08883158B2 Compositions and methods for antibodies targeting complement protein C5 有权
标题翻译：针对补体蛋白C5的抗体的组合物和方法
公开(公告)号：US08883158B2
公开(公告)日：2014-11-11
申请号：US13557562
申请日：2012-07-25
申请人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
发明人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
IPC分类号： A61K39/395 , C07K16/18 , C07K16/46
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
摘要翻译：本发明涉及靶向补体蛋白C5的抗体及其使用方法。

3. 发明授权

US08865174B2 Methods of treatment using human antibodies that bind IL-12 有权
标题翻译：使用结合IL-12的人抗体治疗的方法
公开(公告)号：US08865174B2
公开(公告)日：2014-10-21
申请号：US13418049
申请日：2012-03-12
申请人： Jochen G. Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Edward Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Kantor , John Gawain Elvin , Alexander Robert Duncan , Elaine J. Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen G. Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Edward Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Kantor , John Gawain Elvin , Alexander Robert Duncan , Elaine J. Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： A61K39/395 , A61K39/00 , C07K16/24 , C12P21/08
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译：公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗体部分可用于检测hIL-12和用于抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

4. 发明申请

US20120201831A1 HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING 审中-公开
标题翻译：人类IL-12的人体抗体和生产方法
公开(公告)号：US20120201831A1
公开(公告)日：2012-08-09
申请号：US13416783
申请日：2012-03-09
申请人： Jochen G. Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Edward Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Kantor , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen G. Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Edward Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Kantor , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： A61K39/395 , A61P29/00 , A61P19/02 , A61P19/04 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/16 , A61P11/06 , A61P37/08 , A61P17/06 , A61P17/00 , A61P37/06 , A61P9/10 , A61P13/12 , A61P31/14 , A61P27/02 , A61P37/00 , A61P11/00 , A61P31/00 , A61P33/00 , A61P21/04 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/00 , A61P1/16 , A61P7/06 , A61P9/04 , G01N33/566 , C07K14/54 , C12N5/071 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译：公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

5. 发明申请

US20110008357A1 ANTIBODIES THAT BIND IL-18 AND METHODS OF INHIBITING IL-18 ACTIVITY 审中-公开
标题翻译：阻断IL-18的抗体和抑制IL-18活性的方法
公开(公告)号：US20110008357A1
公开(公告)日：2011-01-13
申请号：US12786095
申请日：2010-05-24
申请人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
发明人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
IPC分类号： A61K39/395 , C12P21/00 , C12N5/07 , C12N15/63 , C40B30/04 , C07K2/00 , C07K14/00 , C07K16/24 , C07H21/00 , A61P1/16 , A61P19/02 , A61P29/00 , A61P3/10 , A61P37/06 , A61P25/28 , A61P25/16 , A61P9/10 , A61P37/08 , A61P17/06 , A61P13/12 , A61P11/00 , A61P9/00 , A61P15/08 , A61P25/24 , A61P11/06 , A61P5/16 , A61P5/18 , A61P5/50
CPC分类号： C07K16/244 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K39/395 , A61K31/00
摘要： Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译：提供了结合人白细胞介素-18（hIL-18）的抗体，特别是结合人IL-18表位的抗体。抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。优选的抗体对hIL-18具有高亲和力，并在体外和体内中和hIL-18活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。

6. 发明授权

US07700739B2 IL-12/p40 binding proteins 有权
标题翻译： IL-12 / p40结合蛋白
公开(公告)号：US07700739B2
公开(公告)日：2010-04-20
申请号：US11478096
申请日：2006-06-29
申请人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
发明人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译：本发明包括IL-12p40结合蛋白，特别是结合人白细胞介素-12（hIL-12）和/或人IL-23（hIL-23）的抗体。具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。优选的抗体对hIL-12和/或hIL-23具有高亲和力，并在体外和体内中和h IL-12和/或hIL-23活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性，例如在患有hIL -12和/或hIL-23活性是有害的。

7. 发明申请

US20090311241A9 Human antibodies that bind human IL-12 and methods for producing 有权
标题翻译：结合人IL-12的人抗体及其生产方法
公开(公告)号：US20090311241A9
公开(公告)日：2009-12-17
申请号：US11645287
申请日：2006-12-22
申请人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas Warne , Angela Kantor , John Elvin , Alexander Duncan , Elaine Derbyshire , Sara Carmen , Stephen Smith , Thor Holtet , Sarah Du Fou
发明人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas Warne , Angela Kantor , John Elvin , Alexander Duncan , Elaine Derbyshire , Sara Carmen , Stephen Smith , Thor Holtet , Sarah Du Fou
IPC分类号： A61K39/395 , A61P37/00 , C07K14/54 , C07K16/24 , G01N33/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译：公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

8. 发明申请

US20050227289A1 Antibodies to erythropoietin receptor and uses thereof 审中-公开
标题翻译：促红细胞生成素受体的抗体及其用途
公开(公告)号：US20050227289A1
公开(公告)日：2005-10-13
申请号：US10822306
申请日：2004-04-12
申请人： Edward Reilly , Susan Lacy , Emma Fung , Jonathan Belk , Michael Roguska
发明人： Edward Reilly , Susan Lacy , Emma Fung , Jonathan Belk , Michael Roguska
IPC分类号： A61K39/395 , C07K16/28 , C12N5/10 , C12N15/13 , C12N15/63 , C12Q1/70 , G01N33/53
CPC分类号： C07K16/2863 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/74 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions.
摘要翻译：本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。本发明还涉及编码这种抗体和抗原结合部分的核酸序列。本发明还涉及使用所述抗体和抗原结合部分，治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。

9. 发明申请

US20170202981A1 COMPOSITIONS AND METHODS FOR VISUALIZATION OF THE VITREOUS 审中-公开
公开(公告)号：US20170202981A1
公开(公告)日：2017-07-20
申请号：US15321025
申请日：2015-06-24
申请人： Joy GHOSH , Thaddeus Peter DRYJA , Michael ROGUSKA , Eric C. CARLSON
发明人： Joy GHOSH , Thaddeus Peter DRYJA , Michael ROGUSKA , Eric C. CARLSON
IPC分类号： A61K49/00 , A61K9/00
摘要： The invention provides compositions for rendering a vitreous cavity visible during a surgical procedure to alleviate a structural disorder caused by the vitreous in an eye, and methods of using the compositions. The compositions are vitreous delineating agents that comprise a hyaluronan binding peptide linked to an optically detectable moiety. Such compositions can be in a formulation that may be a solution, a suspension, or an emulsion, and would be injected into the vitreous shortly prior to use. The composition may additionally contain a therapeutic agent, a diagnostic agent, or a chemosensing material, in use, the composition marks or delineates the vitreous by binding preferentially to the hyaluronan that permeates the vitreous humor and binding little or not at all to surrounding tissues such as the retina. The interface between the labelled vitreous humor and the non-labelled surrounding vital tissues produces a visible signal, thereby allowing a surgeon to clearly visualize the entire vitreous cavity and distinguish it from vital ocular structures. Use of the method improves the accuracy and safety of a vitrectomy and thus prevents suboptimal outcomes or the need for repeated procedures. The compositions comprising chemosensing material are useful as long-lasting biosensors, which when used in the vitreous enable repetitive, non-invasive, in vivo measurements of metabolites or pharmacologic agents in the vitreous of animals or humans.

10. 发明申请

US20140199306A1 COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING EPO 有权
标题翻译：针对EPO抗体的组合物和方法
公开(公告)号：US20140199306A1
公开(公告)日：2014-07-17
申请号：US14095910
申请日：2013-12-03
申请人： Joy GHOSH , Mark Anthony RUTZ , Katrin Ulrike TISSOT-DAGUETTE , Igor SPLAWSKI , Michael ROGUSKA
发明人： Joy GHOSH , Mark Anthony RUTZ , Katrin Ulrike TISSOT-DAGUETTE , Igor SPLAWSKI , Michael ROGUSKA
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for the inhibition of EPO. The invention provides antibodies and antigen binding fragments thereof that bind to EPO and are able to inhibit EPO-dependent cell proliferation and/or EPO-dependent cell signaling.
摘要翻译：本发明涉及抑制EPO的组合物和方法。本发明提供了结合EPO并能够抑制EPO依赖性细胞增殖和/或EPO依赖性细胞信号传导的抗体及其抗原结合片段。

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